Incidental Mutation 'R0101:Mtus2'
ID 33193
Institutional Source Beutler Lab
Gene Symbol Mtus2
Ensembl Gene ENSMUSG00000029651
Gene Name microtubule associated tumor suppressor candidate 2
Synonyms C130038G02Rik, A730013O20Rik, 5730592G18Rik
MMRRC Submission 038387-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R0101 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 147894130-148252875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 148019845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 747 (S747P)
Ref Sequence ENSEMBL: ENSMUSP00000082694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085558]
AlphaFold Q3UHD3
Predicted Effect probably damaging
Transcript: ENSMUST00000085558
AA Change: S747P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: S747P

DomainStartEndE-ValueType
internal_repeat_1 57 290 2.46e-5 PROSPERO
internal_repeat_1 312 525 2.46e-5 PROSPERO
low complexity region 530 541 N/A INTRINSIC
low complexity region 802 818 N/A INTRINSIC
low complexity region 841 852 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
coiled coil region 1029 1080 N/A INTRINSIC
SCOP:d1fxkc_ 1167 1294 3e-4 SMART
low complexity region 1332 1349 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149336
Meta Mutation Damage Score 0.1993 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk C T 11: 119,901,739 (GRCm39) D829N probably benign Het
B3galnt1 A G 3: 69,483,139 (GRCm39) Y41H probably benign Het
Carmil3 A C 14: 55,735,212 (GRCm39) probably benign Het
Cdh17 A G 4: 11,771,341 (GRCm39) Q41R probably benign Het
Cep43 A T 17: 8,388,374 (GRCm39) S76C possibly damaging Het
Chrm2 G T 6: 36,501,430 (GRCm39) C429F probably damaging Het
Cplane1 T A 15: 8,250,444 (GRCm39) C1844S probably benign Het
Cyld T A 8: 89,444,928 (GRCm39) probably null Het
Cyp2d11 C A 15: 82,274,395 (GRCm39) probably benign Het
Dnah1 A G 14: 31,005,856 (GRCm39) Y2308H probably damaging Het
Dnajc27 T C 12: 4,139,142 (GRCm39) V60A probably benign Het
Dnmbp A G 19: 43,862,599 (GRCm39) V850A possibly damaging Het
Emcn A T 3: 137,047,001 (GRCm39) M1L possibly damaging Het
Epc1 A T 18: 6,462,998 (GRCm39) probably benign Het
Fbxo21 T C 5: 118,133,521 (GRCm39) L310P probably damaging Het
Filip1 A G 9: 79,726,810 (GRCm39) I603T probably benign Het
Fndc3b A G 3: 27,512,957 (GRCm39) V723A probably damaging Het
Gemin5 G A 11: 58,036,322 (GRCm39) P674S probably damaging Het
Gsk3a T C 7: 24,928,328 (GRCm39) D471G probably benign Het
Igbp1b G A 6: 138,634,658 (GRCm39) P262L probably damaging Het
Itga11 T C 9: 62,651,768 (GRCm39) L300S probably damaging Het
Itsn2 T C 12: 4,683,058 (GRCm39) probably benign Het
Lhcgr A G 17: 89,072,598 (GRCm39) S150P probably damaging Het
Man1a T C 10: 53,951,120 (GRCm39) M1V probably null Het
Mical2 C T 7: 111,936,074 (GRCm39) R892C possibly damaging Het
Mug1 A G 6: 121,861,206 (GRCm39) K1276E possibly damaging Het
Or1n1b A G 2: 36,780,138 (GRCm39) S241P probably damaging Het
Pfkfb4 C G 9: 108,839,711 (GRCm39) P260R probably benign Het
