Incidental Mutation 'R4566:Ppp2cb'
ID 343322
Institutional Source Beutler Lab
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4566 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 34100723 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 48 (V48A)
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774]
AlphaFold P62715
Predicted Effect possibly damaging
Transcript: ENSMUST00000009774
AA Change: V48A

PolyPhen 2 Score 0.667 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630
AA Change: V48A

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,567,927 (GRCm39) E5082G probably damaging Het
Apol7a A T 15: 77,273,951 (GRCm39) Y170* probably null Het
Cfhr1 T A 1: 139,481,386 (GRCm39) I165F possibly damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Espnl C A 1: 91,272,301 (GRCm39) P510T possibly damaging Het
Fbxw4 A G 19: 45,580,225 (GRCm39) V258A probably benign Het
Foxq1 T C 13: 31,743,471 (GRCm39) M191T probably benign Het
Gabrg1 A T 5: 70,999,484 (GRCm39) L22I probably benign Het
Limk1 A G 5: 134,715,537 (GRCm39) L38P probably benign Het
Mfhas1 C T 8: 36,058,203 (GRCm39) R893C probably damaging Het
Mug2 G A 6: 122,056,597 (GRCm39) V1181I probably benign Het
Or52ac1 A T 7: 104,245,823 (GRCm39) C188* probably null Het
Pithd1 A G 4: 135,704,548 (GRCm39) V56A probably damaging Het
Plxna4 T C 6: 32,494,338 (GRCm39) K93E probably benign Het
Rasl2-9 AGG A 7: 5,128,374 (GRCm39) probably null Het
Rrs1 T C 1: 9,616,452 (GRCm39) F235S probably damaging Het
Rtl1 G A 12: 109,559,293 (GRCm39) L849F probably damaging Het
Slc5a9 C A 4: 111,748,941 (GRCm39) probably null Het
Trps1 A G 15: 50,695,074 (GRCm39) V116A probably damaging Het
Vmn2r51 C T 7: 9,836,341 (GRCm39) E147K probably benign Het
Yy1 T A 12: 108,778,889 (GRCm39) I296K probably damaging Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 34,101,791 (GRCm39) missense probably benign 0.38
IGL02985:Ppp2cb APN 8 34,105,474 (GRCm39) unclassified probably benign
IGL03251:Ppp2cb APN 8 34,100,679 (GRCm39) splice site probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2187:Ppp2cb UTSW 8 34,100,705 (GRCm39) missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 34,109,161 (GRCm39) missense probably benign 0.01
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- GCCTATCTCTTCATAGGGTATTGG -3'
(R):5'- GCAACACTGACATTCTTTTGCC -3'

Sequencing Primer
(F):5'- ACTTCCAAGTGGTTTCCC -3'
(R):5'- GTATCCGTCAACCATACCTTTAATG -3'
Posted On 2015-09-24