Incidental Mutation 'R4839:Dock8'
| ID |
371680 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock8
|
| Ensembl Gene |
ENSMUSG00000052085 |
| Gene Name |
dedicator of cytokinesis 8 |
| Synonyms |
1200017A24Rik, 5830472H07Rik, A130095G14Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.092)
|
| Stock # |
R4839 (G1)
|
| Quality Score |
210 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
24976898-25179796 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 25146858 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1446
(I1446V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000025831
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025831]
|
| AlphaFold |
Q8C147 |
| PDB Structure |
Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant) [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000025831
AA Change: I1446V
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000025831
Gene: ENSMUSG00000052085
AA Change: I1446V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
71 |
164 |
3.9e-25 |
PFAM |
|
Pfam:DOCK-C2
|
557 |
739 |
6.7e-49 |
PFAM |
|
low complexity region
|
786 |
803 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1123 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1246 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1383 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1534 |
2060 |
5e-210 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083700
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
PHENOTYPE: Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(6) : Gene trapped(4) Chemically induced(2)
Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
A |
17: 9,226,845 (GRCm39) |
S467T |
probably benign |
Het |
| 2310030G06Rik |
A |
T |
9: 50,652,023 (GRCm39) |
Y68* |
probably null |
Het |
| Abat |
T |
G |
16: 8,401,512 (GRCm39) |
|
probably benign |
Het |
| Abca2 |
C |
T |
2: 25,330,921 (GRCm39) |
S1203F |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,186,813 (GRCm39) |
P436L |
probably damaging |
Het |
| Ak3 |
A |
C |
19: 29,025,132 (GRCm39) |
L33R |
probably damaging |
Het |
| Arhgap11a |
A |
T |
2: 113,672,374 (GRCm39) |
I198K |
probably damaging |
Het |
| Arl14epl |
A |
T |
18: 47,065,544 (GRCm39) |
K103M |
possibly damaging |
Het |
| Atg16l1 |
T |
A |
1: 87,693,896 (GRCm39) |
N65K |
probably damaging |
Het |
| Btnl2 |
G |
A |
17: 34,584,260 (GRCm39) |
W394* |
probably null |
Het |
| Cacna1e |
C |
A |
1: 154,296,804 (GRCm39) |
R1687L |
probably damaging |
Het |
| Cacna1g |
G |
T |
11: 94,350,433 (GRCm39) |
R471S |
probably benign |
Het |
| Cdh13 |
A |
T |
8: 119,578,587 (GRCm39) |
R205* |
probably null |
Het |
| Cdkl3 |
A |
T |
11: 51,895,861 (GRCm39) |
Y36F |
probably damaging |
Het |
| Cep290 |
T |
A |
10: 100,344,648 (GRCm39) |
N488K |
probably damaging |
Het |
| Cep350 |
A |
T |
1: 155,804,240 (GRCm39) |
C948S |
probably benign |
Het |
| Cep70 |
A |
G |
9: 99,178,138 (GRCm39) |
K446R |
probably benign |
Het |
| Cfap70 |
T |
C |
14: 20,475,597 (GRCm39) |
T375A |
probably damaging |
Het |
| Cfhr1 |
A |
G |
1: 139,487,871 (GRCm39) |
L9S |
probably damaging |
Het |
| Chrm4 |
T |
A |
2: 91,757,952 (GRCm39) |
M120K |
probably damaging |
Het |
| Col1a1 |
A |
G |
11: 94,840,921 (GRCm39) |
|
probably null |
Het |
| Col3a1 |
T |
C |
1: 45,362,963 (GRCm39) |
|
probably null |
Het |
| Csrnp3 |
A |
T |
2: 65,852,375 (GRCm39) |
R256* |
probably null |
Het |
| Dbf4 |
T |
A |
5: 8,458,263 (GRCm39) |
K190* |
probably null |
Het |
| Dnah10 |
A |
T |
5: 124,850,196 (GRCm39) |
I1573F |
probably damaging |
Het |
| Dst |
G |
T |
1: 34,229,943 (GRCm39) |
R2187M |
probably damaging |
Het |
| Ece2 |
C |
T |
16: 20,449,918 (GRCm39) |
R257C |
probably damaging |
Het |
| Espn |
A |
G |
4: 152,222,961 (GRCm39) |
Y306H |
probably damaging |
Het |
| Fkbpl |
G |
A |
17: 34,864,839 (GRCm39) |
M202I |
probably benign |
Het |
| Fn1 |
A |
G |
1: 71,681,242 (GRCm39) |
L362P |
probably damaging |
Het |
| Ganc |
A |
C |
2: 120,290,304 (GRCm39) |
R880S |
probably benign |
Het |
| Gucy1b2 |
A |
T |
14: 62,685,695 (GRCm39) |
L90Q |
probably damaging |
Het |
| Hcn1 |
T |
A |
13: 118,062,246 (GRCm39) |
I504N |
unknown |
Het |
| Hdac2 |
C |
A |
10: 36,873,462 (GRCm39) |
T352K |
probably benign |
Het |
| Hip1 |
T |
C |
5: 135,455,172 (GRCm39) |
|
probably null |
Het |
| Hspa13 |
G |
A |
16: 75,562,169 (GRCm39) |
S10L |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,157,450 (GRCm39) |
I96T |
probably benign |
Het |
| Isl1 |
T |
C |
13: 116,438,220 (GRCm39) |
Y264C |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,275,657 (GRCm39) |
I322T |
probably benign |
Het |
| Kars1 |
A |
C |
8: 112,729,158 (GRCm39) |
V183G |
possibly damaging |
Het |
| Lrrc15 |
C |
A |
16: 30,093,086 (GRCm39) |
M84I |
probably benign |
Het |
| Magi1 |
A |
T |
6: 93,671,177 (GRCm39) |
V796E |
probably damaging |
Het |
| Matn4 |
G |
T |
2: 164,242,896 (GRCm39) |
D67E |
probably benign |
Het |
| Mertk |
A |
G |
2: 128,624,496 (GRCm39) |
M636V |
probably damaging |
Het |
| Mettl27 |
C |
A |
5: 134,963,266 (GRCm39) |
P126T |
probably damaging |
Het |
| Mfrp |
T |
A |
9: 44,013,432 (GRCm39) |
H52Q |
possibly damaging |
Het |
| Mrgprb8 |
T |
G |
7: 48,038,656 (GRCm39) |
I109R |
probably benign |
Het |
| Mroh2a |
G |
A |
1: 88,165,666 (GRCm39) |
G512S |
probably damaging |
Het |
| Ncoa7 |
T |
A |
10: 30,598,655 (GRCm39) |
R89S |
possibly damaging |
Het |
| Nfkb2 |
G |
T |
19: 46,296,006 (GRCm39) |
E170D |
probably benign |
Het |
| Nin |
G |
T |
12: 70,137,325 (GRCm39) |
H84N |
possibly damaging |
Het |
| Nwd2 |
A |
T |
5: 63,962,893 (GRCm39) |
I826F |
possibly damaging |
Het |
| Or10d1 |
A |
G |
9: 39,484,441 (GRCm39) |
M38T |
probably benign |
Het |
| Or14c43 |
T |
C |
7: 86,115,117 (GRCm39) |
F166S |
probably damaging |
Het |
| Or1j11 |
G |
A |
2: 36,312,012 (GRCm39) |
V201I |
probably benign |
Het |
| Or4l15 |
C |
T |
14: 50,197,646 (GRCm39) |
M294I |
probably benign |
Het |
| Or52a5b |
T |
C |
7: 103,416,961 (GRCm39) |
I214M |
possibly damaging |
Het |
| Or5k3 |
A |
G |
16: 58,969,393 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or5p73 |
T |
C |
7: 108,064,938 (GRCm39) |
S136P |
probably benign |
Het |
| Otof |
C |
T |
5: 30,576,748 (GRCm39) |
R168H |
probably damaging |
Het |
| Pcdha6 |
T |
C |
18: 37,101,485 (GRCm39) |
V226A |
possibly damaging |
Het |
| Pggt1b |
T |
C |
18: 46,391,166 (GRCm39) |
I200V |
possibly damaging |
Het |
| Ppat |
G |
A |
5: 77,098,811 (GRCm39) |
Q41* |
probably null |
Het |
| Ppfibp2 |
A |
T |
7: 107,342,192 (GRCm39) |
H27L |
probably damaging |
Het |
| Rbm27 |
T |
A |
18: 42,460,510 (GRCm39) |
I775N |
probably damaging |
Het |
| Rnf40 |
C |
T |
7: 127,191,812 (GRCm39) |
R349* |
probably null |
Het |
| Rtp3 |
A |
T |
9: 110,818,544 (GRCm39) |
W46R |
probably damaging |
Het |
| Sass6 |
C |
T |
3: 116,403,949 (GRCm39) |
R196W |
probably damaging |
Het |
| Sel1l |
A |
T |
12: 91,799,932 (GRCm39) |
D131E |
probably benign |
Het |
| Slain2 |
T |
C |
5: 73,106,066 (GRCm39) |
S234P |
probably damaging |
Het |
| Slc47a1 |
C |
T |
11: 61,264,176 (GRCm39) |
|
probably null |
Het |
| Sp140 |
CAGAAGAAG |
CAGAAG |
1: 85,538,529 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,724,440 (GRCm39) |
T247A |
probably benign |
Het |
| Spef2 |
A |
T |
15: 9,713,264 (GRCm39) |
Y369* |
probably null |
Het |
| Spred2 |
T |
A |
11: 19,948,233 (GRCm39) |
M76K |
possibly damaging |
Het |
| Svs5 |
T |
A |
2: 164,078,806 (GRCm39) |
D367V |
probably benign |
Het |
| Tasor2 |
G |
A |
13: 3,634,807 (GRCm39) |
P667S |
probably damaging |
Het |
| Tefm |
A |
T |
11: 80,027,947 (GRCm39) |
D270E |
probably benign |
Het |
| Tfcp2l1 |
C |
A |
1: 118,597,194 (GRCm39) |
P425H |
probably benign |
Het |
| Thbd |
A |
T |
2: 148,248,591 (GRCm39) |
C426S |
probably damaging |
Het |
| Timm10b |
T |
A |
7: 105,333,219 (GRCm39) |
D968E |
probably damaging |
Het |
| Tle2 |
