Incidental Mutation 'R0218:Ms4a20'
ID 33694
Institutional Source Beutler Lab
Gene Symbol Ms4a20
Ensembl Gene ENSMUSG00000024729
Gene Name membrane-spanning 4-domains, subfamily A, member 20
Synonyms 1700017D01Rik
MMRRC Submission 038467-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R0218 (G1)
Quality Score 200
Status Validated
Chromosome 19
Chromosomal Location 11074180-11108240 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 11093801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 10 (Y10*)
Ref Sequence ENSEMBL: ENSMUSP00000025635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025635]
AlphaFold G5E851
Predicted Effect probably null
Transcript: ENSMUST00000025635
AA Change: Y10*
SMART Domains Protein: ENSMUSP00000025635
Gene: ENSMUSG00000024729
AA Change: Y10*

DomainStartEndE-ValueType
Pfam:CD20 18 118 2.4e-8 PFAM
transmembrane domain 130 152 N/A INTRINSIC
low complexity region 169 185 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188756
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency 98% (53/54)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T G 8: 44,079,477 (GRCm39) Q249P probably benign Het
Adgrv1 C T 13: 81,255,017 (GRCm39) probably null Het
Ccdc110 A G 8: 46,387,761 (GRCm39) probably benign Het
Cd200r1 T A 16: 44,609,106 (GRCm39) probably benign Het
Cdkl1 A T 12: 69,836,809 (GRCm39) D40E probably benign Het
Cdx1 A G 18: 61,153,436 (GRCm39) probably benign Het
Cenpp T A 13: 49,801,108 (GRCm39) K103N possibly damaging Het
Cep162 A G 9: 87,093,862 (GRCm39) Y839H possibly damaging Het
Chac1 T A 2: 119,183,941 (GRCm39) L181* probably null Het
Ciapin1 G T 8: 95,554,938 (GRCm39) Q173K probably damaging Het
Cmklr2 T A 1: 63,222,690 (GRCm39) N182Y probably benign Het
Dgcr2 A G 16: 17,667,650 (GRCm39) C270R probably damaging Het
Dlc1 A G 8: 37,317,383 (GRCm39) S431P probably benign Het
Efcab12 T C 6: 115,791,611 (GRCm39) probably benign Het
Ehbp1 A T 11: 22,181,992 (GRCm39) probably benign Het
Enpp3 A T 10: 24,652,767 (GRCm39) V730D possibly damaging Het
Fam174b A G 7: 73,390,512 (GRCm39) T88A probably benign Het
Fancl A G 11: 26,421,337 (GRCm39) K364E probably benign Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Galc A G 12: 98,188,906 (GRCm39) Y402H probably damaging Het
Gga2 T C 7: 121,598,123 (GRCm39) N324D possibly damaging Het
Hc G T 2: 34,918,086 (GRCm39) F732L probably damaging Het
Heca T C 10: 17,791,463 (GRCm39) M198V probably benign Het
Herc6 C A 6: 57,596,586 (GRCm39) H509N probably benign Het
Irf2bpl A T 12: 86,929,398 (GRCm39) M425K probably benign Het
Mael C T 1: 166,066,159 (GRCm39) G26D probably damaging Het
Map1a A G 2: 121,135,906 (GRCm39) T2241A probably benign Het
Mcc C G 18: 44,652,583 (GRCm39) probably benign Het
Mdga2 A G 12: 66,701,894 (GRCm39) S505P probably damaging Het
Mdm1 A G 10: 117,992,783 (GRCm39) probably benign Het
Mex3b A T 7: 82,518,312 (GRCm39) E209V probably damaging Het
Mrgprx3-ps T C 7: 46,959,154 (GRCm39) E279G possibly damaging Het
Nfe2l1 A T 11: 96,718,439 (GRCm39) L32Q probably damaging Het
Npas1 C T 7: 16,195,818 (GRCm39) V285I probably benign Het
Or5e1 T A 7: 108,354,781 (GRCm39) C239* probably null Het
Or5h19 C T 16: 58,856,456 (GRCm39) V215I probably benign Het
Or9i14 T C 19: 13,792,342 (GRCm39) N204S probably benign Het
Osr1 A G 12: 9,629,639 (GRCm39) T171A probably benign Het
Ppp3cb A T 14: 20,574,044 (GRCm39) C265S probably damaging Het
Pramel27 A G 4: 143,578,401 (GRCm39) I220M probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Simc1 T C 13: 54,674,417 (GRCm39) Y922H probably damaging Het
Slc25a39 A G 11: 102,297,056 (GRCm39) F56L probably benign Het
Smg8 A G 11: 86,976,948 (GRCm39) L211P probably damaging Het
Sncaip A G 18: 53,040,400 (GRCm39) S805G probably benign Het
Sra1 T C 18: 36,809,662 (GRCm39) probably benign Het
Tas2r104 T G 6: 131,662,055 (GRCm39) D218A probably damaging Het
Unc45b A G 11: 82,802,686 (GRCm39) probably benign Het
Unc79 A G 12: 103,075,040 (GRCm39) probably null Het
Washc2 T A 6: 116,225,007 (GRCm39) L785* probably null Het
Zfp30 A G 7: 29,493,063 (GRCm39) E439G probably damaging Het
Zfp518a A G 19: 40,901,072 (GRCm39) T334A probably benign Het
Other mutations in Ms4a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02142:Ms4a20 APN 19 11,087,695 (GRCm39) nonsense probably null
IGL02182:Ms4a20 APN 19 11,074,436 (GRCm39) splice site probably benign
IGL03156:Ms4a20 APN 19 11,083,114 (GRCm39) missense possibly damaging 0.80
R0189:Ms4a20 UTSW 19 11,074,311 (GRCm39) missense possibly damaging 0.46
R0464:Ms4a20 UTSW 19 11,089,801 (GRCm39) missense probably damaging 1.00
R0617:Ms4a20 UTSW 19 11,089,764 (GRCm39) missense probably damaging 1.00
R1171:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably damaging 0.97
R2341:Ms4a20 UTSW 19 11,083,157 (GRCm39) missense probably benign
R5099:Ms4a20 UTSW 19 11,089,825 (GRCm39) critical splice acceptor site probably null
R5330:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R5331:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R5341:Ms4a20 UTSW 19 11,087,745 (GRCm39) intron probably benign
R6109:Ms4a20 UTSW 19 11,079,276 (GRCm39) missense possibly damaging 0.66
R6177:Ms4a20 UTSW 19 11,083,114 (GRCm39) missense possibly damaging 0.53
R6970:Ms4a20 UTSW 19 11,089,678 (GRCm39) critical splice donor site probably null
R7038:Ms4a20 UTSW 19 11,087,675 (GRCm39) missense probably benign
R7584:Ms4a20 UTSW 19 11,087,725 (GRCm39) missense possibly damaging 0.94
R7752:Ms4a20 UTSW 19 11,079,224 (GRCm39) missense probably benign 0.02
R7854:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably benign 0.01
R8261:Ms4a20 UTSW 19 11,087,707 (GRCm39) missense probably damaging 0.97
R8723:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9027:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9264:Ms4a20 UTSW 19 11,093,830 (GRCm39) start codon destroyed probably benign 0.14
X0019:Ms4a20 UTSW 19 11,083,156 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATGTTTTGTGTGACCATTTAGCTCTGG -3'
(R):5'- CAGAACTGCTGCTCTTAGGTAAGACC -3'

Sequencing Primer
(F):5'- GACCATTTAGCTCTGGTATAATTGTC -3'
(R):5'- atttagttctcagcacacacatc -3'
Posted On 2013-05-09