Incidental Mutation 'R4429:Slco6d1'
ID 328303
Institutional Source Beutler Lab
Gene Symbol Slco6d1
Ensembl Gene ENSMUSG00000026336
Gene Name solute carrier organic anion transporter family, member 6d1
Synonyms 4921511I05Rik
MMRRC Submission 041699-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R4429 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 98348849-98444716 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98424091 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 581 (V581A)
Ref Sequence ENSEMBL: ENSMUSP00000123850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027575] [ENSMUST00000160796] [ENSMUST00000162468]
AlphaFold Q9D5W6
Predicted Effect possibly damaging
Transcript: ENSMUST00000027575
AA Change: V581A

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000027575
Gene: ENSMUSG00000026336
AA Change: V581A

DomainStartEndE-ValueType
Pfam:MFS_1 86 463 1.8e-13 PFAM
KAZAL 483 527 2.3e0 SMART
low complexity region 558 572 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000160796
AA Change: V581A

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000123850
Gene: ENSMUSG00000026336
AA Change: V581A

DomainStartEndE-ValueType
Pfam:MFS_1 86 463 2.4e-13 PFAM
KAZAL 483 527 2.3e0 SMART
low complexity region 558 572 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162468
SMART Domains Protein: ENSMUSP00000125258
Gene: ENSMUSG00000026336

DomainStartEndE-ValueType
Pfam:OATP 64 313 2.1e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162782
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Abca5 T C 11: 110,202,236 (GRCm39) T390A probably benign Het
Ahcyl2 T G 6: 29,894,874 (GRCm39) V452G probably damaging Het
Ano4 T A 10: 88,828,804 (GRCm39) N545I probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Catip T A 1: 74,407,891 (GRCm39) probably benign Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cnpy3 T A 17: 47,058,070 (GRCm39) Q111L probably benign Het
Dnah8 A G 17: 30,971,120 (GRCm39) N2725D probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Ephb3 G A 16: 21,033,213 (GRCm39) E66K probably damaging Het
Gm6594 T A 17: 82,846,923 (GRCm39) D79E probably benign Het
Gtf2e2 T A 8: 34,242,521 (GRCm39) Y74* probably null Het
Hacd4 A T 4: 88,353,184 (GRCm39) F103I possibly damaging Het
Hap1 T C 11: 100,245,098 (GRCm39) T38A probably benign Het
Havcr2 T A 11: 46,347,387 (GRCm39) D72E probably damaging Het
Iqcg G A 16: 32,839,860 (GRCm39) T362I probably benign Het
Lect2 C T 13: 56,693,538 (GRCm39) probably null Het
Lemd3 T C 10: 120,813,893 (GRCm39) T447A probably benign Het
Lrrc72 T C 12: 36,258,623 (GRCm39) N78S probably damaging Het
Map3k14 A G 11: 103,118,410 (GRCm39) L592P probably damaging Het
Meioc T C 11: 102,566,546 (GRCm39) Y721H probably damaging Het
Mrps10 T A 17: 47,689,124 (GRCm39) probably null Het
Myo5c A G 9: 75,201,283 (GRCm39) Y1406C probably damaging Het
Myo7a T C 7: 97,702,395 (GRCm39) Y2098C probably damaging Het
Nol9 C T 4: 152,125,631 (GRCm39) T194I probably damaging Het
Nox3 G A 17: 3,733,233 (GRCm39) T206I probably benign Het
Nsd2 T G 5: 34,000,546 (GRCm39) M21R probably damaging Het
Pcdh9 T C 14: 94,124,820 (GRCm39) N327S probably damaging Het
Pclo T G 5: 14,728,114 (GRCm39) probably benign Het
Pparg T A 6: 115,416,984 (GRCm39) M59K probably benign Het
Prag1 A G 8: 36,613,796 (GRCm39) K1116R probably damaging Het
Rhbdf1 C T 11: 32,163,369 (GRCm39) E368K probably benign Het
Rita1 A G 5: 120,747,626 (GRCm39) V224A probably damaging Het
Rsph6a T A 7: 18,807,988 (GRCm39) W384R probably damaging Het
Scn1a A T 2: 66,181,329 (GRCm39) Y65N possibly damaging Het
Serpina5 C A 12: 104,069,665 (GRCm39) F292L probably benign Het
Sf3b3 A C 8: 111,552,750 (GRCm39) L511V probably benign Het
Siglecg C T 7: 43,067,350 (GRCm39) P639L possibly damaging Het
Slc12a3 A T 8: 95,069,713 (GRCm39) I541F probably damaging Het
Sptbn2 T C 19: 4,788,383 (GRCm39) Y1121H probably damaging Het
Sytl5 A T X: 9,826,262 (GRCm39) N412Y probably damaging Het
Timm29 G C 9: 21,504,775 (GRCm39) A148P probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem67 T A 4: 12,051,473 (GRCm39) N785I possibly damaging Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Uba6 C T 5: 86,268,406 (GRCm39) V941I probably damaging Het
Vmn1r174 T C 7: 23,453,565 (GRCm39) V77A probably benign Het
Zfp661 A G 2: 127,420,628 (GRCm39) V57A probably damaging Het
Zfp867 C T 11: 59,355,863 (GRCm39) D64N possibly damaging Het
Zp3r T C 1: 130,519,128 (GRCm39) T294A possibly damaging Het
Other mutations in Slco6d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Slco6d1 APN 1 98,359,955 (GRCm39) splice site probably null
IGL00678:Slco6d1 APN 1 98,424,069 (GRCm39) missense probably benign 0.01
IGL00790:Slco6d1 APN 1 98,348,925 (GRCm39) utr 5 prime probably benign
IGL01694:Slco6d1 APN 1 98,427,570 (GRCm39) missense probably damaging 1.00
IGL02003:Slco6d1 APN 1 98,408,493 (GRCm39) missense probably damaging 1.00
IGL02059:Slco6d1 APN 1 98,374,531 (GRCm39) missense possibly damaging 0.95
IGL02085:Slco6d1 APN 1 98,371,468 (GRCm39) missense probably damaging 1.00
IGL02683:Slco6d1 APN 1 98,408,397 (GRCm39) missense probably benign 0.05
IGL02736:Slco6d1 APN 1 98,356,036 (GRCm39) missense possibly damaging 0.55
IGL03279:Slco6d1 APN 1 98,394,405 (GRCm39) missense probably damaging 1.00
BB008:Slco6d1 UTSW 1 98,356,141 (GRCm39) missense probably damaging 1.00
BB018:Slco6d1 UTSW 1 98,356,141 (GRCm39) missense probably damaging 1.00
PIT4581001:Slco6d1 UTSW 1 98,351,050 (GRCm39) missense possibly damaging 0.46
R0326:Slco6d1 UTSW 1 98,418,359 (GRCm39) missense probably benign 0.02
R0359:Slco6d1 UTSW 1 98,394,422 (GRCm39) missense probably benign 0.21
R0554:Slco6d1 UTSW 1 98,394,422 (GRCm39) missense probably benign 0.21
R0589:Slco6d1 UTSW 1 98,427,472 (GRCm39) splice site probably benign
R0733:Slco6d1 UTSW 1 98,355,994 (GRCm39) nonsense probably null
R0883:Slco6d1 UTSW 1 98,349,124 (GRCm39) missense probably benign 0.00
R1316:Slco6d1 UTSW 1 98,394,518 (GRCm39) missense probably benign 0.02
R1370:Slco6d1 UTSW 1 98,350,819 (GRCm39) missense probably benign 0.01
R1401:Slco6d1 UTSW 1 98,418,341 (GRCm39) missense probably damaging 1.00
R1691:Slco6d1 UTSW 1 98,435,292 (GRCm39) missense probably benign 0.34
R1740:Slco6d1 UTSW 1 98,356,097 (GRCm39) missense probably damaging 1.00
R1767:Slco6d1 UTSW 1 98,418,274 (GRCm39) missense possibly damaging 0.90
R1827:Slco6d1 UTSW 1 98,348,941 (GRCm39) missense probably damaging 0.96
R2138:Slco6d1 UTSW 1 98,371,385 (GRCm39) missense probably benign 0.19
R2849:Slco6d1 UTSW 1 98,394,441 (GRCm39) missense probably benign 0.02
R3753:Slco6d1 UTSW 1 98,427,502 (GRCm39) missense probably damaging 0.99
R4066:Slco6d1 UTSW 1 98,391,571 (GRCm39) critical splice acceptor site probably benign
R4480:Slco6d1 UTSW 1 98,435,299 (GRCm39) nonsense probably null
R4656:Slco6d1 UTSW 1 98,350,928 (GRCm39) missense probably benign 0.06
R4810:Slco6d1 UTSW 1 98,350,979 (GRCm39) missense possibly damaging 0.83
R4814:Slco6d1 UTSW 1 98,350,899 (GRCm39) missense probably benign 0.15
R5389:Slco6d1 UTSW 1 98,371,369 (GRCm39) missense probably benign 0.00
R5504:Slco6d1 UTSW 1 98,349,064 (GRCm39) missense probably damaging 0.99
R5619:Slco6d1 UTSW 1 98,423,947 (GRCm39) missense probably damaging 1.00
R5688:Slco6d1 UTSW 1 98,408,493 (GRCm39) missense probably damaging 1.00
R5820:Slco6d1 UTSW 1 98,427,503 (GRCm39) missense probably damaging 0.97
R5878:Slco6d1 UTSW 1 98,391,561 (GRCm39) splice site probably benign
R6261:Slco6d1 UTSW 1 98,427,588 (GRCm39) missense probably benign 0.10
R6450:Slco6d1 UTSW 1 98,349,192 (GRCm39) missense probably benign 0.29
R6452:Slco6d1 UTSW 1 98,348,937 (GRCm39) missense probably benign 0.44
R7338:Slco6d1 UTSW 1 98,349,097 (GRCm39) missense probably benign 0.11
R7375:Slco6d1 UTSW 1 98,349,172 (GRCm39) missense probably damaging 1.00
R7456:Slco6d1 UTSW 1 98,349,082 (GRCm39) missense possibly damaging 0.66
R7567:Slco6d1 UTSW 1 98,425,252 (GRCm39) missense probably damaging 1.00
R7729:Slco6d1 UTSW 1 98,425,248 (GRCm39) missense probably damaging 0.98
R7931:Slco6d1 UTSW 1 98,356,141 (GRCm39) missense probably damaging 1.00
R8088:Slco6d1 UTSW 1 98,394,431 (GRCm39) missense possibly damaging 0.75
R9021:Slco6d1 UTSW 1 98,371,396 (GRCm39) missense probably benign 0.18
R9080:Slco6d1 UTSW 1 98,348,983 (GRCm39) missense probably benign 0.01
R9123:Slco6d1 UTSW 1 98,423,919 (GRCm39) missense probably damaging 1.00
R9310:Slco6d1 UTSW 1 98,427,619 (GRCm39) missense possibly damaging 0.71
Predicted Primers
Posted On 2015-07-07