Incidental Mutation 'R4777:Il16'
ID 368019
Institutional Source Beutler Lab
Gene Symbol Il16
Ensembl Gene ENSMUSG00000001741
Gene Name interleukin 16
Synonyms
MMRRC Submission 041992-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.255) question?
Stock # R4777 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 83292033-83394934 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 83300104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 396 (D396E)
Ref Sequence ENSEMBL: ENSMUSP00000146496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001792] [ENSMUST00000117410] [ENSMUST00000145610]
AlphaFold O54824
Predicted Effect probably benign
Transcript: ENSMUST00000001792
AA Change: D1094E

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000001792
Gene: ENSMUSG00000001741
AA Change: D1094E

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 99 115 N/A INTRINSIC
PDZ 222 300 6.5e-23 SMART
PDZ 361 438 3.89e-12 SMART
low complexity region 507 526 N/A INTRINSIC
low complexity region 556 577 N/A INTRINSIC
low complexity region 589 602 N/A INTRINSIC
low complexity region 647 680 N/A INTRINSIC
low complexity region 776 787 N/A INTRINSIC
low complexity region 825 839 N/A INTRINSIC
low complexity region 978 989 N/A INTRINSIC
PDZ 1115 1192 3.6e-16 SMART
low complexity region 1201 1216 N/A INTRINSIC
PDZ 1234 1310 4.11e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000117410
SMART Domains Protein: ENSMUSP00000112781
Gene: ENSMUSG00000046027

DomainStartEndE-ValueType
Pfam:START 7 196 5.9e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145610
AA Change: D396E

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151047
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A C 3: 137,771,503 (GRCm39) S231R probably benign Het
5730455P16Rik A T 11: 80,265,041 (GRCm39) I137N probably damaging Het
Abhd10 G A 16: 45,557,279 (GRCm39) Q176* probably null Het
Acer3 T C 7: 97,910,804 (GRCm39) Y86C probably damaging Het
Ankrd36 T C 11: 5,557,120 (GRCm39) V356A probably benign Het
Atp1a1 A G 3: 101,502,312 (GRCm39) probably null Het
Bmp8b G A 4: 123,015,793 (GRCm39) R260Q possibly damaging Het
C2cd3 T A 7: 100,065,539 (GRCm39) V775D possibly damaging Het
Cacna1b T A 2: 24,622,337 (GRCm39) I216F probably damaging Het
Capn5 T A 7: 97,780,925 (GRCm39) N284I probably damaging Het
Cbr1 C A 16: 93,406,942 (GRCm39) D219E probably benign Het
Cdca2 C T 14: 67,950,589 (GRCm39) R114Q probably damaging Het
Cdh20 G A 1: 109,922,055 (GRCm39) W49* probably null Het
Cep152 C T 2: 125,406,015 (GRCm39) V1506I probably benign Het
Cfap97 C T 8: 46,648,334 (GRCm39) Q537* probably null Het
Cpsf2 T A 12: 101,963,091 (GRCm39) V385E probably damaging Het
Dse A G 10: 34,029,584 (GRCm39) V502A possibly damaging Het
Fam171a1 T A 2: 3,224,550 (GRCm39) F300L probably benign Het
Fnip1 T G 11: 54,391,382 (GRCm39) N438K probably damaging Het
Fstl5 C T 3: 76,500,807 (GRCm39) T412M probably damaging Het
Gm11938 T A 11: 99,494,059 (GRCm39) Q12L unknown Het
Hcls1 G T 16: 36,775,678 (GRCm39) A171S probably damaging Het
Hcn1 ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC 13: 118,112,269 (GRCm39) probably benign Het
Hydin G T 8: 111,137,096 (GRCm39) C633F probably damaging Het
Ica1 A T 6: 8,644,145 (GRCm39) D381E probably benign Het
Ift74 A G 4: 94,541,234 (GRCm39) K220E probably benign Het
Igfn1 A T 1: 135,882,600 (GRCm39) D2748E probably benign Het
Impdh1 G T 6: 29,205,201 (GRCm39) A200E possibly damaging Het
Itga4 C T 2: 79,144,054 (GRCm39) T647I possibly damaging Het
Jpt1 A T 11: 115,391,497 (GRCm39) M104K probably benign Het
Krt73 C A 15: 101,702,436 (GRCm39) A476S probably benign Het
Lama3 T C 18: 12,546,828 (GRCm39) Y363H probably damaging Het
Lgr4 C T 2: 109,827,027 (GRCm39) P177L probably damaging Het
Lrp2 T C 2: 69,312,608 (GRCm39) D2560G probably damaging Het
Ly6m T C 15: 74,752,532 (GRCm39) N48S probably benign Het
Macf1 A T 4: 123,270,295 (GRCm39) F6617I probably damaging Het
Mcf2l T A 8: 13,068,051 (GRCm39) probably null Het
Mcub T A 3: 129,763,600 (GRCm39) Q42L probably damaging Het
Mfsd9 C T 1: 40,820,700 (GRCm39) V150I possibly damaging Het
Myo15b T C 11: 115,770,478 (GRCm39) V96A probably damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Or10aa3 T G 1: 173,878,244 (GRCm39) Y102D probably damaging Het
Or10g6 T C 9: 39,933,994 (GRCm39) F102L possibly damaging Het
Or1r1 A G 11: 73,875,221 (GRCm39) V71A probably benign Het
Pgap6 T C 17: 26,340,515 (GRCm39) V633A probably damaging Het
Pinlyp T A 7: 24,241,568 (GRCm39) I153F possibly damaging Het
Plk2 A C 13: 110,534,307 (GRCm39) M296L probably benign Het
Plvap T C 8: 71,960,630 (GRCm39) Y262C probably benign Het
Ppfia3 C A 7: 44,990,581 (GRCm39) G1066V probably damaging Het
Prokr1 A G 6: 87,565,842 (GRCm39) M1T probably null Het
Ptgs2 G T 1: 149,981,138 (GRCm39) A474S probably benign Het
Pth2r A G 1: 65,427,676 (GRCm39) T450A possibly damaging Het
Ranbp6 A T 19: 29,789,037 (GRCm39) F438L probably damaging Het
Ripor1 A T 8: 106,341,622 (GRCm39) Q102L probably damaging Het
Rprd2 C T 3: 95,694,686 (GRCm39) V116I probably benign Het
Sacs T C 14: 61,449,258 (GRCm39) V3768A probably damaging Het
Scn8a T C 15: 100,913,832 (GRCm39) Y1075H probably damaging Het
Senp3 C T 11: 69,569,063 (GRCm39) G366D probably damaging Het
Smim1 T C 4: 154,108,107 (GRCm39) probably benign Het
Sptan1 A G 2: 29,886,447 (GRCm39) I817V probably damaging Het
Stag3 A T 5: 138,307,461 (GRCm39) probably benign Het
Stk17b A T 1: 53,810,867 (GRCm39) H79Q probably damaging Het
Svil A G 18: 5,088,813 (GRCm39) K1296E probably damaging Het
Tmem117 T A 15: 94,992,331 (GRCm39) Y330* probably null Het
Tnxb G T 17: 34,890,917 (GRCm39) R420L probably damaging Het
Trim9 C A 12: 70,393,845 (GRCm39) C33F probably damaging Het
Usp29 A C 7: 6,965,747 (GRCm39) Y530S probably benign Het
Vps26b T C 9: 26,921,752 (GRCm39) T258A possibly damaging Het
Vrtn C A 12: 84,695,600 (GRCm39) H117N probably damaging Het
Wdr33 C T 18: 32,014,301 (GRCm39) H388Y probably damaging Het
Zfp451 A T 1: 33,821,186 (GRCm39) V222D possibly damaging Het
Zfp953 A G 13: 67,491,193 (GRCm39) I253T probably benign Het
Zfy2 A G Y: 2,116,194 (GRCm39) V282A probably benign Het
Zscan29 A T 2: 120,999,805 (GRCm39) V132D probably damaging Het
Zswim4 G T 8: 84,963,586 (GRCm39) D16E probably benign Het
Other mutations in Il16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Il16 APN 7 83,301,666 (GRCm39) missense probably benign 0.02
IGL01743:Il16 APN 7 83,301,507 (GRCm39) missense probably benign 0.00
IGL01770:Il16 APN 7 83,322,234 (GRCm39) splice site probably benign
IGL02025:Il16 APN 7 83,302,056 (GRCm39) missense probably damaging 1.00
IGL02317:Il16 APN 7 83,316,097 (GRCm39) missense probably damaging 1.00
IGL02412:Il16 APN 7 83,301,899 (GRCm39) missense probably benign 0.03
IGL02550:Il16 APN 7 83,323,704 (GRCm39) missense possibly damaging 0.90
IGL02568:Il16 APN 7 83,310,484 (GRCm39) missense probably damaging 1.00
IGL02578:Il16 APN 7 83,327,194 (GRCm39) critical splice donor site probably null
IGL02815:Il16 APN 7 83,300,249 (GRCm39) missense probably damaging 0.98
IGL03157:Il16 APN 7 83,371,611 (GRCm39) missense probably damaging 1.00
IGL03161:Il16 APN 7 83,371,707 (GRCm39) missense probably damaging 1.00
IGL03188:Il16 APN 7 83,337,371 (GRCm39) missense probably benign 0.00
IGL03213:Il16 APN 7 83,295,708 (GRCm39) missense probably damaging 1.00
IGL03274:Il16 APN 7 83,310,442 (GRCm39) missense probably damaging 1.00
R0201:Il16 UTSW 7 83,371,516 (GRCm39) missense probably damaging 0.99
R0309:Il16 UTSW 7 83,371,762 (GRCm39) missense probably damaging 1.00
R0597:Il16 UTSW 7 83,327,183 (GRCm39) splice site probably benign
R0942:Il16 UTSW 7 83,312,349 (GRCm39) missense probably benign 0.01
R1018:Il16 UTSW 7 83,323,746 (GRCm39) missense probably damaging 1.00
R1434:Il16 UTSW 7 83,304,520 (GRCm39) missense probably benign
R1715:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.01
R2179:Il16 UTSW 7 83,337,287 (GRCm39) splice site probably null
R2520:Il16 UTSW 7 83,301,202 (GRCm39) missense probably benign 0.03
R3425:Il16 UTSW 7 83,293,248 (GRCm39) missense probably damaging 1.00
R3761:Il16 UTSW 7 83,300,093 (GRCm39) missense possibly damaging 0.96
R3943:Il16 UTSW 7 83,301,223 (GRCm39) missense probably damaging 0.97
R4470:Il16 UTSW 7 83,300,046 (GRCm39) intron probably benign
R4530:Il16 UTSW 7 83,330,518 (GRCm39) intron probably benign
R4583:Il16 UTSW 7 83,332,107 (GRCm39) missense probably damaging 1.00
R4874:Il16 UTSW 7 83,310,153 (GRCm39) missense possibly damaging 0.56
R4876:Il16 UTSW 7 83,322,302 (GRCm39) missense probably benign
R5677:Il16 UTSW 7 83,323,761 (GRCm39) missense probably damaging 1.00
R5686:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.36
R5920:Il16 UTSW 7 83,301,552 (GRCm39) missense probably benign 0.03
R6115:Il16 UTSW 7 83,301,775 (GRCm39) nonsense probably null
R6459:Il16 UTSW 7 83,371,536 (GRCm39) missense probably damaging 1.00
R6459:Il16 UTSW 7 83,371,529 (GRCm39) missense probably damaging 1.00
R6601:Il16 UTSW 7 83,371,677 (GRCm39) missense probably damaging 1.00
R6616:Il16 UTSW 7 83,295,684 (GRCm39) missense probably benign 0.37
R6642:Il16 UTSW 7 83,337,335 (GRCm39) missense probably benign 0.03
R6721:Il16 UTSW 7 83,312,270 (GRCm39) critical splice donor site probably null
R7009:Il16 UTSW 7 83,295,596 (GRCm39) missense probably benign
R7144:Il16 UTSW 7 83,295,659 (GRCm39) missense probably damaging 0.97
R7346:Il16 UTSW 7 83,293,249 (GRCm39) missense probably damaging 1.00
R7403:Il16 UTSW 7 83,319,343 (GRCm39) missense probably damaging 1.00
R7499:Il16 UTSW 7 83,323,702 (GRCm39) missense probably damaging 0.99
R7814:Il16 UTSW 7 83,319,348 (GRCm39) missense possibly damaging 0.46
R7941:Il16 UTSW 7 83,332,037 (GRCm39) missense probably damaging 0.98
R8098:Il16 UTSW 7 83,295,767 (GRCm39) missense probably damaging 1.00
R8317:Il16 UTSW 7 83,304,538 (GRCm39) missense probably benign
R8437:Il16 UTSW 7 83,301,351 (GRCm39) missense probably damaging 1.00
R9094:Il16 UTSW 7 83,301,559 (GRCm39) missense probably benign
R9267:Il16 UTSW 7 83,371,757 (GRCm39) missense probably benign 0.01
R9445:Il16 UTSW 7 83,337,380 (GRCm39) nonsense probably null
R9595:Il16 UTSW 7 83,322,273 (GRCm39) nonsense probably null
R9651:Il16 UTSW 7 83,332,064 (GRCm39) missense probably damaging 0.96
Z1176:Il16 UTSW 7 83,302,035 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TCCCAGCTAAAATCAGGTGTTAAC -3'
(R):5'- GTTATCTCTGCTTGTGAAAGCC -3'

Sequencing Primer
(F):5'- AAGTGACATGGTGTCCCTCTAC -3'
(R):5'- GCCTTTCAGAGCTGAGAGAATATTC -3'
Posted On 2015-12-29