Incidental Mutation 'R4411:Vmn2r86'
ID 327925
Institutional Source Beutler Lab
Gene Symbol Vmn2r86
Ensembl Gene ENSMUSG00000092162
Gene Name vomeronasal 2, receptor 86
Synonyms EG625109
MMRRC Submission 041693-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R4411 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 130282068-130291763 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130288469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 344 (I344T)
Ref Sequence ENSEMBL: ENSMUSP00000126596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170257]
AlphaFold G5E8Y4
Predicted Effect possibly damaging
Transcript: ENSMUST00000170257
AA Change: I344T

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: I344T

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 1.1e-25 PFAM
Pfam:NCD3G 508 562 2.4e-19 PFAM
Pfam:7tm_3 595 829 6.4e-55 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 95% (62/65)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,042,781 (GRCm39) I423V probably benign Het
Abl2 T C 1: 156,457,652 (GRCm39) V306A possibly damaging Het
Adcy4 T C 14: 56,006,900 (GRCm39) Y1006C probably damaging Het
Adprhl1 T C 8: 13,296,114 (GRCm39) K144E probably benign Het
Arid5b T C 10: 67,932,519 (GRCm39) R885G probably damaging Het
Atp9a A T 2: 168,503,853 (GRCm39) V613E probably damaging Het
Atxn7l1 G T 12: 33,244,886 (GRCm39) probably benign Het
Brd8 C A 18: 34,756,497 (GRCm39) probably benign Het
Bsnd C T 4: 106,343,868 (GRCm39) R146H probably benign Het
C4b C T 17: 34,947,838 (GRCm39) R1659H probably damaging Het
Duox1 G A 2: 122,168,115 (GRCm39) R1080H probably benign Het
Eml2 T C 7: 18,916,326 (GRCm39) probably null Het
Fbxo44 G A 4: 148,238,065 (GRCm39) R221C probably damaging Het
Frem1 T C 4: 82,881,481 (GRCm39) D166G probably damaging Het
Galnt5 T C 2: 57,889,207 (GRCm39) L269P probably benign Het
Gigyf2 A G 1: 87,364,582 (GRCm39) E954G probably damaging Het
Gpc6 T C 14: 118,188,590 (GRCm39) V408A probably benign Het
Hspg2 A G 4: 137,289,535 (GRCm39) T3832A probably benign Het
Ift88 A G 14: 57,715,436 (GRCm39) N493S probably damaging Het
Ighv1-76 A T 12: 115,811,731 (GRCm39) C41S probably damaging Het
Igkv12-46 G A 6: 69,741,930 (GRCm39) T16I probably benign Het
Igkv3-9 G T 6: 70,565,547 (GRCm39) V49F probably damaging Het
Isoc2b A T 7: 4,852,433 (GRCm39) probably benign Het
Lcp2 T A 11: 34,037,173 (GRCm39) probably benign Het
Lmntd1 A G 6: 145,373,003 (GRCm39) probably null Het
Mdm2 A T 10: 117,545,694 (GRCm39) probably null Het
Mrgprx3-ps T C 7: 46,959,746 (GRCm39) noncoding transcript Het
Msh2 T C 17: 88,025,032 (GRCm39) S637P probably damaging Het
Myo5b T C 18: 74,831,345 (GRCm39) F765S possibly damaging Het
Nav2 T A 7: 49,047,857 (GRCm39) N91K probably benign Het
Ndor1 G A 2: 25,138,492 (GRCm39) P363S probably benign Het
Npr3 G C 15: 11,905,235 (GRCm39) T164R probably benign Het
Pcdhb5 T C 18: 37,455,050 (GRCm39) S477P possibly damaging Het
Pde3b GTGATGATGATGATGATGATGATGATG GTGATGATGATGATGATGATGATG 7: 114,133,984 (GRCm39) probably benign Het
Pnpla7 G A 2: 24,941,716 (GRCm39) W13* probably null Het
Pnpla8 T C 12: 44,330,225 (GRCm39) V41A probably benign Het
Prdm2 A T 4: 142,860,240 (GRCm39) S1017T probably benign Het
Prdm5 T A 6: 65,878,771 (GRCm39) Y108* probably null Het
Rab34 T A 11: 78,079,592 (GRCm39) probably null Het
Skic3 A G 13: 76,275,623 (GRCm39) E410G possibly damaging Het
Smpd5 G T 15: 76,179,112 (GRCm39) R160L possibly damaging Het
Spmip10 A G 18: 56,727,720 (GRCm39) T65A probably benign Het
Srrm2 A G 17: 24,029,442 (GRCm39) probably benign Het
Taf5 T A 19: 47,059,453 (GRCm39) V199D probably damaging Het
Tas2r114 C T 6: 131,666,585 (GRCm39) V148I probably benign Het
Tas2r136 C A 6: 132,754,972 (GRCm39) V52L probably damaging Het
Tnfrsf25 G A 4: 152,202,843 (GRCm39) probably benign Het
Tpd52l1 T C 10: 31,255,315 (GRCm39) T11A possibly damaging Het
Trmt1l G A 1: 151,327,905 (GRCm39) E472K probably benign Het
Ttc17 T C 2: 94,173,098 (GRCm39) K766E probably damaging Het
Ttn C T 2: 76,560,633 (GRCm39) R29256Q probably damaging Het
Ttn T C 2: 76,572,414 (GRCm39) I26160V probably damaging Het
Ubxn6 A T 17: 56,376,303 (GRCm39) V311E probably damaging Het
Usp2 T C 9: 44,002,360 (GRCm39) S351P probably damaging Het
Usp7 C A 16: 8,526,778 (GRCm39) D187Y probably damaging Het
Vmn1r115 C T 7: 20,578,207 (GRCm39) R235K probably benign Het
Vmn2r50 A C 7: 9,784,235 (GRCm39) F80V probably damaging Het
Vmn2r58 T A 7: 41,511,360 (GRCm39) K481M possibly damaging Het
Zfp455 A T 13: 67,355,389 (GRCm39) N219I probably damaging Het
Other mutations in Vmn2r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Vmn2r86 APN 10 130,288,895 (GRCm39) missense probably damaging 0.99
IGL01328:Vmn2r86 APN 10 130,288,365 (GRCm39) missense possibly damaging 0.78
IGL01377:Vmn2r86 APN 10 130,288,855 (GRCm39) missense probably damaging 0.99
IGL01548:Vmn2r86 APN 10 130,282,151 (GRCm39) missense probably benign 0.22
IGL01804:Vmn2r86 APN 10 130,288,858 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn2r86 APN 10 130,291,610 (GRCm39) missense probably benign 0.00
IGL02406:Vmn2r86 APN 10 130,284,508 (GRCm39) missense possibly damaging 0.81
IGL02625:Vmn2r86 APN 10 130,288,781 (GRCm39) missense probably damaging 1.00
IGL02960:Vmn2r86 APN 10 130,289,636 (GRCm39) missense possibly damaging 0.74
IGL03104:Vmn2r86 APN 10 130,282,501 (GRCm39) missense probably damaging 1.00
R0408:Vmn2r86 UTSW 10 130,282,723 (GRCm39) missense probably damaging 1.00
R0437:Vmn2r86 UTSW 10 130,282,412 (GRCm39) missense probably damaging 1.00
R0577:Vmn2r86 UTSW 10 130,288,444 (GRCm39) missense probably benign 0.04
R0726:Vmn2r86 UTSW 10 130,282,265 (GRCm39) missense probably damaging 1.00
R0811:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R0812:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R1055:Vmn2r86 UTSW 10 130,282,226 (GRCm39) missense probably damaging 1.00
R1066:Vmn2r86 UTSW 10 130,282,145 (GRCm39) missense probably benign 0.01
R1199:Vmn2r86 UTSW 10 130,284,443 (GRCm39) splice site probably benign
R1332:Vmn2r86 UTSW 10 130,282,739 (GRCm39) missense probably damaging 1.00
R1568:Vmn2r86 UTSW 10 130,289,010 (GRCm39) missense probably benign 0.09
R1866:Vmn2r86 UTSW 10 130,282,255 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r86 UTSW 10 130,288,314 (GRCm39) missense probably damaging 1.00
R2017:Vmn2r86 UTSW 10 130,282,582 (GRCm39) missense probably benign 0.39
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3858:Vmn2r86 UTSW 10 130,291,594 (GRCm39) missense probably benign
R4049:Vmn2r86 UTSW 10 130,282,966 (GRCm39) missense probably damaging 0.98
R4378:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4413:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4422:Vmn2r86 UTSW 10 130,288,845 (GRCm39) missense possibly damaging 0.87
R4738:Vmn2r86 UTSW 10 130,282,939 (GRCm39) missense probably damaging 0.99
R4767:Vmn2r86 UTSW 10 130,291,606 (GRCm39) missense probably benign 0.00
R4872:Vmn2r86 UTSW 10 130,289,460 (GRCm39) missense probably damaging 0.98
R4880:Vmn2r86 UTSW 10 130,289,484 (GRCm39) missense probably benign 0.33
R5092:Vmn2r86 UTSW 10 130,282,456 (GRCm39) missense probably damaging 1.00
R5421:Vmn2r86 UTSW 10 130,282,805 (GRCm39) missense probably benign 0.41
R6007:Vmn2r86 UTSW 10 130,289,535 (GRCm39) missense probably damaging 1.00
R6330:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R6355:Vmn2r86 UTSW 10 130,291,763 (GRCm39) start codon destroyed probably damaging 0.98
R6397:Vmn2r86 UTSW 10 130,282,131 (GRCm39) nonsense probably null
R6419:Vmn2r86 UTSW 10 130,282,795 (GRCm39) missense probably damaging 1.00
R6933:Vmn2r86 UTSW 10 130,282,126 (GRCm39) missense probably damaging 1.00
R6937:Vmn2r86 UTSW 10 130,284,523 (GRCm39) missense probably damaging 1.00
R6959:Vmn2r86 UTSW 10 130,282,400 (GRCm39) missense probably damaging 1.00
R7010:Vmn2r86 UTSW 10 130,291,726 (GRCm39) missense probably benign
R7549:Vmn2r86 UTSW 10 130,282,697 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r86 UTSW 10 130,288,953 (GRCm39) missense probably benign 0.00
R8257:Vmn2r86 UTSW 10 130,288,279 (GRCm39) missense possibly damaging 0.87
R8286:Vmn2r86 UTSW 10 130,285,855 (GRCm39) missense probably benign 0.03
R8479:Vmn2r86 UTSW 10 130,282,735 (GRCm39) missense probably damaging 1.00
R8805:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R8960:Vmn2r86 UTSW 10 130,289,672 (GRCm39) missense probably benign 0.27
R9021:Vmn2r86 UTSW 10 130,282,934 (GRCm39) missense probably damaging 1.00
R9120:Vmn2r86 UTSW 10 130,289,677 (GRCm39) missense probably benign 0.00
R9137:Vmn2r86 UTSW 10 130,282,409 (GRCm39) missense probably damaging 1.00
R9311:Vmn2r86 UTSW 10 130,288,440 (GRCm39) missense probably damaging 1.00
R9312:Vmn2r86 UTSW 10 130,288,406 (GRCm39) missense probably benign 0.02
R9433:Vmn2r86 UTSW 10 130,282,567 (GRCm39) missense possibly damaging 0.88
R9696:Vmn2r86 UTSW 10 130,285,702 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- TGTGGGCCACAGCATAAACAG -3'
(R):5'- GACATCTTCAGCAAAGGTTGTTATC -3'

Sequencing Primer
(F):5'- GGGCCACAGCATAAACAGCATTATAC -3'
(R):5'- AGAAGATGGGTATATTTAGGTGCTC -3'
Posted On 2015-07-07