Incidental Mutation 'R0207:Tns1'
| ID |
33361 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tns1
|
| Ensembl Gene |
ENSMUSG00000055322 |
| Gene Name |
tensin 1 |
| Synonyms |
E030018G17Rik, 1110018I21Rik, E030037J05Rik, 1200014E20Rik, Tns |
| MMRRC Submission |
038460-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.565)
|
| Stock # |
R0207 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
73949390-74163608 bp(-) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
C to T
at 73976477 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148638
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169786]
[ENSMUST00000169786]
[ENSMUST00000187584]
[ENSMUST00000187584]
[ENSMUST00000191104]
[ENSMUST00000191104]
[ENSMUST00000212888]
[ENSMUST00000212888]
|
| AlphaFold |
E9Q0S6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000169786
|
| SMART Domains |
Protein: ENSMUSP00000127715
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
1.77e-2 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
SCOP:d1d5ra2
|
176 |
348 |
3e-32 |
SMART |
|
PTEN_C2
|
350 |
477 |
1.12e-51 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1227 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1284 |
1300 |
N/A |
INTRINSIC |
|
low complexity region
|
1459 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1518 |
1530 |
N/A |
INTRINSIC |
|
SH2
|
1614 |
1716 |
6.85e-17 |
SMART |
|
PTB
|
1747 |
1888 |
1.69e-29 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169786
|
| SMART Domains |
Protein: ENSMUSP00000127715
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
1.77e-2 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
SCOP:d1d5ra2
|
176 |
348 |
3e-32 |
SMART |
|
PTEN_C2
|
350 |
477 |
1.12e-51 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1227 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1284 |
1300 |
N/A |
INTRINSIC |
|
low complexity region
|
1459 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1518 |
1530 |
N/A |
INTRINSIC |
|
SH2
|
1614 |
1716 |
6.85e-17 |
SMART |
|
PTB
|
1747 |
1888 |
1.69e-29 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000185331
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000185331
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000185702
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000185702
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000187584
|
| SMART Domains |
Protein: ENSMUSP00000140254
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
21 |
67 |
8.6e-5 |
SMART |
|
low complexity region
|
113 |
124 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
197 |
319 |
9.9e-6 |
SMART |
|
PTEN_C2
|
306 |
433 |
5.6e-56 |
SMART |
|
low complexity region
|
778 |
789 |
N/A |
INTRINSIC |
|
low complexity region
|
861 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1174 |
N/A |
INTRINSIC |
|
low complexity region
|
1219 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1394 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1453 |
1465 |
N/A |
INTRINSIC |
|
SH2
|
1549 |
1651 |
4.3e-19 |
SMART |
|
PTB
|
1682 |
1823 |
9e-32 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000187584
|
| SMART Domains |
Protein: ENSMUSP00000140254
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
21 |
67 |
8.6e-5 |
SMART |
|
low complexity region
|
113 |
124 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
197 |
319 |
9.9e-6 |
SMART |
|
PTEN_C2
|
306 |
433 |
5.6e-56 |
SMART |
|
low complexity region
|
778 |
789 |
N/A |
INTRINSIC |
|
low complexity region
|
861 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1174 |
N/A |
INTRINSIC |
|
low complexity region
|
1219 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1394 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1453 |
1465 |
N/A |
INTRINSIC |
|
SH2
|
1549 |
1651 |
4.3e-19 |
SMART |
|
PTB
|
1682 |
1823 |
9e-32 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000189228
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000191104
|
| SMART Domains |
Protein: ENSMUSP00000140317
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
8.6e-5 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
241 |
363 |
9.9e-6 |
SMART |
|
PTEN_C2
|
350 |
477 |
5.6e-56 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1206 |
1218 |
N/A |
INTRINSIC |
|
low complexity region
|
1263 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1509 |
N/A |
INTRINSIC |
|
SH2
|
1593 |
1695 |
4.3e-19 |
SMART |
|
PTB
|
1726 |
1867 |
9e-32 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000191104
|
| SMART Domains |
Protein: ENSMUSP00000140317
Gene: ENSMUSG00000055322
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
8.6e-5 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
241 |
363 |
9.9e-6 |
SMART |
|
PTEN_C2
|
350 |
477 |
5.6e-56 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1206 |
1218 |
N/A |
INTRINSIC |
|
low complexity region
|
1263 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1509 |
N/A |
INTRINSIC |
|
SH2
|
1593 |
1695 |
4.3e-19 |
SMART |
|
PTB
|
1726 |
1867 |
9e-32 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000212888
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000212888
|
| Meta Mutation Damage Score |
0.9475 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.2%
- 20x: 95.5%
|
| Validation Efficiency |
95% (76/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca1 |
A |
G |
4: 53,086,039 (GRCm39) |
F488S |
probably damaging |
Het |
| Acap3 |
C |
T |
4: 155,983,881 (GRCm39) |
R116W |
probably damaging |
Het |
| Adamts10 |
C |
A |
17: 33,764,364 (GRCm39) |
P663T |
possibly damaging |
Het |
| Akap12 |
G |
A |
10: 4,303,333 (GRCm39) |
G48S |
probably damaging |
Het |
| Ankrd7 |
T |
A |
6: 18,870,030 (GRCm39) |
M261K |
probably benign |
Het |
| Ankzf1 |
C |
A |
1: 75,174,948 (GRCm39) |
D599E |
possibly damaging |
Het |
| Aox1 |
T |
C |
1: 58,144,173 (GRCm39) |
I1278T |
possibly damaging |
Het |
| Apcdd1 |
T |
C |
18: 63,083,150 (GRCm39) |
Y327H |
probably benign |
Het |
| Asxl3 |
T |
A |
18: 22,544,553 (GRCm39) |
|
probably benign |
Het |
| Birc6 |
C |
A |
17: 74,969,827 (GRCm39) |
|
probably benign |
Het |
| Btaf1 |
T |
A |
19: 36,987,048 (GRCm39) |
L1714* |
probably null |
Het |
| Cacng6 |
T |
A |
7: 3,473,520 (GRCm39) |
|
probably benign |
Het |
| Cdc20b |
A |
G |
13: 113,215,146 (GRCm39) |
D238G |
probably damaging |
Het |
| Celf5 |
T |
A |
10: 81,306,532 (GRCm39) |
R113W |
probably null |
Het |
| Cfap251 |
T |
C |
5: 123,421,510 (GRCm39) |
V182A |
probably damaging |
Het |
| Cfap70 |
C |
A |
14: 20,462,415 (GRCm39) |
E659D |
probably damaging |
Het |
| Clspn |
T |
A |
4: 126,484,391 (GRCm39) |
M1183K |
possibly damaging |
Het |
| Dpy19l1 |
G |
A |
9: 24,365,187 (GRCm39) |
R275C |
probably damaging |
Het |
| Dst |
C |
T |
1: 34,226,016 (GRCm39) |
S1721L |
probably benign |
Het |
| Faap100 |
T |
C |
11: 120,265,191 (GRCm39) |
T562A |
probably damaging |
Het |
| Fam168b |
T |
C |
1: 34,858,769 (GRCm39) |
M133V |
probably damaging |
Het |
| Farp2 |
T |
C |
1: 93,496,809 (GRCm39) |
I172T |
probably damaging |
Het |
| Fer |
T |
G |
17: 64,203,273 (GRCm39) |
S68A |
probably damaging |
Het |
| Fmo5 |
A |
G |
3: 97,552,997 (GRCm39) |
E315G |
probably damaging |
Het |
| Gpr89 |
A |
T |
3: 96,778,796 (GRCm39) |
F426I |
probably damaging |
Het |
| Hinfp |
T |
C |
9: 44,207,624 (GRCm39) |
I461V |
possibly damaging |
Het |
| Hsd11b1 |
A |
T |
1: 192,922,556 (GRCm39) |
V167D |
probably damaging |
Het |
| Htt |
A |
G |
5: 35,054,252 (GRCm39) |
K2574E |
probably benign |
Het |
| I830077J02Rik |
A |
G |
3: 105,833,821 (GRCm39) |
S112P |
probably benign |
Het |
| Igf2bp3 |
T |
A |
6: 49,082,551 (GRCm39) |
M344L |
probably benign |
Het |
| Itch |
A |
T |
2: 155,044,177 (GRCm39) |
Q494L |
probably benign |
Het |
| Itga9 |
T |
C |
9: 118,598,321 (GRCm39) |
|
probably benign |
Het |
| Jaml |
T |
A |
9: 45,005,065 (GRCm39) |
D152E |
probably benign |
Het |
| Kif22 |
A |
C |
7: 126,641,572 (GRCm39) |
M1R |
probably null |
Het |
| Kifap3 |
T |
C |
1: 163,710,955 (GRCm39) |
Y663H |
probably benign |
Het |
| Letm2 |
T |
A |
8: 26,068,786 (GRCm39) |
N472I |
probably damaging |
Het |
| Mthfr |
T |
G |
4: 148,136,681 (GRCm39) |
V446G |
probably damaging |
Het |
| Myh11 |
T |
C |
16: 14,029,124 (GRCm39) |
E1206G |
possibly damaging |
Het |
| Myo6 |
G |
A |
9: 80,195,338 (GRCm39) |
V903I |
probably damaging |
Het |
| Myo9b |
C |
T |
8: 71,807,869 (GRCm39) |
|
probably benign |
Het |
| Nr2f2 |
G |
C |
7: 70,009,923 (GRCm39) |
P52R |
probably damaging |
Het |
| Nsd3 |
A |
G |
8: 26,173,273 (GRCm39) |
N859S |
probably benign |
Het |
| Nucb2 |
C |
A |
7: 116,135,245 (GRCm39) |
A384E |
probably damaging |
Het |
| Ogdhl |
C |
A |
14: 32,063,994 (GRCm39) |
|
probably null |
Het |
| Or10al3 |
C |
A |
17: 38,011,949 (GRCm39) |
C129* |
probably null |
Het |
| Or1e22 |
A |
T |
11: 73,377,401 (GRCm39) |
L83Q |
probably benign |
Het |
| Or1i2 |
T |
C |
10: 78,447,705 (GRCm39) |
T257A |
probably benign |
Het |
| Or4a74 |
G |
A |
2: 89,440,207 (GRCm39) |
L80F |
probably damaging |
Het |
| Or5b105 |
G |
A |
19: 13,080,642 (GRCm39) |
R3C |
possibly damaging |
Het |
| Parp10 |
C |
T |
15: 76,126,833 (GRCm39) |
S145N |
probably benign |
Het |
| Pigh |
A |
G |
12: 79,130,483 (GRCm39) |
|
probably benign |
Het |
| Pigo |
A |
G |
4: 43,023,824 (GRCm39) |
|
probably benign |
Het |
| Pkp4 |
T |
A |
2: 59,135,832 (GRCm39) |
V199D |
possibly damaging |
Het |
| Polr1e |
C |
A |
4: 45,025,143 (GRCm39) |
|
probably null |
Het |
| Ppfia3 |
C |
A |
7: 44,997,958 (GRCm39) |
R723L |
probably damaging |
Het |
| Prex1 |
C |
A |
2: 166,427,818 (GRCm39) |
A945S |
possibly damaging |
Het |
| Prrt3 |
A |
T |
6: 113,472,801 (GRCm39) |
V457E |
probably damaging |
Het |
| Rab39 |
A |
G |
9: 53,617,271 (GRCm39) |
F49L |
possibly damaging |
Het |
| Rrs1 |
C |
A |
1: 9,615,987 (GRCm39) |
|
probably null |
Het |
| Rrs1 |
G |
A |
1: 9,615,992 (GRCm39) |
E82K |
probably damaging |
Het |
| Serpinb3c |
T |
C |
1: 107,204,722 (GRCm39) |
D8G |
probably benign |
Het |
| Slc17a6 |
A |
G |
7: 51,295,928 (GRCm39) |
|
probably benign |
Het |
| Slc24a4 |
T |
A |
12: 102,195,210 (GRCm39) |
|
probably null |
Het |
| Smc1b |
C |
T |
15: 85,007,960 (GRCm39) |
M272I |
probably benign |
Het |
| Smc6 |
T |
C |
12: 11,333,179 (GRCm39) |
|
probably benign |
Het |
| Tcf20 |
T |
C |
15: 82,739,286 (GRCm39) |
T722A |
probably benign |
Het |
| Tesmin |
A |
T |
19: 3,454,088 (GRCm39) |
M141L |
probably benign |
Het |
| Tmprss5 |
T |
A |
9: 49,024,460 (GRCm39) |
H274Q |
possibly damaging |
Het |
| Tpr |
T |
C |
1: 150,293,178 (GRCm39) |
S868P |
possibly damaging |
Het |
| Trank1 |
C |
T |
9: 111,195,321 (GRCm39) |
T1115I |
probably damaging |
Het |
| Trmt44 |
A |
T |
5: 35,730,261 (GRCm39) |
I203K |
possibly damaging |
Het |
| Ulk2 |
A |
T |
11: 61,668,611 (GRCm39) |
V1037E |
probably benign |
Het |
| Usp43 |
A |
G |
11: 67,767,325 (GRCm39) |
Y682H |
probably damaging |
Het |
| Vipr2 |
A |
T |
12: 116,106,502 (GRCm39) |
Q366L |
probably damaging |
Het |
| Vmn1r185 |
C |
A |
7: 26,311,014 (GRCm39) |
V164L |
possibly damaging |
Het |
| Vmn2r120 |
C |
T |
17: 57,832,052 (GRCm39) |
V246I |
probably benign |
Het |
| Wiz |
C |
T |
17: 32,576,007 (GRCm39) |
G790R |
probably damaging |
Het |
| Wnk1 |
A |
T |
6: 119,929,694 (GRCm39) |
S1016R |
probably damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,288,109 (GRCm39) |
L909S |
probably benign |
Het |
| Zfp236 |
T |
A |
18: 82,658,352 (GRCm39) |
I637F |
probably damaging |
Het |
| Zfp788 |
G |
A |
7: 41,299,020 (GRCm39) |
G532D |
probably damaging |
Het |
| Zranb1 |
T |
C |
7: 132,552,114 (GRCm39) |
I255T |
probably damaging |
Het |
|
| Other mutations in Tns1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Tns1
|
APN |
1 |
73,964,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01288:Tns1
|
APN |
1 |
73,992,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01536:Tns1
|
APN |
1 |
73,958,807 (GRCm39) |
splice site |
probably benign |
|
|
IGL01568:Tns1
|
APN |
1 |
73,992,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01683:Tns1
|
APN |
1 |
73,992,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02267:Tns1
|
APN |
1 |
74,031,290 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02597:Tns1
|
APN |
1 |
74,025,032 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02819:Tns1
|
APN |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03370:Tns1
|
APN |
1 |
74,025,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0087:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0411:Tns1
|
UTSW |
1 |
73,964,920 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0543:Tns1
|
UTSW |
1 |
73,991,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0552:Tns1
|
UTSW |
1 |
73,959,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0720:Tns1
|
UTSW |
1 |
73,964,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0828:Tns1
|
UTSW |
1 |
73,958,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1034:Tns1
|
UTSW |
1 |
73,981,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1061:Tns1
|
UTSW |
1 |
73,956,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Tns1
|
UTSW |
1 |
73,955,635 (GRCm39) |
splice site |
probably benign |
|
|
R1826:Tns1
|
UTSW |
1 |
73,992,793 (GRCm39) |
start codon destroyed |
probably null |
0.91 |
|
R2208:Tns1
|
UTSW |
1 |
74,118,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3723:Tns1
|
UTSW |
1 |
73,964,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Tns1
|
UTSW |
1 |
74,034,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4111:Tns1
|
UTSW |
1 |
73,981,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4155:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4156:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Tns1
|
UTSW |
1 |
73,967,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Tns1
|
UTSW |
1 |
74,024,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4649:Tns1
|
UTSW |
1 |
73,992,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4742:Tns1
|
UTSW |
1 |
74,163,449 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4869:Tns1
|
UTSW |
1 |
73,991,774 (GRCm39) |
missense |
probably benign |
|
|
R4961:Tns1
|
UTSW |
1 |
73,975,074 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5025:Tns1
|
UTSW |
1 |
73,964,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5035:Tns1
|
UTSW |
1 |
73,992,979 (GRCm39) |
start gained |
probably benign |
|
|
R5062:Tns1
|
UTSW |
1 |
73,992,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Tns1
|
UTSW |
1 |
73,992,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5213:Tns1
|
UTSW |
1 |
73,992,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Tns1
|
UTSW |
1 |
74,034,585 (GRCm39) |
intron |
probably benign |
|
|
R5368:Tns1
|
UTSW |
1 |
73,980,176 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5391:Tns1
|
UTSW |
1 |
74,029,568 (GRCm39) |
splice site |
probably null |
|
|
R5587:Tns1
|
UTSW |
1 |
73,959,755 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5735:Tns1
|
UTSW |
1 |
73,967,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5855:Tns1
|
UTSW |
1 |
73,957,192 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5999:Tns1
|
UTSW |
1 |
73,967,256 (GRCm39) |
nonsense |
probably null |
|
|
R6122:Tns1
|
UTSW |
1 |
73,991,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6148:Tns1
|
UTSW |
1 |
73,992,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Tns1
|
UTSW |
1 |
73,957,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6525:Tns1
|
UTSW |
1 |
73,992,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6712:Tns1
|
UTSW |
1 |
74,118,460 (GRCm39) |
nonsense |
probably null |
|
|
R6773:Tns1
|
UTSW |
1 |
73,958,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6825:Tns1
|
UTSW |
1 |
74,041,482 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Tns1
|
UTSW |
1 |
73,964,621 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Tns1
|
UTSW |
1 |
74,034,463 (GRCm39) |
missense |
|
|
|
R7209:Tns1
|
UTSW |
1 |
73,993,074 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7348:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7570:Tns1
|
UTSW |
1 |
73,992,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7670:Tns1
|
UTSW |
1 |
73,991,636 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7769:Tns1
|
UTSW |
1 |
73,992,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7833:Tns1
|
UTSW |
1 |
74,130,490 (GRCm39) |
intron |
probably benign |
|
|
R8052:Tns1
|
UTSW |
1 |
73,992,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8225:Tns1
|
UTSW |
1 |
74,025,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Tns1
|
UTSW |
1 |
73,976,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8321:Tns1
|
UTSW |
1 |
74,024,939 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8344:Tns1
|
UTSW |
1 |
74,024,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8378:Tns1
|
UTSW |
1 |
73,976,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8434:Tns1
|
UTSW |
1 |
73,964,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8773:Tns1
|
UTSW |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9211:Tns1
|
UTSW |
1 |
73,956,948 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9251:Tns1
|
UTSW |
1 |
74,030,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9315:Tns1
|
UTSW |
1 |
73,980,141 (GRCm39) |
missense |
|
|
|
R9411:Tns1
|
UTSW |
1 |
73,992,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9592:Tns1
|
UTSW |
1 |
74,029,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,183 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,182 (GRCm39) |
missense |
probably benign |
0.14 |
|
Z1177:Tns1
|
UTSW |
1 |
74,041,466 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGTCTCAAAATCCTAAGGCCCAG -3'
(R):5'- TCTCTTAGTAGTGGGCAAGGGTCAG -3'
Sequencing Primer
(F):5'- AAACCTCTGCTCTGTGAGGAATC -3'
(R):5'- TCAGGACAGGGTGTCACTTC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation