Incidental Mutation 'R4677:Vmn2r65'
ID 349661
Institutional Source Beutler Lab
Gene Symbol Vmn2r65
Ensembl Gene ENSMUSG00000066372
Gene Name vomeronasal 2, receptor 65
Synonyms ENSMUSG00000070600
MMRRC Submission 042014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R4677 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 84589377-84613217 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 84613082 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 46 (I46L)
Ref Sequence ENSEMBL: ENSMUSP00000036551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044583]
AlphaFold G3X931
Predicted Effect possibly damaging
Transcript: ENSMUST00000044583
AA Change: I46L

PolyPhen 2 Score 0.548 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: I46L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 73 435 5.6e-41 PFAM
Pfam:NCD3G 501 553 1.3e-21 PFAM
Pfam:7tm_3 584 821 2.3e-53 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 100% (85/85)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 T C 6: 92,793,587 (GRCm39) M1T probably null Het
Akap3 T C 6: 126,842,226 (GRCm39) S282P probably damaging Het
Anxa10 A G 8: 62,516,054 (GRCm39) I206T probably damaging Het
Apobec3 A G 15: 79,779,713 (GRCm39) D52G probably damaging Het
Arl6 A T 16: 59,439,228 (GRCm39) probably null Het
Calcoco1 T C 15: 102,626,329 (GRCm39) E87G probably damaging Het
Ccdc88b C A 19: 6,825,636 (GRCm39) A1206S probably damaging Het
Ccpg1 A G 9: 72,923,197 (GRCm39) probably benign Het
Cdon A G 9: 35,389,901 (GRCm39) N852D probably damaging Het
Cobl T A 11: 12,336,665 (GRCm39) Q41L possibly damaging Het
Cspg4b A G 13: 113,516,020 (GRCm39) T145A unknown Het
Dcdc2b T C 4: 129,507,936 (GRCm39) T39A probably damaging Het
Ddx55 A T 5: 124,705,997 (GRCm39) D474V probably benign Het
Dipk2a A T 9: 94,402,457 (GRCm39) C402S probably damaging Het
Dnah17 A G 11: 118,010,640 (GRCm39) L521P probably damaging Het
Exoc1 A G 5: 76,707,010 (GRCm39) D497G probably null Het
Fam151a A G 4: 106,605,456 (GRCm39) E606G possibly damaging Het
Fbxw11 T A 11: 32,692,535 (GRCm39) L502* probably null Het
Fcrl1 A G 3: 87,297,563 (GRCm39) S337G possibly damaging Het
G6pc1 C A 11: 101,267,439 (GRCm39) F296L probably benign Het
Gm17472 C A 6: 42,957,809 (GRCm39) T26N probably damaging Het
Grin2b A G 6: 135,751,870 (GRCm39) V564A probably benign Het
H2-Ob T C 17: 34,461,618 (GRCm39) I119T probably benign Het
Hhip A G 8: 80,771,726 (GRCm39) Y195H probably damaging Het
Igkc A T 6: 70,703,662 (GRCm39) probably benign Het
Islr A T 9: 58,064,642 (GRCm39) D288E probably damaging Het
Kdelr1 A G 7: 45,523,197 (GRCm39) S36G probably benign Het
Lama5 G T 2: 179,821,159 (GRCm39) H3134Q possibly damaging Het
Loricrin A G 3: 91,989,050 (GRCm39) Y79H unknown Het
Lrp1b A G 2: 40,691,496 (GRCm39) F3327S probably damaging Het
Lrrc41 C T 4: 115,952,332 (GRCm39) H637Y probably benign Het
Map2k6 C T 11: 110,290,220 (GRCm39) probably benign Het
Mcm3ap T G 10: 76,306,404 (GRCm39) F172L probably damaging Het
Muc19 G A 15: 91,772,411 (GRCm39) noncoding transcript Het
Muc21 T A 17: 35,930,599 (GRCm39) probably benign Het
Muc6 T A 7: 141,224,212 (GRCm39) probably benign Het
Nek1 A T 8: 61,481,840 (GRCm39) I252L probably damaging Het
Nrg2 A T 18: 36,154,152 (GRCm39) H588Q possibly damaging Het
Nt5dc2 T C 14: 30,860,878 (GRCm39) V351A possibly damaging Het
Or1j12 A G 2: 36,343,062 (GRCm39) N155S probably benign Het
Or51b17 T C 7: 103,542,615 (GRCm39) E109G probably damaging Het
Or5m5 A G 2: 85,814,315 (GRCm39) T44A possibly damaging Het
Or8k1 A T 2: 86,048,032 (GRCm39) S7R probably benign Het
Pde3a A G 6: 141,411,865 (GRCm39) N480D probably benign Het
Pde6c A G 19: 38,145,833 (GRCm39) K374E probably damaging Het
Pdhx G A 2: 102,903,811 (GRCm39) probably null Het
Pi4ka A G 16: 17,100,237 (GRCm39) Y1888H probably damaging Het
Pnpla2 T A 7: 141,038,356 (GRCm39) M203K probably damaging Het
Prrc2c C T 1: 162,532,748 (GRCm39) probably benign Het
Ptcd3 G T 6: 71,870,498 (GRCm39) H321N probably benign Het
Ptprt A G 2: 161,743,366 (GRCm39) probably null Het
Ptx4 A G 17: 25,342,100 (GRCm39) T192A probably benign Het
Qars1 A G 9: 108,386,889 (GRCm39) probably benign Het
Ralgapa2 G A 2: 146,187,387 (GRCm39) P1372S possibly damaging Het
Rps6ka4 G T 19: 6,816,854 (GRCm39) T107K probably damaging Het
Rsf1 A G 7: 97,329,980 (GRCm39) T1169A possibly damaging Het
Ryr2 C A 13: 11,721,553 (GRCm39) W2626L probably damaging Het
Scn4a C T 11: 106,214,788 (GRCm39) V1270I probably damaging Het
Serpinb9b T C 13: 33,223,806 (GRCm39) S333P probably damaging Het
Sned1 A G 1: 93,224,019 (GRCm39) probably benign Het
Sult1c2 C T 17: 54,137,137 (GRCm39) V262M possibly damaging Het
Tll1 A T 8: 64,504,411 (GRCm39) F662I probably benign Het
Tmem161a A T 8: 70,633,597 (GRCm39) probably null Het
Top1mt A C 15: 75,535,907 (GRCm39) V465G possibly damaging Het
Trcg1 A G 9: 57,153,144 (GRCm39) K596E possibly damaging Het
Trim27 T A 13: 21,365,086 (GRCm39) probably null Het
Trpm3 A G 19: 22,964,752 (GRCm39) I1406V possibly damaging Het
Tssc4 T A 7: 142,624,246 (GRCm39) S254T probably damaging Het
Ttc7 C A 17: 87,678,163 (GRCm39) probably benign Het
Usp30 A G 5: 114,257,705 (GRCm39) T288A probably damaging Het
Usp48 C A 4: 137,343,692 (GRCm39) R441S probably benign Het
Vmn1r29 T C 6: 58,284,285 (GRCm39) S2P probably benign Het
Zeb1 A T 18: 5,766,775 (GRCm39) I429F probably damaging Het
Zfp943 A G 17: 22,212,176 (GRCm39) R421G probably benign Het
Other mutations in Vmn2r65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Vmn2r65 APN 7 84,592,761 (GRCm39) missense probably damaging 0.99
IGL01104:Vmn2r65 APN 7 84,589,996 (GRCm39) missense possibly damaging 0.93
IGL01154:Vmn2r65 APN 7 84,592,729 (GRCm39) missense probably benign 0.00
IGL01453:Vmn2r65 APN 7 84,589,708 (GRCm39) missense probably damaging 1.00
IGL01675:Vmn2r65 APN 7 84,596,587 (GRCm39) missense probably benign 0.00
IGL01748:Vmn2r65 APN 7 84,589,507 (GRCm39) missense probably damaging 1.00
IGL01997:Vmn2r65 APN 7 84,589,978 (GRCm39) missense probably damaging 1.00
IGL02527:Vmn2r65 APN 7 84,595,724 (GRCm39) missense possibly damaging 0.82
IGL02617:Vmn2r65 APN 7 84,589,549 (GRCm39) missense probably damaging 1.00
IGL02676:Vmn2r65 APN 7 84,589,381 (GRCm39) missense possibly damaging 0.86
IGL03084:Vmn2r65 APN 7 84,592,354 (GRCm39) missense probably damaging 1.00
A4554:Vmn2r65 UTSW 7 84,595,791 (GRCm39) missense probably damaging 0.96
PIT4651001:Vmn2r65 UTSW 7 84,595,461 (GRCm39) missense probably benign 0.12
R0322:Vmn2r65 UTSW 7 84,595,756 (GRCm39) missense probably benign 0.01
R0453:Vmn2r65 UTSW 7 84,595,442 (GRCm39) missense probably benign 0.03
R0862:Vmn2r65 UTSW 7 84,592,853 (GRCm39) missense probably benign 0.00
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1508:Vmn2r65 UTSW 7 84,589,886 (GRCm39) missense probably benign 0.00
R1687:Vmn2r65 UTSW 7 84,590,026 (GRCm39) missense probably benign 0.02
R1876:Vmn2r65 UTSW 7 84,595,505 (GRCm39) missense probably damaging 1.00
R2136:Vmn2r65 UTSW 7 84,592,781 (GRCm39) missense probably damaging 0.96
R2259:Vmn2r65 UTSW 7 84,590,119 (GRCm39) missense possibly damaging 0.86
R2338:Vmn2r65 UTSW 7 84,590,051 (GRCm39) missense possibly damaging 0.86
R2880:Vmn2r65 UTSW 7 84,613,094 (GRCm39) missense probably damaging 1.00
R3410:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3411:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3770:Vmn2r65 UTSW 7 84,589,623 (GRCm39) missense probably damaging 1.00
R3800:Vmn2r65 UTSW 7 84,589,738 (GRCm39) missense possibly damaging 0.93
R3850:Vmn2r65 UTSW 7 84,595,859 (GRCm39) missense probably benign 0.00
R4105:Vmn2r65 UTSW 7 84,595,691 (GRCm39) missense probably benign 0.03
R4568:Vmn2r65 UTSW 7 84,596,677 (GRCm39) missense probably damaging 1.00
R4768:Vmn2r65 UTSW 7 84,596,602 (GRCm39) missense probably damaging 1.00
R4778:Vmn2r65 UTSW 7 84,592,801 (GRCm39) missense possibly damaging 0.47
R5057:Vmn2r65 UTSW 7 84,589,819 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r65 UTSW 7 84,589,849 (GRCm39) missense probably damaging 1.00
R5280:Vmn2r65 UTSW 7 84,595,542 (GRCm39) missense probably damaging 0.99
R5394:Vmn2r65 UTSW 7 84,595,862 (GRCm39) missense probably benign 0.04
R5487:Vmn2r65 UTSW 7 84,595,529 (GRCm39) missense possibly damaging 0.76
R5580:Vmn2r65 UTSW 7 84,596,802 (GRCm39) missense probably damaging 0.99
R5638:Vmn2r65 UTSW 7 84,590,047 (GRCm39) missense probably damaging 1.00
R5673:Vmn2r65 UTSW 7 84,596,615 (GRCm39) missense probably benign 0.23
R5688:Vmn2r65 UTSW 7 84,589,900 (GRCm39) missense probably benign 0.00
R5935:Vmn2r65 UTSW 7 84,592,869 (GRCm39) missense probably benign 0.00
R6354:Vmn2r65 UTSW 7 84,589,574 (GRCm39) missense probably benign 0.35
R6372:Vmn2r65 UTSW 7 84,589,861 (GRCm39) missense probably damaging 1.00
R6924:Vmn2r65 UTSW 7 84,613,198 (GRCm39) missense probably benign 0.20
R7021:Vmn2r65 UTSW 7 84,596,587 (GRCm39) missense probably benign 0.00
R7195:Vmn2r65 UTSW 7 84,592,347 (GRCm39) critical splice donor site probably null
R7422:Vmn2r65 UTSW 7 84,595,569 (GRCm39) missense probably damaging 0.99
R7654:Vmn2r65 UTSW 7 84,590,261 (GRCm39) missense probably damaging 1.00
R7686:Vmn2r65 UTSW 7 84,589,744 (GRCm39) missense probably damaging 0.99
R7691:Vmn2r65 UTSW 7 84,592,851 (GRCm39) missense probably benign 0.30
R7798:Vmn2r65 UTSW 7 84,596,192 (GRCm39) missense probably damaging 1.00
R7798:Vmn2r65 UTSW 7 84,595,530 (GRCm39) missense probably benign 0.00
R8103:Vmn2r65 UTSW 7 84,595,919 (GRCm39) missense probably damaging 1.00
R8272:Vmn2r65 UTSW 7 84,596,817 (GRCm39) missense probably benign 0.02
R8303:Vmn2r65 UTSW 7 84,589,391 (GRCm39) nonsense probably null
R8354:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8454:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8489:Vmn2r65 UTSW 7 84,589,964 (GRCm39) missense possibly damaging 0.85
R8554:Vmn2r65 UTSW 7 84,595,960 (GRCm39) missense probably benign 0.00
R8680:Vmn2r65 UTSW 7 84,589,388 (GRCm39) missense probably benign 0.00
R8731:Vmn2r65 UTSW 7 84,589,447 (GRCm39) nonsense probably null
R8839:Vmn2r65 UTSW 7 84,595,489 (GRCm39) nonsense probably null
R8847:Vmn2r65 UTSW 7 84,590,212 (GRCm39) missense probably damaging 1.00
R8916:Vmn2r65 UTSW 7 84,595,665 (GRCm39) missense probably benign 0.21
R9254:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9379:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9392:Vmn2r65 UTSW 7 84,589,718 (GRCm39) missense possibly damaging 0.95
R9563:Vmn2r65 UTSW 7 84,589,880 (GRCm39) nonsense probably null
R9686:Vmn2r65 UTSW 7 84,590,084 (GRCm39) missense probably benign 0.45
X0067:Vmn2r65 UTSW 7 84,590,113 (GRCm39) missense probably benign 0.04
Z1088:Vmn2r65 UTSW 7 84,592,473 (GRCm39) critical splice acceptor site probably null
Z1177:Vmn2r65 UTSW 7 84,590,234 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GGGTGAACAAAATGCCTAATCCAG -3'
(R):5'- ACTCAGGCTCAAGGCATAGG -3'

Sequencing Primer
(F):5'- CAAAATGCCTAATCCAGAAATAGGG -3'
(R):5'- CTCAAGGCATAGGGGATGTG -3'
Posted On 2015-10-08