Incidental Mutation 'R4465:F11'
ID 330306
Institutional Source Beutler Lab
Gene Symbol F11
Ensembl Gene ENSMUSG00000031645
Gene Name coagulation factor XI
Synonyms plasma thromboplastin antecedent, 1600027G01Rik, Cf11, FXI
MMRRC Submission 041580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R4465 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 45694211-45715068 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 45694511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 617 (I617F)
Ref Sequence ENSEMBL: ENSMUSP00000034064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034064]
AlphaFold Q91Y47
Predicted Effect probably damaging
Transcript: ENSMUST00000034064
AA Change: I617F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034064
Gene: ENSMUSG00000031645
AA Change: I617F

DomainStartEndE-ValueType
APPLE 20 103 2.89e-29 SMART
APPLE 110 193 1.02e-29 SMART
APPLE 200 283 2.29e-32 SMART
APPLE 291 376 1.04e-30 SMART
Tryp_SPc 389 617 1.54e-98 SMART
Meta Mutation Damage Score 0.8094 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a knock-out allele show a tendency for slightly prolonged tail transection bleeding times and are protected from vessel-occluding fibrin formation after transient ischemic brain injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Acsbg2 A G 17: 57,168,580 (GRCm39) Y180H probably damaging Het
Adgrb3 G T 1: 25,133,447 (GRCm39) T1213K probably damaging Het
Atrn A G 2: 130,802,388 (GRCm39) T510A probably benign Het
Clasp1 C A 1: 118,488,808 (GRCm39) T857N probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Col12a1 C A 9: 79,580,192 (GRCm39) V1562F possibly damaging Het
Cyp4f40 T A 17: 32,890,186 (GRCm39) D285E probably benign Het
Dis3 G A 14: 99,321,550 (GRCm39) S599L possibly damaging Het
Dnah11 T C 12: 117,951,186 (GRCm39) T3041A probably benign Het
Erbin T C 13: 103,981,393 (GRCm39) N511D probably benign Het
Gm11541 A T 11: 94,595,048 (GRCm39) C7S unknown Het
Klk12 A T 7: 43,422,807 (GRCm39) R245W probably damaging Het
Lao1 C A 4: 118,822,504 (GRCm39) S141R probably benign Het
Lrrk2 A G 15: 91,632,023 (GRCm39) K1316E probably damaging Het
Map3k6 A G 4: 132,973,644 (GRCm39) Y445C possibly damaging Het
Mup6 T C 4: 60,004,000 (GRCm39) I31T probably damaging Het
Ndnf T A 6: 65,681,180 (GRCm39) D486E probably benign Het
Or2a54 T C 6: 43,092,852 (GRCm39) Y59H probably damaging Het
Or8h7 A T 2: 86,721,494 (GRCm39) N8K probably benign Het
Or8k37 A T 2: 86,469,478 (GRCm39) N191K probably benign Het
Rab19 T C 6: 39,365,060 (GRCm39) S107P probably damaging Het
Slc22a29 A T 19: 8,140,088 (GRCm39) L439* probably null Het
Slc5a1 A G 5: 33,303,860 (GRCm39) E225G possibly damaging Het
Slx4 A G 16: 3,806,919 (GRCm39) V508A possibly damaging Het
Snx25 A G 8: 46,521,266 (GRCm39) S373P possibly damaging Het
Stag2 A G X: 41,322,749 (GRCm39) S400G probably benign Homo
Tas2r107 A G 6: 131,636,972 (GRCm39) Y26H probably benign Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Zdhhc22 G A 12: 87,034,997 (GRCm39) L152F probably benign Het
Zfpm2 T G 15: 40,959,557 (GRCm39) M80R probably benign Het
Other mutations in F11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:F11 APN 8 45,703,132 (GRCm39) missense probably damaging 1.00
IGL02096:F11 APN 8 45,699,791 (GRCm39) missense probably benign 0.05
IGL02363:F11 APN 8 45,694,568 (GRCm39) missense probably damaging 1.00
IGL02694:F11 APN 8 45,705,196 (GRCm39) missense probably damaging 1.00
IGL03374:F11 APN 8 45,714,111 (GRCm39) missense possibly damaging 0.63
R0225:F11 UTSW 8 45,702,114 (GRCm39) missense probably benign 0.00
R0525:F11 UTSW 8 45,706,086 (GRCm39) missense probably benign 0.01
R0842:F11 UTSW 8 45,705,196 (GRCm39) missense probably damaging 1.00
R0961:F11 UTSW 8 45,694,531 (GRCm39) missense probably damaging 1.00
R1605:F11 UTSW 8 45,694,617 (GRCm39) missense probably damaging 1.00
R2044:F11 UTSW 8 45,705,155 (GRCm39) missense probably benign 0.03
R2113:F11 UTSW 8 45,699,869 (GRCm39) missense probably benign 0.00
R2273:F11 UTSW 8 45,705,184 (GRCm39) missense possibly damaging 0.94
R2274:F11 UTSW 8 45,705,184 (GRCm39) missense possibly damaging 0.94
R2275:F11 UTSW 8 45,705,184 (GRCm39) missense possibly damaging 0.94
R2318:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2319:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2403:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2510:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2512:F11 UTSW 8 45,714,098 (GRCm39) missense probably benign 0.01
R2893:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2894:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R2910:F11 UTSW 8 45,694,486 (GRCm39) makesense probably null
R3030:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R3105:F11 UTSW 8 45,698,754 (GRCm39) missense probably damaging 0.97
R3721:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R3726:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R3906:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R3909:F11 UTSW 8 45,701,675 (GRCm39) missense probably damaging 1.00
R4467:F11 UTSW 8 45,694,511 (GRCm39) missense probably damaging 1.00
R4710:F11 UTSW 8 45,703,183 (GRCm39) missense probably damaging 1.00
R4824:F11 UTSW 8 45,708,379 (GRCm39) missense probably damaging 0.99
R4968:F11 UTSW 8 45,698,770 (GRCm39) missense probably benign 0.19
R5225:F11 UTSW 8 45,708,341 (GRCm39) missense probably benign 0.09
R5288:F11 UTSW 8 45,699,833 (GRCm39) missense probably damaging 1.00
R5378:F11 UTSW 8 45,705,180 (GRCm39) missense probably benign 0.19
R6155:F11 UTSW 8 45,705,119 (GRCm39) missense probably damaging 1.00
R6213:F11 UTSW 8 45,694,537 (GRCm39) missense probably damaging 1.00
R6615:F11 UTSW 8 45,701,811 (GRCm39) missense probably benign
R6797:F11 UTSW 8 45,706,092 (GRCm39) missense probably benign 0.02
R7147:F11 UTSW 8 45,703,183 (GRCm39) missense probably damaging 1.00
R7683:F11 UTSW 8 45,702,545 (GRCm39) missense probably damaging 0.97
R7688:F11 UTSW 8 45,703,127 (GRCm39) missense probably damaging 1.00
R7720:F11 UTSW 8 45,705,127 (GRCm39) missense possibly damaging 0.89
R8064:F11 UTSW 8 45,698,810 (GRCm39) missense probably benign 0.01
R8273:F11 UTSW 8 45,701,644 (GRCm39) missense possibly damaging 0.70
R8848:F11 UTSW 8 45,695,281 (GRCm39) nonsense probably null
R8901:F11 UTSW 8 45,701,851 (GRCm39) missense probably benign 0.01
R9141:F11 UTSW 8 45,703,092 (GRCm39) critical splice donor site probably null
R9188:F11 UTSW 8 45,698,736 (GRCm39) missense probably benign 0.00
R9658:F11 UTSW 8 45,698,671 (GRCm39) missense probably damaging 1.00
R9664:F11 UTSW 8 45,694,566 (GRCm39) nonsense probably null
U24488:F11 UTSW 8 45,695,349 (GRCm39) missense probably benign 0.04
Z1088:F11 UTSW 8 45,698,809 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- AGTGGTTCTCCCAGATCAGG -3'
(R):5'- GAAATGCCTACCATGATCCCG -3'

Sequencing Primer
(F):5'- AGTGGTTCTCCCAGATCAGGAATTC -3'
(R):5'- TACCATGATCCCGGCATGTG -3'
Posted On 2015-07-21