Incidental Mutation 'R4824:Kntc1'
| ID |
374207 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kntc1
|
| Ensembl Gene |
ENSMUSG00000029414 |
| Gene Name |
kinetochore associated 1 |
| Synonyms |
jgl |
| MMRRC Submission |
042440-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R4824 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123887779-123959656 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 123928196 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 1231
(L1231*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031366]
|
| AlphaFold |
Q8C3Y4 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000031366
AA Change: L1231*
|
| SMART Domains |
Protein: ENSMUSP00000031366
Gene: ENSMUSG00000029414
AA Change: L1231*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
345 |
357 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1044 |
N/A |
INTRINSIC |
|
Pfam:Rod_C
|
1579 |
2128 |
3.2e-256 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198716
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
98% (123/126) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,771,437 (GRCm39) |
T209A |
probably benign |
Het |
| 1700086D15Rik |
T |
C |
11: 65,043,441 (GRCm39) |
|
probably benign |
Het |
| A130010J15Rik |
G |
A |
1: 192,856,965 (GRCm39) |
V106I |
probably benign |
Het |
| Abca16 |
C |
A |
7: 120,074,702 (GRCm39) |
N580K |
possibly damaging |
Het |
| Actrt2 |
A |
T |
4: 154,751,344 (GRCm39) |
F264Y |
probably damaging |
Het |
| Adh4 |
G |
A |
3: 138,134,807 (GRCm39) |
S327N |
possibly damaging |
Het |
| Alkbh5 |
T |
C |
11: 60,444,697 (GRCm39) |
|
probably null |
Het |
| Anapc1 |
T |
A |
2: 128,470,610 (GRCm39) |
T1507S |
possibly damaging |
Het |
| Anapc2 |
A |
G |
2: 25,167,764 (GRCm39) |
R444G |
probably damaging |
Het |
| Apoh |
G |
T |
11: 108,305,087 (GRCm39) |
W335L |
probably benign |
Het |
| B4galt7 |
A |
T |
13: 55,752,162 (GRCm39) |
H71L |
possibly damaging |
Het |
| Bicd2 |
A |
G |
13: 49,532,488 (GRCm39) |
E358G |
probably damaging |
Het |
| Bmper |
T |
A |
9: 23,134,956 (GRCm39) |
V7D |
possibly damaging |
Het |
| Brca2 |
T |
C |
5: 150,463,200 (GRCm39) |
F988S |
probably damaging |
Het |
| Brix1 |
A |
G |
15: 10,485,828 (GRCm39) |
V49A |
possibly damaging |
Het |
| Brpf3 |
T |
C |
17: 29,025,460 (GRCm39) |
S178P |
probably benign |
Het |
| Btaf1 |
A |
G |
19: 36,958,448 (GRCm39) |
Y655C |
possibly damaging |
Het |
| C1rl |
C |
G |
6: 124,486,040 (GRCm39) |
Y470* |
probably null |
Het |
| Cacnb4 |
A |
G |
2: 52,565,822 (GRCm39) |
V21A |
probably benign |
Het |
| Caskin1 |
C |
A |
17: 24,720,103 (GRCm39) |
P437T |
probably benign |
Het |
| Casz1 |
C |
A |
4: 149,029,028 (GRCm39) |
P1158T |
probably damaging |
Het |
| Ccdc141 |
T |
A |
2: 76,954,680 (GRCm39) |
Q189L |
probably damaging |
Het |
| Ccr3 |
T |
C |
9: 123,828,809 (GRCm39) |
V48A |
probably damaging |
Het |
| Cebpd |
G |
A |
16: 15,705,978 (GRCm39) |
G264S |
probably benign |
Het |
| Cert1 |
C |
T |
13: 96,752,995 (GRCm39) |
P350S |
probably benign |
Het |
| Cfap20dc |
A |
T |
14: 8,665,997 (GRCm38) |
M1K |
probably null |
Het |
| Chd1 |
C |
A |
17: 15,953,386 (GRCm39) |
S440R |
probably damaging |
Het |
| Clip1 |
T |
A |
5: 123,769,086 (GRCm39) |
E504D |
probably damaging |
Het |
| Cmya5 |
T |
C |
13: 93,230,082 (GRCm39) |
R1669G |
probably benign |
Het |
| Col11a2 |
T |
A |
17: 34,269,937 (GRCm39) |
F456I |
probably damaging |
Het |
| Ctnna2 |
A |
T |
6: 76,957,764 (GRCm39) |
M130K |
probably damaging |
Het |
| Elmo2 |
A |
T |
2: 165,133,922 (GRCm39) |
|
probably benign |
Het |
| F11 |
T |
C |
8: 45,708,379 (GRCm39) |
D27G |
probably damaging |
Het |
| Faap100 |
A |
T |
11: 120,266,412 (GRCm39) |
|
probably null |
Het |
| Fat1 |
A |
G |
8: 45,442,151 (GRCm39) |
E1151G |
probably damaging |
Het |
| Fbll1 |
T |
A |
11: 35,688,652 (GRCm39) |
I204F |
probably damaging |
Het |
| Gle1 |
T |
A |
2: 29,830,215 (GRCm39) |
V257D |
possibly damaging |
Het |
| Hoxc9 |
T |
A |
15: 102,890,225 (GRCm39) |
C47* |
probably null |
Het |
| Hsd17b6 |
A |
G |
10: 127,829,524 (GRCm39) |
V226A |
probably benign |
Het |
| Hsd17b7 |
C |
T |
1: 169,788,764 (GRCm39) |
R151Q |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Ido2 |
A |
G |
8: 25,023,875 (GRCm39) |
I321T |
probably benign |
Het |
| Irf2bp2 |
T |
C |
8: 127,318,172 (GRCm39) |
T465A |
probably benign |
Het |
| Kdm2a |
A |
G |
19: 4,412,815 (GRCm39) |
M34T |
probably damaging |
Het |
| Klhl6 |
C |
T |
16: 19,775,778 (GRCm39) |
R260H |
probably damaging |
Het |
| Lca5l |
A |
C |
16: 95,963,229 (GRCm39) |
Y412* |
probably null |
Het |
| Lipt1 |
T |
C |
1: 37,914,513 (GRCm39) |
S190P |
possibly damaging |
Het |
| Ly6f |
T |
A |
15: 75,143,569 (GRCm39) |
V92D |
probably damaging |
Het |
| Matn4 |
T |
A |
2: 164,235,151 (GRCm39) |
M433L |
probably benign |
Het |
| Mbtd1 |
C |
A |
11: 93,816,528 (GRCm39) |
P370T |
probably benign |
Het |
| Mcph1 |
T |
A |
8: 18,682,703 (GRCm39) |
|
probably null |
Het |
| Muc5b |
T |
A |
7: 141,417,922 (GRCm39) |
C3623S |
probably damaging |
Het |
| Myt1l |
C |
A |
12: 29,899,399 (GRCm39) |
H134N |
probably benign |
Het |
| Nav2 |
A |
T |
7: 49,058,749 (GRCm39) |
|
probably benign |
Het |
| Ndufaf8 |
T |
C |
11: 119,989,992 (GRCm39) |
C35R |
probably damaging |
Het |
| Neb |
G |
A |
2: 52,094,891 (GRCm39) |
T5130I |
possibly damaging |
Het |
| Nlrp9c |
T |
C |
7: 26,079,989 (GRCm39) |
N624S |
possibly damaging |
Het |
| Nr0b2 |
C |
A |
4: 133,283,334 (GRCm39) |
H190Q |
probably damaging |
Het |
| Nrg4 |
A |
G |
9: 55,156,405 (GRCm39) |
|
probably benign |
Het |
| Nup88 |
A |
T |
11: 70,852,450 (GRCm39) |
V215E |
probably benign |
Het |
| Oas2 |
T |
G |
5: 120,876,411 (GRCm39) |
T511P |
probably benign |
Het |
| Or1e25 |
A |
G |
11: 73,493,426 (GRCm39) |
T7A |
possibly damaging |
Het |
| Or2t6 |
A |
G |
14: 14,175,885 (GRCm38) |
S66P |
probably damaging |
Het |
| Or5d14 |
A |
C |
2: 87,880,432 (GRCm39) |
F179V |
probably damaging |
Het |
| Or5w8 |
T |
C |
2: 87,687,621 (GRCm39) |
V34A |
probably benign |
Het |
| Or8g26 |
A |
G |
9: 39,095,501 (GRCm39) |
N9S |
probably benign |
Het |
| Or9q1 |
A |
C |
19: 13,805,718 (GRCm39) |
L14R |
probably damaging |
Het |
| Pcdhgb2 |
T |
A |
18: 37,823,502 (GRCm39) |
N164K |
probably damaging |
Het |
| Pde4d |
C |
G |
13: 109,253,400 (GRCm39) |
P76A |
probably benign |
Het |
| Phlda1 |
T |
C |
10: 111,343,516 (GRCm39) |
|
probably benign |
Het |
| Plekhh1 |
A |
G |
12: 79,101,577 (GRCm39) |
T216A |
probably benign |
Het |
| Plppr3 |
T |
A |
10: 79,701,507 (GRCm39) |
E445V |
possibly damaging |
Het |
| Prom1 |
A |
G |
5: 44,191,732 (GRCm39) |
V337A |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 33,001,743 (GRCm39) |
|
probably benign |
Het |
| Psmd1 |
A |
G |
1: 86,064,820 (GRCm39) |
I951V |
probably benign |
Het |
| Rab35 |
T |
G |
5: 115,781,454 (GRCm39) |
I85M |
possibly damaging |
Het |
| Rad9a |
A |
T |
19: 4,250,536 (GRCm39) |
S93T |
probably benign |
Het |
| Ric1 |
G |
A |
19: 29,563,242 (GRCm39) |
C555Y |
probably damaging |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Ror2 |
T |
A |
13: 53,264,719 (GRCm39) |
Q791L |
probably benign |
Het |
| Rps8 |
G |
C |
4: 117,012,352 (GRCm39) |
|
probably benign |
Het |
| Sdr16c5 |
C |
T |
4: 4,016,216 (GRCm39) |
W70* |
probably null |
Het |
| Senp3 |
A |
G |
11: 69,568,821 (GRCm39) |
V408A |
probably benign |
Het |
| Sh2d4b |
C |
A |
14: 40,562,301 (GRCm39) |
W288L |
probably benign |
Het |
| Slc38a9 |
A |
T |
13: 112,859,832 (GRCm39) |
D422V |
probably damaging |
Het |
| Slc4a2 |
T |
C |
5: 24,645,141 (GRCm39) |
F1104L |
probably damaging |
Het |
| Slc4a3 |
A |
G |
1: 75,527,267 (GRCm39) |
K113E |
possibly damaging |
Het |
| Spata3 |
G |
A |
1: 85,952,048 (GRCm39) |
|
probably null |
Het |
| Spata31d1d |
A |
T |
13: 59,877,055 (GRCm39) |
V160E |
possibly damaging |
Het |
| Sprr2f |
A |
G |
3: 92,273,203 (GRCm39) |
M1V |
probably null |
Het |
| Sptbn1 |
A |
G |
11: 30,068,295 (GRCm39) |
V1733A |
possibly damaging |
Het |
| Syce1 |
C |
A |
7: 140,359,809 (GRCm39) |
L83F |
probably damaging |
Het |
| Tardbp |
A |
G |
4: 148,702,050 (GRCm39) |
I295T |
probably benign |
Het |
| Tmem212 |
A |
G |
3: 27,939,157 (GRCm39) |
S110P |
probably damaging |
Het |
| Tnc |
G |
A |
4: 63,935,857 (GRCm39) |
Q360* |
probably null |
Het |
| Tnrc6c |
C |
A |
11: 117,613,731 (GRCm39) |
Q630K |
probably damaging |
Het |
| Ttc19 |
G |
A |
11: 62,199,922 (GRCm39) |
R235H |
probably benign |
Het |
| Ube3b |
T |
A |
5: 114,553,787 (GRCm39) |
|
probably null |
Het |
| Vmn2r31 |
C |
T |
7: 7,390,062 (GRCm39) |
|
probably null |
Het |
| Vmn2r92 |
T |
A |
17: 18,372,183 (GRCm39) |
|
probably benign |
Het |
| Washc5 |
A |
T |
15: 59,205,485 (GRCm39) |
Y685* |
probably null |
Het |
| Wdr93 |
T |
A |
7: 79,399,817 (GRCm39) |
Y135* |
probably null |
Het |
| Wdr95 |
T |
A |
5: 149,518,797 (GRCm39) |
I546K |
probably damaging |
Het |
| Zbtb38 |
T |
A |
9: 96,570,254 (GRCm39) |
T277S |
probably benign |
Het |
| Zfp13 |
T |
C |
17: 23,795,797 (GRCm39) |
D258G |
possibly damaging |
Het |
| Zfp397 |
T |
A |
18: 24,093,249 (GRCm39) |
S245T |
probably benign |
Het |
| Zfp646 |
T |
C |
7: 127,482,907 (GRCm39) |
Y1695H |
probably benign |
Het |
|
| Other mutations in Kntc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Kntc1
|
APN |
5 |
123,928,222 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00514:Kntc1
|
APN |
5 |
123,929,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01103:Kntc1
|
APN |
5 |
123,902,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01106:Kntc1
|
APN |
5 |
123,900,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01357:Kntc1
|
APN |
5 |
123,895,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01367:Kntc1
|
APN |
5 |
123,896,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Kntc1
|
APN |
5 |
123,919,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Kntc1
|
APN |
5 |
123,903,068 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01595:Kntc1
|
APN |
5 |
123,941,758 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01725:Kntc1
|
APN |
5 |
123,902,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01916:Kntc1
|
APN |
5 |
123,939,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Kntc1
|
APN |
5 |
123,949,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01942:Kntc1
|
APN |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01973:Kntc1
|
APN |
5 |
123,904,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01982:Kntc1
|
APN |
5 |
123,947,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02145:Kntc1
|
APN |
5 |
123,900,661 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02510:Kntc1
|
APN |
5 |
123,957,125 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02611:Kntc1
|
APN |
5 |
123,950,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Kntc1
|
APN |
5 |
123,893,727 (GRCm39) |
splice site |
probably benign |
|
|
IGL02737:Kntc1
|
APN |
5 |
123,957,183 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02793:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02809:Kntc1
|
APN |
5 |
123,914,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02860:Kntc1
|
APN |
5 |
123,907,936 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02875:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02931:Kntc1
|
APN |
5 |
123,937,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03169:Kntc1
|
APN |
5 |
123,913,884 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03267:Kntc1
|
APN |
5 |
123,896,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0017:Kntc1
|
UTSW |
5 |
123,919,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Kntc1
|
UTSW |
5 |
123,903,120 (GRCm39) |
splice site |
probably benign |
|
|
R0324:Kntc1
|
UTSW |
5 |
123,916,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0580:Kntc1
|
UTSW |
5 |
123,941,732 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0608:Kntc1
|
UTSW |
5 |
123,924,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0725:Kntc1
|
UTSW |
5 |
123,907,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0733:Kntc1
|
UTSW |
5 |
123,928,979 (GRCm39) |
missense |
probably null |
|
|
R0781:Kntc1
|
UTSW |
5 |
123,937,965 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Kntc1
|
UTSW |
5 |
123,934,167 (GRCm39) |
missense |
probably benign |
|
|
R1250:Kntc1
|
UTSW |
5 |
123,922,262 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1253:Kntc1
|
UTSW |
5 |
123,948,925 (GRCm39) |
frame shift |
probably null |
|
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1481:Kntc1
|
UTSW |
5 |
123,916,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1572:Kntc1
|
UTSW |
5 |
123,910,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1624:Kntc1
|
UTSW |
5 |
123,896,540 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1749:Kntc1
|
UTSW |
5 |
123,927,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1993:Kntc1
|
UTSW |
5 |
123,948,874 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1993:Kntc1
|
UTSW |
5 |
123,897,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2071:Kntc1
|
UTSW |
5 |
123,932,340 (GRCm39) |
splice site |
probably null |
|
|
R2237:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2239:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2366:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2382:Kntc1
|
UTSW |
5 |
123,898,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2389:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2413:Kntc1
|
UTSW |
5 |
123,902,212 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2442:Kntc1
|
UTSW |
5 |
123,948,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Kntc1
|
UTSW |
5 |
123,916,410 (GRCm39) |
nonsense |
probably null |
|
|
R2943:Kntc1
|
UTSW |
5 |
123,935,847 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3116:Kntc1
|
UTSW |
5 |
123,940,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4107:Kntc1
|
UTSW |
5 |
123,900,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Kntc1
|
UTSW |
5 |
123,914,680 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4275:Kntc1
|
UTSW |
5 |
123,905,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4440:Kntc1
|
UTSW |
5 |
123,932,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4578:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4612:Kntc1
|
UTSW |
5 |
123,950,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Kntc1
|
UTSW |
5 |
123,949,496 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4720:Kntc1
|
UTSW |
5 |
123,903,086 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4784:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4785:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4847:Kntc1
|
UTSW |
5 |
123,940,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4849:Kntc1
|
UTSW |
5 |
123,897,128 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4904:Kntc1
|
UTSW |
5 |
123,916,396 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4922:Kntc1
|
UTSW |
5 |
123,940,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5080:Kntc1
|
UTSW |
5 |
123,900,649 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5114:Kntc1
|
UTSW |
5 |
123,919,118 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5171:Kntc1
|
UTSW |
5 |
123,937,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5220:Kntc1
|
UTSW |
5 |
123,950,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Kntc1
|
UTSW |
5 |
123,932,235 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5278:Kntc1
|
UTSW |
5 |
123,919,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Kntc1
|
UTSW |
5 |
123,902,254 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5496:Kntc1
|
UTSW |
5 |
123,922,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5503:Kntc1
|
UTSW |
5 |
123,957,939 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5633:Kntc1
|
UTSW |
5 |
123,957,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Kntc1
|
UTSW |
5 |
123,956,538 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Kntc1
|
UTSW |
5 |
123,903,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5757:Kntc1
|
UTSW |
5 |
123,945,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5773:Kntc1
|
UTSW |
5 |
123,932,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5940:Kntc1
|
UTSW |
5 |
123,924,258 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6019:Kntc1
|
UTSW |
5 |
123,900,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6230:Kntc1
|
UTSW |
5 |
123,927,072 (GRCm39) |
splice site |
probably null |
|
|
R6437:Kntc1
|
UTSW |
5 |
123,907,754 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6888:Kntc1
|
UTSW |
5 |
123,949,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6907:Kntc1
|
UTSW |
5 |
123,939,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7123:Kntc1
|
UTSW |
5 |
123,919,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7262:Kntc1
|
UTSW |
5 |
123,925,036 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7381:Kntc1
|
UTSW |
5 |
123,948,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7485:Kntc1
|
UTSW |
5 |
123,925,019 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7512:Kntc1
|
UTSW |
5 |
123,929,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Kntc1
|
UTSW |
5 |
123,954,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7687:Kntc1
|
UTSW |
5 |
123,897,152 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7798:Kntc1
|
UTSW |
5 |
123,957,180 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7798:Kntc1
|
UTSW |
5 |
123,924,357 (GRCm39) |
missense |
probably benign |
|
|
R7871:Kntc1
|
UTSW |
5 |
123,922,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Kntc1
|
UTSW |
5 |
123,913,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Kntc1
|
UTSW |
5 |
123,919,951 (GRCm39) |
missense |
unknown |
|
|
R7997:Kntc1
|
UTSW |
5 |
123,916,117 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8231:Kntc1
|
UTSW |
5 |
123,920,959 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8257:Kntc1
|
UTSW |
5 |
123,896,586 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8345:Kntc1
|
UTSW |
5 |
123,924,993 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8354:Kntc1
|
UTSW |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8732:Kntc1
|
UTSW |
5 |
123,928,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8754:Kntc1
|
UTSW |
5 |
123,897,115 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8947:Kntc1
|
UTSW |
5 |
123,925,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9041:Kntc1
|
UTSW |
5 |
123,927,093 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Kntc1
|
UTSW |
5 |
123,940,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Kntc1
|
UTSW |
5 |
123,925,112 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9460:Kntc1
|
UTSW |
5 |
123,941,378 (GRCm39) |
nonsense |
probably null |
|
|
R9468:Kntc1
|
UTSW |
5 |
123,954,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9643:Kntc1
|
UTSW |
5 |
123,949,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Kntc1
|
UTSW |
5 |
123,897,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9721:Kntc1
|
UTSW |
5 |
123,939,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9789:Kntc1
|
UTSW |
5 |
123,898,706 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
X0027:Kntc1
|
UTSW |
5 |
123,948,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Kntc1
|
UTSW |
5 |
123,916,100 (GRCm39) |
nonsense |
probably null |
|
|
X0067:Kntc1
|
UTSW |
5 |
123,916,137 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGATAGGACTTGCTATGAACTTGC -3'
(R):5'- AGGCTGGATTTAGACCACAAG -3'
Sequencing Primer
(F):5'- ATCTGTCACCAAAGTGCTGG -3'
(R):5'- GCTGGATTTAGACCACAAGATAATG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation