Mutagenetix > Incidental Mutation

Incidental Mutation 'R4491:Or7a37'

330740

Institutional Source

Beutler Lab

Gene Symbol

Or7a37

Ensembl Gene

ENSMUSG00000042774

Gene Name

olfactory receptor family 7 subfamily A member 37

Synonyms

GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2

MMRRC Submission

041747-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R4491 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

78799143-78806446 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 78806151 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 223 (S223P)

Ref Sequence

ENSEMBL: ENSMUSP00000145073 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]

AlphaFold

Q8VGU8

Predicted Effect

probably damaging
Transcript: ENSMUST00000039718
AA Change: S223P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: S223P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.9e-6	PFAM
Pfam:7tm_1	41	290	9.3e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000204849
AA Change: S223P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: S223P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.9e-6	PFAM
Pfam:7tm_1	41	290	9.3e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000205193
AA Change: S223P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: S223P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	95	5.8e-10	PFAM
Pfam:7tm_1	41	94	3.5e-8	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219714

Meta Mutation Damage Score

0.4215

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.8%

Validation Efficiency

98% (64/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	C	A	5: 64,055,812 (GRCm39)	P183T	probably damaging	Het
Bcan	G	A	3: 87,897,540 (GRCm39)	R682*	probably null	Het
Bzw1	T	A	1: 58,443,418 (GRCm39)	L410Q	probably damaging	Het
Cdh5	A	T	8: 104,839,672 (GRCm39)	I48F	probably damaging	Het
Cdhr5	T	C	7: 140,853,970 (GRCm39)	N173D	possibly damaging	Het
Cfap74	T	C	4: 155,513,628 (GRCm39)	M480T	probably benign	Het
Col6a5	C	T	9: 105,817,211 (GRCm39)	A367T	unknown	Het
Cpsf1	A	C	15: 76,481,922 (GRCm39)	Y1064D	possibly damaging	Het
Defb6	A	T	8: 19,278,090 (GRCm39)	H54L	probably benign	Het
Dmtf1	A	G	5: 9,190,379 (GRCm39)		probably benign	Het
Dnah12	T	C	14: 26,455,758 (GRCm39)	L827S	possibly damaging	Het
Dnai4	T	C	4: 102,923,596 (GRCm39)	E411G	probably benign	Het
Dsc3	T	C	18: 20,134,922 (GRCm39)	T21A	probably benign	Het
Epb41l1	G	T	2: 156,364,088 (GRCm39)	D866Y	probably benign	Het
Epha1	T	C	6: 42,337,600 (GRCm39)	M860V	probably damaging	Het
Far2	T	C	6: 148,074,907 (GRCm39)	L380P	possibly damaging	Het
Fgd5	A	G	6: 91,966,280 (GRCm39)	I680V	possibly damaging	Het
Fnbp4	T	C	2: 90,583,312 (GRCm39)		probably null	Het
Focad	G	A	4: 88,278,142 (GRCm39)		probably null	Het
Gm14180	T	A	11: 99,621,139 (GRCm39)		probably benign	Het
Hbb-bh2	T	C	7: 103,489,622 (GRCm39)	T5A	probably benign	Het
Ighv7-2	A	G	12: 113,876,100 (GRCm39)	F2L	probably benign	Het
Igsf5	A	G	16: 96,165,281 (GRCm39)	T19A	probably benign	Het
Kcnd3	C	T	3: 105,566,082 (GRCm39)	A421V	probably damaging	Het
Klb	A	G	5: 65,533,137 (GRCm39)	N482S	probably benign	Het
Lipo2	A	C	19: 33,699,100 (GRCm39)	L310R	probably damaging	Het
Mc3r	A	G	2: 172,091,123 (GRCm39)	H115R	possibly damaging	Het
Meioc	A	G	11: 102,565,746 (GRCm39)	D398G	possibly damaging	Het
Or10ag60	G	A	2: 87,437,736 (GRCm39)	M1I	probably null	Het
Or56a5	A	T	7: 104,792,983 (GRCm39)	C172*	probably null	Het
Pds5a	T	C	5: 65,792,780 (GRCm39)	T718A	probably benign	Het
Pdzd2	C	T	15: 12,385,723 (GRCm39)	D1016N	possibly damaging	Het
Pla2g2c	T	C	4: 138,461,719 (GRCm39)		probably null	Het
Plch1	T	C	3: 63,648,160 (GRCm39)	I404V	probably damaging	Het
Pou2af3	A	G	9: 51,181,955 (GRCm39)	F206L	probably benign	Het
Ppp2r5c	A	T	12: 110,546,956 (GRCm39)	D522V	possibly damaging	Het
Prex2	T	A	1: 11,232,487 (GRCm39)	S851R	probably benign	Het
Rapgef1	C	T	2: 29,609,668 (GRCm39)	P702S	possibly damaging	Het
Rasal3	T	A	17: 32,610,359 (GRCm39)	D976V	probably damaging	Het
Rasef	A	C	4: 73,652,740 (GRCm39)	L587R	probably damaging	Het
Rptn	A	T	3: 93,303,818 (GRCm39)	R384*	probably null	Het
Sema6a	G	A	18: 47,439,524 (GRCm39)		probably benign	Het
Sycp2	G	T	2: 178,016,778 (GRCm39)	T608K	probably damaging	Het
Syde1	C	T	10: 78,426,062 (GRCm39)	R35H	probably benign	Het
Taf1	G	T	X: 100,586,665 (GRCm39)	M313I	possibly damaging	Het
Taf15	A	T	11: 83,375,520 (GRCm39)	T31S	probably benign	Het
Tktl2	T	C	8: 66,964,664 (GRCm39)	V74A	probably damaging	Het
Tle4	A	G	19: 14,432,229 (GRCm39)	V489A	probably damaging	Het
Tmem30a	T	C	9: 79,684,567 (GRCm39)	H95R	probably damaging	Het
Trmt9b	G	A	8: 36,972,760 (GRCm39)	C70Y	probably damaging	Het
Vmn1r75	C	A	7: 11,614,909 (GRCm39)	Q214K	probably damaging	Het
Vps13c	C	T	9: 67,817,475 (GRCm39)	T1049M	probably benign	Het
Zfp37	T	C	4: 62,110,365 (GRCm39)	Q274R	probably benign	Het
Zfp648	T	G	1: 154,080,873 (GRCm39)	L344R	probably damaging	Het

Other mutations in Or7a37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02135:Or7a37	APN	10	78,805,940 (GRCm39)	missense	probably damaging	1.00
IGL02159:Or7a37	APN	10	78,805,735 (GRCm39)	missense	probably damaging	1.00
R0355:Or7a37	UTSW	10	78,806,267 (GRCm39)	missense	probably damaging	1.00
R0561:Or7a37	UTSW	10	78,805,729 (GRCm39)	nonsense	probably null
R1305:Or7a37	UTSW	10	78,805,933 (GRCm39)	missense	probably benign	0.03
R1921:Or7a37	UTSW	10	78,805,975 (GRCm39)	nonsense	probably null
R1922:Or7a37	UTSW	10	78,805,975 (GRCm39)	nonsense	probably null
R2382:Or7a37	UTSW	10	78,805,990 (GRCm39)	missense	probably damaging	0.99
R2920:Or7a37	UTSW	10	78,805,846 (GRCm39)	missense	probably damaging	1.00
R5113:Or7a37	UTSW	10	78,806,037 (GRCm39)	missense	probably benign
R5305:Or7a37	UTSW	10	78,806,390 (GRCm39)	missense	possibly damaging	0.68
R5744:Or7a37	UTSW	10	78,806,017 (GRCm39)	missense	probably damaging	1.00
R5861:Or7a37	UTSW	10	78,805,765 (GRCm39)	missense	probably damaging	1.00
R6197:Or7a37	UTSW	10	78,805,974 (GRCm39)	missense	probably damaging	1.00
R6314:Or7a37	UTSW	10	78,806,179 (GRCm39)	missense	probably benign
R7693:Or7a37	UTSW	10	78,806,137 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAGCTCTGTGGATTTCTGG -3'
(R):5'- AGTGTACGTGACTGAGGCTG -3'

Sequencing Primer
(F):5'- CAAAGCTTAATGATGTTGGAGCTGC -3'
(R):5'- CGTGACTGAGGCTGTTGCAC -3'

Posted On

2015-07-21