Incidental Mutation 'R3440:Fignl2'
ID 334566
Institutional Source Beutler Lab
Gene Symbol Fignl2
Ensembl Gene ENSMUSG00000095440
Gene Name fidgetin-like 2
Synonyms
MMRRC Submission 040658-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R3440 (G1)
Quality Score 40
Status Validated
Chromosome 15
Chromosomal Location 100948075-100976448 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 100951004 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 426 (F426S)
Ref Sequence ENSEMBL: ENSMUSP00000150618 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178140] [ENSMUST00000213610]
AlphaFold J3QK54
Predicted Effect unknown
Transcript: ENSMUST00000178140
AA Change: F426S
SMART Domains Protein: ENSMUSP00000137256
Gene: ENSMUSG00000095440
AA Change: F426S

DomainStartEndE-ValueType
low complexity region 94 105 N/A INTRINSIC
low complexity region 112 135 N/A INTRINSIC
low complexity region 152 201 N/A INTRINSIC
low complexity region 203 255 N/A INTRINSIC
low complexity region 267 296 N/A INTRINSIC
low complexity region 310 329 N/A INTRINSIC
low complexity region 394 412 N/A INTRINSIC
AAA 419 550 3.31e-8 SMART
Predicted Effect unknown
Transcript: ENSMUST00000213610
AA Change: F426S
Meta Mutation Damage Score 0.0728 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (29/30)
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 C A 2: 103,397,577 (GRCm39) A169E probably benign Het
Adam3 T C 8: 25,170,759 (GRCm39) probably benign Het
Agmo C T 12: 37,293,799 (GRCm39) T74I probably damaging Het
Ano6 T C 15: 95,865,602 (GRCm39) V862A probably damaging Het
Bltp1 C T 3: 37,096,061 (GRCm39) Q4614* probably null Het
Cavin2 T A 1: 51,340,565 (GRCm39) V414E probably damaging Het
Clrn3 A C 7: 135,115,854 (GRCm39) Y165* probably null Het
Cp A T 3: 20,029,121 (GRCm39) M533L probably benign Het
Dhrs3 T A 4: 144,646,628 (GRCm39) M226K probably damaging Het
Fpr1 C T 17: 18,097,420 (GRCm39) D190N probably benign Het
Grik3 C A 4: 125,587,763 (GRCm39) L628M probably damaging Het
Grik3 T A 4: 125,587,764 (GRCm39) L628Q probably damaging Het
Grin2c T A 11: 115,141,469 (GRCm39) D883V probably damaging Het
Gtf3c6 T A 10: 40,127,169 (GRCm39) E123V probably null Het
H2-Eb1 A G 17: 34,528,655 (GRCm39) E62G probably damaging Het
Kif1a C T 1: 92,964,575 (GRCm39) D1334N possibly damaging Het
Lef1 A G 3: 130,978,407 (GRCm39) D175G probably damaging Het
Myom1 A G 17: 71,352,658 (GRCm39) probably null Het
Or6k2 A T 1: 173,986,746 (GRCm39) M136L probably benign Het
Pgr A T 9: 8,922,630 (GRCm39) N600I probably damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Selp T C 1: 163,951,344 (GRCm39) F26S probably benign Het
Tchh A T 3: 93,352,414 (GRCm39) D618V unknown Het
Tenm4 A T 7: 96,202,723 (GRCm39) M88L probably benign Het
Zfat A T 15: 67,956,402 (GRCm39) D1143E probably benign Het
Other mutations in Fignl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0068:Fignl2 UTSW 15 100,952,129 (GRCm39) missense probably damaging 1.00
R0068:Fignl2 UTSW 15 100,952,129 (GRCm39) missense probably damaging 1.00
R0375:Fignl2 UTSW 15 100,951,974 (GRCm39) missense probably benign 0.06
R1616:Fignl2 UTSW 15 100,951,997 (GRCm39) missense probably damaging 0.96
R2240:Fignl2 UTSW 15 100,951,916 (GRCm39) missense probably damaging 1.00
R3976:Fignl2 UTSW 15 100,950,467 (GRCm39) missense unknown
R4418:Fignl2 UTSW 15 100,951,830 (GRCm39) missense possibly damaging 0.84
R5869:Fignl2 UTSW 15 100,951,161 (GRCm39) missense unknown
R6249:Fignl2 UTSW 15 100,952,060 (GRCm39) missense possibly damaging 0.49
R6894:Fignl2 UTSW 15 100,951,854 (GRCm39) missense probably benign 0.00
R7302:Fignl2 UTSW 15 100,951,259 (GRCm39) missense unknown
R7323:Fignl2 UTSW 15 100,951,382 (GRCm39) missense unknown
R7548:Fignl2 UTSW 15 100,951,079 (GRCm39) missense unknown
R7558:Fignl2 UTSW 15 100,952,264 (GRCm39) missense probably damaging 1.00
R7776:Fignl2 UTSW 15 100,951,301 (GRCm39) missense unknown
R7782:Fignl2 UTSW 15 100,951,188 (GRCm39) missense unknown
R8708:Fignl2 UTSW 15 100,950,734 (GRCm39) missense unknown
R8936:Fignl2 UTSW 15 100,951,339 (GRCm39) missense unknown
R9328:Fignl2 UTSW 15 100,951,271 (GRCm39) missense unknown
R9393:Fignl2 UTSW 15 100,951,466 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAAAGCCCTGAGTTCCCTGC -3'
(R):5'- TTTGACAAGTTCCCGGAGCG -3'

Sequencing Primer
(F):5'- GTCCAGCTCGCTGATGAG -3'
(R):5'- ACGGAGGCTTCGCGGAG -3'
Posted On 2015-09-03