Mutagenetix > Incidental Mutation

Incidental Mutation 'R4603:Prkdc'

345819

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DNA-PK, XRCC7, DNAPDcs, DOXNPH, dxnph, DNA-PKcs

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R4603 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

15455730-15660099 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 15628688 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 3478 (E3478K)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000023352
AA Change: E3478K

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: E3478K

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810024B03Rik	A	G	2: 127,029,019 (GRCm39)	V60A	probably damaging	Het
AAdacl4fm3	A	G	4: 144,429,798 (GRCm39)	V397A	probably benign	Het
Afg3l1	A	G	8: 124,228,674 (GRCm39)	T747A	probably benign	Het
Aldh4a1	T	C	4: 139,370,740 (GRCm39)	S408P	probably damaging	Het
Ank2	T	C	3: 126,825,665 (GRCm39)	T445A	probably benign	Het
Antxrl	A	G	14: 33,797,792 (GRCm39)	E589G	possibly damaging	Het
Arhgef12	C	T	9: 42,921,489 (GRCm39)	G329R	probably benign	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
AY358078	T	A	14: 52,063,532 (GRCm39)	C393S	possibly damaging	Het
Bpnt2	T	C	4: 4,767,878 (GRCm39)	I299M	probably damaging	Het
Brca2	T	A	5: 150,459,630 (GRCm39)	C302S	possibly damaging	Het
Ccdc169	T	A	3: 55,058,226 (GRCm39)	M4K	probably benign	Het
Ccdc66	T	C	14: 27,222,377 (GRCm39)	N122S	probably damaging	Het
Cd226	T	C	18: 89,225,343 (GRCm39)	V80A	probably damaging	Het
Cdc73	T	C	1: 143,553,595 (GRCm39)		probably null	Het
Cfap96	A	T	8: 46,423,505 (GRCm39)	I69N	probably damaging	Het
Cse1l	T	C	2: 166,786,452 (GRCm39)	V604A	probably benign	Het
Cxcr1	G	C	1: 74,231,896 (GRCm39)	T42S	probably benign	Het
Dhx9	TCC	TC	1: 153,342,797 (GRCm39)		probably null	Het
Ercc3	G	A	18: 32,378,624 (GRCm39)	A202T	probably benign	Het
Erp27	A	G	6: 136,896,947 (GRCm39)	V85A	probably damaging	Het
Fam3d	T	A	14: 8,358,429 (GRCm38)	S57C	probably damaging	Het
Fgf8	T	G	19: 45,726,592 (GRCm39)	I137L	probably benign	Het
Fgfrl1	T	A	5: 108,851,401 (GRCm39)	V106D	probably damaging	Het
Gaa	T	C	11: 119,169,784 (GRCm39)	W613R	probably damaging	Het
Gabarap	A	G	11: 69,885,287 (GRCm39)	N66S	probably benign	Het
Gp1bb	A	T	16: 18,439,893 (GRCm39)	L67Q	probably damaging	Het
Gpn1	T	C	5: 31,654,696 (GRCm39)		probably null	Het
Gstt1	T	C	10: 75,629,969 (GRCm39)	Y48C	probably damaging	Het
Iqcg	C	T	16: 32,861,134 (GRCm39)	R194K	probably null	Het
Iqcg	C	G	16: 32,861,133 (GRCm39)		probably null	Het
Kcnj3	C	T	2: 55,336,991 (GRCm39)	R286*	probably null	Het
Klhl38	T	A	15: 58,186,616 (GRCm39)	I38F	possibly damaging	Het
Kmo	C	A	1: 175,479,208 (GRCm39)	P248Q	probably benign	Het
Mbtps1	A	T	8: 120,262,086 (GRCm39)	D354E	probably damaging	Het
Mcpt9	C	T	14: 56,266,049 (GRCm39)	V60M	probably damaging	Het
Mical3	C	A	6: 120,911,799 (GRCm39)	E1083*	probably null	Het
Mprip	T	C	11: 59,622,399 (GRCm39)	V162A	probably damaging	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Myocd	T	C	11: 65,078,571 (GRCm39)	D408G	possibly damaging	Het
Myt1l	A	G	12: 29,892,539 (GRCm39)	T59A	probably benign	Het
Ndufb7	A	G	8: 84,293,494 (GRCm39)	E16G	probably damaging	Het
Ndufs7	T	A	10: 80,092,501 (GRCm39)	Y203*	probably null	Het
Nploc4	C	T	11: 120,276,613 (GRCm39)	V478I	probably benign	Het
Nrap	A	G	19: 56,323,456 (GRCm39)		probably null	Het
Or5e1	A	T	7: 108,354,834 (GRCm39)	Y257F	probably damaging	Het
Or6c207	G	A	10: 129,104,274 (GRCm39)	A306V	probably benign	Het
Pald1	T	C	10: 61,184,395 (GRCm39)	T241A	probably benign	Het
Pdss2	T	C	10: 43,248,197 (GRCm39)	S234P	probably damaging	Het
Pias2	T	A	18: 77,217,803 (GRCm39)	V335E	probably damaging	Het
Ppip5k2	C	A	1: 97,682,861 (GRCm39)	K187N	probably damaging	Het
Ppp3cb	T	C	14: 20,570,714 (GRCm39)	N339S	possibly damaging	Het
Ppp4r1	T	G	17: 66,120,459 (GRCm39)	C181G	probably damaging	Het
Pramel27	T	A	4: 143,579,451 (GRCm39)	H345Q	probably benign	Het
Prpf4b	T	C	13: 35,072,147 (GRCm39)		probably benign	Het
Psme3	T	A	11: 101,208,435 (GRCm39)		probably null	Het
Ptpre	C	A	7: 135,269,372 (GRCm39)	Y284*	probably null	Het
Scnn1a	A	G	6: 125,299,123 (GRCm39)	I94V	probably damaging	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Shc2	T	C	10: 79,459,690 (GRCm39)	D418G	probably benign	Het
Sidt1	A	T	16: 44,075,389 (GRCm39)	D661E	probably damaging	Het
Slc35e2	T	C	4: 155,702,106 (GRCm39)	F290S	probably benign	Het
Sorcs1	A	G	19: 50,301,402 (GRCm39)		probably null	Het
Stox2	A	G	8: 47,645,970 (GRCm39)	S497P	probably damaging	Het
Tmem270	C	A	5: 134,930,482 (GRCm39)	E260*	probably null	Het
Tmtc2	T	C	10: 105,249,391 (GRCm39)	Y114C	probably benign	Het
Trim46	A	G	3: 89,150,958 (GRCm39)	F188S	probably benign	Het
Trim7	T	A	11: 48,728,355 (GRCm39)	M1K	probably null	Het
Txnip	A	G	3: 96,465,604 (GRCm39)	E18G	probably benign	Het
Usp34	A	G	11: 23,414,633 (GRCm39)	N2859D	probably damaging	Het
Vmn2r94	T	A	17: 18,477,647 (GRCm39)	I255F	probably benign	Het
Xkr5	T	A	8: 18,983,733 (GRCm39)	N603I	possibly damaging	Het
Zfp512	C	T	5: 31,637,570 (GRCm39)	A497V	probably benign	Het
Zfp518b	T	C	5: 38,830,970 (GRCm39)	N345S	probably damaging	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,515,090 (GRCm39)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,627,508 (GRCm39)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,608,330 (GRCm39)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,593,711 (GRCm39)	splice site	probably null
IGL00489:Prkdc	APN	16	15,617,790 (GRCm39)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,482,103 (GRCm39)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,470,222 (GRCm39)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,554,699 (GRCm39)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,605,022 (GRCm39)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,597,290 (GRCm39)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,634,503 (GRCm39)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,577,618 (GRCm39)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,557,428 (GRCm39)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,519,979 (GRCm39)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,487,185 (GRCm39)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,544,568 (GRCm39)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,647,556 (GRCm39)	missense	probably benign
IGL01335:Prkdc	APN	16	15,634,760 (GRCm39)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,653,030 (GRCm39)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,531,451 (GRCm39)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,470,166 (GRCm39)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,485,609 (GRCm39)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,552,858 (GRCm39)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,516,751 (GRCm39)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,526,643 (GRCm39)	missense	probably benign
IGL02121:Prkdc	APN	16	15,535,048 (GRCm39)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,487,149 (GRCm39)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,627,623 (GRCm39)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,603,843 (GRCm39)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,603,842 (GRCm39)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,634,622 (GRCm39)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,488,399 (GRCm39)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,532,146 (GRCm39)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,544,406 (GRCm39)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,488,465 (GRCm39)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,587,689 (GRCm39)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,653,907 (GRCm39)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,570,590 (GRCm39)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,651,530 (GRCm39)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,649,191 (GRCm39)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,469,383 (GRCm39)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,617,880 (GRCm39)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,617,848 (GRCm39)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,523,174 (GRCm39)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,531,499 (GRCm39)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,518,608 (GRCm39)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,587,665 (GRCm39)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,488,490 (GRCm39)	nonsense	probably null
anhimid	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
anhinga	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
Bushtit	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
clover	UTSW	16	15,520,020 (GRCm39)	splice site	probably benign
crackle	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
Daffy	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
darter	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
envenomation	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
hobgoblin	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
Incubus	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
liming	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
newt	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
primitive	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
roadrunner	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
Schreier	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
screamer	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
Screamer10	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
screamer2	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
screamer3	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
screamer4	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
screamer5	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
screamer6	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
screamer7	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
Screamer8	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
Screamer9	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
Tweetie	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
updock	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,526,565 (GRCm39)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,544,368 (GRCm39)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,516,871 (GRCm39)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,554,663 (GRCm39)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,609,791 (GRCm39)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,651,604 (GRCm39)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,651,652 (GRCm39)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,625,952 (GRCm39)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,589,921 (GRCm39)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,508,271 (GRCm39)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,628,665 (GRCm39)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,603,835 (GRCm39)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,647,580 (GRCm39)	missense	probably benign
R1027:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,472,613 (GRCm39)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,585,815 (GRCm39)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,570,646 (GRCm39)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,577,610 (GRCm39)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,508,146 (GRCm39)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,577,587 (GRCm39)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,482,091 (GRCm39)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,485,564 (GRCm39)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,549,430 (GRCm39)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
R1531:Prkdc	UTSW	16	15,589,970 (GRCm39)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,493,192 (GRCm39)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,551,922 (GRCm39)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,494,853 (GRCm39)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
R1762:Prkdc	UTSW	16	15,455,825 (GRCm39)	missense	probably benign
R1789:Prkdc	UTSW	16	15,557,388 (GRCm39)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,647,499 (GRCm39)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,543,300 (GRCm39)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,532,079 (GRCm39)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,532,130 (GRCm39)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R1939:Prkdc	UTSW	16	15,653,777 (GRCm39)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,494,873 (GRCm39)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,505,216 (GRCm39)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,533,827 (GRCm39)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,505,254 (GRCm39)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,523,071 (GRCm39)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,516,688 (GRCm39)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2271:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2272:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2356:Prkdc	UTSW	16	15,502,068 (GRCm39)	missense	probably benign
R2852:Prkdc	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,617,831 (GRCm39)	missense	probably benign
R3834:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,647,475 (GRCm39)	splice site	probably null
R4151:Prkdc	UTSW	16	15,634,637 (GRCm39)	missense	probably benign
R4233:Prkdc	UTSW	16	15,653,783 (GRCm39)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,623,963 (GRCm39)	splice site	probably null
R4296:Prkdc	UTSW	16	15,555,769 (GRCm39)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,585,886 (GRCm39)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,591,603 (GRCm39)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,518,517 (GRCm39)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,554,734 (GRCm39)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,585,830 (GRCm39)	missense	possibly damaging	0.64
R4615:Prkdc	UTSW	16	15,480,938 (GRCm39)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,634,638 (GRCm39)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,551,916 (GRCm39)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,589,894 (GRCm39)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,519,976 (GRCm39)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,628,701 (GRCm39)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,485,579 (GRCm39)	missense	probably benign
R4785:Prkdc	UTSW	16	15,466,840 (GRCm39)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,519,939 (GRCm39)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,496,173 (GRCm39)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,655,882 (GRCm39)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,589,912 (GRCm39)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,608,444 (GRCm39)	missense	probably benign
R5151:Prkdc	UTSW	16	15,533,899 (GRCm39)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,589,985 (GRCm39)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,552,819 (GRCm39)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,532,838 (GRCm39)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,649,176 (GRCm39)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,623,814 (GRCm39)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,612,961 (GRCm39)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,587,739 (GRCm39)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,496,172 (GRCm39)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,469,333 (GRCm39)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,524,655 (GRCm39)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,627,476 (GRCm39)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,647,633 (GRCm39)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,628,634 (GRCm39)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,482,097 (GRCm39)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,597,252 (GRCm39)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,634,616 (GRCm39)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,555,698 (GRCm39)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,551,962 (GRCm39)	missense	probably benign
R5883:Prkdc	UTSW	16	15,533,778 (GRCm39)	missense	probably benign
R5895:Prkdc	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,601,021 (GRCm39)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,557,335 (GRCm39)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,589,937 (GRCm39)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,608,456 (GRCm39)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,605,019 (GRCm39)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,532,783 (GRCm39)	missense	probably benign
R6376:Prkdc	UTSW	16	15,587,749 (GRCm39)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,516,679 (GRCm39)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,612,939 (GRCm39)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,469,402 (GRCm39)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,594,936 (GRCm39)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,626,020 (GRCm39)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,601,127 (GRCm39)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,617,853 (GRCm39)	missense	probably benign
R6950:Prkdc	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,587,830 (GRCm39)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,608,317 (GRCm39)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,507,207 (GRCm39)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,516,667 (GRCm39)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,532,127 (GRCm39)	missense	probably benign
R7283:Prkdc	UTSW	16	15,535,628 (GRCm39)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,466,602 (GRCm39)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,555,807 (GRCm39)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,649,183 (GRCm39)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,623,960 (GRCm39)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,507,141 (GRCm39)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,532,870 (GRCm39)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,526,767 (GRCm39)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,597,315 (GRCm39)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,634,749 (GRCm39)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,482,108 (GRCm39)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,523,117 (GRCm39)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,532,005 (GRCm39)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,608,540 (GRCm39)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,469,400 (GRCm39)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,466,788 (GRCm39)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,482,232 (GRCm39)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,480,899 (GRCm39)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,626,068 (GRCm39)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,601,029 (GRCm39)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,545,523 (GRCm39)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,491,624 (GRCm39)	intron	probably benign
R8971:Prkdc	UTSW	16	15,493,229 (GRCm39)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,617,726 (GRCm39)	splice site	probably null
R9052:Prkdc	UTSW	16	15,508,160 (GRCm39)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,523,153 (GRCm39)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,526,792 (GRCm39)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,485,465 (GRCm39)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,657,079 (GRCm39)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,548,335 (GRCm39)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,548,334 (GRCm39)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,548,341 (GRCm39)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,617,818 (GRCm39)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,533,819 (GRCm39)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,657,044 (GRCm39)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,558,142 (GRCm39)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,505,286 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GGGGAAGAGAATCATTTGTCAGA -3'
(R):5'- GTCGAGGAGTGATGCCTGAG -3'

Sequencing Primer
(F):5'- ATTTATGGTTTATGTGCTAACCTTCG -3'
(R):5'- GATGCCTGAGATTGTCCTCTGAC -3'

Posted On

2015-09-25