Incidental Mutation 'R0047:Cacna1d'
| ID |
32995 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cacna1d
|
| Ensembl Gene |
ENSMUSG00000015968 |
| Gene Name |
calcium channel, voltage-dependent, L type, alpha 1D subunit |
| Synonyms |
Cacnl1a2, Cchl1a2, C79217, Cchl1a, Cav1.3alpha1, 8430418G19Rik, D-LTCC |
| MMRRC Submission |
038341-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.900)
|
| Stock # |
R0047 (G1)
|
| Quality Score |
177 |
|
Status
|
Validated
(trace)
|
| Chromosome |
14 |
| Chromosomal Location |
29761898-30213113 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to G
at 30068747 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153293
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112249]
[ENSMUST00000112250]
[ENSMUST00000223803]
[ENSMUST00000224198]
[ENSMUST00000224395]
[ENSMUST00000224785]
|
| AlphaFold |
Q99246 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112249
|
| SMART Domains |
Protein: ENSMUSP00000107868
Gene: ENSMUSG00000015968
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
10 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
67 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
163 |
405 |
4.8e-59 |
PFAM |
|
PDB:4DEY|B
|
406 |
502 |
3e-38 |
PDB |
|
low complexity region
|
503 |
517 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
557 |
751 |
5.5e-46 |
PFAM |
|
low complexity region
|
766 |
781 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
840 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
921 |
1151 |
7.2e-51 |
PFAM |
|
Pfam:Ion_trans
|
1239 |
1448 |
3.6e-67 |
PFAM |
|
Pfam:PKD_channel
|
1285 |
1455 |
1.9e-9 |
PFAM |
|
Blast:EFh
|
1469 |
1497 |
2e-9 |
BLAST |
|
Ca_chan_IQ
|
1583 |
1617 |
5.05e-16 |
SMART |
|
low complexity region
|
1649 |
1661 |
N/A |
INTRINSIC |
|
low complexity region
|
1722 |
1728 |
N/A |
INTRINSIC |
|
low complexity region
|
1830 |
1840 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1905 |
N/A |
INTRINSIC |
|
low complexity region
|
1921 |
1936 |
N/A |
INTRINSIC |
|
low complexity region
|
2122 |
2133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112250
|
| SMART Domains |
Protein: ENSMUSP00000107869
Gene: ENSMUSG00000015968
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
76 |
89 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
147 |
439 |
5.6e-72 |
PFAM |
|
low complexity region
|
473 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
539 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
544 |
784 |
2e-56 |
PFAM |
|
low complexity region
|
788 |
803 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
862 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1185 |
2.6e-63 |
PFAM |
|
Pfam:Ion_trans
|
1226 |
1482 |
1.7e-70 |
PFAM |
|
Pfam:PKD_channel
|
1306 |
1477 |
1.2e-9 |
PFAM |
|
Pfam:GPHH
|
1484 |
1553 |
2.3e-38 |
PFAM |
|
Ca_chan_IQ
|
1605 |
1639 |
5.05e-16 |
SMART |
|
Pfam:CAC1F_C
|
1649 |
2165 |
1.1e-68 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223803
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223985
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224198
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224395
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224785
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.8%
|
| Validation Efficiency |
100% (98/98) |
| MGI Phenotype |
FUNCTION: This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for targeted mutations exhibit small size, hypoinsulinemia, glucose intolerance, decreased number and size of pancreatic islets, deafness with degeneration of hair cells, bradycardia, and arrhythmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,772,025 (GRCm39) |
T405A |
probably damaging |
Het |
| Acer1 |
A |
T |
17: 57,262,624 (GRCm39) |