C |
T |
10: 81,413,518 (GRCm39) |
T119I |
probably damaging |
Het |
| Tnik |
T |
A |
3: 28,650,224 (GRCm39) |
Y446N |
possibly damaging |
Het |
| Tpr |
T |
A |
1: 150,324,948 (GRCm39) |
L2400* |
probably null |
Het |
| Trrap |
T |
C |
5: 144,782,402 (GRCm39) |
F3328S |
probably damaging |
Het |
| Vldlr |
G |
A |
19: 27,215,465 (GRCm39) |
C154Y |
probably damaging |
Het |
| Vmn1r79 |
T |
G |
7: 11,910,361 (GRCm39) |
M81R |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,812,000 (GRCm39) |
T3305A |
possibly damaging |
Het |
| Wdr62 |
T |
C |
7: 29,970,111 (GRCm39) |
E232G |
probably damaging |
Het |
| Wdr62 |
T |
A |
7: 29,940,890 (GRCm39) |
I843F |
probably benign |
Het |
| Zfp747l1 |
T |
C |
7: 126,984,179 (GRCm39) |
S308G |
probably benign |
Het |
| Zfp873 |
T |
A |
10: 81,896,353 (GRCm39) |
H361Q |
probably damaging |
Het |
| Zfp949 |
A |
C |
9: 88,452,047 (GRCm39) |
H539P |
probably damaging |
Het |
|
| Other mutations in Dock8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
captain_morgan
|
APN |
19 |
25,105,076 (GRCm39) |
critical splice donor site |
probably benign |
|
|
primurus
|
APN |
19 |
25,160,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00737:Dock8
|
APN |
19 |
25,160,340 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00755:Dock8
|
APN |
19 |
25,028,873 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00822:Dock8
|
APN |
19 |
25,165,773 (GRCm39) |
nonsense |
probably null |
|
|
IGL00838:Dock8
|
APN |
19 |
25,152,823 (GRCm39) |
nonsense |
probably null |
|
|
IGL01419:Dock8
|
APN |
19 |
25,096,816 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01456:Dock8
|
APN |
19 |
25,096,863 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01532:Dock8
|
APN |
19 |
25,146,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01602:Dock8
|
APN |
19 |
25,067,252 (GRCm39) |
splice site |
probably benign |
|
|
IGL01605:Dock8
|
APN |
19 |
25,067,252 (GRCm39) |
splice site |
probably benign |
|
|
IGL01753:Dock8
|
APN |
19 |
25,038,656 (GRCm39) |
splice site |
probably benign |
|
|
IGL01843:Dock8
|
APN |
19 |
25,067,292 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02032:Dock8
|
APN |
19 |
25,107,769 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02073:Dock8
|
APN |
19 |
25,178,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02192:Dock8
|
APN |
19 |
25,055,569 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02402:Dock8
|
APN |
19 |
25,055,509 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02529:Dock8
|
APN |
19 |
25,078,290 (GRCm39) |
nonsense |
probably null |
|
|
IGL02728:Dock8
|
APN |
19 |
25,109,584 (GRCm39) |
missense |
probably benign |
|
|
IGL02739:Dock8
|
APN |
19 |
25,165,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03037:Dock8
|
APN |
19 |
25,063,545 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03104:Dock8
|
APN |
19 |
25,178,384 (GRCm39) |
nonsense |
probably null |
|
|
IGL03137:Dock8
|
APN |
19 |
25,133,312 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03365:Dock8
|
APN |
19 |
25,077,048 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Defenseless
|
UTSW |
19 |
25,028,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
Guardate
|
UTSW |
19 |
25,127,195 (GRCm39) |
missense |
probably benign |
|
|
hillock
|
UTSW |
19 |
25,151,697 (GRCm39) |
critical splice donor site |
probably null |
|
|
Molehill
|
UTSW |
19 |
25,107,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pap
|
UTSW |
19 |
25,099,805 (GRCm39) |
missense |
probably benign |
0.31 |
|
Papilla
|
UTSW |
19 |
25,055,448 (GRCm39) |
nonsense |
probably null |
|
|
snowdrop
|
UTSW |
19 |
25,162,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
warts_and_all
|
UTSW |
19 |
25,146,865 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0021:Dock8
|
UTSW |
19 |
25,140,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0147:Dock8
|
UTSW |
19 |
25,096,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0148:Dock8
|
UTSW |
19 |
25,096,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0294:Dock8
|
UTSW |
19 |
25,165,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0537:Dock8
|
UTSW |
19 |
25,148,941 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0630:Dock8
|
UTSW |
19 |
25,038,524 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1163:Dock8
|
UTSW |
19 |
25,028,867 (GRCm39) |
missense |
probably benign |
|
|
R1164:Dock8
|
UTSW |
19 |
25,067,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1471:Dock8
|
UTSW |
19 |
25,178,400 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1477:Dock8
|
UTSW |
19 |
25,072,914 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1633:Dock8
|
UTSW |
19 |
25,028,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1803:Dock8
|
UTSW |
19 |
25,109,599 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1822:Dock8
|
UTSW |
19 |
25,138,422 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1852:Dock8
|
UTSW |
19 |
25,104,492 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1916:Dock8
|
UTSW |
19 |
25,038,521 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1984:Dock8
|
UTSW |
19 |
25,098,545 (GRCm39) |
missense |
probably null |
|
|
R2311:Dock8
|
UTSW |
19 |
25,160,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2341:Dock8
|
UTSW |
19 |
25,177,757 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2483:Dock8
|
UTSW |
19 |
25,057,241 (GRCm39) |
missense |
probably benign |
|
|
R3116:Dock8
|
UTSW |
19 |
25,165,858 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3157:Dock8
|
UTSW |
19 |
25,127,195 (GRCm39) |
missense |
probably benign |
|
|
R3623:Dock8
|
UTSW |
19 |
25,057,241 (GRCm39) |
missense |
probably benign |
|
|
R3624:Dock8
|
UTSW |
19 |
25,057,241 (GRCm39) |
missense |
probably benign |
|
|
R3800:Dock8
|
UTSW |
19 |
25,141,716 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3844:Dock8
|
UTSW |
19 |
25,042,794 (GRCm39) |
nonsense |
probably null |
|
|
R3895:Dock8
|
UTSW |
19 |
25,028,865 (GRCm39) |
missense |
probably benign |
0.31 |
|
R3901:Dock8
|
UTSW |
19 |
25,078,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3959:Dock8
|
UTSW |
19 |
25,162,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4428:Dock8
|
UTSW |
19 |
25,042,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4428:Dock8
|
UTSW |
19 |
25,177,863 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4429:Dock8
|
UTSW |
19 |
25,042,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4431:Dock8
|
UTSW |
19 |
25,042,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4545:Dock8
|
UTSW |
19 |
25,165,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4897:Dock8
|
UTSW |
19 |
25,159,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4939:Dock8
|
UTSW |
19 |
25,099,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4995:Dock8
|
UTSW |
19 |
25,135,747 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5035:Dock8
|
UTSW |
19 |
25,063,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5294:Dock8
|
UTSW |
19 |
25,038,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5324:Dock8
|
UTSW |
19 |
25,140,458 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5478:Dock8
|
UTSW |
19 |
25,057,186 (GRCm39) |
missense |
probably benign |
|
|
R5704:Dock8
|
UTSW |
19 |
25,151,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Dock8
|
UTSW |
19 |
25,099,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5745:Dock8
|
UTSW |
19 |
25,107,761 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5864:Dock8
|
UTSW |
19 |
25,038,584 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5870:Dock8
|
UTSW |
19 |
25,109,490 (GRCm39) |
missense |
probably benign |
|
|
R5893:Dock8
|
UTSW |
19 |
25,099,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5954:Dock8
|
UTSW |
19 |
25,148,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6087:Dock8
|
UTSW |
19 |
25,138,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6223:Dock8
|
UTSW |
19 |
25,138,416 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6391:Dock8
|
UTSW |
19 |
25,072,914 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6759:Dock8
|
UTSW |
19 |
25,104,848 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6786:Dock8
|
UTSW |
19 |
25,160,386 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6794:Dock8
|
UTSW |
19 |
25,099,805 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6818:Dock8
|
UTSW |
19 |
25,146,865 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6885:Dock8
|
UTSW |
19 |
25,124,742 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6908:Dock8
|
UTSW |
19 |
25,165,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6923:Dock8
|
UTSW |
19 |
25,072,970 (GRCm39) |
missense |
probably benign |
|
|
R7001:Dock8
|
UTSW |
19 |
25,077,041 (GRCm39) |
missense |
probably benign |
|
|
R7141:Dock8
|
UTSW |
19 |
25,158,984 (GRCm39) |
missense |
probably null |
0.75 |
|
R7203:Dock8
|
UTSW |
19 |
25,158,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Dock8
|
UTSW |
19 |
25,104,449 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7296:Dock8
|
UTSW |
19 |
25,162,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7538:Dock8
|
UTSW |
19 |
25,135,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7555:Dock8
|
UTSW |
19 |
25,152,764 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7641:Dock8
|
UTSW |
19 |
25,151,697 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7764:Dock8
|
UTSW |
19 |
25,074,899 (GRCm39) |
missense |
probably benign |
|
|
R7859:Dock8
|
UTSW |
19 |
25,160,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7864:Dock8
|
UTSW |
19 |
25,140,864 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8090:Dock8
|
UTSW |
19 |
25,131,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8160:Dock8
|
UTSW |
19 |
25,124,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8287:Dock8
|
UTSW |
19 |
25,107,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8295:Dock8
|
UTSW |
19 |
25,100,600 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8443:Dock8
|
UTSW |
19 |
25,133,281 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8537:Dock8
|
UTSW |
19 |
25,107,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8673:Dock8
|
UTSW |
19 |
25,160,867 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8709:Dock8
|
UTSW |
19 |
25,055,448 (GRCm39) |
nonsense |
probably null |
|
|
R8834:Dock8
|
UTSW |
19 |
25,140,834 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8991:Dock8
|
UTSW |
19 |
25,165,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9292:Dock8
|
UTSW |
19 |
25,160,995 (GRCm39) |
splice site |
probably benign |
|
|
R9509:Dock8
|
UTSW |
19 |
25,072,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9526:Dock8
|
UTSW |
19 |
25,165,739 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9622:Dock8
|
UTSW |
19 |
25,098,545 (GRCm39) |
missense |
probably null |
|
|
R9634:Dock8
|
UTSW |
19 |
25,169,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Dock8
|
UTSW |
19 |
25,124,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9670:Dock8
|
UTSW |
19 |
25,148,926 (GRCm39) |
missense |
probably null |
0.01 |
|
R9699:Dock8
|
UTSW |
19 |
25,133,388 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9726:Dock8
|
UTSW |
19 |
25,154,374 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9765:Dock8
|
UTSW |
19 |
25,146,832 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
X0027:Dock8
|
UTSW |
19 |
25,138,493 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Dock8
|
UTSW |
19 |
25,133,336 (GRCm39) |
missense |
probably benign |
0.16 |
|
Z1177:Dock8
|
UTSW |
19 |
25,109,487 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTGAGATTGGCTATGTTGAG -3'
(R):5'- ACCTCTGGAATCTGCAAGGG -3'
Sequencing Primer
(F):5'- CGGTTGTAAAGAATCCTTCAGG -3'
(R):5'- ATCTGCAAGGGAGGCAAC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation