Incidental Mutation 'R4777:Fstl5'
ID 368000
Institutional Source Beutler Lab
Gene Symbol Fstl5
Ensembl Gene ENSMUSG00000034098
Gene Name follistatin-like 5
Synonyms 9130207J01Rik
MMRRC Submission 041992-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R4777 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 75981582-76617317 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 76500807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 412 (T412M)
Ref Sequence ENSEMBL: ENSMUSP00000125393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038364] [ENSMUST00000160261] [ENSMUST00000162471]
AlphaFold Q8BFR2
Predicted Effect probably damaging
Transcript: ENSMUST00000038364
AA Change: T412M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038506
Gene: ENSMUSG00000034098
AA Change: T412M

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000160261
AA Change: T412M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125393
Gene: ENSMUSG00000034098
AA Change: T412M

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162471
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191664
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A C 3: 137,771,503 (GRCm39) S231R probably benign Het
5730455P16Rik A T 11: 80,265,041 (GRCm39) I137N probably damaging Het
Abhd10 G A 16: 45,557,279 (GRCm39) Q176* probably null Het
Acer3 T C 7: 97,910,804 (GRCm39) Y86C probably damaging Het
Ankrd36 T C 11: 5,557,120 (GRCm39) V356A probably benign Het
Atp1a1 A G 3: 101,502,312 (GRCm39) probably null Het
Bmp8b G A 4: 123,015,793 (GRCm39) R260Q possibly damaging Het
C2cd3 T A 7: 100,065,539 (GRCm39) V775D possibly damaging Het
Cacna1b T A 2: 24,622,337 (GRCm39) I216F probably damaging Het
Capn5 T A 7: 97,780,925 (GRCm39) N284I probably damaging Het
Cbr1 C A 16: 93,406,942 (GRCm39) D219E probably benign Het
Cdca2 C T 14: 67,950,589 (GRCm39) R114Q probably damaging Het
Cdh20 G A 1: 109,922,055 (GRCm39) W49* probably null Het
Cep152 C T 2: 125,406,015 (GRCm39) V1506I probably benign Het
Cfap97 C T 8: 46,648,334 (GRCm39) Q537* probably null Het
Cpsf2 T A 12: 101,963,091 (GRCm39) V385E probably damaging Het
Dse A G 10: 34,029,584 (GRCm39) V502A possibly damaging Het
Fam171a1 T A 2: 3,224,550 (GRCm39) F300L probably benign Het
Fnip1 T G 11: 54,391,382 (GRCm39) N438K probably damaging Het
Gm11938 T A 11: 99,494,059 (GRCm39) Q12L unknown Het
Hcls1 G T 16: 36,775,678 (GRCm39) A171S probably damaging Het
Hcn1 ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC 13: 118,112,269 (GRCm39) probably benign Het
Hydin G T 8: 111,137,096 (GRCm39) C633F probably damaging Het
Ica1 A T 6: 8,644,145 (GRCm39) D381E probably benign Het
Ift74 A G 4: 94,541,234 (GRCm39) K220E probably benign Het
Igfn1 A T 1: 135,882,600 (GRCm39) D2748E probably benign Het
Il16 A C 7: 83,300,104 (GRCm39) D396E probably benign Het
Impdh1 G T 6: 29,205,201 (GRCm39) A200E possibly damaging Het
Itga4 C T 2: 79,144,054 (GRCm39) T647I possibly damaging Het
Jpt1 A T 11: 115,391,497 (GRCm39) M104K probably benign Het
Krt73 C A 15: 101,702,436 (GRCm39) A476S probably benign Het
Lama3 T C 18: 12,546,828 (GRCm39) Y363H probably damaging Het
Lgr4 C T 2: 109,827,027 (GRCm39) P177L probably damaging Het
Lrp2 T C 2: 69,312,608 (GRCm39) D2560G probably damaging Het
Ly6m T C 15: 74,752,532 (GRCm39) N48S probably benign Het
Macf1 A T 4: 123,270,295 (GRCm39) F6617I probably damaging Het
Mcf2l T A 8: 13,068,051 (GRCm39) probably null Het
Mcub T A 3: 129,763,600 (GRCm39) Q42L probably damaging Het
Mfsd9 C T 1: 40,820,700 (GRCm39) V150I possibly damaging Het
Myo15b T C 11: 115,770,478 (GRCm39) V96A probably damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Or10aa3 T G 1: 173,878,244 (GRCm39) Y102D probably damaging Het
Or10g6 T C 9: 39,933,994 (GRCm39) F102L possibly damaging Het
Or1r1 A G 11: 73,875,221 (GRCm39) V71A probably benign Het
Pgap6 T C 17: 26,340,515 (GRCm39) V633A probably damaging Het
Pinlyp T A 7: 24,241,568 (GRCm39) I153F possibly damaging Het
Plk2 A C 13: 110,534,307 (GRCm39) M296L probably benign Het
Plvap T C 8: 71,960,630 (GRCm39) Y262C probably benign Het
Ppfia3 C A 7: 44,990,581 (GRCm39) G1066V probably damaging Het
Prokr1 A G 6: 87,565,842 (GRCm39) M1T probably null Het
Ptgs2 G T 1: 149,981,138 (GRCm39) A474S probably benign Het
Pth2r A G 1: 65,427,676 (GRCm39) T450A possibly damaging Het
Ranbp6 A T 19: 29,789,037 (GRCm39) F438L probably damaging Het
Ripor1 A T 8: 106,341,622 (GRCm39) Q102L probably damaging Het
Rprd2 C T 3: 95,694,686 (GRCm39) V116I probably benign Het
Sacs T C 14: 61,449,258 (GRCm39) V3768A probably damaging Het
Scn8a T C 15: 100,913,832 (GRCm39) Y1075H probably damaging Het
Senp3 C T 11: 69,569,063 (GRCm39) G366D probably damaging Het
Smim1 T C 4: 154,108,107 (GRCm39) probably benign Het
Sptan1 A G 2: 29,886,447 (GRCm39) I817V probably damaging Het
Stag3 A T 5: 138,307,461 (GRCm39) probably benign Het
Stk17b A T 1: 53,810,867 (GRCm39) H79Q probably damaging Het
Svil A G 18: 5,088,813 (GRCm39) K1296E probably damaging Het
Tmem117 T A 15: 94,992,331 (GRCm39) Y330* probably null Het
Tnxb G T 17: 34,890,917 (GRCm39) R420L probably damaging Het
Trim9 C A 12: 70,393,845 (GRCm39) C33F probably damaging Het
Usp29 A C 7: 6,965,747 (GRCm39) Y530S probably benign Het
Vps26b T C 9: 26,921,752 (GRCm39) T258A possibly damaging Het
Vrtn C A 12: 84,695,600 (GRCm39) H117N probably damaging Het
Wdr33 C T 18: 32,014,301 (GRCm39) H388Y probably damaging Het
Zfp451 A T 1: 33,821,186 (GRCm39) V222D possibly damaging Het
Zfp953 A G 13: 67,491,193 (GRCm39) I253T probably benign Het
Zfy2 A G Y: 2,116,194 (GRCm39) V282A probably benign Het
Zscan29 A T 2: 120,999,805 (GRCm39) V132D probably damaging Het
Zswim4 G T 8: 84,963,586 (GRCm39) D16E probably benign Het
Other mutations in Fstl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Fstl5 APN 3 76,615,135 (GRCm39) missense probably benign 0.30
IGL01658:Fstl5 APN 3 76,389,562 (GRCm39) missense possibly damaging 0.70
IGL01917:Fstl5 APN 3 76,615,153 (GRCm39) missense probably damaging 1.00
IGL02073:Fstl5 APN 3 76,566,959 (GRCm39) splice site probably benign
IGL02329:Fstl5 APN 3 76,496,302 (GRCm39) missense probably damaging 1.00
IGL02651:Fstl5 APN 3 76,500,841 (GRCm39) missense probably damaging 1.00
IGL02967:Fstl5 APN 3 76,229,498 (GRCm39) missense probably damaging 1.00
IGL03004:Fstl5 APN 3 76,555,738 (GRCm39) splice site probably benign
IGL03107:Fstl5 APN 3 76,443,618 (GRCm39) missense probably damaging 1.00
IGL03113:Fstl5 APN 3 76,337,099 (GRCm39) nonsense probably null
P0038:Fstl5 UTSW 3 76,052,369 (GRCm39) missense probably damaging 1.00
PIT4131001:Fstl5 UTSW 3 76,567,006 (GRCm39) missense probably damaging 0.99
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0078:Fstl5 UTSW 3 76,566,952 (GRCm39) splice site probably benign
R0137:Fstl5 UTSW 3 76,614,786 (GRCm39) missense probably damaging 1.00
R0183:Fstl5 UTSW 3 76,229,579 (GRCm39) missense possibly damaging 0.86
R0330:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R0427:Fstl5 UTSW 3 76,615,034 (GRCm39) nonsense probably null
R0687:Fstl5 UTSW 3 76,615,119 (GRCm39) missense possibly damaging 0.62
R1642:Fstl5 UTSW 3 76,317,929 (GRCm39) missense possibly damaging 0.80
R1765:Fstl5 UTSW 3 76,500,783 (GRCm39) missense possibly damaging 0.90
R1900:Fstl5 UTSW 3 76,615,467 (GRCm39) missense probably damaging 1.00
R1996:Fstl5 UTSW 3 76,615,141 (GRCm39) missense probably benign 0.19
R2157:Fstl5 UTSW 3 76,615,372 (GRCm39) missense possibly damaging 0.46
R2228:Fstl5 UTSW 3 76,389,659 (GRCm39) missense probably damaging 1.00
R2851:Fstl5 UTSW 3 76,337,045 (GRCm39) splice site probably benign
R4021:Fstl5 UTSW 3 76,536,282 (GRCm39) missense probably benign 0.00
R4086:Fstl5 UTSW 3 76,555,593 (GRCm39) missense probably damaging 1.00
R4829:Fstl5 UTSW 3 76,229,489 (GRCm39) missense probably damaging 1.00
R4934:Fstl5 UTSW 3 76,496,272 (GRCm39) missense probably damaging 1.00
R4955:Fstl5 UTSW 3 76,131,183 (GRCm39) critical splice donor site probably null
R4977:Fstl5 UTSW 3 76,317,801 (GRCm39) nonsense probably null
R5166:Fstl5 UTSW 3 76,536,267 (GRCm39) missense possibly damaging 0.86
R5232:Fstl5 UTSW 3 76,052,284 (GRCm39) missense possibly damaging 0.89
R5313:Fstl5 UTSW 3 76,500,812 (GRCm39) missense possibly damaging 0.90
R5584:Fstl5 UTSW 3 76,229,574 (GRCm39) missense probably damaging 1.00
R5647:Fstl5 UTSW 3 76,496,399 (GRCm39) missense probably damaging 1.00
R5842:Fstl5 UTSW 3 76,229,590 (GRCm39) missense possibly damaging 0.94
R5978:Fstl5 UTSW 3 76,052,392 (GRCm39) missense probably damaging 1.00
R6007:Fstl5 UTSW 3 76,317,899 (GRCm39) missense probably damaging 1.00
R6064:Fstl5 UTSW 3 76,229,605 (GRCm39) missense probably benign 0.13
R6327:Fstl5 UTSW 3 76,615,108 (GRCm39) missense probably benign 0.31
R6386:Fstl5 UTSW 3 76,229,373 (GRCm39) missense probably benign 0.13
R6523:Fstl5 UTSW 3 76,443,641 (GRCm39) missense probably benign 0.00
R6852:Fstl5 UTSW 3 76,615,162 (GRCm39) missense probably damaging 1.00
R6861:Fstl5 UTSW 3 76,229,523 (GRCm39) missense probably damaging 1.00
R6866:Fstl5 UTSW 3 76,229,532 (GRCm39) missense probably damaging 0.99
R7100:Fstl5 UTSW 3 76,443,600 (GRCm39) missense probably benign 0.11
R7341:Fstl5 UTSW 3 76,389,704 (GRCm39) splice site probably null
R7495:Fstl5 UTSW 3 76,615,099 (GRCm39) missense possibly damaging 0.85
R7558:Fstl5 UTSW 3 76,337,092 (GRCm39) missense possibly damaging 0.95
R7731:Fstl5 UTSW 3 76,569,069 (GRCm39) missense probably damaging 1.00
R7787:Fstl5 UTSW 3 76,337,131 (GRCm39) missense probably damaging 1.00
R7852:Fstl5 UTSW 3 76,615,275 (GRCm39) missense probably benign 0.00
R7874:Fstl5 UTSW 3 76,569,093 (GRCm39) missense probably benign 0.10
R7881:Fstl5 UTSW 3 76,443,605 (GRCm39) missense probably damaging 1.00
R7986:Fstl5 UTSW 3 76,337,097 (GRCm39) missense probably damaging 0.98
R8039:Fstl5 UTSW 3 76,555,725 (GRCm39) missense possibly damaging 0.69
R8050:Fstl5 UTSW 3 76,614,810 (GRCm39) missense probably benign 0.00
R8844:Fstl5 UTSW 3 76,337,154 (GRCm39) missense possibly damaging 0.71
R8929:Fstl5 UTSW 3 76,615,138 (GRCm39) missense probably damaging 0.98
R9012:Fstl5 UTSW 3 76,567,027 (GRCm39) missense probably damaging 1.00
R9069:Fstl5 UTSW 3 76,615,416 (GRCm39) missense probably damaging 0.99
R9221:Fstl5 UTSW 3 76,569,114 (GRCm39) missense probably damaging 0.98
R9373:Fstl5 UTSW 3 76,555,669 (GRCm39) nonsense probably null
R9427:Fstl5 UTSW 3 76,229,583 (GRCm39) missense
R9490:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R9603:Fstl5 UTSW 3 76,496,260 (GRCm39) missense probably damaging 1.00
Z1176:Fstl5 UTSW 3 76,615,289 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCATATCTCCAAAGTAAGGAAGC -3'
(R):5'- TGCACCTGCTCTCAAACATC -3'

Sequencing Primer
(F):5'- TATCTCCAAAGTAAGGAAGCAGGAAG -3'
(R):5'- AGATTTCCAATCTTCCTGAAAACAG -3'
Posted On 2015-12-29