D175E |
possibly damaging |
Het |
| Acsf2 |
T |
C |
11: 94,460,168 (GRCm39) |
I395V |
probably benign |
Het |
| Adamts9 |
G |
A |
6: 92,882,287 (GRCm39) |
|
probably benign |
Het |
| Amigo3 |
T |
C |
9: 107,931,857 (GRCm39) |
S427P |
probably benign |
Het |
| Ankrd35 |
A |
G |
3: 96,591,379 (GRCm39) |
K555R |
probably benign |
Het |
| Arhgap35 |
A |
T |
7: 16,295,917 (GRCm39) |
H1049Q |
probably benign |
Het |
| Arhgef5 |
G |
A |
6: 43,242,555 (GRCm39) |
|
probably null |
Het |
| Arid4a |
T |
G |
12: 71,122,193 (GRCm39) |
L858W |
probably damaging |
Het |
| Bbox1 |
A |
G |
2: 110,098,647 (GRCm39) |
F310S |
probably damaging |
Het |
| Bhlhe22 |
T |
C |
3: 18,109,733 (GRCm39) |
L261P |
probably damaging |
Het |
| Bltp1 |
T |
A |
3: 36,962,341 (GRCm39) |
L481M |
possibly damaging |
Het |
| Bmper |
T |
A |
9: 23,317,982 (GRCm39) |
C534S |
probably damaging |
Het |
| Camk2g |
G |
A |
14: 20,821,136 (GRCm39) |
|
probably benign |
Het |
| Capn12 |
G |
A |
7: 28,589,812 (GRCm39) |
|
probably null |
Het |
| Cdkl4 |
T |
G |
17: 80,858,274 (GRCm39) |
N115T |
probably benign |
Het |
| Chchd1 |
T |
C |
14: 20,754,231 (GRCm39) |
S48P |
possibly damaging |
Het |
| Chia1 |
G |
T |
3: 106,022,573 (GRCm39) |
C49F |
probably damaging |
Het |
| Cnot7 |
A |
G |
8: 40,948,962 (GRCm39) |
|
probably benign |
Het |
| Crh |
T |
C |
3: 19,748,201 (GRCm39) |
E147G |
probably damaging |
Het |
| Cux1 |
T |
C |
5: 136,392,107 (GRCm39) |
|
probably benign |
Het |
| Cyp2b19 |
T |
A |
7: 26,466,251 (GRCm39) |
D351E |
probably benign |
Het |
| Dctn1 |
G |
T |
6: 83,159,614 (GRCm39) |
G31* |
probably null |
Het |
| Duox1 |
T |
A |
2: 122,177,122 (GRCm39) |
|
probably benign |
Het |
| Egflam |
T |
G |
15: 7,282,911 (GRCm39) |
E382A |
possibly damaging |
Het |
| Ext1 |
T |
C |
15: 53,208,542 (GRCm39) |
N73S |
probably benign |
Het |
| Ffar4 |
A |
G |
19: 38,102,452 (GRCm39) |
|
probably benign |
Het |
| Glg1 |
A |
T |
8: 111,892,214 (GRCm39) |
M866K |
probably damaging |
Het |
| Golm1 |
T |
A |
13: 59,792,914 (GRCm39) |
H197L |
probably benign |
Het |
| Gtse1 |
A |
G |
15: 85,746,579 (GRCm39) |
K132E |
probably damaging |
Het |
| Gxylt2 |
A |
T |
6: 100,710,339 (GRCm39) |
|
probably benign |
Het |
| Hrc |
T |
A |
7: 44,986,113 (GRCm39) |
S421R |
probably benign |
Het |
| Ighg2c |
T |
A |
12: 113,251,788 (GRCm39) |
|
probably benign |
Het |
| Ihh |
A |
G |
1: 74,985,750 (GRCm39) |
I245T |
probably benign |
Het |
| Ilf3 |
T |
A |
9: 21,300,010 (GRCm39) |
M65K |
possibly damaging |
Het |
| Insr |
A |
G |
8: 3,252,947 (GRCm39) |
V404A |
probably damaging |
Het |
| Irak2 |
G |
T |
6: 113,649,914 (GRCm39) |
|
probably benign |
Het |
| Irak2 |
G |
A |
6: 113,655,699 (GRCm39) |
V367I |
probably benign |
Het |
| Kat7 |
A |
C |
11: 95,191,034 (GRCm39) |
N119K |
probably benign |
Het |
| Kif9 |
A |
G |
9: 110,314,106 (GRCm39) |
I33V |
probably benign |
Het |
| Klf17 |
A |
G |
4: 117,618,229 (GRCm39) |
Y43H |
probably benign |
Het |
| Kng2 |
T |
A |
16: 22,806,313 (GRCm39) |
T629S |
possibly damaging |
Het |
| Lama1 |
A |
T |
17: 68,102,181 (GRCm39) |
|
probably benign |
Het |
| Lamb1 |
T |
C |
12: 31,328,600 (GRCm39) |
I188T |
possibly damaging |
Het |
| Lpp |
T |
A |
16: 24,480,550 (GRCm39) |
|
probably benign |
Het |
| Lrp12 |
T |
C |
15: 39,741,635 (GRCm39) |
E360G |
probably damaging |
Het |
| Mark2 |
A |
C |
19: 7,260,942 (GRCm39) |
|
probably benign |
Het |
| Mmp3 |
T |
C |
9: 7,451,910 (GRCm39) |
|
probably benign |
Het |
| Mthfd1l |
T |
A |
10: 3,928,727 (GRCm39) |
|
probably benign |
Het |
| Mtr |
A |
T |
13: 12,237,112 (GRCm39) |
S569T |
probably damaging |
Het |
| Myh13 |
T |
A |
11: 67,258,063 (GRCm39) |
S1752T |
probably benign |
Het |
| Myo5a |
T |
A |
9: 75,063,489 (GRCm39) |
L565H |
probably damaging |
Het |
| Nanos3 |
C |
T |
8: 84,902,763 (GRCm39) |
R133Q |
probably damaging |
Het |
| Nfkb1 |
A |
T |
3: 135,300,814 (GRCm39) |
L72* |
probably null |
Het |
| Numa1 |
A |
G |
7: 101,658,660 (GRCm39) |
K296E |
probably damaging |
Het |
| Obi1 |
T |
A |
14: 104,740,780 (GRCm39) |
|
probably null |
Het |
| Or51ab3 |
A |
T |
7: 103,201,529 (GRCm39) |
Y179F |
probably damaging |
Het |
| Or5ac19 |
C |
T |
16: 59,089,574 (GRCm39) |
G152D |
probably damaging |
Het |
| Or5b120 |
A |
G |
19: 13,479,953 (GRCm39) |
E82G |
probably benign |
Het |
| Or5h18 |
T |
A |
16: 58,847,587 (GRCm39) |
M228L |
probably benign |
Het |
| Or5p80 |
A |
G |
7: 108,229,759 (GRCm39) |
I187V |
probably benign |
Het |
| Pcdhb5 |
A |
T |
18: 37,454,321 (GRCm39) |
I234F |
possibly damaging |
Het |
| Pgm5 |
T |
A |
19: 24,661,920 (GRCm39) |
I545F |
probably damaging |
Het |
| Pla2g2c |
T |
C |
4: 138,470,901 (GRCm39) |
|
probably benign |
Het |
| Pnpla7 |
A |
T |
2: 24,901,618 (GRCm39) |
E548V |
probably damaging |
Het |
| Ppm1m |
C |
A |
9: 106,073,895 (GRCm39) |
E273* |
probably null |
Het |
| Ppp2r1b |
C |
T |
9: 50,772,873 (GRCm39) |
R117* |
probably null |
Het |
| Rabgap1l |
G |
A |
1: 160,059,359 (GRCm39) |
|
probably benign |
Het |
| Rapgef6 |
T |
A |
11: 54,437,204 (GRCm39) |
M49K |
possibly damaging |
Het |
| Rhox4f |
A |
C |
X: 36,789,122 (GRCm39) |
V15G |
probably benign |
Het |
| Rtel1 |
T |
G |
2: 180,965,198 (GRCm39) |
I146M |
probably damaging |
Het |
| Sdr9c7 |
A |
T |
10: 127,739,541 (GRCm39) |
M219L |
probably benign |
Het |
| Serpina3g |
T |
A |
12: 104,206,543 (GRCm39) |
S115T |
possibly damaging |
Het |
| Serpinb1a |
A |
T |
13: 33,034,259 (GRCm39) |
L44Q |
probably damaging |
Het |
| Slc13a4 |
A |
G |
6: 35,264,297 (GRCm39) |
I190T |
possibly damaging |
Het |
| Slc46a2 |
A |
G |
4: 59,914,392 (GRCm39) |
L177P |
probably damaging |
Het |
| Slc47a2 |
C |
T |
11: 61,227,068 (GRCm39) |
V167M |
possibly damaging |
Het |
| Snrnp200 |
C |
T |
2: 127,076,874 (GRCm39) |
|
probably benign |
Het |
| Snx13 |
C |
A |
12: 35,151,123 (GRCm39) |
|
probably benign |
Het |
| Snx25 |
C |
T |
8: 46,494,402 (GRCm39) |
A828T |
probably damaging |
Het |
| Spic |
A |
G |
10: 88,511,803 (GRCm39) |
L151P |
probably damaging |
Het |
| Ssu2 |
G |
A |
6: 112,351,781 (GRCm39) |
H315Y |
probably damaging |
Het |
| Stk32a |
T |
C |
18: 43,446,443 (GRCm39) |
|
probably benign |
Het |
| Tbx3 |
A |
T |
5: 119,818,511 (GRCm39) |
E382V |
probably damaging |
Het |
| Tcaf2 |
A |
G |
6: 42,606,547 (GRCm39) |
I469T |
probably benign |
Het |
| Tln2 |
A |
G |
9: 67,147,954 (GRCm39) |
|
probably benign |
Het |
| Top2a |
T |
A |
11: 98,888,682 (GRCm39) |
I1260L |
probably benign |
Het |
| Treml1 |
C |
A |
17: 48,672,008 (GRCm39) |
S91* |
probably null |
Het |
| Trim26 |
T |
C |
17: 37,168,756 (GRCm39) |
|
probably benign |
Het |
| Trmt11 |
T |
C |
10: 30,411,239 (GRCm39) |
N418S |
probably benign |
Het |
| Ttf1 |
A |
G |
2: 28,974,667 (GRCm39) |
Y801C |
probably damaging |
Het |
| Usp34 |
C |
T |
11: 23,414,403 (GRCm39) |
A2782V |
probably benign |
Het |
| Vmn2r77 |
T |
C |
7: 86,460,858 (GRCm39) |
V728A |
probably benign |
Het |
| Vps4a |
T |
C |
8: 107,763,333 (GRCm39) |
L29P |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,091,899 (GRCm39) |
I480T |
probably damaging |
Het |
| Wdr41 |
A |
G |
13: 95,146,795 (GRCm39) |
I197V |
probably damaging |
Het |
| Ywhag |
A |
T |
5: 135,940,153 (GRCm39) |
V147E |
probably damaging |
Het |
| Zan |
A |
G |
5: 137,401,918 (GRCm39) |
M4058T |
unknown |
Het |
| Zfp236 |
C |
T |
18: 82,698,817 (GRCm39) |
C88Y |
probably damaging |
Het |
|
| Other mutations in Cacna1d |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00494:Cacna1d
|
APN |
14 |
29,818,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00857:Cacna1d
|
APN |
14 |
30,072,638 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01015:Cacna1d
|
APN |
14 |
29,773,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01420:Cacna1d
|
APN |
14 |
29,773,595 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01470:Cacna1d
|
APN |
14 |
29,821,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01560:Cacna1d
|
APN |
14 |
29,821,163 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01617:Cacna1d
|
APN |
14 |
29,824,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01820:Cacna1d
|
APN |
14 |
29,764,823 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01948:Cacna1d
|
APN |
14 |
29,846,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02702:Cacna1d
|
APN |
14 |
29,845,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02864:Cacna1d
|
APN |
14 |
29,773,663 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03082:Cacna1d
|
APN |
14 |
29,821,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Brisk
|
UTSW |
14 |
29,893,271 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Troppo
|
UTSW |
14 |
29,845,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4651001:Cacna1d
|
UTSW |
14 |
29,900,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0015:Cacna1d
|
UTSW |
14 |
29,836,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0015:Cacna1d
|
UTSW |
14 |
29,836,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0033:Cacna1d
|
UTSW |
14 |
29,827,446 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0047:Cacna1d
|
UTSW |
14 |
30,068,747 (GRCm39) |
splice site |
probably benign |
|
|
R0051:Cacna1d
|
UTSW |
14 |
29,833,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0051:Cacna1d
|
UTSW |
14 |
29,833,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Cacna1d
|
UTSW |
14 |
29,796,967 (GRCm39) |
unclassified |
probably benign |
|
|
R0067:Cacna1d
|
UTSW |
14 |
29,796,967 (GRCm39) |
unclassified |
probably benign |
|
|
R0238:Cacna1d
|
UTSW |
14 |
29,845,453 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0238:Cacna1d
|
UTSW |
14 |
29,845,453 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0239:Cacna1d
|
UTSW |
14 |
29,845,453 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0239:Cacna1d
|
UTSW |
14 |
29,845,453 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0240:Cacna1d
|
UTSW |
14 |
29,818,926 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0240:Cacna1d
|
UTSW |
14 |
29,818,926 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Cacna1d
|
UTSW |
14 |
29,794,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Cacna1d
|
UTSW |
14 |
29,822,645 (GRCm39) |
splice site |
probably benign |
|
|
R0427:Cacna1d
|
UTSW |
14 |
30,068,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0517:Cacna1d
|
UTSW |
14 |
29,901,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Cacna1d
|
UTSW |
14 |
29,893,251 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0727:Cacna1d
|
UTSW |
14 |
29,852,072 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0732:Cacna1d
|
UTSW |
14 |
29,764,877 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0843:Cacna1d
|
UTSW |
14 |
29,846,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0900:Cacna1d
|
UTSW |
14 |
29,833,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1278:Cacna1d
|
UTSW |
14 |
29,900,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1340:Cacna1d
|
UTSW |
14 |
29,794,024 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1527:Cacna1d
|
UTSW |
14 |
29,829,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1711:Cacna1d
|
UTSW |
14 |
29,788,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1736:Cacna1d
|
UTSW |
14 |
29,811,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1763:Cacna1d
|
UTSW |
14 |
29,821,153 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2034:Cacna1d
|
UTSW |
14 |
29,811,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2086:Cacna1d
|
UTSW |
14 |
29,769,314 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2126:Cacna1d
|
UTSW |
14 |
29,845,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2218:Cacna1d
|
UTSW |
14 |
29,845,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Cacna1d
|
UTSW |
14 |
29,764,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Cacna1d
|
UTSW |
14 |
30,212,973 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2291:Cacna1d
|
UTSW |
14 |
29,764,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2399:Cacna1d
|
UTSW |
14 |
29,774,444 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2424:Cacna1d
|
UTSW |
14 |
29,770,980 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2568:Cacna1d
|
UTSW |
14 |
29,804,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4038:Cacna1d
|
UTSW |
14 |
29,788,040 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4509:Cacna1d
|
UTSW |
14 |
29,818,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Cacna1d
|
UTSW |
14 |
29,817,365 (GRCm39) |
missense |
probably benign |
|
|
R4650:Cacna1d
|
UTSW |
14 |
29,817,365 (GRCm39) |
missense |
probably benign |
|
|
R4652:Cacna1d
|
UTSW |
14 |
29,817,365 (GRCm39) |
missense |
probably benign |
|
|
R5009:Cacna1d
|
UTSW |
14 |
29,801,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5058:Cacna1d
|
UTSW |
14 |
29,836,201 (GRCm39) |
nonsense |
probably null |
|
|
R5063:Cacna1d
|
UTSW |
14 |
29,773,340 (GRCm39) |
missense |
probably benign |
|
|
R5138:Cacna1d
|
UTSW |
14 |
30,212,929 (GRCm39) |
missense |
probably benign |
|
|
R5151:Cacna1d
|
UTSW |
14 |
29,845,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Cacna1d
|
UTSW |
14 |
30,074,881 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5286:Cacna1d
|
UTSW |
14 |
30,072,682 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5313:Cacna1d
|
UTSW |
14 |
30,068,798 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5383:Cacna1d
|
UTSW |
14 |
29,767,236 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5387:Cacna1d
|
UTSW |
14 |
29,822,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Cacna1d
|
UTSW |
14 |
30,072,790 (GRCm39) |
nonsense |
probably null |
|
|
R5524:Cacna1d
|
UTSW |
14 |
29,764,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5663:Cacna1d
|
UTSW |
14 |
29,845,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Cacna1d
|
UTSW |
14 |
29,796,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5796:Cacna1d
|
UTSW |
14 |
29,788,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Cacna1d
|
UTSW |
14 |
29,818,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5923:Cacna1d
|
UTSW |
14 |
29,833,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Cacna1d
|
UTSW |
14 |
29,893,271 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5938:Cacna1d
|
UTSW |
14 |
29,825,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Cacna1d
|
UTSW |
14 |
29,764,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6432:Cacna1d
|
UTSW |
14 |
29,845,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6486:Cacna1d
|
UTSW |
14 |
29,836,190 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6600:Cacna1d
|
UTSW |
14 |
29,836,192 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6661:Cacna1d
|
UTSW |
14 |
29,811,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6753:Cacna1d
|
UTSW |
14 |
29,764,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Cacna1d
|
UTSW |
14 |
29,773,622 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6851:Cacna1d
|
UTSW |
14 |
29,764,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6863:Cacna1d
|
UTSW |
14 |
29,797,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6916:Cacna1d
|
UTSW |
14 |
29,817,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Cacna1d
|
UTSW |
14 |
29,773,594 (GRCm39) |
missense |
probably benign |
|
|
R7066:Cacna1d
|
UTSW |
14 |
30,074,935 (GRCm39) |
intron |
probably benign |
|
|
R7188:Cacna1d
|
UTSW |
14 |
29,811,790 (GRCm39) |
missense |
probably benign |
|
|
R7242:Cacna1d
|
UTSW |
14 |
29,900,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Cacna1d
|
UTSW |
14 |
29,864,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7250:Cacna1d
|
UTSW |
14 |
29,797,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7274:Cacna1d
|
UTSW |
14 |
29,864,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7336:Cacna1d
|
UTSW |
14 |
29,767,239 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7343:Cacna1d
|
UTSW |
14 |
29,845,014 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7411:Cacna1d
|
UTSW |
14 |
30,074,947 (GRCm39) |
start codon destroyed |
probably null |
|
|
R7461:Cacna1d
|
UTSW |
14 |
29,788,120 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7534:Cacna1d
|
UTSW |
14 |
29,801,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Cacna1d
|
UTSW |
14 |
29,788,120 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7661:Cacna1d
|
UTSW |
14 |
29,769,177 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7754:Cacna1d
|
UTSW |
14 |
29,797,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7759:Cacna1d
|
UTSW |
14 |
29,821,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7784:Cacna1d
|
UTSW |
14 |
29,845,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Cacna1d
|
UTSW |
14 |
29,833,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Cacna1d
|
UTSW |
14 |
29,769,270 (GRCm39) |
nonsense |
probably null |
|
|
R8225:Cacna1d
|
UTSW |
14 |
29,844,990 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8259:Cacna1d
|
UTSW |
14 |
29,773,475 (GRCm39) |
missense |
probably benign |
|
|
R8348:Cacna1d
|
UTSW |
14 |
29,824,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8448:Cacna1d
|
UTSW |
14 |
29,824,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Cacna1d
|
UTSW |
14 |
29,900,692 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8848:Cacna1d
|
UTSW |
14 |
29,845,283 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9122:Cacna1d
|
UTSW |
14 |
29,852,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9122:Cacna1d
|
UTSW |
14 |
29,845,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9169:Cacna1d
|
UTSW |
14 |
29,796,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9199:Cacna1d
|
UTSW |
14 |
29,764,893 (GRCm39) |
missense |
probably benign |
0.26 |
|
R9203:Cacna1d
|
UTSW |
14 |
29,773,669 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9263:Cacna1d
|
UTSW |
14 |
29,796,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9346:Cacna1d
|
UTSW |
14 |
29,818,880 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9444:Cacna1d
|
UTSW |
14 |
29,829,741 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9487:Cacna1d
|
UTSW |
14 |
29,845,419 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9542:Cacna1d
|
UTSW |
14 |
29,845,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9651:Cacna1d
|
UTSW |
14 |
29,764,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9785:Cacna1d
|
UTSW |
14 |
29,824,300 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Cacna1d
|
UTSW |
14 |
29,833,073 (GRCm39) |
missense |
probably benign |
0.15 |
|
Z1176:Cacna1d
|
UTSW |
14 |
29,901,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACGAGATGTAAACTCCACTTCC -3'
(R):5'- TGTGAGATGCCTGGGGCTATAAGAG -3'
Sequencing Primer
(F):5'- ccagaaagattaaccacagtatcc -3'
(R):5'- TGGGGCTATAAGAGGGATAGATAATG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation