Incidental Mutation 'R4428:Or3a1c'
ID 328283
Institutional Source Beutler Lab
Gene Symbol Or3a1c
Ensembl Gene ENSMUSG00000070379
Gene Name olfactory receptor family 3 subfamily A member 1C
Synonyms MOR255-4, GA_x6K02T2P1NL-4307199-4308146, Olfr402
MMRRC Submission 041698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4428 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 74045982-74046929 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 74046025 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 15 (F15S)
Ref Sequence ENSEMBL: ENSMUSP00000151050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073675] [ENSMUST00000216722]
AlphaFold Q8VFX8
Predicted Effect probably damaging
Transcript: ENSMUST00000073675
AA Change: F15S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000073356
Gene: ENSMUSG00000070379
AA Change: F15S

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 9e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 210 2.2e-6 PFAM
Pfam:7tm_1 44 293 9.9e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216722
AA Change: F15S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.7488 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Abcc1 T A 16: 14,263,164 (GRCm39) V708E probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Ccdc18 A G 5: 108,283,943 (GRCm39) Y82C probably benign Het
Cd82 T C 2: 93,250,214 (GRCm39) Y266C probably damaging Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cmpk1 T C 4: 114,820,559 (GRCm39) E180G probably benign Het
Dock8 T C 19: 25,177,863 (GRCm39) I2066T probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Fgf3 T C 7: 144,394,444 (GRCm39) V86A probably damaging Het
Frem2 A G 3: 53,561,759 (GRCm39) I916T probably benign Het
Gsk3b T A 16: 38,014,298 (GRCm39) L252Q probably damaging Het
Kif18a A G 2: 109,118,466 (GRCm39) T94A probably damaging Het
Klhdc1 T A 12: 69,315,000 (GRCm39) probably benign Het
Klhl25 T A 7: 75,515,162 (GRCm39) F23I probably damaging Het
Mapk7 T C 11: 61,380,055 (GRCm39) D701G possibly damaging Het
Mbd5 A T 2: 49,169,776 (GRCm39) Q47L possibly damaging Het
Nrcam A G 12: 44,623,558 (GRCm39) D1049G possibly damaging Het
Olfml2a G T 2: 38,831,755 (GRCm39) M111I probably damaging Het
Pld2 A T 11: 70,432,160 (GRCm39) H93L probably damaging Het
Pomgnt2 T C 9: 121,811,320 (GRCm39) E487G possibly damaging Het
Psg17 G T 7: 18,550,717 (GRCm39) N379K probably benign Het
Rfk T A 19: 17,375,959 (GRCm39) H84Q possibly damaging Het
Scn8a A G 15: 100,881,784 (GRCm39) Y617C probably damaging Het
Sema3d T C 5: 12,498,087 (GRCm39) F31S probably benign Het
Shq1 T C 6: 100,647,889 (GRCm39) Y45C probably damaging Het
Siglecg C T 7: 43,067,350 (GRCm39) P639L possibly damaging Het
Skp2 A T 15: 9,117,034 (GRCm39) N325K probably benign Het
Sost G A 11: 101,857,670 (GRCm39) P44S probably damaging Het
Sp8 T A 12: 118,812,938 (GRCm39) S264R possibly damaging Het
Sun1 T C 5: 139,220,230 (GRCm39) probably benign Het
Tardbp A G 4: 148,709,659 (GRCm39) V54A possibly damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem68 A T 4: 3,569,534 (GRCm39) I52K probably benign Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Umps A C 16: 33,781,956 (GRCm39) V322G probably damaging Het
Vmn2r109 T C 17: 20,773,286 (GRCm39) D445G probably benign Het
Vmn2r22 T C 6: 123,614,817 (GRCm39) T258A possibly damaging Het
Vmn2r4 C T 3: 64,322,590 (GRCm39) G43E probably damaging Het
Other mutations in Or3a1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01732:Or3a1c APN 11 74,046,279 (GRCm39) missense probably damaging 1.00
IGL03085:Or3a1c APN 11 74,046,511 (GRCm39) missense probably damaging 1.00
IGL03192:Or3a1c APN 11 74,046,076 (GRCm39) missense probably benign 0.13
IGL03230:Or3a1c APN 11 74,046,099 (GRCm39) missense probably benign
R1478:Or3a1c UTSW 11 74,045,963 (GRCm39) splice site probably null
R1573:Or3a1c UTSW 11 74,046,196 (GRCm39) missense probably benign 0.11
R1728:Or3a1c UTSW 11 74,046,802 (GRCm39) missense probably damaging 0.99
R1912:Or3a1c UTSW 11 74,046,711 (GRCm39) missense probably damaging 1.00
R2030:Or3a1c UTSW 11 74,046,769 (GRCm39) missense possibly damaging 0.94
R3151:Or3a1c UTSW 11 74,046,466 (GRCm39) missense probably damaging 0.99
R4796:Or3a1c UTSW 11 74,046,417 (GRCm39) missense probably benign 0.02
R4974:Or3a1c UTSW 11 74,046,745 (GRCm39) missense probably benign 0.42
R4996:Or3a1c UTSW 11 74,046,157 (GRCm39) missense probably damaging 1.00
R5308:Or3a1c UTSW 11 74,046,397 (GRCm39) missense probably damaging 0.99
R5912:Or3a1c UTSW 11 74,046,046 (GRCm39) missense possibly damaging 0.64
R6083:Or3a1c UTSW 11 74,046,396 (GRCm39) missense possibly damaging 0.92
R7131:Or3a1c UTSW 11 74,046,606 (GRCm39) missense probably benign 0.02
R7460:Or3a1c UTSW 11 74,046,672 (GRCm39) missense probably damaging 0.99
R7540:Or3a1c UTSW 11 74,046,414 (GRCm39) missense probably benign 0.00
R7795:Or3a1c UTSW 11 74,046,844 (GRCm39) missense probably damaging 1.00
R8550:Or3a1c UTSW 11 74,046,015 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAGTCAAGCACTCCCAGTTCC -3'
(R):5'- CTGACAGATTCCCCAGGAAG -3'

Sequencing Primer
(F):5'- AAGCACTCCCAGTTCCTTTAAC -3'
(R):5'- TTCCCCAGGAAGAAGTACATGG -3'
Posted On 2015-07-07