Incidental Mutation 'R4688:Lrp6'
| ID |
353855 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
041939-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.964)
|
| Stock # |
R4688 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 134456706 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 853
(R853S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032322
AA Change: R853S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: R853S
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
A |
G |
6: 83,139,680 (GRCm39) |
N535S |
probably damaging |
Het |
| Abcc12 |
T |
C |
8: 87,275,323 (GRCm39) |
S452G |
possibly damaging |
Het |
| Acacb |
C |
A |
5: 114,342,824 (GRCm39) |
Q897K |
probably benign |
Het |
| Acot3 |
C |
A |
12: 84,100,691 (GRCm39) |
R145S |
probably damaging |
Het |
| Ankrd54 |
A |
T |
15: 78,938,782 (GRCm39) |
Y247N |
probably damaging |
Het |
| Arl11 |
G |
A |
14: 61,548,546 (GRCm39) |
V119I |
probably benign |
Het |
| Atosb |
A |
G |
4: 43,034,663 (GRCm39) |
F352S |
probably damaging |
Het |
| Atxn7 |
T |
A |
14: 14,089,288 (GRCm38) |
M268K |
probably benign |
Het |
| Bms1 |
G |
A |
6: 118,369,667 (GRCm39) |
R934C |
probably damaging |
Het |
| Brd10 |
A |
G |
19: 29,694,501 (GRCm39) |
I1664T |
probably benign |
Het |
| Chrnb3 |
T |
C |
8: 27,884,147 (GRCm39) |
S295P |
probably damaging |
Het |
| Cic |
TCCCCC |
TCCCCCCC |
7: 24,991,095 (GRCm39) |
|
probably null |
Het |
| Cnr1 |
A |
T |
4: 33,944,571 (GRCm39) |
I320F |
probably benign |
Het |
| Cntn4 |
C |
T |
6: 106,414,910 (GRCm39) |
P147L |
probably damaging |
Het |
| Col24a1 |
G |
A |
3: 145,020,144 (GRCm39) |
V172I |
probably benign |
Het |
| Col9a3 |
A |
G |
2: 180,249,424 (GRCm39) |
D262G |
probably damaging |
Het |
| Csrnp2 |
A |
G |
15: 100,380,241 (GRCm39) |
V350A |
probably damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,173,592 (GRCm39) |
V192A |
possibly damaging |
Het |
| Deptor |
A |
G |
15: 55,072,177 (GRCm39) |
M219V |
probably benign |
Het |
| Dmrtb1 |
A |
T |
4: 107,541,247 (GRCm39) |
L38Q |
probably damaging |
Het |
| Dvl2 |
G |
A |
11: 69,898,344 (GRCm39) |
R367Q |
possibly damaging |
Het |
| Dync1h1 |
T |
G |
12: 110,621,962 (GRCm39) |
I3435S |
probably damaging |
Het |
| Ecpas |
A |
G |
4: 58,840,757 (GRCm39) |
V667A |
probably damaging |
Het |
| Eif2b3 |
A |
G |
4: 116,916,046 (GRCm39) |
N218D |
probably benign |
Het |
| Epha2 |
A |
G |
4: 141,046,292 (GRCm39) |
D497G |
probably benign |
Het |
| Epha7 |
G |
T |
4: 28,821,367 (GRCm39) |
L177F |
probably damaging |
Het |
| Fam98c |
C |
T |
7: 28,854,666 (GRCm39) |
E147K |
probably damaging |
Het |
| Fbxo17 |
A |
G |
7: 28,431,979 (GRCm39) |
T19A |
probably benign |
Het |
| Fbxo47 |
A |
G |
11: 97,747,049 (GRCm39) |
F339S |
probably damaging |
Het |
| Frmd4a |
G |
T |
2: 4,542,122 (GRCm39) |
V234L |
possibly damaging |
Het |
| Gal3st2 |
A |
G |
1: 93,800,245 (GRCm39) |
D32G |
probably damaging |
Het |
| Gpr135 |
T |
C |
12: 72,117,720 (GRCm39) |
T16A |
probably benign |
Het |
| Gpr160 |
A |
T |
3: 30,950,835 (GRCm39) |
R302S |
probably benign |
Het |
| Hrh2 |
C |
A |
13: 54,368,820 (GRCm39) |
N265K |
probably benign |
Het |
| Htatip2 |
C |
A |
7: 49,423,171 (GRCm39) |
A242E |
probably damaging |
Het |
| Igfbp7 |
T |
C |
5: 77,555,482 (GRCm39) |
Y127C |
probably damaging |
Het |
| Igkv16-104 |
A |
G |
6: 68,402,878 (GRCm39) |
Q57R |
possibly damaging |
Het |
| Ino80c |
A |
G |
18: 24,241,903 (GRCm39) |
S161P |
probably damaging |
Het |
| Itprid1 |
G |
A |
6: 55,944,132 (GRCm39) |
|
probably null |
Het |
| Kcnc1 |
A |
G |
7: 46,047,259 (GRCm39) |
D53G |
probably benign |
Het |
| Khdc4 |
T |
A |
3: 88,593,824 (GRCm39) |
M71K |
probably damaging |
Het |
| Lce1h |
G |
T |
3: 92,670,874 (GRCm39) |
R93S |
unknown |
Het |
| Lce1k |
T |
C |
3: 92,713,951 (GRCm39) |
S78G |
unknown |
Het |
| Lhcgr |
T |
A |
17: 89,072,580 (GRCm39) |
I156F |
probably damaging |
Het |
| Lpl |
T |
C |
8: 69,352,077 (GRCm39) |
Y343H |
probably damaging |
Het |
| Lrrc7 |
A |
G |
3: 157,854,242 (GRCm39) |
V1322A |
probably damaging |
Het |
| Lrrc74a |
C |
T |
12: 86,784,472 (GRCm39) |
Q67* |
probably null |
Het |
| Megf6 |
A |
T |
4: 154,338,271 (GRCm39) |
D447V |
probably damaging |
Het |
| Mep1a |
T |
C |
17: 43,793,139 (GRCm39) |
D355G |
possibly damaging |
Het |
| Ncoa1 |
T |
C |
12: 4,365,781 (GRCm39) |
D95G |
probably benign |
Het |
| Npepl1 |
A |
T |
2: 173,956,235 (GRCm39) |
I139F |
possibly damaging |
Het |
| Nrcam |
T |
C |
12: 44,594,020 (GRCm39) |
S262P |
probably benign |
Het |
| Nrp1 |
A |
G |
8: 129,229,047 (GRCm39) |
N842D |
probably benign |
Het |
| Olfml3 |
A |
G |
3: 103,639,497 (GRCm39) |
|
probably benign |
Het |
| Or1x6 |
A |
G |
11: 50,939,815 (GRCm39) |
R294G |
probably damaging |
Het |
| Or4b1d |
T |
A |
2: 89,969,343 (GRCm39) |
N47Y |
possibly damaging |
Het |
| Or6b6 |
T |
A |
7: 106,571,068 (GRCm39) |
Y161F |
probably benign |
Het |
| Or6c204 |
G |
A |
10: 129,022,514 (GRCm39) |
P259S |
probably damaging |
Het |
| Or6k8-ps1 |
T |
C |
1: 173,979,162 (GRCm39) |
Y27H |
possibly damaging |
Het |
| Or8b3b |
A |
G |
9: 38,584,659 (GRCm39) |
L27P |
probably damaging |
Het |
| Or9i1b |
A |
T |
19: 13,896,605 (GRCm39) |
T74S |
probably benign |
Het |
| Pde2a |
A |
G |
7: 101,152,041 (GRCm39) |
N316S |
probably benign |
Het |
| Pde4dip |
T |
A |
3: 97,750,993 (GRCm39) |
R74* |
probably null |
Het |
| Pex13 |
A |
T |
11: 23,605,472 (GRCm39) |
W253R |
possibly damaging |
Het |
| Piezo1 |
A |
T |
8: 123,215,278 (GRCm39) |
W1444R |
probably damaging |
Het |
| Pla2g4e |
T |
C |
2: 119,998,414 (GRCm39) |
K843R |
possibly damaging |
Het |
| Plxna2 |
C |
T |
1: 194,326,753 (GRCm39) |
P229L |
probably damaging |
Het |
| Prelid3b |
G |
T |
2: 174,308,592 (GRCm39) |
T131K |
probably benign |
Het |
| Pros1 |
T |
C |
16: 62,709,370 (GRCm39) |
|
probably null |
Het |
| Prrc2c |
G |
T |
1: 162,525,256 (GRCm39) |
P450Q |
unknown |
Het |
| Ptbp1 |
G |
T |
10: 79,692,342 (GRCm39) |
V5F |
possibly damaging |
Het |
| Ptk2 |
T |
A |
15: 73,078,074 (GRCm39) |
L997F |
probably damaging |
Het |
| Rims1 |
G |
T |
1: 22,518,528 (GRCm39) |
S525* |
probably null |
Het |
| Sanbr |
A |
G |
11: 23,543,449 (GRCm39) |
S530P |
probably benign |
Het |
| Sh2b3 |
T |
A |
5: 121,956,697 (GRCm39) |
D318V |
probably benign |
Het |
| Slc16a13 |
A |
T |
11: 70,111,101 (GRCm39) |
I88N |
probably damaging |
Het |
| Slit2 |
T |
A |
5: 48,414,345 (GRCm39) |
|
probably null |
Het |
| Snx10 |
A |
G |
6: 51,556,918 (GRCm39) |
N67S |
probably damaging |
Het |
| Stil |
A |
G |
4: 114,898,505 (GRCm39) |
Y1045C |
probably damaging |
Het |
| Stra6 |
A |
G |
9: 58,042,359 (GRCm39) |
|
probably null |
Het |
| Sympk |
A |
G |
7: 18,788,335 (GRCm39) |
S1254G |
probably benign |
Het |
| Syt15 |
G |
T |
14: 33,950,011 (GRCm39) |
G377V |
probably damaging |
Het |
| Taar4 |
A |
T |
10: 23,836,731 (GRCm39) |
I114F |
probably damaging |
Het |
| Tcaf3 |
G |
A |
6: 42,570,300 (GRCm39) |
|
probably null |
Het |
| Tgm7 |
A |
T |
2: 120,924,502 (GRCm39) |
N558K |
probably benign |
Het |
| Tln2 |
T |
G |
9: 67,304,935 (GRCm39) |
M1L |
probably benign |
Het |
| Trim50 |
C |
T |
5: 135,395,994 (GRCm39) |
T314I |
probably damaging |
Het |
| Trp53rka |
A |
T |
2: 165,333,312 (GRCm39) |
Y192* |
probably null |
Het |
| Ube3b |
T |
C |
5: 114,531,139 (GRCm39) |
V211A |
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,132,138 (GRCm39) |
S787G |
probably benign |
Het |
| Vmn1r189 |
T |
C |
13: 22,286,289 (GRCm39) |
M183V |
probably damaging |
Het |
| Vps13d |
G |
T |
4: 144,904,782 (GRCm39) |
Q115K |
probably benign |
Het |
| Zfp358 |
A |
G |
8: 3,545,493 (GRCm39) |
D25G |
probably damaging |
Het |
| Zfp521 |
T |
G |
18: 13,977,647 (GRCm39) |
K922T |
probably damaging |
Het |
| Zfp521 |
T |
A |
18: 13,977,648 (GRCm39) |
K922* |
probably null |
Het |
| Zfp68 |
T |
A |
5: 138,614,743 (GRCm39) |
K4* |
probably null |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Lrp6
|
UTSW |
6 |
134,484,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0492:Lrp6
|
UTSW |
6 |
134,457,481 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7341:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8812:Lrp6
|
UTSW |
6 |
134,433,141 (GRCm39) |
missense |
probably benign |
|
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGCATTCAGGGAGTAGTGG -3'
(R):5'- AGTCAGACTACGCATGGACTAC -3'
Sequencing Primer
(F):5'- AGTAGTGGGCAGGGCATCC -3'
(R):5'- GATGACTTGCCTCATCCT -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation