Incidental Mutation 'R0225:Vmn1r58'
ID 33851
Institutional Source Beutler Lab
Gene Symbol Vmn1r58
Ensembl Gene ENSMUSG00000078808
Gene Name vomeronasal 1 receptor 58
Synonyms V3R4, V1rd4
MMRRC Submission 038470-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R0225 (G1)
Quality Score 188
Status Validated
Chromosome 7
Chromosomal Location 5411886-5416144 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 5413865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 122 (S122A)
Ref Sequence ENSEMBL: ENSMUSP00000154393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108569] [ENSMUST00000228728]
AlphaFold G3X9U3
Predicted Effect probably benign
Transcript: ENSMUST00000108569
AA Change: S122A

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000104209
Gene: ENSMUSG00000078808
AA Change: S122A

DomainStartEndE-ValueType
Pfam:TAS2R 1 296 7.8e-13 PFAM
Pfam:7tm_1 20 279 4.4e-7 PFAM
Pfam:V1R 31 296 7.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209136
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226315
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227549
Predicted Effect probably benign
Transcript: ENSMUST00000228728
AA Change: S122A

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.2718 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,139,378 (GRCm39) L1470Q probably damaging Het
Abraxas2 G A 7: 132,476,584 (GRCm39) R105Q probably damaging Het
Arhgap23 G T 11: 97,335,154 (GRCm39) V70L probably benign Het
Bicd1 T C 6: 149,414,448 (GRCm39) I387T probably benign Het
Cd59b G A 2: 103,909,286 (GRCm39) probably null Het
Chn2 T C 6: 54,267,436 (GRCm39) probably benign Het
Col18a1 T C 10: 76,924,748 (GRCm39) S14G possibly damaging Het
Col5a2 A G 1: 45,446,195 (GRCm39) I461T probably benign Het
Dele1 G A 18: 38,394,317 (GRCm39) V505I probably benign Het
Dnlz T C 2: 26,241,380 (GRCm39) N116S probably damaging Het
Esyt2 A G 12: 116,331,330 (GRCm39) N736S probably damaging Het
F11 T C 8: 45,702,114 (GRCm39) T267A probably benign Het
Fam234b T G 6: 135,194,072 (GRCm39) S242A possibly damaging Het
Gadd45b A G 10: 80,766,181 (GRCm39) N11S probably benign Het
Garnl3 T C 2: 32,896,816 (GRCm39) T608A possibly damaging Het
Gata3 T C 2: 9,879,620 (GRCm39) T119A probably benign Het
Gm10647 A G 9: 66,705,777 (GRCm39) probably benign Het
Gm10936 G A 10: 117,084,035 (GRCm39) noncoding transcript Het
Gzmd A G 14: 56,367,161 (GRCm39) W244R probably damaging Het
Hdac2 T A 10: 36,865,180 (GRCm39) D131E probably benign Het
Hira T A 16: 18,774,921 (GRCm39) F949I probably benign Het
Ighv15-2 T G 12: 114,528,657 (GRCm39) probably benign Het
Il3 A G 11: 54,156,506 (GRCm39) probably null Het
Itgae A C 11: 73,002,168 (GRCm39) M91L probably benign Het
Jkampl A G 6: 73,446,402 (GRCm39) L49P possibly damaging Het
Kat2b A G 17: 53,948,238 (GRCm39) E336G probably damaging Het
Kctd21 T A 7: 96,997,298 (GRCm39) I257N probably benign Het
Kif23 C G 9: 61,832,976 (GRCm39) probably benign Het
Lgi3 A T 14: 70,770,261 (GRCm39) I109L probably benign Het
Lhx9 A T 1: 138,766,417 (GRCm39) C124S probably damaging Het
Lipo4 A G 19: 33,479,006 (GRCm39) V278A probably benign Het
Lrch3 T A 16: 32,782,124 (GRCm39) probably benign Het
Lrp1b T C 2: 40,486,995 (GRCm39) E142G probably damaging Het
Map9 G A 3: 82,267,290 (GRCm39) probably benign Het
Miox C T 15: 89,218,657 (GRCm39) probably benign Het
Mndal A T 1: 173,685,079 (GRCm39) probably benign Het
Mug2 G T 6: 122,051,673 (GRCm39) V952L possibly damaging Het
Nepn A T 10: 52,276,533 (GRCm39) T29S probably damaging Het
Or14a260 A G 7: 85,984,803 (GRCm39) I267T probably benign Het
Or4k5 T G 14: 50,386,092 (GRCm39) K80Q probably damaging Het
Or8d1b A G 9: 38,887,574 (GRCm39) I201V probably benign Het
Or8k53 T C 2: 86,178,072 (GRCm39) I13V possibly damaging Het
Phf3 A T 1: 30,844,146 (GRCm39) D1604E probably benign Het
Plekhn1 T C 4: 156,312,700 (GRCm39) R53G probably benign Het
Prickle1 A G 15: 93,408,658 (GRCm39) L47P possibly damaging Het
Ptar1 T A 19: 23,695,459 (GRCm39) C309S probably benign Het
Rapgef2 A T 3: 79,011,412 (GRCm39) S224R probably damaging Het
Rimoc1 T C 15: 4,015,776 (GRCm39) K263E probably damaging Het
Siglecg G A 7: 43,060,595 (GRCm39) G325D probably damaging Het
Skor2 A T 18: 76,946,793 (GRCm39) I172F unknown Het
Slc9a1 A G 4: 133,147,916 (GRCm39) K645E probably benign Het
St14 T A 9: 31,019,580 (GRCm39) probably null Het
Tas2r120 T A 6: 132,634,552 (GRCm39) Y211* probably null Het
Tbxa2r C A 10: 81,168,734 (GRCm39) T141K possibly damaging Het
Tpd52l1 A G 10: 31,255,252 (GRCm39) S32P probably damaging Het
Ttn T A 2: 76,540,468 (GRCm39) R34173W probably damaging Het
Ttn C A 2: 76,623,474 (GRCm39) V15368L possibly damaging Het
Tyms A G 5: 30,268,256 (GRCm39) I148T probably damaging Het
Vmn1r45 A T 6: 89,910,492 (GRCm39) Y159* probably null Het
Vmn2r13 C A 5: 109,322,915 (GRCm39) V125L probably benign Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Vps13b T C 15: 35,887,407 (GRCm39) I3272T probably benign Het
Wfdc8 A G 2: 164,439,105 (GRCm39) Y426H probably benign Het
Zfp948 A T 17: 21,807,556 (GRCm39) K249N probably damaging Het
Zfyve1 A G 12: 83,601,847 (GRCm39) probably benign Het
Zyg11a G A 4: 108,061,838 (GRCm39) T321I probably damaging Het
Other mutations in Vmn1r58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn1r58 APN 7 5,414,054 (GRCm39) missense probably benign 0.19
IGL02792:Vmn1r58 APN 7 5,414,228 (GRCm39) start codon destroyed probably null 0.04
IGL03215:Vmn1r58 APN 7 5,413,835 (GRCm39) missense probably benign 0.00
IGL03259:Vmn1r58 APN 7 5,414,086 (GRCm39) nonsense probably null
K7894:Vmn1r58 UTSW 7 5,413,702 (GRCm39) missense probably benign 0.01
R0033:Vmn1r58 UTSW 7 5,413,387 (GRCm39) missense probably damaging 1.00
R0304:Vmn1r58 UTSW 7 5,413,495 (GRCm39) missense probably damaging 1.00
R0360:Vmn1r58 UTSW 7 5,413,329 (GRCm39) missense probably benign 0.25
R0363:Vmn1r58 UTSW 7 5,413,636 (GRCm39) missense probably damaging 1.00
R0454:Vmn1r58 UTSW 7 5,413,997 (GRCm39) missense possibly damaging 0.69
R0565:Vmn1r58 UTSW 7 5,414,165 (GRCm39) missense probably benign 0.06
R0612:Vmn1r58 UTSW 7 5,413,618 (GRCm39) missense probably damaging 1.00
R0646:Vmn1r58 UTSW 7 5,413,676 (GRCm39) missense probably benign 0.00
R0853:Vmn1r58 UTSW 7 5,413,324 (GRCm39) missense probably damaging 1.00
R0920:Vmn1r58 UTSW 7 5,413,788 (GRCm39) missense probably benign 0.00
R1696:Vmn1r58 UTSW 7 5,413,727 (GRCm39) missense possibly damaging 0.67
R1823:Vmn1r58 UTSW 7 5,413,405 (GRCm39) missense possibly damaging 0.95
R2326:Vmn1r58 UTSW 7 5,413,939 (GRCm39) missense probably damaging 1.00
R4088:Vmn1r58 UTSW 7 5,413,654 (GRCm39) missense probably damaging 1.00
R5065:Vmn1r58 UTSW 7 5,413,834 (GRCm39) missense probably benign 0.00
R5087:Vmn1r58 UTSW 7 5,413,666 (GRCm39) missense probably benign 0.04
R5407:Vmn1r58 UTSW 7 5,413,872 (GRCm39) missense probably benign 0.01
R6855:Vmn1r58 UTSW 7 5,413,451 (GRCm39) missense possibly damaging 0.56
R7052:Vmn1r58 UTSW 7 5,414,134 (GRCm39) missense probably benign 0.04
R7334:Vmn1r58 UTSW 7 5,414,066 (GRCm39) missense probably benign 0.04
R7763:Vmn1r58 UTSW 7 5,413,912 (GRCm39) missense probably damaging 1.00
R7840:Vmn1r58 UTSW 7 5,414,242 (GRCm39) start gained probably benign
R7875:Vmn1r58 UTSW 7 5,413,753 (GRCm39) missense probably damaging 0.98
R8004:Vmn1r58 UTSW 7 5,413,506 (GRCm39) nonsense probably null
R8115:Vmn1r58 UTSW 7 5,413,341 (GRCm39) missense probably benign 0.00
R8781:Vmn1r58 UTSW 7 5,413,482 (GRCm39) missense probably benign 0.00
R8802:Vmn1r58 UTSW 7 5,414,080 (GRCm39) missense probably damaging 1.00
X0058:Vmn1r58 UTSW 7 5,413,394 (GRCm39) missense possibly damaging 0.89
Z1176:Vmn1r58 UTSW 7 5,413,903 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTCTACACTGACCCCAGAGATGG -3'
(R):5'- TCTTGACTGACTCCAGACTGAAGCC -3'

Sequencing Primer
(F):5'- CCCCAGAGATGGAGCATATTG -3'
(R):5'- GACTGAAGCCAATACAGGTCATTC -3'
Posted On 2013-05-09