Incidental Mutation 'R4778:Or5p60'
ID |
368087 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or5p60
|
Ensembl Gene |
ENSMUSG00000110171 |
Gene Name |
olfactory receptor family 5 subfamily P member 60 |
Synonyms |
GA_x6K02T2PBJ9-10454128-10453163, MOR204-16, Olfr484 |
MMRRC Submission |
042414-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.144)
|
Stock # |
R4778 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
107723503-107724468 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 107723687 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 261
(I261N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000150774
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000210881]
[ENSMUST00000214722]
|
AlphaFold |
Q8VFD3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000073580
AA Change: I261N
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000073267 Gene: ENSMUSG00000059996 AA Change: I261N
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
34 |
311 |
2.5e-53 |
PFAM |
Pfam:7tm_1
|
44 |
293 |
4.5e-21 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000157612
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000210881
AA Change: I261N
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000214722
AA Change: I261N
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
Meta Mutation Damage Score |
0.5570 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
Validation Efficiency |
98% (54/55) |
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 48 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc10 |
T |
C |
17: 46,615,342 (GRCm39) |
N1349S |
probably damaging |
Het |
Ahnak |
T |
C |
19: 8,989,339 (GRCm39) |
V3541A |
possibly damaging |
Het |
Arhgap33 |
T |
A |
7: 30,231,518 (GRCm39) |
T156S |
probably benign |
Het |
Bltp1 |
T |
A |
3: 36,991,214 (GRCm39) |
M897K |
possibly damaging |
Het |
Card11 |
G |
T |
5: 140,869,537 (GRCm39) |
|
probably null |
Het |
Cdh3 |
T |
A |
8: 107,270,458 (GRCm39) |
I445N |
probably damaging |
Het |
Csrp3 |
T |
G |
7: 48,482,311 (GRCm39) |
K169N |
probably damaging |
Het |
Cyp2c69 |
T |
C |
19: 39,866,038 (GRCm39) |
N185S |
probably benign |
Het |
Czib |
T |
C |
4: 107,749,195 (GRCm39) |
V64A |
probably damaging |
Het |
Dpysl3 |
C |
T |
18: 43,487,867 (GRCm39) |
V159I |
probably benign |
Het |
Erc1 |
A |
T |
6: 119,774,298 (GRCm39) |
|
probably null |
Het |
Fat1 |
T |
C |
8: 45,491,363 (GRCm39) |
V3808A |
probably benign |
Het |
Fbxw19 |
T |
C |
9: 109,323,714 (GRCm39) |
D87G |
probably damaging |
Het |
Gm1123 |
T |
C |
9: 98,900,560 (GRCm39) |
I99V |
probably benign |
Het |
Gm11677 |
C |
T |
11: 111,615,537 (GRCm39) |
|
noncoding transcript |
Het |
Hand1 |
T |
C |
11: 57,722,449 (GRCm39) |
D55G |
possibly damaging |
Het |
Lrguk |
T |
A |
6: 34,033,015 (GRCm39) |
I227K |
probably damaging |
Het |
Mdn1 |
C |
T |
4: 32,683,583 (GRCm39) |
R726* |
probably null |
Het |
Minar1 |
T |
A |
9: 89,485,155 (GRCm39) |
I81F |
probably damaging |
Het |
Myo16 |
T |
A |
8: 10,619,694 (GRCm39) |
V1415E |
probably damaging |
Het |
Myof |
T |
C |
19: 37,938,011 (GRCm39) |
D901G |
probably damaging |
Het |
Naip1 |
A |
G |
13: 100,563,156 (GRCm39) |
Y670H |
probably damaging |
Het |
Nmd3 |
T |
A |
3: 69,638,924 (GRCm39) |
Y171* |
probably null |
Het |
Notch4 |
C |
T |
17: 34,801,485 (GRCm39) |
A1111V |
possibly damaging |
Het |
Nphp4 |
T |
A |
4: 152,640,748 (GRCm39) |
D1038E |
probably benign |
Het |
Or2ag1b |
A |
C |
7: 106,288,874 (GRCm39) |
S21R |
probably damaging |
Het |
Osbpl10 |
C |
T |
9: 114,938,598 (GRCm39) |
S86L |
probably damaging |
Het |
Pcsk6 |
G |
A |
7: 65,608,893 (GRCm39) |
G252R |
probably damaging |
Het |
Pole |
T |
G |
5: 110,478,698 (GRCm39) |
H15Q |
probably benign |
Het |
Pstpip1 |
A |
G |
9: 56,035,904 (GRCm39) |
D383G |
possibly damaging |
Het |
Ptprq |
T |
C |
10: 107,426,883 (GRCm39) |
T1551A |
probably benign |
Het |
Rasgrf2 |
A |
G |
13: 92,131,780 (GRCm39) |
F626L |
