Incidental Mutation 'R4778:Gm1123'
ID 368094
Institutional Source Beutler Lab
Gene Symbol Gm1123
Ensembl Gene ENSMUSG00000044860
Gene Name predicted gene 1123
Synonyms LOC382097
MMRRC Submission 042414-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R4778 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 98889018-98917743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98900560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 99 (I99V)
Ref Sequence ENSEMBL: ENSMUSP00000076020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076730]
AlphaFold Q1RME4
Predicted Effect probably benign
Transcript: ENSMUST00000076730
AA Change: I99V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076020
Gene: ENSMUSG00000044860
AA Change: I99V

DomainStartEndE-ValueType
low complexity region 3 10 N/A INTRINSIC
IGv 36 123 1.85e-7 SMART
IG 151 264 3.33e-9 SMART
IGv 286 373 6.02e-7 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,615,342 (GRCm39) N1349S probably damaging Het
Ahnak T C 19: 8,989,339 (GRCm39) V3541A possibly damaging Het
Arhgap33 T A 7: 30,231,518 (GRCm39) T156S probably benign Het
Bltp1 T A 3: 36,991,214 (GRCm39) M897K possibly damaging Het
Card11 G T 5: 140,869,537 (GRCm39) probably null Het
Cdh3 T A 8: 107,270,458 (GRCm39) I445N probably damaging Het
Csrp3 T G 7: 48,482,311 (GRCm39) K169N probably damaging Het
Cyp2c69 T C 19: 39,866,038 (GRCm39) N185S probably benign Het
Czib T C 4: 107,749,195 (GRCm39) V64A probably damaging Het
Dpysl3 C T 18: 43,487,867 (GRCm39) V159I probably benign Het
Erc1 A T 6: 119,774,298 (GRCm39) probably null Het
Fat1 T C 8: 45,491,363 (GRCm39) V3808A probably benign Het
Fbxw19 T C 9: 109,323,714 (GRCm39) D87G probably damaging Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Hand1 T C 11: 57,722,449 (GRCm39) D55G possibly damaging Het
Lrguk T A 6: 34,033,015 (GRCm39) I227K probably damaging Het
Mdn1 C T 4: 32,683,583 (GRCm39) R726* probably null Het
Minar1 T A 9: 89,485,155 (GRCm39) I81F probably damaging Het
Myo16 T A 8: 10,619,694 (GRCm39) V1415E probably damaging Het
Myof T C 19: 37,938,011 (GRCm39) D901G probably damaging Het
Naip1 A G 13: 100,563,156 (GRCm39) Y670H probably damaging Het
Nmd3 T A 3: 69,638,924 (GRCm39) Y171* probably null Het
Notch4 C T 17: 34,801,485 (GRCm39) A1111V possibly damaging Het
Nphp4 T A 4: 152,640,748 (GRCm39) D1038E probably benign Het
Or2ag1b A C 7: 106,288,874 (GRCm39) S21R probably damaging Het
Or5p60 A T 7: 107,723,687 (GRCm39) I261N possibly damaging Het
Osbpl10 C T 9: 114,938,598 (GRCm39) S86L probably damaging Het
Pcsk6 G A 7: 65,608,893 (GRCm39) G252R probably damaging Het
Pole T G 5: 110,478,698 (GRCm39) H15Q probably benign Het
Pstpip1 A G 9: 56,035,904 (GRCm39) D383G possibly damaging Het
Ptprq T C 10: 107,426,883 (GRCm39) T1551A probably benign Het
Rasgrf2 A G 13: 92,131,780 (GRCm39) F626L probably damaging Het
Retreg1 C A 15: 25,971,871 (GRCm39) N394K possibly damaging Het
Rpl7-ps8 T A 15: 59,083,252 (GRCm39) noncoding transcript Het
Rpp14 T A 14: 8,090,203 (GRCm38) D42E probably benign Het
Rrp8 T A 7: 105,386,481 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Snx1 T C 9: 66,008,698 (GRCm39) probably benign Het
Stau1 A T 2: 166,805,442 (GRCm39) N51K probably benign Het
Tdrd5 T A 1: 156,083,157 (GRCm39) D960V probably damaging Het
Tex10 T C 4: 48,436,468 (GRCm39) D750G probably damaging Het
Tmem43 T C 6: 91,459,237 (GRCm39) V236A probably damaging Het
Tmem89 T C 9: 108,744,443 (GRCm39) V112A probably damaging Het
Traf7 C G 17: 24,729,412 (GRCm39) probably benign Het
Vmn1r41 A C 6: 89,724,257 (GRCm39) K266T probably damaging Het
Vmn2r65 T C 7: 84,592,801 (GRCm39) K469E possibly damaging Het
Zfp831 A G 2: 174,488,600 (GRCm39) T1092A possibly damaging Het
Zfp981 T A 4: 146,622,112 (GRCm39) S346T probably benign Het
Other mutations in Gm1123
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01759:Gm1123 APN 9 98,905,307 (GRCm39) missense probably benign
IGL02502:Gm1123 APN 9 98,891,443 (GRCm39) nonsense probably null
R0091:Gm1123 UTSW 9 98,905,405 (GRCm39) missense possibly damaging 0.80
R4628:Gm1123 UTSW 9 98,896,289 (GRCm39) missense probably damaging 0.98
R4668:Gm1123 UTSW 9 98,891,426 (GRCm39) missense probably damaging 1.00
R4754:Gm1123 UTSW 9 98,905,294 (GRCm39) critical splice donor site probably null
R4754:Gm1123 UTSW 9 98,905,293 (GRCm39) splice site probably null
R4840:Gm1123 UTSW 9 98,900,622 (GRCm39) missense probably damaging 0.98
R4905:Gm1123 UTSW 9 98,891,369 (GRCm39) missense probably benign 0.16
R5645:Gm1123 UTSW 9 98,896,244 (GRCm39) missense probably benign 0.41
R5685:Gm1123 UTSW 9 98,891,486 (GRCm39) critical splice acceptor site probably null
R7390:Gm1123 UTSW 9 98,893,033 (GRCm39) missense probably benign 0.19
R7858:Gm1123 UTSW 9 98,896,107 (GRCm39) missense possibly damaging 0.87
R8196:Gm1123 UTSW 9 98,905,309 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGTCTTCCATAAGTGTTGTGACTTCAG -3'
(R):5'- TTGATTCTATGGCAGCAGGATATG -3'

Sequencing Primer
(F):5'- TAAGTGTTGTGACTTCAGCCCCG -3'
(R):5'- TTCTATGGCAGCAGGATATGTAAAG -3'
Posted On 2015-12-29