Mutagenetix > Incidental Mutation

Incidental Mutation 'R4824:Tnc'

374194

Institutional Source

Beutler Lab

Gene Symbol

Tnc

Ensembl Gene

ENSMUSG00000028364

Gene Name

tenascin C

Synonyms

cytotactin, C130033P17Rik, TN-C, hexabrachion, tenascin-C, Hxb, TN

MMRRC Submission

042440-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4824 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

63878022-63965252 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 63935857 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 360 (Q360*)

Ref Sequence

ENSEMBL: ENSMUSP00000103000 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030056] [ENSMUST00000107371] [ENSMUST00000107372] [ENSMUST00000107377]

AlphaFold

Q80YX1

Predicted Effect

probably null
Transcript: ENSMUST00000030056
AA Change: Q360*

SMART Domains

Protein: ENSMUSP00000030056
Gene: ENSMUSG00000028364
AA Change: Q360*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
low complexity region	121	138	N/A	INTRINSIC
EGF	189	217	1.87e1	SMART
EGF_like	220	248	3.5e1	SMART
EGF	251	280	4.89e0	SMART
EGF	283	311	3.23e0	SMART
EGF_like	314	342	2.98e1	SMART
EGF	345	373	1.87e1	SMART
EGF	376	404	3.97e0	SMART
EGF	407	435	8.52e0	SMART
EGF	438	466	3.01e0	SMART
EGF	469	497	3.46e0	SMART
EGF	500	528	3.71e0	SMART
EGF	531	559	4.32e-1	SMART
EGF	562	590	1.84e1	SMART
EGF	593	621	3.82e-2	SMART
FN3	623	701	8.9e-8	SMART
FN3	712	794	1.53e-6	SMART
FN3	803	884	7.23e-8	SMART
FN3	893	974	1.71e-9	SMART
FN3	985	1062	2.56e-8	SMART
FN3	1074	1152	8.58e-1	SMART
FN3	1165	1245	2.72e-3	SMART
FN3	1256	1334	5.36e-2	SMART
FN3	1347	1427	4.93e0	SMART
FN3	1438	1517	3.4e-4	SMART
FN3	1528	1606	1.55e-7	SMART
FN3	1617	1694	1.53e-6	SMART
FN3	1705	1782	7.75e-8	SMART
FBG	1797	2007	4.08e-124	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000107371
AA Change: Q360*

SMART Domains

Protein: ENSMUSP00000102994
Gene: ENSMUSG00000028364
AA Change: Q360*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
low complexity region	121	138	N/A	INTRINSIC
Pfam:hEGF	173	185	4e-4	PFAM
EGF	189	217	1.87e1	SMART
EGF_like	220	248	3.5e1	SMART
EGF	251	280	4.89e0	SMART
EGF	283	311	3.23e0	SMART
EGF_like	314	342	2.98e1	SMART
EGF	345	373	1.87e1	SMART
EGF	376	404	3.97e0	SMART
EGF	407	435	8.52e0	SMART
EGF	438	466	3.01e0	SMART
EGF	469	497	3.46e0	SMART
EGF	500	528	3.71e0	SMART
EGF	531	559	4.32e-1	SMART
EGF	562	590	1.84e1	SMART
EGF	593	621	3.82e-2	SMART
FN3	623	701	8.9e-8	SMART
FN3	712	794	1.53e-6	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000107372
AA Change: Q360*

SMART Domains

Protein: ENSMUSP00000102995
Gene: ENSMUSG00000028364
AA Change: Q360*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
low complexity region	121	138	N/A	INTRINSIC
EGF	189	217	1.87e1	SMART
EGF_like	220	248	3.5e1	SMART
EGF	251	280	4.89e0	SMART
EGF	283	311	3.23e0	SMART
EGF_like	314	342	2.98e1	SMART
EGF	345	373	1.87e1	SMART
EGF	376	404	3.97e0	SMART
EGF	407	435	8.52e0	SMART
EGF	438	466	3.01e0	SMART
EGF	469	497	3.46e0	SMART
EGF	500	528	3.71e0	SMART
EGF	531	559	4.32e-1	SMART
EGF	562	590	1.84e1	SMART
EGF	593	621	3.82e-2	SMART
FN3	623	701	8.9e-8	SMART
FN3	712	794	1.53e-6	SMART
FN3	803	884	7.23e-8	SMART
FN3	893	974	1.71e-9	SMART
FN3	985	1062	2.56e-8	SMART
FN3	1074	1152	8.58e-1	SMART
FN3	1165	1245	2.72e-3	SMART
FN3	1256	1334	5.36e-2	SMART
FN3	1347	1427	4.93e0	SMART
FN3	1438	1517	2.75e0	SMART
FN3	1529	1608	3.4e-4	SMART
FN3	1619	1697	1.55e-7	SMART
FN3	1708	1785	1.53e-6	SMART
FN3	1796	1873	7.75e-8	SMART
FBG	1888	2098	4.08e-124	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000107377
AA Change: Q360*

SMART Domains

Protein: ENSMUSP00000103000
Gene: ENSMUSG00000028364
AA Change: Q360*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
low complexity region	121	138	N/A	INTRINSIC
EGF	189	217	1.87e1	SMART
EGF_like	220	248	3.5e1	SMART
EGF	251	280	4.89e0	SMART
EGF	283	311	3.23e0	SMART
EGF_like	314	342	2.98e1	SMART
EGF	345	373	1.87e1	SMART
EGF	376	404	3.97e0	SMART
EGF	407	435	8.52e0	SMART
EGF	438	466	3.01e0	SMART
EGF	469	497	3.46e0	SMART
EGF	500	528	3.71e0	SMART
EGF	531	559	4.32e-1	SMART
EGF	562	590	1.84e1	SMART
EGF	593	621	3.82e-2	SMART
FN3	623	701	8.9e-8	SMART
FN3	712	794	1.53e-6	SMART
FN3	803	884	7.23e-8	SMART
FN3	893	974	1.71e-9	SMART
FN3	985	1062	2.56e-8	SMART
FN3	1074	1152	8.58e-1	SMART
FN3	1165	1245	2.72e-3	SMART
FN3	1256	1334	5.36e-2	SMART
FN3	1347	1427	4.93e0	SMART
FN3	1438	1517	3.4e-4	SMART
FN3	1528	1606	1.55e-7	SMART
FN3	1617	1694	1.53e-6	SMART
FN3	1705	1782	7.75e-8	SMART
FBG	1797	2007	4.08e-124	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135042

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141428

Meta Mutation Damage Score

0.9754

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.8%
20x: 94.0%

Validation Efficiency

98% (123/126)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 107 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	A	G	3: 137,771,437 (GRCm39)	T209A	probably benign	Het
1700086D15Rik	T	C	11: 65,043,441 (GRCm39)		probably benign	Het
A130010J15Rik	G	A	1: 192,856,965 (GRCm39)	V106I	probably benign	Het
Abca16	C	A	7: 120,074,702 (GRCm39)	N580K	possibly damaging	Het
Actrt2	A	T	4: 154,751,344 (GRCm39)	F264Y	probably damaging	Het
Adh4	G	A	3: 138,134,807 (GRCm39)	S327N	possibly damaging	Het
Alkbh5	T	C	11: 60,444,697 (GRCm39)		probably null	Het
Anapc1	T	A	2: 128,470,610 (GRCm39)	T1507S	possibly damaging	Het
Anapc2	A	G	2: 25,167,764 (GRCm39)	R444G	probably damaging	Het
Apoh	G	T	11: 108,305,087 (GRCm39)	W335L	probably benign	Het
B4galt7	A	T	13: 55,752,162 (GRCm39)	H71L	possibly damaging	Het
Bicd2	A	G	13: 49,532,488 (GRCm39)	E358G	probably damaging	Het
Bmper	T	A	9: 23,134,956 (GRCm39)	V7D	possibly damaging	Het
Brca2	T	C	5: 150,463,200 (GRCm39)	F988S	probably damaging	Het
Brix1	A	G	15: 10,485,828 (GRCm39)	V49A	possibly damaging	Het
Brpf3	T	C	17: 29,025,460 (GRCm39)	S178P	probably benign	Het
Btaf1	A	G	19: 36,958,448 (GRCm39)	Y655C	possibly damaging	Het
C1rl	C	G	6: 124,486,040 (GRCm39)	Y470*	probably null	Het
Cacnb4	A	G	2: 52,565,822 (GRCm39)	V21A	probably benign	Het
Caskin1	C	A	17: 24,720,103 (GRCm39)	P437T	probably benign	Het
Casz1	C	A	4: 149,029,028 (GRCm39)	P1158T	probably damaging	Het
Ccdc141	T	A	2: 76,954,680 (GRCm39)	Q189L	probably damaging	Het
Ccr3	T	C	9: 123,828,809 (GRCm39)	V48A	probably damaging	Het
Cebpd	G	A	16: 15,705,978 (GRCm39)	G264S	probably benign	Het
Cert1	C	T	13: 96,752,995 (GRCm39)	P350S	probably benign	Het
Cfap20dc	A	T	14: 8,665,997 (GRCm38)	M1K	probably null	Het
Chd1	C	A	17: 15,953,386 (GRCm39)	S440R	probably damaging	Het
Clip1	T	A	5: 123,769,086 (GRCm39)	E504D	probably damaging	Het
Cmya5	T	C	13: 93,230,082 (GRCm39)	R1669G	probably benign	Het
Col11a2	T	A	17: 34,269,937 (GRCm39)	F456I	probably damaging	Het
Ctnna2	A	T	6: 76,957,764 (GRCm39)	M130K	probably damaging	Het
Elmo2	A	T	2: 165,133,922 (GRCm39)		probably benign	Het
F11	T	C	8: 45,708,379 (GRCm39)	D27G	probably damaging	Het
Faap100	A	T	11: 120,266,412 (GRCm39)		probably null	Het
Fat1	A	G	8: 45,442,151 (GRCm39)	E1151G	probably damaging	Het
Fbll1	T	A	11: 35,688,652 (GRCm39)	I204F	probably damaging	Het
Gle1	T	A	2: 29,830,215 (GRCm39)	V257D	possibly damaging	Het
Hoxc9	T	A	15: 102,890,225 (GRCm39)	C47*	probably null	Het
Hsd17b6	A	G	10: 127,829,524 (GRCm39)	V226A	probably benign	Het
Hsd17b7	C	T	1: 169,788,764 (GRCm39)	R151Q	probably benign	Het
Hsh2d	G	A	8: 72,954,304 (GRCm39)	D229N	probably benign	Het
Ido2	A	G	8: 25,023,875 (GRCm39)	I321T	probably benign	Het
Irf2bp2	T	C	8: 127,318,172 (GRCm39)	T465A	probably benign	Het
Kdm2a	A	G	19: 4,412,815 (GRCm39)	M34T	probably damaging	Het
Klhl6	C	T	16: 19,775,778 (GRCm39)	R260H	probably damaging	Het
Kntc1	T	A	5: 123,928,196 (GRCm39)	L1231*	probably null	Het
Lca5l	A	C	16: 95,963,229 (GRCm39)	Y412*	probably null	Het
Lipt1	T	C	1: 37,914,513 (GRCm39)	S190P	possibly damaging	Het
Ly6f	T	A	15: 75,143,569 (GRCm39)	V92D	probably damaging	Het
Matn4	T	A	2: 164,235,151 (GRCm39)	M433L	probably benign	Het
Mbtd1	C	A	11: 93,816,528 (GRCm39)	P370T	probably benign	Het
Mcph1	T	A	8: 18,682,703 (GRCm39)		probably null	Het
Muc5b	T	A	7: 141,417,922 (GRCm39)	C3623S	probably damaging	Het
Myt1l	C	A	12: 29,899,399 (GRCm39)	H134N	probably benign	Het
Nav2	A	T	7: 49,058,749 (GRCm39)		probably benign	Het
Ndufaf8	T	C	11: 119,989,992 (GRCm39)	C35R	probably damaging	Het
Neb	G	A	2: 52,094,891 (GRCm39)	T5130I	possibly damaging	Het
Nlrp9c	T	C	7: 26,079,989 (GRCm39)	N624S	possibly damaging	Het
Nr0b2	C	A	4: 133,283,334 (GRCm39)	H190Q	probably damaging	Het
Nrg4	A	G	9: 55,156,405 (GRCm39)		probably benign	Het
Nup88	A	T	11: 70,852,450 (GRCm39)	V215E	probably benign	Het
Oas2	T	G	5: 120,876,411 (GRCm39)	T511P	probably benign	Het
Or1e25	A	G	11: 73,493,426 (GRCm39)	T7A	possibly damaging	Het
Or2t6	A	G	14: 14,175,885 (GRCm38)	S66P	probably damaging	Het
Or5d14	A	C	2: 87,880,432 (GRCm39)	F179V	probably damaging	Het
Or5w8	T	C	2: 87,687,621 (GRCm39)	V34A	probably benign	Het
Or8g26	A	G	9: 39,095,501 (GRCm39)	N9S	probably benign	Het
Or9q1	A	C	19: 13,805,718 (GRCm39)	L14R	probably damaging	Het
Pcdhgb2	T	A	18: 37,823,502 (GRCm39)	N164K	probably damaging	Het
Pde4d	C	G	13: 109,253,400 (GRCm39)	P76A	probably benign	Het
Phlda1	T	C	10: 111,343,516 (GRCm39)		probably benign	Het
Plekhh1	A	G	12: 79,101,577 (GRCm39)	T216A	probably benign	Het
Plppr3	T	A	10: 79,701,507 (GRCm39)	E445V	possibly damaging	Het
Prom1	A	G	5: 44,191,732 (GRCm39)	V337A	probably damaging	Het
Prr14l	T	C	5: 33,001,743 (GRCm39)		probably benign	Het
Psmd1	A	G	1: 86,064,820 (GRCm39)	I951V	probably benign	Het
Rab35	T	G	5: 115,781,454 (GRCm39)	I85M	possibly damaging	Het
Rad9a	A	T	19: 4,250,536 (GRCm39)	S93T	probably benign	Het
Ric1	G	A	19: 29,563,242 (GRCm39)	C555Y	probably damaging	Het
Rnd2	C	T	11: 101,359,825 (GRCm39)	L57F	probably damaging	Het
Ror2	T	A	13: 53,264,719 (GRCm39)	Q791L	probably benign	Het
Rps8	G	C	4: 117,012,352 (GRCm39)		probably benign	Het
Sdr16c5	C	T	4: 4,016,216 (GRCm39)	W70*	probably null	Het
Senp3	A	G	11: 69,568,821 (GRCm39)	V408A	probably benign	Het
Sh2d4b	C	A	14: 40,562,301 (GRCm39)	W288L	probably benign	Het
Slc38a9	A	T	13: 112,859,832 (GRCm39)	D422V	probably damaging	Het
Slc4a2	T	C	5: 24,645,141 (GRCm39)	F1104L	probably damaging	Het
Slc4a3	A	G	1: 75,527,267 (GRCm39)	K113E	possibly damaging	Het
Spata3	G	A	1: 85,952,048 (GRCm39)		probably null	Het
Spata31d1d	A	T	13: 59,877,055 (GRCm39)	V160E	possibly damaging	Het
Sprr2f	A	G	3: 92,273,203 (GRCm39)	M1V	probably null	Het
Sptbn1	A	G	11: 30,068,295 (GRCm39)	V1733A	possibly damaging	Het
Syce1	C	A	7: 140,359,809 (GRCm39)	L83F	probably damaging	Het
Tardbp	A	G	4: 148,702,050 (GRCm39)	I295T	probably benign	Het
Tmem212	A	G	3: 27,939,157 (GRCm39)	S110P	probably damaging	Het
Tnrc6c	C	A	11: 117,613,731 (GRCm39)	Q630K	probably damaging	Het
Ttc19	G	A	11: 62,199,922 (GRCm39)	R235H	probably benign	Het
Ube3b	T	A	5: 114,553,787 (GRCm39)		probably null	Het
Vmn2r31	C	T	7: 7,390,062 (GRCm39)		probably null	Het
Vmn2r92	T	A	17: 18,372,183 (GRCm39)		probably benign	Het
Washc5	A	T	15: 59,205,485 (GRCm39)	Y685*	probably null	Het
Wdr93	T	A	7: 79,399,817 (GRCm39)	Y135*	probably null	Het
Wdr95	T	A	5: 149,518,797 (GRCm39)	I546K	probably damaging	Het
Zbtb38	T	A	9: 96,570,254 (GRCm39)	T277S	probably benign	Het
Zfp13	T	C	17: 23,795,797 (GRCm39)	D258G	possibly damaging	Het
Zfp397	T	A	18: 24,093,249 (GRCm39)	S245T	probably benign	Het
Zfp646	T	C	7: 127,482,907 (GRCm39)	Y1695H	probably benign	Het

Other mutations in Tnc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Tnc	APN	4	63,935,061 (GRCm39)	splice site	probably benign
IGL00531:Tnc	APN	4	63,889,390 (GRCm39)	splice site	probably benign
IGL00674:Tnc	APN	4	63,883,844 (GRCm39)	missense	probably damaging	1.00
IGL01015:Tnc	APN	4	63,935,571 (GRCm39)	missense	probably benign	0.19
IGL01090:Tnc	APN	4	63,918,317 (GRCm39)	missense	probably damaging	1.00
IGL01310:Tnc	APN	4	63,931,314 (GRCm39)	missense	probably benign	0.03
IGL01331:Tnc	APN	4	63,901,112 (GRCm39)	missense	probably damaging	0.99
IGL01393:Tnc	APN	4	63,932,291 (GRCm39)	splice site	probably benign
IGL01411:Tnc	APN	4	63,918,959 (GRCm39)	missense	probably damaging	0.96
IGL01472:Tnc	APN	4	63,924,656 (GRCm39)	missense	probably benign	0.00
IGL01552:Tnc	APN	4	63,888,645 (GRCm39)	missense	probably damaging	1.00
IGL01661:Tnc	APN	4	63,888,544 (GRCm39)	splice site	probably benign
IGL01669:Tnc	APN	4	63,918,938 (GRCm39)	missense	probably damaging	1.00
IGL01912:Tnc	APN	4	63,926,977 (GRCm39)	missense	probably damaging	1.00
IGL02028:Tnc	APN	4	63,884,909 (GRCm39)	splice site	probably benign
IGL02100:Tnc	APN	4	63,918,398 (GRCm39)	missense	possibly damaging	0.84
IGL02549:Tnc	APN	4	63,933,309 (GRCm39)	missense	probably damaging	1.00
IGL02642:Tnc	APN	4	63,883,816 (GRCm39)	splice site	probably benign
IGL02712:Tnc	APN	4	63,893,493 (GRCm39)	missense	probably damaging	1.00
IGL02876:Tnc	APN	4	63,933,338 (GRCm39)	missense	possibly damaging	0.56
IGL02886:Tnc	APN	4	63,918,344 (GRCm39)	missense	probably damaging	0.96
IGL02972:Tnc	APN	4	63,894,715 (GRCm39)	missense	probably benign	0.11
IGL03073:Tnc	APN	4	63,889,461 (GRCm39)	missense	possibly damaging	0.58
IGL03116:Tnc	APN	4	63,932,270 (GRCm39)	missense	probably damaging	1.00
IGL03181:Tnc	APN	4	63,885,543 (GRCm39)	missense	possibly damaging	0.95
IGL03358:Tnc	APN	4	63,935,852 (GRCm39)	nonsense	probably null
tancredo	UTSW	4	63,911,534 (GRCm39)	nonsense	probably null
BB009:Tnc	UTSW	4	63,926,857 (GRCm39)	missense	probably benign
BB019:Tnc	UTSW	4	63,926,857 (GRCm39)	missense	probably benign
P0020:Tnc	UTSW	4	63,927,094 (GRCm39)	missense	possibly damaging	0.63
PIT4377001:Tnc	UTSW	4	63,935,973 (GRCm39)	missense	probably damaging	1.00
PIT4403001:Tnc	UTSW	4	63,882,904 (GRCm39)	missense	probably damaging	1.00
PIT4468001:Tnc	UTSW	4	63,882,904 (GRCm39)	missense	probably damaging	1.00
R0243:Tnc	UTSW	4	63,888,657 (GRCm39)	missense	probably damaging	0.98
R0362:Tnc	UTSW	4	63,935,679 (GRCm39)	missense	probably damaging	1.00
R0410:Tnc	UTSW	4	63,925,931 (GRCm39)	missense	probably benign	0.00
R0420:Tnc	UTSW	4	63,918,396 (GRCm39)	missense	probably benign	0.00
R0540:Tnc	UTSW	4	63,938,692 (GRCm39)	missense	probably damaging	1.00
R0650:Tnc	UTSW	4	63,926,971 (GRCm39)	missense	probably benign	0.00
R1019:Tnc	UTSW	4	63,880,319 (GRCm39)	missense	probably damaging	1.00
R1102:Tnc	UTSW	4	63,938,705 (GRCm39)	missense	probably benign	0.05
R1126:Tnc	UTSW	4	63,936,357 (GRCm39)	missense	probably damaging	0.99
R1141:Tnc	UTSW	4	63,932,231 (GRCm39)	missense	probably damaging	1.00
R1142:Tnc	UTSW	4	63,932,231 (GRCm39)	missense	probably damaging	1.00
R1307:Tnc	UTSW	4	63,927,096 (GRCm39)	missense	probably damaging	0.98
R1322:Tnc	UTSW	4	63,932,231 (GRCm39)	missense	probably damaging	1.00
R1414:Tnc	UTSW	4	63,883,932 (GRCm39)	splice site	probably benign
R1470:Tnc	UTSW	4	63,884,811 (GRCm39)	missense	probably damaging	1.00
R1470:Tnc	UTSW	4	63,884,811 (GRCm39)	missense	probably damaging	1.00
R1499:Tnc	UTSW	4	63,882,991 (GRCm39)	missense	probably benign	0.15
R1506:Tnc	UTSW	4	63,925,921 (GRCm39)	missense	possibly damaging	0.90
R1597:Tnc	UTSW	4	63,924,621 (GRCm39)	missense	probably benign
R1750:Tnc	UTSW	4	63,890,972 (GRCm39)	missense	probably damaging	1.00
R1765:Tnc	UTSW	4	63,932,231 (GRCm39)	missense	probably damaging	1.00
R1783:Tnc	UTSW	4	63,936,333 (GRCm39)	missense	probably damaging	0.98
R1808:Tnc	UTSW	4	63,918,168 (GRCm39)	missense	probably damaging	1.00
R1903:Tnc	UTSW	4	63,918,299 (GRCm39)	missense	probably benign	0.00
R1932:Tnc	UTSW	4	63,911,262 (GRCm39)	critical splice donor site	probably null
R1941:Tnc	UTSW	4	63,933,201 (GRCm39)	missense	probably damaging	1.00
R1983:Tnc	UTSW	4	63,902,867 (GRCm39)	missense	possibly damaging	0.95
R2024:Tnc	UTSW	4	63,882,858 (GRCm39)	missense	probably damaging	1.00
R2075:Tnc	UTSW	4	63,913,903 (GRCm39)	missense	possibly damaging	0.94
R2327:Tnc	UTSW	4	63,893,475 (GRCm39)	missense	possibly damaging	0.78
R2444:Tnc	UTSW	4	63,933,200 (GRCm39)	missense	probably damaging	1.00
R2982:Tnc	UTSW	4	63,938,756 (GRCm39)	missense	possibly damaging	0.81
R3874:Tnc	UTSW	4	63,926,947 (GRCm39)	missense	probably damaging	1.00
R4110:Tnc	UTSW	4	63,933,188 (GRCm39)	missense	probably damaging	1.00
R4360:Tnc	UTSW	4	63,935,161 (GRCm39)	missense	probably benign	0.35
R4371:Tnc	UTSW	4	63,888,588 (GRCm39)	missense	probably damaging	1.00
R4434:Tnc	UTSW	4	63,926,066 (GRCm39)	missense	possibly damaging	0.91
R4438:Tnc	UTSW	4	63,926,066 (GRCm39)	missense	possibly damaging	0.91
R4570:Tnc	UTSW	4	63,913,909 (GRCm39)	missense	probably damaging	0.99
R4595:Tnc	UTSW	4	63,913,982 (GRCm39)	missense	probably damaging	1.00
R4749:Tnc	UTSW	4	63,913,876 (GRCm39)	missense	possibly damaging	0.56
R4756:Tnc	UTSW	4	63,885,580 (GRCm39)	missense	probably damaging	0.99
R4957:Tnc	UTSW	4	63,894,793 (GRCm39)	missense	probably damaging	1.00
R4977:Tnc	UTSW	4	63,924,485 (GRCm39)	missense	possibly damaging	0.82
R5001:Tnc	UTSW	4	63,918,299 (GRCm39)	missense	probably benign	0.16
R5001:Tnc	UTSW	4	63,902,726 (GRCm39)	missense	probably damaging	1.00
R5015:Tnc	UTSW	4	63,924,739 (GRCm39)	missense	probably damaging	1.00
R5049:Tnc	UTSW	4	63,936,223 (GRCm39)	missense	probably damaging	1.00
R5066:Tnc	UTSW	4	63,893,466 (GRCm39)	missense	probably damaging	0.96
R5073:Tnc	UTSW	4	63,938,648 (GRCm39)	missense	probably damaging	1.00
R5116:Tnc	UTSW	4	63,885,452 (GRCm39)	critical splice donor site	probably null
R5195:Tnc	UTSW	4	63,885,489 (GRCm39)	missense	probably damaging	1.00
R5200:Tnc	UTSW	4	63,889,515 (GRCm39)	missense	probably damaging	1.00
R5221:Tnc	UTSW	4	63,911,534 (GRCm39)	nonsense	probably null
R5237:Tnc	UTSW	4	63,880,333 (GRCm39)	missense	probably damaging	1.00
R5265:Tnc	UTSW	4	63,911,443 (GRCm39)	missense	probably benign	0.00
R5275:Tnc	UTSW	4	63,882,967 (GRCm39)	nonsense	probably null
R5346:Tnc	UTSW	4	63,926,892 (GRCm39)	missense	probably benign
R5409:Tnc	UTSW	4	63,925,654 (GRCm39)	missense	probably damaging	1.00
R5409:Tnc	UTSW	4	63,884,773 (GRCm39)	missense	probably damaging	1.00
R5469:Tnc	UTSW	4	63,932,162 (GRCm39)	splice site	probably null
R5518:Tnc	UTSW	4	63,935,916 (GRCm39)	missense	probably damaging	1.00
R5560:Tnc	UTSW	4	63,926,946 (GRCm39)	missense	probably damaging	1.00
R5588:Tnc	UTSW	4	63,924,659 (GRCm39)	missense	possibly damaging	0.57
R5686:Tnc	UTSW	4	63,925,967 (GRCm39)	splice site	probably null
R5686:Tnc	UTSW	4	63,927,032 (GRCm39)	missense	possibly damaging	0.78
R5837:Tnc	UTSW	4	63,931,451 (GRCm39)	missense	probably damaging	1.00
R5976:Tnc	UTSW	4	63,936,403 (GRCm39)	missense	probably benign	0.17
R6156:Tnc	UTSW	4	63,888,589 (GRCm39)	missense	probably damaging	1.00
R6182:Tnc	UTSW	4	63,927,033 (GRCm39)	missense	probably damaging	0.99
R6360:Tnc	UTSW	4	63,918,970 (GRCm39)	missense	probably damaging	1.00
R6416:Tnc	UTSW	4	63,926,053 (GRCm39)	missense	probably benign	0.05
R6778:Tnc	UTSW	4	63,913,835 (GRCm39)	missense	probably benign	0.12
R6798:Tnc	UTSW	4	63,883,841 (GRCm39)	missense	probably benign	0.02
R6799:Tnc	UTSW	4	63,883,841 (GRCm39)	missense	probably benign	0.02
R6943:Tnc	UTSW	4	63,900,982 (GRCm39)	missense	probably damaging	0.97
R7027:Tnc	UTSW	4	63,902,826 (GRCm39)	missense	probably benign	0.02
R7183:Tnc	UTSW	4	63,931,365 (GRCm39)	missense	probably damaging	1.00
R7204:Tnc	UTSW	4	63,889,392 (GRCm39)	splice site	probably null
R7317:Tnc	UTSW	4	63,890,959 (GRCm39)	missense	probably damaging	0.99
R7323:Tnc	UTSW	4	63,889,469 (GRCm39)	missense	probably damaging	0.96
R7327:Tnc	UTSW	4	63,882,999 (GRCm39)	splice site	probably null
