Incidental Mutation 'R4413:Vmn2r86'
| ID |
328025 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r86
|
| Ensembl Gene |
ENSMUSG00000092162 |
| Gene Name |
vomeronasal 2, receptor 86 |
| Synonyms |
EG625109 |
| MMRRC Submission |
041136-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R4413 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130282068-130291763 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130288469 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 344
(I344T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
| AlphaFold |
G5E8Y4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170257
AA Change: I344T
PolyPhen 2
Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: I344T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
93% (42/45) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adprhl1 |
T |
C |
8: 13,296,114 (GRCm39) |
K144E |
probably benign |
Het |
| Bcdin3d |
A |
G |
15: 99,368,614 (GRCm39) |
L195P |
probably damaging |
Het |
| Bltp1 |
A |
G |
3: 37,012,830 (GRCm39) |
|
probably null |
Het |
| Col11a1 |
T |
A |
3: 113,901,965 (GRCm39) |
S553R |
unknown |
Het |
| Cp |
A |
T |
3: 20,020,517 (GRCm39) |
D170V |
probably damaging |
Het |
| Dnah17 |
C |
T |
11: 117,915,994 (GRCm39) |
A4303T |
probably benign |
Het |
| Dpp4 |
G |
A |
2: 62,217,484 (GRCm39) |
R38C |
possibly damaging |
Het |
| Dusp6 |
C |
T |
10: 99,099,786 (GRCm39) |
T78M |
probably damaging |
Het |
| Exoc1 |
A |
G |
5: 76,689,866 (GRCm39) |
|
probably benign |
Het |
| Fbxl13 |
A |
T |
5: 21,787,051 (GRCm39) |
C295* |
probably null |
Het |
| Gpsm1 |
G |
A |
2: 26,209,843 (GRCm39) |
|
probably benign |
Het |
| Gstm4 |
T |
A |
3: 107,950,644 (GRCm39) |
D85V |
possibly damaging |
Het |
| Hectd4 |
A |
G |
5: 121,488,544 (GRCm39) |
N3612D |
possibly damaging |
Het |
| Izumo3 |
T |
C |
4: 92,035,136 (GRCm39) |
D27G |
probably damaging |
Het |
| Kcna4 |
T |
A |
2: 107,125,718 (GRCm39) |
C151S |
probably benign |
Het |
| Lrrc10 |
A |
G |
10: 116,881,719 (GRCm39) |
N131S |
probably damaging |
Het |
| Madd |
A |
G |
2: 90,997,932 (GRCm39) |
S699P |
probably damaging |
Het |
| Mcpt4 |
A |
T |
14: 56,297,993 (GRCm39) |
V186D |
probably damaging |
Het |
| Mrgprx3-ps |
T |
C |
7: 46,959,746 (GRCm39) |
|
noncoding transcript |
Het |
| Mrm1 |
G |
T |
11: 84,710,054 (GRCm39) |
R49S |
possibly damaging |
Het |
| Nav2 |
T |
A |
7: 49,047,857 (GRCm39) |
N91K |
probably benign |
Het |
| Noct |
C |
T |
3: 51,157,756 (GRCm39) |
R365W |
probably damaging |
Het |
| Ntn1 |
C |
T |
11: 68,276,736 (GRCm39) |
G71S |
probably damaging |
Het |
| Or10x1 |
T |
C |
1: 174,197,040 (GRCm39) |
S186P |
probably damaging |
Het |
| Plekhg3 |
A |
C |
12: 76,624,538 (GRCm39) |
T1127P |
probably damaging |
Het |
| Rhbdl2 |
A |
T |
4: 123,703,880 (GRCm39) |
M52L |
probably benign |
Het |
| Saxo5 |
T |
A |
8: 3,533,529 (GRCm39) |
H278Q |
probably damaging |
Het |
| Slc10a1 |
T |
C |
12: 81,004,906 (GRCm39) |
N212S |
probably benign |
Het |
| Sohlh2 |
C |
A |
3: 55,104,423 (GRCm39) |
T264K |
probably damaging |
Het |
| Srrm2 |
A |
G |
17: 24,029,442 (GRCm39) |
|
probably benign |
Het |
| Syn3 |
C |
A |
10: 85,891,456 (GRCm39) |
|
probably benign |
Het |
| Taf5 |
T |
A |
19: 47,059,453 (GRCm39) |
V199D |
probably damaging |
Het |
| Tas2r136 |
C |
A |
6: 132,754,972 (GRCm39) |
V52L |
probably damaging |
Het |
| Tnk2 |
C |
T |
16: 32,488,319 (GRCm39) |
R191C |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,556,120 (GRCm39) |
I21968T |
probably damaging |
Het |
| Ubxn6 |
A |
T |
17: 56,376,303 (GRCm39) |
V311E |
probably damaging |
Het |
| Usp7 |
C |
A |
16: 8,526,778 (GRCm39) |
D187Y |
probably damaging |
Het |
| Vmn1r115 |
C |
T |
7: 20,578,207 (GRCm39) |
R235K |
probably benign |
Het |
| Vmn2r50 |
A |
C |
7: 9,784,235 (GRCm39) |
F80V |
probably damaging |
Het |
| Vmn2r58 |
T |
A |
7: 41,511,360 (GRCm39) |
K481M |
possibly damaging |
Het |
| Vmn2r99 |
T |
A |
17: 19,599,522 (GRCm39) |
V402E |
probably damaging |
Het |
| Zfp462 |
A |
G |
4: 55,012,672 (GRCm39) |
D1546G |
probably damaging |
Het |
|
| Other mutations in Vmn2r86 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Vmn2r86
|
APN |
10 |
130,288,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01328:Vmn2r86
|
APN |
10 |
130,288,365 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01377:Vmn2r86
|
APN |
10 |
130,288,855 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01548:Vmn2r86
|
APN |
10 |
130,282,151 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01804:Vmn2r86
|
APN |
10 |
130,288,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01921:Vmn2r86
|
APN |
10 |
130,291,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02406:Vmn2r86
|
APN |
10 |
130,284,508 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02625:Vmn2r86
|
APN |
10 |
130,288,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Vmn2r86
|
APN |
10 |
130,289,636 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL03104:Vmn2r86
|
APN |
10 |
130,282,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0408:Vmn2r86
|
UTSW |
10 |
130,282,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0437:Vmn2r86
|
UTSW |
10 |
130,282,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0577:Vmn2r86
|
UTSW |
10 |
130,288,444 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0726:Vmn2r86
|
UTSW |
10 |
130,282,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0812:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1055:Vmn2r86
|
UTSW |
10 |
130,282,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1066:Vmn2r86
|
UTSW |
10 |
130,282,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn2r86
|
UTSW |
10 |
130,284,443 (GRCm39) |
splice site |
probably benign |
|
|
R1332:Vmn2r86
|
UTSW |
10 |
130,282,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Vmn2r86
|
UTSW |
10 |
130,289,010 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1866:Vmn2r86
|
UTSW |
10 |
130,282,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r86
|
UTSW |
10 |
130,288,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn2r86
|
UTSW |
10 |
130,282,582 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3858:Vmn2r86
|
UTSW |
10 |
130,291,594 (GRCm39) |
missense |
probably benign |
|
|
R4049:Vmn2r86
|
UTSW |
10 |
130,282,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4378:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4411:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4422:Vmn2r86
|
UTSW |
10 |
130,288,845 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4738:Vmn2r86
|
UTSW |
10 |
130,282,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4767:Vmn2r86
|
UTSW |
10 |
130,291,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4872:Vmn2r86
|
UTSW |
10 |
130,289,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4880:Vmn2r86
|
UTSW |
10 |
130,289,484 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5092:Vmn2r86
|
UTSW |
10 |
130,282,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Vmn2r86
|
UTSW |
10 |
130,282,805 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6007:Vmn2r86
|
UTSW |
10 |
130,289,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6330:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6355:Vmn2r86
|
UTSW |
10 |
130,291,763 (GRCm39) |
start codon destroyed |
probably damaging |
0.98 |
|
R6397:Vmn2r86
|
UTSW |
10 |
130,282,131 (GRCm39) |
nonsense |
probably null |
|
|
R6419:Vmn2r86
|
UTSW |
10 |
130,282,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Vmn2r86
|
UTSW |
10 |
130,282,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6937:Vmn2r86
|
UTSW |
10 |
130,284,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Vmn2r86
|
UTSW |
10 |
130,282,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7010:Vmn2r86
|
UTSW |
10 |
130,291,726 (GRCm39) |
missense |
probably benign |
|
|
R7549:Vmn2r86
|
UTSW |
10 |
130,282,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8179:Vmn2r86
|
UTSW |
10 |
130,288,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8257:Vmn2r86
|
UTSW |
10 |
130,288,279 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8286:Vmn2r86
|
UTSW |
10 |
130,285,855 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8479:Vmn2r86
|
UTSW |
10 |
130,282,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8805:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8960:Vmn2r86
|
UTSW |
10 |
130,289,672 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9021:Vmn2r86
|
UTSW |
10 |
130,282,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Vmn2r86
|
UTSW |
10 |
130,289,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Vmn2r86
|
UTSW |
10 |
130,282,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Vmn2r86
|
UTSW |
10 |
130,288,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Vmn2r86
|
UTSW |
10 |
130,288,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9433:Vmn2r86
|
UTSW |
10 |
130,282,567 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9696:Vmn2r86
|
UTSW |
10 |
130,285,702 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGGCCACAGCATAAACAG -3'
(R):5'- GACATCTTCAGCAAAGGTTGTTATC -3'
Sequencing Primer
(F):5'- GGGCCACAGCATAAACAGCATTATAC -3'
(R):5'- AGAAGATGGGTATATTTAGGTGCTC -3'
|
| Posted On |
2015-07-07 |
Incidental Mutation