Mutagenetix > Incidental Mutation

Incidental Mutation 'R4464:Gm7535'

330287

Institutional Source

Beutler Lab

Gene Symbol

Gm7535

Ensembl Gene

ENSMUSG00000090957

Gene Name

predicted gene 7535

Synonyms

MMRRC Submission

041722-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R4464 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18131304-18132987 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

C to A at 18131924 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093316 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000164167]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000054871

SMART Domains

Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	302	2.2e-43	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164167

SMART Domains

Protein: ENSMUSP00000125897
Gene: ENSMUSG00000090957

Domain	Start	End	E-Value	Type
Pfam:CNDH2_C	15	292	6.7e-90	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231820

Meta Mutation Damage Score

0.2981

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.8%

Validation Efficiency

97% (35/36)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	G	T	5: 64,056,182 (GRCm39)		probably benign	Het
Abcc3	A	G	11: 94,249,612 (GRCm39)	V1111A	probably benign	Het
Acot10	G	A	15: 20,665,830 (GRCm39)	R304*	probably null	Het
Aldh8a1	C	A	10: 21,264,840 (GRCm39)		probably benign	Het
Alms1	A	G	6: 85,597,003 (GRCm39)	T1079A	possibly damaging	Het
Armc3	T	C	2: 19,253,470 (GRCm39)	Y204H	probably damaging	Het
Asnsd1	C	A	1: 53,391,686 (GRCm39)		probably null	Het
Atad5	T	A	11: 79,991,137 (GRCm39)		probably null	Het
Cst12	G	A	2: 148,631,437 (GRCm39)	V53I	possibly damaging	Het
Cylc2	C	G	4: 51,229,651 (GRCm39)	T331R	unknown	Het
Dennd1a	A	T	2: 38,133,402 (GRCm39)		probably benign	Het
Gpr158	T	A	2: 21,831,810 (GRCm39)	M970K	probably damaging	Het
Ifngr1	G	A	10: 19,473,265 (GRCm39)	V72I	possibly damaging	Het
Kifap3	C	A	1: 163,645,464 (GRCm39)	Q269K	probably benign	Het
Krt86	G	A	15: 101,371,795 (GRCm39)	D122N	probably damaging	Het
Lrrcc1	A	G	3: 14,622,378 (GRCm39)	K694E	probably damaging	Het
Mbd4	A	G	6: 115,826,463 (GRCm39)	L155S	probably damaging	Het
Nalcn	T	C	14: 123,560,762 (GRCm39)	N772D	probably benign	Het
Or12d17	C	T	17: 37,777,742 (GRCm39)	S215F	probably damaging	Het
Prxl2a	T	A	14: 40,719,832 (GRCm39)	K127N	probably damaging	Het
Psg29	A	T	7: 16,944,575 (GRCm39)	N362Y	possibly damaging	Het
Ptpn23	G	A	9: 110,215,881 (GRCm39)	T1325I	probably damaging	Het
Rad51ap1	T	C	6: 126,911,731 (GRCm39)	N52S	possibly damaging	Het
Rb1	C	A	14: 73,436,638 (GRCm39)		probably null	Het
Slc34a2	T	C	5: 53,226,524 (GRCm39)	L490P	probably damaging	Het
Sost	G	A	11: 101,857,670 (GRCm39)	P44S	probably damaging	Het
St3gal2	A	G	8: 111,694,134 (GRCm39)	N207D	probably benign	Het
Stat1	T	G	1: 52,176,575 (GRCm39)	D257E	possibly damaging	Het
Tkt	A	G	14: 30,290,231 (GRCm39)	T165A	possibly damaging	Het
Trim66	A	T	7: 109,076,897 (GRCm39)	S347R	possibly damaging	Het
Zfp429	T	C	13: 67,538,617 (GRCm39)	I276V	probably benign	Het

Other mutations in Gm7535

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00422:Gm7535	APN	17	18,132,150 (GRCm39)	intron	probably benign
IGL01663:Gm7535	APN	17	18,131,619 (GRCm39)	intron	probably benign
R0165:Gm7535	UTSW	17	18,131,437 (GRCm39)	intron	probably benign
R0335:Gm7535	UTSW	17	18,131,374 (GRCm39)	intron	probably benign
R1985:Gm7535	UTSW	17	18,131,800 (GRCm39)	intron	probably benign
R2217:Gm7535	UTSW	17	18,131,936 (GRCm39)	intron	probably benign
R2218:Gm7535	UTSW	17	18,131,936 (GRCm39)	intron	probably benign
R4581:Gm7535	UTSW	17	18,131,345 (GRCm39)	intron	probably benign
R4887:Gm7535	UTSW	17	18,131,333 (GRCm39)	intron	probably benign
R5225:Gm7535	UTSW	17	18,131,809 (GRCm39)	intron	probably benign
R5305:Gm7535	UTSW	17	18,132,061 (GRCm39)	intron	probably benign
R5641:Gm7535	UTSW	17	18,131,788 (GRCm39)	intron	probably benign
R5658:Gm7535	UTSW	17	18,131,582 (GRCm39)	intron	probably benign
R5760:Gm7535	UTSW	17	18,132,080 (GRCm39)	intron	probably benign

Predicted Primers

PCR Primer
(F):5'- TCGAACCAGCTCCTTGTATC -3'
(R):5'- CTATTCTGTGCCACCTGGTG -3'

Sequencing Primer
(F):5'- TCTGCATCAAGGTCAGCAG -3'
(R):5'- ACCTGGTGTGGAGGAGGC -3'

Posted On

2015-07-21