R7382:Tnc	UTSW	4	63,932,280 (GRCm39)	nonsense	probably null
R7399:Tnc	UTSW	4	63,938,894 (GRCm39)	start gained	probably benign
R7479:Tnc	UTSW	4	63,935,865 (GRCm39)	missense	possibly damaging	0.95
R7585:Tnc	UTSW	4	63,938,648 (GRCm39)	missense	probably damaging	1.00
R7932:Tnc	UTSW	4	63,926,857 (GRCm39)	missense	probably benign
R7947:Tnc	UTSW	4	63,935,580 (GRCm39)	missense	probably damaging	1.00
R7974:Tnc	UTSW	4	63,918,961 (GRCm39)	missense	possibly damaging	0.84
R7991:Tnc	UTSW	4	63,926,983 (GRCm39)	missense	probably benign	0.42
R8004:Tnc	UTSW	4	63,902,894 (GRCm39)	missense	probably benign	0.04
R8080:Tnc	UTSW	4	63,894,706 (GRCm39)	missense	possibly damaging	0.52
R8109:Tnc	UTSW	4	63,927,000 (GRCm39)	missense	probably benign	0.11
R8145:Tnc	UTSW	4	63,935,716 (GRCm39)	missense	probably benign
R8340:Tnc	UTSW	4	63,926,036 (GRCm39)	missense	probably damaging	1.00
R8360:Tnc	UTSW	4	63,885,511 (GRCm39)	missense	probably benign	0.00
R8671:Tnc	UTSW	4	63,935,683 (GRCm39)	missense	probably damaging	1.00
R8691:Tnc	UTSW	4	63,880,313 (GRCm39)	missense	probably damaging	1.00
R8759:Tnc	UTSW	4	63,924,501 (GRCm39)	missense	possibly damaging	0.86
R8864:Tnc	UTSW	4	63,911,296 (GRCm39)	missense	probably damaging	0.98
R8927:Tnc	UTSW	4	63,925,595 (GRCm39)	missense	probably damaging	1.00
R8928:Tnc	UTSW	4	63,925,595 (GRCm39)	missense	probably damaging	1.00
R8949:Tnc	UTSW	4	63,927,087 (GRCm39)	missense	probably damaging	1.00
R8956:Tnc	UTSW	4	63,918,970 (GRCm39)	missense	probably damaging	1.00
R9016:Tnc	UTSW	4	63,935,331 (GRCm39)	missense	probably benign	0.23
R9049:Tnc	UTSW	4	63,918,247 (GRCm39)	missense	possibly damaging	0.83
R9097:Tnc	UTSW	4	63,888,622 (GRCm39)	missense	possibly damaging	0.62
R9114:Tnc	UTSW	4	63,890,973 (GRCm39)	missense	probably benign	0.03
R9151:Tnc	UTSW	4	63,938,686 (GRCm39)	missense	possibly damaging	0.46
R9488:Tnc	UTSW	4	63,913,942 (GRCm39)	missense	probably damaging	0.99
R9537:Tnc	UTSW	4	63,884,821 (GRCm39)	missense	probably damaging	0.99
R9666:Tnc	UTSW	4	63,926,045 (GRCm39)	missense	probably damaging	1.00
R9700:Tnc	UTSW	4	63,933,186 (GRCm39)	missense	probably damaging	0.99
R9703:Tnc	UTSW	4	63,889,412 (GRCm39)	missense	probably benign	0.00
R9771:Tnc	UTSW	4	63,925,600 (GRCm39)	missense	probably damaging	1.00
S24628:Tnc	UTSW	4	63,936,249 (GRCm39)	missense	probably damaging	1.00
Z1177:Tnc	UTSW	4	63,925,663 (GRCm39)	nonsense	probably null
Z1177:Tnc	UTSW	4	63,878,781 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- CTACAGTCTTCTCCGGTATAGC -3'
(R):5'- AGAACGAGTGTGTCTGCGAC -3'

Sequencing Primer
(F):5'- GTTGACACAACGGCCATG -3'
(R):5'- TGTCTGCGACGAGGGCTTC -3'

Posted On

2016-03-01