Prkca A T 11: 107,948,626 (GRCm39) L121Q probably damaging Het
Prpf40b T C 15: 99,204,681 (GRCm39) probably benign Het
Ripor2 T C 13: 24,864,615 (GRCm39) M215T probably damaging Het
Rpn1 A G 6: 88,070,769 (GRCm39) D213G possibly damaging Het
Rreb1 C A 13: 38,115,518 (GRCm39) P959Q probably benign Het
Sema5b T C 16: 35,483,472 (GRCm39) probably benign Het
Slc38a10 A G 11: 120,041,903 (GRCm39) M1T probably null Het
Slco1c1 G T 6: 141,477,236 (GRCm39) L11F probably damaging Het
Spef2 T C 15: 9,713,194 (GRCm39) T393A probably damaging Het
Srp54b A G 12: 55,302,405 (GRCm39) probably benign Het
St14 G T 9: 31,008,403 (GRCm39) N512K probably benign Het
Syce1l T A 8: 114,382,061 (GRCm39) S237T probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Tamm41 A T 6: 115,009,207 (GRCm39) Y129N probably damaging Het
Tctn2 T C 5: 124,753,357 (GRCm39) noncoding transcript Het
Tpr T C 1: 150,285,053 (GRCm39) probably benign Het
Vsig10 T A 5: 117,473,134 (GRCm39) probably null Het
Zfp335 T C 2: 164,741,910 (GRCm39) K635R probably damaging Het
Zfp541 A G 7: 15,811,968 (GRCm39) Y207C probably damaging Het
Other mutations in Mtus2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Mtus2 APN 5 148,013,819 (GRCm39) splice site probably null
IGL01911:Mtus2 APN 5 148,015,030 (GRCm39) missense probably benign 0.00
IGL01973:Mtus2 APN 5 148,240,286 (GRCm39) splice site probably benign
IGL02452:Mtus2 APN 5 148,014,473 (GRCm39) missense probably benign 0.01
IGL02476:Mtus2 APN 5 148,014,748 (GRCm39) missense probably benign 0.01
IGL02716:Mtus2 APN 5 148,173,120 (GRCm39) missense probably benign 0.05
IGL03194:Mtus2 APN 5 148,043,913 (GRCm39) missense probably damaging 1.00
rumblado UTSW 5 148,243,518 (GRCm39) nonsense probably null
IGL02991:Mtus2 UTSW 5 148,250,310 (GRCm39) missense probably damaging 1.00
PIT4431001:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0310:Mtus2 UTSW 5 148,043,829 (GRCm39) missense probably benign 0.17
R0729:Mtus2 UTSW 5 148,014,097 (GRCm39) missense probably benign 0.08
R0968:Mtus2 UTSW 5 148,014,994 (GRCm39) missense probably benign 0.09
R1231:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1253:Mtus2 UTSW 5 148,240,380 (GRCm39) nonsense probably null
R1556:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1561:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1574:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1750:Mtus2 UTSW 5 148,214,443 (GRCm39) missense probably damaging 0.97
R2318:Mtus2 UTSW 5 148,043,892 (GRCm39) nonsense probably null
R2327:Mtus2 UTSW 5 148,014,725 (GRCm39) missense probably benign 0.00
R3153:Mtus2 UTSW 5 148,019,870 (GRCm39) missense probably damaging 1.00
R3154:Mtus2 UTSW 5 148,240,083 (GRCm39) intron probably benign
R3158:Mtus2 UTSW 5 148,168,637 (GRCm39) missense probably damaging 1.00
R3548:Mtus2 UTSW 5 148,232,316 (GRCm39) missense probably damaging 1.00
R3861:Mtus2 UTSW 5 148,250,223 (GRCm39) missense probably damaging 1.00
R4395:Mtus2 UTSW 5 148,013,432 (GRCm39) missense probably benign 0.17