probably damaging |
Het |
Retreg1 |
C |
A |
15: 25,971,871 (GRCm39) |
N394K |
possibly damaging |
Het |
Rpl7-ps8 |
T |
A |
15: 59,083,252 (GRCm39) |
|
noncoding transcript |
Het |
Rpp14 |
T |
A |
14: 8,090,203 (GRCm38) |
D42E |
probably benign |
Het |
Rrp8 |
T |
A |
7: 105,386,481 (GRCm39) |
|
probably benign |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Snx1 |
T |
C |
9: 66,008,698 (GRCm39) |
|
probably benign |
Het |
Stau1 |
A |
T |
2: 166,805,442 (GRCm39) |
N51K |
probably benign |
Het |
Tdrd5 |
T |
A |
1: 156,083,157 (GRCm39) |
D960V |
probably damaging |
Het |
Tex10 |
T |
C |
4: 48,436,468 (GRCm39) |
D750G |
probably damaging |
Het |
Tmem43 |
T |
C |
6: 91,459,237 (GRCm39) |
V236A |
probably damaging |
Het |
Tmem89 |
T |
C |
9: 108,744,443 (GRCm39) |
V112A |
probably damaging |
Het |
Traf7 |
C |
G |
17: 24,729,412 (GRCm39) |
|
probably benign |
Het |
Vmn1r41 |
A |
C |
6: 89,724,257 (GRCm39) |
K266T |
probably damaging |
Het |
Vmn2r65 |
T |
C |
7: 84,592,801 (GRCm39) |
K469E |
possibly damaging |
Het |
Zfp831 |
A |
G |
2: 174,488,600 (GRCm39) |
T1092A |
possibly damaging |
Het |
Zfp981 |
T |
A |
4: 146,622,112 (GRCm39) |
S346T |
probably benign |
Het |
|
Other mutations in Or5p60 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01879:Or5p60
|
APN |
7 |
107,724,371 (GRCm39) |
missense |
possibly damaging |
0.88 |
IGL01899:Or5p60
|
APN |
7 |
107,724,048 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02124:Or5p60
|
APN |
7 |
107,724,249 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02622:Or5p60
|
APN |
7 |
107,723,595 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03188:Or5p60
|
APN |
7 |
107,723,841 (GRCm39) |
missense |
probably benign |
0.00 |
R0389:Or5p60
|
UTSW |
7 |
107,724,023 (GRCm39) |
missense |
probably benign |
0.00 |
R0443:Or5p60
|
UTSW |
7 |
107,724,023 (GRCm39) |
missense |
probably benign |
0.00 |
R0731:Or5p60
|
UTSW |
7 |
107,723,941 (GRCm39) |
missense |
probably benign |
0.12 |
R1061:Or5p60
|
UTSW |
7 |
107,723,663 (GRCm39) |
missense |
probably damaging |
1.00 |
R1505:Or5p60
|
UTSW |
7 |
107,724,200 (GRCm39) |
missense |
probably benign |
0.00 |
R1591:Or5p60
|
UTSW |
7 |
107,723,571 (GRCm39) |
missense |
possibly damaging |
0.56 |
R1789:Or5p60
|
UTSW |
7 |
107,724,122 (GRCm39) |
missense |
probably benign |
0.44 |
R2988:Or5p60
|
UTSW |
7 |
107,724,045 (GRCm39) |
nonsense |
probably null |
|
R5288:Or5p60
|
UTSW |
7 |
107,724,375 (GRCm39) |
missense |
probably benign |
0.00 |
R5644:Or5p60
|
UTSW |
7 |
107,723,858 (GRCm39) |
missense |
probably benign |
0.04 |
R6112:Or5p60
|
UTSW |
7 |
107,724,369 (GRCm39) |
missense |
probably benign |
0.01 |
R6351:Or5p60
|
UTSW |
7 |
107,723,637 (GRCm39) |
missense |
probably damaging |
1.00 |
R6934:Or5p60
|
UTSW |
7 |
107,724,026 (GRCm39) |
missense |
probably benign |
0.14 |
R7094:Or5p60
|
UTSW |
7 |
107,723,840 (GRCm39) |
missense |
probably benign |
0.35 |
R7135:Or5p60
|
UTSW |
7 |
107,723,781 (GRCm39) |
missense |
probably damaging |
0.99 |
R7422:Or5p60
|
UTSW |
7 |
107,724,068 (GRCm39) |
missense |
probably damaging |
1.00 |
R7660:Or5p60
|
UTSW |
7 |
107,724,041 (GRCm39) |
missense |
probably benign |
0.04 |
R7916:Or5p60
|
UTSW |
7 |
107,724,329 (GRCm39) |
missense |
possibly damaging |
0.59 |
R8489:Or5p60
|
UTSW |
7 |
107,724,372 (GRCm39) |
missense |
probably benign |
0.03 |
R9204:Or5p60
|
UTSW |
7 |
107,723,935 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9526:Or5p60
|
UTSW |
7 |
107,723,801 (GRCm39) |
missense |
probably benign |
0.06 |
X0021:Or5p60
|
UTSW |
7 |
107,724,314 (GRCm39) |
missense |
probably damaging |
1.00 |
X0025:Or5p60
|
UTSW |
7 |
107,723,606 (GRCm39) |
nonsense |
probably null |
|
Z1176:Or5p60
|
UTSW |
7 |
107,724,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTCCCACTGTCTTGAGTAATTGTC -3'
(R):5'- GCTCTCCTGTTCTGATGTCAGG -3'
Sequencing Primer
(F):5'- AGAGCCCCCTTAATCTCA -3'
(R):5'- ATGTCAGGATCTCTGTACTTGTTAC -3'
|
Posted On |
2015-12-29 |