Mutagenetix > Incidental Mutation

Incidental Mutation 'R4731:Pkp4'

358801

Institutional Source

Beutler Lab

Gene Symbol

Pkp4

Ensembl Gene

ENSMUSG00000026991

Gene Name

plakophilin 4

Synonyms

p0071, 5031422I09Rik, Armrp, 9430019K17Rik

MMRRC Submission

042021-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4731 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

58991194-59185552 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 59165276 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129836 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037903] [ENSMUST00000037903] [ENSMUST00000102754] [ENSMUST00000112577] [ENSMUST00000112577] [ENSMUST00000123908] [ENSMUST00000168631] [ENSMUST00000183359] [ENSMUST00000184332]

AlphaFold

Q68FH0

Predicted Effect

probably null
Transcript: ENSMUST00000037903

SMART Domains

Protein: ENSMUSP00000042249
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC
low complexity region	230	246	N/A	INTRINSIC
low complexity region	324	337	N/A	INTRINSIC
low complexity region	467	478	N/A	INTRINSIC
ARM	574	614	5.68e-9	SMART
ARM	618	659	1.61e-8	SMART
ARM	660	717	4.54e1	SMART
ARM	719	766	9.97e0	SMART
low complexity region	777	788	N/A	INTRINSIC
ARM	876	916	3.34e-6	SMART
ARM	964	1008	1.32e-4	SMART
low complexity region	1057	1073	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000037903

SMART Domains

Protein: ENSMUSP00000042249
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC
low complexity region	230	246	N/A	INTRINSIC
low complexity region	324	337	N/A	INTRINSIC
low complexity region	467	478	N/A	INTRINSIC
ARM	574	614	5.68e-9	SMART
ARM	618	659	1.61e-8	SMART
ARM	660	717	4.54e1	SMART
ARM	719	766	9.97e0	SMART
low complexity region	777	788	N/A	INTRINSIC
ARM	876	916	3.34e-6	SMART
ARM	964	1008	1.32e-4	SMART
low complexity region	1057	1073	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000102754

SMART Domains

Protein: ENSMUSP00000099815
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC
low complexity region	230	246	N/A	INTRINSIC
low complexity region	324	337	N/A	INTRINSIC
low complexity region	467	478	N/A	INTRINSIC
ARM	558	598	5.68e-9	SMART
ARM	602	643	1.61e-8	SMART
ARM	644	701	4.54e1	SMART
ARM	703	750	9.97e0	SMART
low complexity region	761	772	N/A	INTRINSIC
ARM	860	900	3.34e-6	SMART
ARM	948	992	1.32e-4	SMART
low complexity region	1083	1100	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112577

SMART Domains

Protein: ENSMUSP00000108196
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
low complexity region	126	137	N/A	INTRINSIC
ARM	217	257	5.68e-9	SMART
ARM	261	302	1.61e-8	SMART
ARM	303	360	4.54e1	SMART
ARM	362	409	9.97e0	SMART
low complexity region	420	431	N/A	INTRINSIC
ARM	519	559	3.34e-6	SMART
ARM	607	651	1.32e-4	SMART
low complexity region	742	759	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112577

SMART Domains

Protein: ENSMUSP00000108196
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
low complexity region	126	137	N/A	INTRINSIC
ARM	217	257	5.68e-9	SMART
ARM	261	302	1.61e-8	SMART
ARM	303	360	4.54e1	SMART
ARM	362	409	9.97e0	SMART
low complexity region	420	431	N/A	INTRINSIC
ARM	519	559	3.34e-6	SMART
ARM	607	651	1.32e-4	SMART
low complexity region	742	759	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000123908

SMART Domains

Protein: ENSMUSP00000122152
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC
low complexity region	230	246	N/A	INTRINSIC
low complexity region	324	337	N/A	INTRINSIC
low complexity region	467	478	N/A	INTRINSIC
ARM	574	614	5.68e-9	SMART
ARM	618	659	1.61e-8	SMART
ARM	660	717	4.54e1	SMART
ARM	719	766	9.97e0	SMART
low complexity region	777	788	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151452

Predicted Effect

probably null
Transcript: ENSMUST00000168631

SMART Domains

Protein: ENSMUSP00000129836
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC
low complexity region	230	246	N/A	INTRINSIC
low complexity region	324	337	N/A	INTRINSIC
low complexity region	467	478	N/A	INTRINSIC
ARM	558	598	5.68e-9	SMART
ARM	602	643	1.61e-8	SMART
ARM	644	701	4.54e1	SMART
ARM	703	750	9.97e0	SMART
low complexity region	761	772	N/A	INTRINSIC
ARM	860	900	3.34e-6	SMART
ARM	948	992	1.32e-4	SMART
low complexity region	1041	1057	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000183359

SMART Domains

Protein: ENSMUSP00000139141
Gene: ENSMUSG00000026991

Domain	Start	End	E-Value	Type
coiled coil region	41	63	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000184332

Meta Mutation Damage Score

0.9584

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.9%

Validation Efficiency

99% (117/118)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
PHENOTYPE: An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 115 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actmap	T	A	7: 26,900,468 (GRCm39)	M149K	probably damaging	Het
Adamts12	A	T	15: 11,270,748 (GRCm39)	S668C	probably damaging	Het
Adcy8	A	G	15: 64,626,711 (GRCm39)	V709A	possibly damaging	Het
Aim2	T	A	1: 173,291,442 (GRCm39)	D282E	possibly damaging	Het
Akap9	T	A	5: 4,012,266 (GRCm39)	S990T	possibly damaging	Het
Aloxe3	A	T	11: 69,019,480 (GRCm39)	D131V	probably null	Het
Ankrd28	A	C	14: 31,477,698 (GRCm39)	C115G	probably benign	Het
Anxa2	A	T	9: 69,393,812 (GRCm39)	M217L	probably benign	Het
Asah2	T	C	19: 31,972,758 (GRCm39)	N659S	probably benign	Het
Btaf1	A	G	19: 36,958,478 (GRCm39)	D665G	probably benign	Het
Cdc42bpg	T	A	19: 6,361,221 (GRCm39)	V282E	probably damaging	Het
Cdh15	G	A	8: 123,588,763 (GRCm39)	R279Q	probably damaging	Het
Cdipt	T	A	7: 126,577,530 (GRCm39)	L92H	probably damaging	Het
Cep104	T	A	4: 154,072,883 (GRCm39)	D380E	probably damaging	Het
Cfap74	T	A	4: 155,548,059 (GRCm39)		probably benign	Het
Chd1	A	T	17: 17,598,079 (GRCm39)	E55D	probably benign	Het
Cldnd2	T	A	7: 43,091,613 (GRCm39)	C65S	possibly damaging	Het
Clec9a	G	T	6: 129,393,299 (GRCm39)	A108S	probably benign	Het
Cog7	T	C	7: 121,563,467 (GRCm39)	D215G	probably benign	Het
Col9a3	G	A	2: 180,252,474 (GRCm39)	E373K	probably damaging	Het
Deptor	C	A	15: 55,044,406 (GRCm39)	H191N	probably benign	Het
Dgkz	A	T	2: 91,768,684 (GRCm39)	I699N	probably damaging	Het
Dnah7c	T	A	1: 46,809,333 (GRCm39)	N3550K	probably damaging	Het
Dnah8	A	G	17: 30,994,035 (GRCm39)	K3384R	probably null	Het
Dnajc13	CT	C	9: 104,064,004 (GRCm39)		probably benign	Het
Dnhd1	C	A	7: 105,323,056 (GRCm39)	N521K	probably benign	Het
Efhb	G	A	17: 53,733,272 (GRCm39)	T533I	probably damaging	Het
Ercc4	A	T	16: 12,965,471 (GRCm39)	H701L	probably damaging	Het
Ern1	A	T	11: 106,325,676 (GRCm39)		probably benign	Het
Etfb	T	C	7: 43,093,624 (GRCm39)	V17A	probably damaging	Het
Evc	T	A	5: 37,481,141 (GRCm39)	M235L	probably benign	Het
Fbxw22	T	C	9: 109,207,937 (GRCm39)	I445V	probably benign	Het
Fmnl2	A	G	2: 53,007,081 (GRCm39)	T764A	possibly damaging	Het
Fto	T	A	8: 92,136,342 (GRCm39)	D205E	probably damaging	Het
Galntl6	G	A	8: 58,880,847 (GRCm39)	P147L	probably damaging	Het
Gm6871	T	C	7: 41,196,173 (GRCm39)	I39V	probably benign	Het
Gpr83	A	G	9: 14,777,470 (GRCm39)		probably benign	Het
Gucy1a2	A	T	9: 3,759,424 (GRCm39)	H410L	probably benign	Het
Helb	T	C	10: 119,930,193 (GRCm39)		probably null	Het
Ifi214	T	C	1: 173,354,157 (GRCm39)	Q171R	probably benign	Het
Ifit1bl1	T	C	19: 34,571,721 (GRCm39)	I245M	probably benign	Het
Igdcc3	A	G	9: 65,089,279 (GRCm39)	T492A	probably damaging	Het
Ighv13-1	T	C	12: 114,231,252 (GRCm39)		probably benign	Het
Igkv4-50	T	C	6: 69,677,984 (GRCm39)	K40R	probably benign	Het
Igkv8-18	T	A	6: 70,333,280 (GRCm39)	I74N	probably damaging	Het
Iho1	A	G	9: 108,282,584 (GRCm39)	V368A	probably benign	Het
Kbtbd7	T	C	14: 79,666,240 (GRCm39)	*691Q	probably null	Het
Khnyn	T	A	14: 56,123,946 (GRCm39)		probably null	Het
Kif26a	G	A	12: 112,142,007 (GRCm39)	A754T	probably benign	Het
Llgl1	T	A	11: 60,597,051 (GRCm39)	L194*	probably null	Het
Map3k12	G	T	15: 102,409,717 (GRCm39)	T686N	probably benign	Het
Myo18a	C	A	11: 77,720,585 (GRCm39)	P741Q	probably benign	Het
Ncaph2	G	A	15: 89,240,030 (GRCm39)		probably benign	Het
Nfkb2	A	G	19: 46,297,403 (GRCm39)	Q406R	possibly damaging	Het
Or10g9b	A	T	9: 39,917,564 (GRCm39)	I227N	probably damaging	Het
Or11g2	T	A	14: 50,856,026 (GRCm39)	C116S	probably benign	Het
Or1ad6	G	A	11: 50,860,093 (GRCm39)	V83M	possibly damaging	Het
Or2i1	T	C	17: 37,507,915 (GRCm39)	T315A	probably damaging	Het
Or2n1e	T	A	17: 38,586,438 (GRCm39)	Y259N	probably damaging	Het
Or8b12	A	T	9: 37,657,831 (GRCm39)	T134S	probably benign	Het
Ostm1	C	T	10: 42,554,975 (GRCm39)		probably benign	Het
Pabpc1	A	T	15: 36,599,528 (GRCm39)	V389E	probably benign	Het
Pank4	A	T	4: 155,055,847 (GRCm39)	M291L	probably benign	Het
Pex6	A	G	17: 47,033,214 (GRCm39)	D579G	probably benign	Het
Pex6	A	G	17: 47,035,633 (GRCm39)		probably null	Het
Phc2	C	T	4: 128,601,764 (GRCm39)	T73M	probably damaging	Het
Plekhg1	T	A	10: 3,907,506 (GRCm39)	S808T	probably benign	Het
Plk5	A	T	10: 80,194,631 (GRCm39)	H118L	probably damaging	Het
Pnlip	T	C	19: 58,664,919 (GRCm39)	I249T	probably benign	Het
Ptov1	T	C	7: 44,516,533 (GRCm39)	D134G	probably benign	Het
Ptprb	T	C	10: 116,155,238 (GRCm39)	V664A	probably benign	Het
Ptprz1	T	A	6: 23,002,609 (GRCm39)	S1566R	probably benign	Het
Pum1	T	C	4: 130,445,504 (GRCm39)	S158P	probably benign	Het
Rae1	G	T	2: 172,857,185 (GRCm39)		probably benign	Het
Ros1	A	C	10: 52,018,325 (GRCm39)	W778G	probably damaging	Het
Ryr2	A	T	13: 11,592,795 (GRCm39)	M4653K	possibly damaging	Het
Sacm1l	G	A	9: 123,419,895 (GRCm39)	V553I	probably benign	Het
Samd4b	G	A	7: 28,106,088 (GRCm39)	R377W	probably benign	Het
Selenoo	A	G	15: 88,983,531 (GRCm39)	Q524R	probably benign	Het
Slc30a3	T	C	5: 31,250,638 (GRCm39)	S22G	probably benign	Het
Slc35g2	A	C	9: 100,434,555 (GRCm39)	V372G	probably benign	Het
Slc5a8	T	C	10: 88,761,649 (GRCm39)		probably null	Het
Slc7a7	T	C	14: 54,646,190 (GRCm39)	Y91C	probably damaging	Het
Slc7a9	T	A	7: 35,152,988 (GRCm39)	Y135*	probably null	Het
Slfn1	A	T	11: 83,012,661 (GRCm39)	E259V	probably damaging	Het
Slmap	T	C	14: 26,189,690 (GRCm39)	N156S	probably damaging	Het
Smim29	A	G	17: 27,784,244 (GRCm39)		probably benign	Het
Sorbs1	T	A	19: 40,303,133 (GRCm39)	R485S	probably benign	Het
Sptbn2	T	A	19: 4,792,508 (GRCm39)	F1388I	probably damaging	Het
Stac2	C	T	11: 97,930,521 (GRCm39)	G349E	probably damaging	Het
Tigd2	T	A	6: 59,188,400 (GRCm39)	H422Q	probably benign	Het
Tle1	T	C	4: 72,043,256 (GRCm39)	N538D	possibly damaging	Het
Tmtc1	A	C	6: 148,186,478 (GRCm39)		probably null	Het
Tns3	C	T	11: 8,400,986 (GRCm39)	R1104H	probably benign	Het
Tom1l2	C	G	11: 60,161,259 (GRCm39)	R84P	probably damaging	Het
Trank1	T	C	9: 111,219,478 (GRCm39)	F2072L	probably damaging	Het
Trim6	T	C	7: 103,881,855 (GRCm39)	Y369H	probably damaging	Het
Trpc7	A	G	13: 56,952,366 (GRCm39)	S541P	probably damaging	Het
Trpv4	T	C	5: 114,760,814 (GRCm39)	D732G	possibly damaging	Het
Tsc2	C	A	17: 24,822,249 (GRCm39)	V1141F	possibly damaging	Het
Tspoap1	T	A	11: 87,656,473 (GRCm39)	V257E	probably benign	Het
Ttn	A	T	2: 76,773,355 (GRCm39)	M2395K	unknown	Het
Ubd	A	C	17: 37,506,593 (GRCm39)	T160P	probably benign	Het
Ubr7	A	G	12: 102,735,485 (GRCm39)	T315A	probably benign	Het
Ugt2b36	G	T	5: 87,229,397 (GRCm39)	Y156*	probably null	Het
Ulk4	G	A	9: 121,092,704 (GRCm39)	R178*	probably null	Het
Urod	G	A	4: 116,848,870 (GRCm39)	A92V	possibly damaging	Het
Utp20	T	C	10: 88,590,382 (GRCm39)	D2364G	possibly damaging	Het
Vmn1r87	A	T	7: 12,866,254 (GRCm39)	M11K	possibly damaging	Het
Vstm4	A	G	14: 32,639,859 (GRCm39)	K96E	possibly damaging	Het
Wwp1	T	C	4: 19,661,990 (GRCm39)	D172G	probably benign	Het
Zfhx3	A	G	8: 109,682,716 (GRCm39)	Q3385R	unknown	Het
Zfp229	C	T	17: 21,964,267 (GRCm39)	H166Y	possibly damaging	Het
Zfp738	A	T	13: 67,818,033 (GRCm39)	C653S	probably damaging	Het
Zp2	C	A	7: 119,737,343 (GRCm39)	V282L	probably damaging	Het

Other mutations in Pkp4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Pkp4	APN	2	59,169,099 (GRCm39)	missense	probably damaging	0.99
IGL00987:Pkp4	APN	2	59,138,701 (GRCm39)	missense	probably damaging	0.98
IGL01321:Pkp4	APN	2	59,180,971 (GRCm39)	splice site	probably null
IGL01393:Pkp4	APN	2	59,178,269 (GRCm39)	missense	probably damaging	1.00
IGL02058:Pkp4	APN	2	59,142,073 (GRCm39)	nonsense	probably null
IGL02313:Pkp4	APN	2	59,140,598 (GRCm39)	nonsense	probably null
IGL02635:Pkp4	APN	2	59,135,842 (GRCm39)	unclassified	probably benign
IGL03017:Pkp4	APN	2	59,096,769 (GRCm39)	missense	probably benign	0.06
IGL03051:Pkp4	APN	2	59,142,106 (GRCm39)	missense	probably benign	0.29
Degrasso	UTSW	2	59,148,944 (GRCm39)	missense	probably damaging	1.00
melted	UTSW	2	59,165,276 (GRCm39)	critical splice donor site	probably null
BB004:Pkp4	UTSW	2	59,142,098 (GRCm39)	missense	probably damaging	0.97
BB014:Pkp4	UTSW	2	59,142,098 (GRCm39)	missense	probably damaging	0.97
R0206:Pkp4	UTSW	2	59,096,780 (GRCm39)	missense	probably damaging	0.99
R0207:Pkp4	UTSW	2	59,135,832 (GRCm39)	missense	possibly damaging	0.89
R0208:Pkp4	UTSW	2	59,096,780 (GRCm39)	missense	probably damaging	0.99
R0325:Pkp4	UTSW	2	59,148,873 (GRCm39)	missense	probably damaging	1.00
R0620:Pkp4	UTSW	2	59,152,987 (GRCm39)	missense	possibly damaging	0.46
R0781:Pkp4	UTSW	2	59,169,109 (GRCm39)	missense	probably damaging	1.00
R1110:Pkp4	UTSW	2	59,169,109 (GRCm39)	missense	probably damaging	1.00
R1537:Pkp4	UTSW	2	59,045,147 (GRCm39)	missense	probably damaging	1.00
R1607:Pkp4	UTSW	2	59,152,898 (GRCm39)	missense	probably benign	0.00
R1654:Pkp4	UTSW	2	59,167,963 (GRCm39)	missense	probably damaging	0.96
R1760:Pkp4	UTSW	2	59,142,185 (GRCm39)	missense	probably damaging	0.97
R2051:Pkp4	UTSW	2	59,165,248 (GRCm39)	missense	probably benign	0.37
R2871:Pkp4	UTSW	2	59,138,500 (GRCm39)	missense	probably benign	0.35
R2871:Pkp4	UTSW	2	59,138,500 (GRCm39)	missense	probably benign	0.35
R3161:Pkp4	UTSW	2	59,138,449 (GRCm39)	missense	probably damaging	1.00
R4261:Pkp4	UTSW	2	59,135,506 (GRCm39)	missense	probably damaging	1.00
R4342:Pkp4	UTSW	2	59,180,952 (GRCm39)	missense	probably damaging	0.98
R4799:Pkp4	UTSW	2	59,172,449 (GRCm39)	missense	probably damaging	1.00
R4913:Pkp4	UTSW	2	59,135,794 (GRCm39)	missense	probably damaging	1.00
R5383:Pkp4	UTSW	2	59,140,617 (GRCm39)	nonsense	probably null
R5418:Pkp4	UTSW	2	59,140,506 (GRCm39)	missense	probably benign	0.09
R5906:Pkp4	UTSW	2	59,135,420 (GRCm39)	missense	possibly damaging	0.79
R5946:Pkp4	UTSW	2	59,135,411 (GRCm39)	missense	probably benign	0.01
R6360:Pkp4	UTSW	2	59,045,091 (GRCm39)	missense	probably benign	0.01
R6616:Pkp4	UTSW	2	59,180,896 (GRCm39)	nonsense	probably null
R6817:Pkp4	UTSW	2	59,148,944 (GRCm39)	missense	probably damaging	1.00
R7390:Pkp4	UTSW	2	59,140,484 (GRCm39)	missense	possibly damaging	0.94
R7408:Pkp4	UTSW	2	59,142,110 (GRCm39)	missense	probably damaging	1.00
R7464:Pkp4	UTSW	2	59,138,481 (GRCm39)	missense	probably benign	0.12
R7702:Pkp4	UTSW	2	59,138,757 (GRCm39)	missense	probably damaging	0.99
R7787:Pkp4	UTSW	2	59,152,881 (GRCm39)	missense	probably damaging	0.98
R7927:Pkp4	UTSW	2	59,142,098 (GRCm39)	missense	probably damaging	0.97
R8055:Pkp4	UTSW	2	59,138,359 (GRCm39)	missense	probably benign
R8359:Pkp4	UTSW	2	59,180,895 (GRCm39)	missense	probably damaging	1.00
R8465:Pkp4	UTSW	2	59,172,525 (GRCm39)	missense	possibly damaging	0.90
R8555:Pkp4	UTSW	2	59,138,379 (GRCm39)	nonsense	probably null
R8909:Pkp4	UTSW	2	59,184,758 (GRCm39)	missense	possibly damaging	0.71
R9224:Pkp4	UTSW	2	59,144,738 (GRCm39)	missense	probably benign	0.41
R9397:Pkp4	UTSW	2	59,148,856 (GRCm39)	nonsense	probably null
R9486:Pkp4	UTSW	2	59,138,722 (GRCm39)	missense	probably benign	0.27
R9583:Pkp4	UTSW	2	59,178,104 (GRCm39)	missense	possibly damaging	0.80
R9732:Pkp4	UTSW	2	59,138,797 (GRCm39)	missense	possibly damaging	0.94
Z1176:Pkp4	UTSW	2	59,172,588 (GRCm39)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- TCTATCTTCGTGTGATGCTGTAAAG -3'
(R):5'- AGGAGAAACTGTTGGAACTGCC -3'

Sequencing Primer
(F):5'- GATGACAATCATTCGAGACGCGC -3'
(R):5'- CAAGACAGTTGCCTTGGGG -3'

Posted On

2015-11-11