R4396:Mtus2 UTSW 5 148,140,748 (GRCm39) missense possibly damaging 0.81
R4667:Mtus2 UTSW 5 148,235,070 (GRCm39) missense possibly damaging 0.64
R4887:Mtus2 UTSW 5 148,013,913 (GRCm39) nonsense probably null
R4931:Mtus2 UTSW 5 148,014,226 (GRCm39) missense probably benign 0.09
R5097:Mtus2 UTSW 5 148,232,392 (GRCm39) missense probably damaging 0.99
R5318:Mtus2 UTSW 5 148,013,382 (GRCm39) missense probably benign 0.05
R5372:Mtus2 UTSW 5 148,250,222 (GRCm39) missense probably damaging 1.00
R5388:Mtus2 UTSW 5 148,243,518 (GRCm39) nonsense probably null
R5622:Mtus2 UTSW 5 148,015,244 (GRCm39) missense probably benign 0.09
R6009:Mtus2 UTSW 5 148,243,462 (GRCm39) missense probably damaging 1.00
R6379:Mtus2 UTSW 5 148,014,008 (GRCm39) missense probably benign 0.00
R6409:Mtus2 UTSW 5 148,014,425 (GRCm39) missense probably benign
R6527:Mtus2 UTSW 5 148,214,408 (GRCm39) critical splice acceptor site probably null
R6853:Mtus2 UTSW 5 148,043,821 (GRCm39) missense probably damaging 1.00
R7001:Mtus2 UTSW 5 148,214,438 (GRCm39) missense probably damaging 1.00
R7187:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R7276:Mtus2 UTSW 5 148,013,368 (GRCm39) missense probably benign
R7594:Mtus2 UTSW 5 148,014,216 (GRCm39) missense probably benign 0.44
R7790:Mtus2 UTSW 5 148,014,998 (GRCm39) missense probably benign 0.09
R7967:Mtus2 UTSW 5 148,014,656 (GRCm39) missense probably benign 0.32
R7987:Mtus2 UTSW 5 148,168,836 (GRCm39) splice site probably null
R8112:Mtus2 UTSW 5 148,013,713 (GRCm39) nonsense probably null
R8273:Mtus2 UTSW 5 148,043,815 (GRCm39) missense probably damaging 1.00
R8527:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8542:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8783:Mtus2 UTSW 5 148,019,861 (GRCm39) missense probably damaging 1.00
R8805:Mtus2 UTSW 5 148,015,303 (GRCm39) missense possibly damaging 0.58
R9204:Mtus2 UTSW 5 148,238,293 (GRCm39) missense probably damaging 1.00
R9210:Mtus2 UTSW 5 148,014,124 (GRCm39) missense probably benign 0.00
R9261:Mtus2 UTSW 5 148,243,453 (GRCm39) nonsense probably null
R9419:Mtus2 UTSW 5 148,243,451 (GRCm39) missense probably damaging 1.00
R9477:Mtus2 UTSW 5 148,014,740 (GRCm39) missense probably benign
R9483:Mtus2 UTSW 5 148,232,300 (GRCm39) missense possibly damaging 0.80
R9563:Mtus2 UTSW 5 148,250,217 (GRCm39) missense
R9643:Mtus2 UTSW 5 148,014,025 (GRCm39) missense probably benign 0.04
R9716:Mtus2 UTSW 5 148,013,464 (GRCm39) missense possibly damaging 0.82
R9745:Mtus2 UTSW 5 148,013,311 (GRCm39) missense possibly damaging 0.81
X0017:Mtus2 UTSW 5 148,214,410 (GRCm39) missense possibly damaging 0.83
X0028:Mtus2 UTSW 5 148,014,128 (GRCm39) missense probably benign 0.03
Z1088:Mtus2 UTSW 5 148,240,073 (GRCm39) intron probably benign
Z1176:Mtus2 UTSW 5 148,014,068 (GRCm39) missense probably benign 0.05
Z1176:Mtus2 UTSW 5 148,013,552 (GRCm39) missense probably benign 0.31
Z1177:Mtus2 UTSW 5 148,140,887 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTTACCACAGGCAGGGACGAAAG -3'
(R):5'- TCAGAACCGTAGAAACTGGCAGC -3'

Posted On 2013-05-09