Incidental Mutation 'R4430:Ugt2b37'
ID 328559
Institutional Source Beutler Lab
Gene Symbol Ugt2b37
Ensembl Gene ENSMUSG00000057425
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms 0610033E06Rik
MMRRC Submission 041700-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R4430 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 87388351-87402647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87401951 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 227 (M227V)
Ref Sequence ENSEMBL: ENSMUSP00000075255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075858]
AlphaFold Q8VCN3
Predicted Effect probably benign
Transcript: ENSMUST00000075858
AA Change: M227V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: M227V

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 5.5e-256 PFAM
Pfam:Glyco_tran_28_C 328 449 2.5e-9 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Aak1 A G 6: 86,963,348 (GRCm39) N926S unknown Het
Ahi1 T A 10: 20,847,977 (GRCm39) C462S probably damaging Het
Ahnak A G 19: 8,980,404 (GRCm39) I563V probably benign Het
Ankrd55 G A 13: 112,459,717 (GRCm39) probably null Het
Bag3 A G 7: 128,125,647 (GRCm39) D22G probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Col15a1 T C 4: 47,245,705 (GRCm39) F152S probably damaging Het
Cxcr2 T C 1: 74,198,004 (GRCm39) I166T probably benign Het
Dnah11 T C 12: 117,946,746 (GRCm39) I3113V probably benign Het
Gli2 T C 1: 118,764,974 (GRCm39) H1059R probably benign Het
Gm14412 C A 2: 177,007,625 (GRCm39) S90I probably benign Het
L1td1 A G 4: 98,625,388 (GRCm39) R528G probably benign Het
Mcm3 A T 1: 20,882,217 (GRCm39) L449* probably null Het
Mif4gd T C 11: 115,499,328 (GRCm39) T185A probably benign Het
Mphosph9 T C 5: 124,403,509 (GRCm39) S840G possibly damaging Het
Nherf4 C T 9: 44,161,041 (GRCm39) S175N probably benign Het
Nim1k C A 13: 120,174,078 (GRCm39) R272L possibly damaging Het
Or5b104 C T 19: 13,072,452 (GRCm39) V187I probably benign Het
Or6c213 T A 10: 129,574,130 (GRCm39) I219F probably damaging Het
Or8k32 A G 2: 86,368,731 (GRCm39) I176T probably damaging Het
Pax3 A G 1: 78,171,961 (GRCm39) V83A probably damaging Het
Pde3b C T 7: 114,133,905 (GRCm39) P974S probably damaging Het
Pglyrp3 T A 3: 91,938,798 (GRCm39) D324E probably damaging Het
Pus7 A G 5: 23,951,487 (GRCm39) Y521H probably benign Het
Ryr2 A G 13: 11,750,413 (GRCm39) S1953P probably damaging Het
Sost G A 11: 101,857,670 (GRCm39) P44S probably damaging Het
Sox5 A G 6: 143,987,000 (GRCm39) I188T possibly damaging Het
Spata4 T C 8: 55,054,878 (GRCm39) I86T probably benign Het
Ssc5d T C 7: 4,946,663 (GRCm39) S1006P probably benign Het
Stk10 T C 11: 32,483,552 (GRCm39) V50A possibly damaging Het
Sytl4 A G,T X: 132,849,972 (GRCm39) S338R probably damaging Homo
Sytl5 A T X: 9,826,262 (GRCm39) N412Y probably damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem201 A C 4: 149,815,596 (GRCm39) V118G probably benign Het
Tmem67 T A 4: 12,051,473 (GRCm39) N785I possibly damaging Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Vmn2r22 T C 6: 123,614,817 (GRCm39) T258A possibly damaging Het
Vmn2r73 A T 7: 85,519,449 (GRCm39) M503K probably benign Het
Zfp54 T G 17: 21,655,222 (GRCm39) V572G probably damaging Het
Other mutations in Ugt2b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Ugt2b37 APN 5 87,390,340 (GRCm39) missense possibly damaging 0.90
IGL00567:Ugt2b37 APN 5 87,401,933 (GRCm39) missense probably damaging 1.00
IGL00787:Ugt2b37 APN 5 87,390,288 (GRCm39) missense probably benign 0.00
IGL01560:Ugt2b37 APN 5 87,399,698 (GRCm39) missense probably damaging 1.00
IGL01617:Ugt2b37 APN 5 87,399,738 (GRCm39) missense probably damaging 1.00
IGL01982:Ugt2b37 APN 5 87,390,291 (GRCm39) missense probably damaging 1.00
IGL02299:Ugt2b37 APN 5 87,390,174 (GRCm39) missense probably benign 0.00
IGL02323:Ugt2b37 APN 5 87,398,423 (GRCm39) splice site probably benign
IGL02326:Ugt2b37 APN 5 87,388,861 (GRCm39) missense probably benign 0.25
IGL02516:Ugt2b37 APN 5 87,388,741 (GRCm39) missense probably damaging 1.00
IGL03285:Ugt2b37 APN 5 87,388,734 (GRCm39) missense probably damaging 1.00
R0076:Ugt2b37 UTSW 5 87,402,080 (GRCm39) missense probably benign 0.31
R0141:Ugt2b37 UTSW 5 87,388,842 (GRCm39) missense probably damaging 1.00
R0312:Ugt2b37 UTSW 5 87,398,524 (GRCm39) missense probably damaging 1.00
R0359:Ugt2b37 UTSW 5 87,398,443 (GRCm39) missense probably benign 0.10
R0523:Ugt2b37 UTSW 5 87,399,691 (GRCm39) missense possibly damaging 0.91
R1938:Ugt2b37 UTSW 5 87,388,716 (GRCm39) missense probably damaging 1.00
R1962:Ugt2b37 UTSW 5 87,402,193 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b37 UTSW 5 87,402,569 (GRCm39) missense probably damaging 0.97
R3704:Ugt2b37 UTSW 5 87,390,846 (GRCm39) missense possibly damaging 0.55
R4825:Ugt2b37 UTSW 5 87,398,498 (GRCm39) missense possibly damaging 0.91
R5043:Ugt2b37 UTSW 5 87,399,719 (GRCm39) nonsense probably null
R5098:Ugt2b37 UTSW 5 87,390,812 (GRCm39) missense probably damaging 1.00
R5174:Ugt2b37 UTSW 5 87,399,739 (GRCm39) missense probably benign 0.00
R5522:Ugt2b37 UTSW 5 87,388,759 (GRCm39) missense probably benign 0.14
R5879:Ugt2b37 UTSW 5 87,402,265 (GRCm39) missense probably benign
R5999:Ugt2b37 UTSW 5 87,402,036 (GRCm39) missense probably benign 0.25
R6374:Ugt2b37 UTSW 5 87,390,279 (GRCm39) missense probably damaging 1.00
R6454:Ugt2b37 UTSW 5 87,388,836 (GRCm39) missense probably damaging 1.00
R6857:Ugt2b37 UTSW 5 87,388,705 (GRCm39) missense probably damaging 0.98
R6875:Ugt2b37 UTSW 5 87,390,288 (GRCm39) missense probably benign 0.00
R6916:Ugt2b37 UTSW 5 87,402,459 (GRCm39) missense probably benign 0.07
R7099:Ugt2b37 UTSW 5 87,388,848 (GRCm39) missense probably benign 0.00
R7239:Ugt2b37 UTSW 5 87,402,590 (GRCm39) missense probably benign
R7470:Ugt2b37 UTSW 5 87,401,971 (GRCm39) missense probably benign 0.24
R7810:Ugt2b37 UTSW 5 87,402,118 (GRCm39) missense probably damaging 1.00
R7841:Ugt2b37 UTSW 5 87,398,489 (GRCm39) missense probably benign 0.05
R7860:Ugt2b37 UTSW 5 87,402,189 (GRCm39) missense probably damaging 1.00
R7861:Ugt2b37 UTSW 5 87,390,299 (GRCm39) nonsense probably null
R8200:Ugt2b37 UTSW 5 87,388,750 (GRCm39) nonsense probably null
R8211:Ugt2b37 UTSW 5 87,390,235 (GRCm39) missense probably benign 0.07
R8282:Ugt2b37 UTSW 5 87,402,440 (GRCm39) missense probably benign 0.01
R8312:Ugt2b37 UTSW 5 87,390,799 (GRCm39) missense probably benign 0.15
R8520:Ugt2b37 UTSW 5 87,388,714 (GRCm39) missense probably benign 0.04
R8688:Ugt2b37 UTSW 5 87,390,240 (GRCm39) missense possibly damaging 0.52
R8695:Ugt2b37 UTSW 5 87,390,243 (GRCm39) missense probably benign 0.00
R8772:Ugt2b37 UTSW 5 87,402,345 (GRCm39) missense probably benign 0.00
R8839:Ugt2b37 UTSW 5 87,402,415 (GRCm39) missense probably damaging 1.00
R9087:Ugt2b37 UTSW 5 87,401,996 (GRCm39) missense probably benign 0.01
R9139:Ugt2b37 UTSW 5 87,399,636 (GRCm39) missense probably benign 0.09
R9424:Ugt2b37 UTSW 5 87,402,217 (GRCm39) missense probably damaging 0.99
R9432:Ugt2b37 UTSW 5 87,402,046 (GRCm39) missense probably damaging 0.97
R9498:Ugt2b37 UTSW 5 87,402,244 (GRCm39) missense probably benign 0.07
R9711:Ugt2b37 UTSW 5 87,402,532 (GRCm39) missense possibly damaging 0.85
R9718:Ugt2b37 UTSW 5 87,390,802 (GRCm39) missense probably benign 0.11
R9783:Ugt2b37 UTSW 5 87,388,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGTACTGATACCGATACCTTCTC -3'
(R):5'- AGTCTTCGCTTCACTGCAG -3'

Sequencing Primer
(F):5'- TGATACCGATACCTTCTCCTATTTG -3'
(R):5'- CGCTTCACTGCAGGTTACAGAATTG -3'
Posted On 2015-07-21