Incidental Mutation 'R3162:Or6x1'
ID 349845
Institutional Source Beutler Lab
Gene Symbol Or6x1
Ensembl Gene ENSMUSG00000051095
Gene Name olfactory receptor family 6 subfamily X member 1
Synonyms MOR104-3, GA_x6K02T2PVTD-33886895-33887833, Olfr986
MMRRC Submission 040613-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R3162 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 40098375-40099390 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 40098901 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Histidine at position 163 (Q163H)
Ref Sequence ENSEMBL: ENSMUSP00000152019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026693] [ENSMUST00000062229] [ENSMUST00000168691] [ENSMUST00000168832] [ENSMUST00000214763] [ENSMUST00000216720] [ENSMUST00000218134]
AlphaFold Q8VFN6
Predicted Effect probably benign
Transcript: ENSMUST00000026693
SMART Domains Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602

DomainStartEndE-ValueType
SCAN 42 154 1.19e-75 SMART
KRAB 237 297 1.7e-17 SMART
ZnF_C2H2 391 413 9.44e-2 SMART
ZnF_C2H2 419 441 6.42e-4 SMART
ZnF_C2H2 473 495 3.44e-4 SMART
ZnF_C2H2 501 523 1.47e-3 SMART
ZnF_C2H2 529 551 1.64e-1 SMART
ZnF_C2H2 557 579 3.11e-2 SMART
ZnF_C2H2 585 607 8.47e-4 SMART
ZnF_C2H2 613 635 3.39e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000062229
AA Change: Q163H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000056713
Gene: ENSMUSG00000051095
AA Change: Q163H

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.1e-54 PFAM
Pfam:7tm_1 39 288 3.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168691
SMART Domains Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602

DomainStartEndE-ValueType
SCAN 42 132 1.03e-56 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168832
SMART Domains Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602

DomainStartEndE-ValueType
SCAN 42 154 1.19e-75 SMART
KRAB 237 277 5.32e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000214763
AA Change: Q163H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000216720
AA Change: Q163H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000218134
AA Change: Q163H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
Meta Mutation Damage Score 0.4130 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik T A 15: 59,888,134 (GRCm39) E102V probably damaging Het
9930014A18Rik A T 15: 60,695,296 (GRCm39) V150E probably damaging Het
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Atad2b C A 12: 4,989,689 (GRCm39) N133K possibly damaging Het
AW551984 C A 9: 39,504,325 (GRCm39) R547L probably damaging Het
B3galt6 A G 4: 156,076,464 (GRCm39) Y204H probably benign Het
Camk1g T C 1: 193,042,115 (GRCm39) T45A possibly damaging Het
Caps2 C A 10: 112,018,391 (GRCm39) Y180* probably null Het
Cfap54 T A 10: 92,881,140 (GRCm39) K349N probably damaging Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Ddb1 T C 19: 10,603,335 (GRCm39) L881P probably damaging Het
Decr1 T A 4: 15,930,972 (GRCm39) D120V probably damaging Het
Dennd1c C T 17: 57,373,562 (GRCm39) G637D possibly damaging Het
Dhrs3 A G 4: 144,646,016 (GRCm39) D108G possibly damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dusp6 T C 10: 99,099,944 (GRCm39) Y131H probably damaging Het
Eif2b2 A T 12: 85,266,435 (GRCm39) M34L probably benign Het
Errfi1 G A 4: 150,951,816 (GRCm39) E415K probably damaging Het
Ext1 T C 15: 53,208,000 (GRCm39) N254D possibly damaging Het
Gm13141 GGTTTCTTGATGCC G 4: 147,612,561 (GRCm39) noncoding transcript Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Hpx C T 7: 105,248,847 (GRCm39) probably benign Het
Hyal3 T A 9: 107,464,005 (GRCm39) C407S probably damaging Het
Insr T G 8: 3,211,416 (GRCm39) N1141T possibly damaging Het
Ipo9 T C 1: 135,337,214 (GRCm39) T174A probably benign Het
Ivd T C 2: 118,692,650 (GRCm39) probably null Het
Leprot C T 4: 101,515,090 (GRCm39) T89I probably damaging Het
Msh6 T C 17: 88,292,909 (GRCm39) Y555H probably damaging Het
Nup155 G T 15: 8,177,867 (GRCm39) R1083S possibly damaging Het
Nusap1 A T 2: 119,460,885 (GRCm39) Q126L possibly damaging Het
Or13c7b T A 4: 43,820,544 (GRCm39) K272N probably benign Het
Or5al1 T C 2: 85,990,439 (GRCm39) I92V probably benign Het
Or7a35 C A 10: 78,853,438 (GRCm39) T94N probably benign Het
Pdik1l A G 4: 134,011,561 (GRCm39) L94S probably damaging Het
Pkdrej T A 15: 85,700,818 (GRCm39) D1706V probably damaging Het
Pkhd1l1 A G 15: 44,368,924 (GRCm39) I856M probably damaging Het
Prkcz A T 4: 155,374,981 (GRCm39) D114E probably benign Het
Psap T C 10: 60,113,575 (GRCm39) L4P possibly damaging Het
Ptprk T C 10: 28,468,822 (GRCm39) V1402A probably benign Het
Rai14 T C 15: 10,633,250 (GRCm39) T47A possibly damaging Het
Rlf A G 4: 121,006,044 (GRCm39) S979P probably damaging Het
Skic2 C T 17: 35,066,789 (GRCm39) W88* probably null Het
Skic8 T A 9: 54,631,473 (GRCm39) probably benign Het
Srbd1 A T 17: 86,437,643 (GRCm39) D233E probably benign Het
Tacr2 A G 10: 62,101,024 (GRCm39) D378G probably benign Het
Taok2 A G 7: 126,474,347 (GRCm39) I294T possibly damaging Het
Tert A G 13: 73,775,528 (GRCm39) E93G possibly damaging Het
Tns2 A G 15: 102,021,771 (GRCm39) E1118G possibly damaging Het
Ttc22 A T 4: 106,480,276 (GRCm39) I177F probably damaging Het
Vmn2r86 T C 10: 130,291,673 (GRCm39) R31G probably damaging Het
Wnt5a T C 14: 28,244,445 (GRCm39) Y231H probably benign Het
Zw10 T C 9: 48,988,860 (GRCm39) Y709H probably damaging Het
Other mutations in Or6x1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Or6x1 APN 9 40,099,052 (GRCm39) missense probably benign 0.01
IGL02342:Or6x1 APN 9 40,098,823 (GRCm39) missense probably benign
IGL02961:Or6x1 APN 9 40,098,897 (GRCm39) missense probably benign 0.00
R0379:Or6x1 UTSW 9 40,098,729 (GRCm39) missense probably damaging 1.00
R1411:Or6x1 UTSW 9 40,098,435 (GRCm39) missense possibly damaging 0.93
R1712:Or6x1 UTSW 9 40,099,161 (GRCm39) missense probably damaging 1.00
R1818:Or6x1 UTSW 9 40,098,558 (GRCm39) missense probably benign
R2249:Or6x1 UTSW 9 40,098,980 (GRCm39) missense possibly damaging 0.59
R3162:Or6x1 UTSW 9 40,098,901 (GRCm39) missense probably benign 0.02
R5071:Or6x1 UTSW 9 40,098,960 (GRCm39) missense probably damaging 1.00
R5464:Or6x1 UTSW 9 40,099,080 (GRCm39) missense probably damaging 1.00
R5475:Or6x1 UTSW 9 40,099,005 (GRCm39) missense possibly damaging 0.84
R5695:Or6x1 UTSW 9 40,098,897 (GRCm39) missense probably benign 0.00
R5878:Or6x1 UTSW 9 40,098,867 (GRCm39) missense probably benign 0.02
R6978:Or6x1 UTSW 9 40,099,085 (GRCm39) missense probably damaging 1.00
R7252:Or6x1 UTSW 9 40,098,657 (GRCm39) missense probably benign 0.25
R8040:Or6x1 UTSW 9 40,098,717 (GRCm39) missense probably damaging 0.97
R8410:Or6x1 UTSW 9 40,098,732 (GRCm39) missense possibly damaging 0.93
R8726:Or6x1 UTSW 9 40,098,663 (GRCm39) missense probably damaging 0.96
R8829:Or6x1 UTSW 9 40,099,209 (GRCm39) missense probably benign 0.42
Predicted Primers PCR Primer
(F):5'- CACTGAGTTCTTGATTCTGGGC -3'
(R):5'- ACTACTGTCAGGTGAGAGGC -3'

Sequencing Primer
(F):5'- CTTGATTCTGGGCAGCATGTC -3'
(R):5'- GCACAAGTAGAAAAAGCCTTTTG -3'
Posted On 2015-10-08