Incidental Mutation 'R4373:Zfp112'
ID 326063
Institutional Source Beutler Lab
Gene Symbol Zfp112
Ensembl Gene ENSMUSG00000052675
Gene Name zinc finger protein 112
Synonyms
MMRRC Submission 041675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R4373 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 23811739-23827377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 23824473 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 147 (I147N)
Ref Sequence ENSEMBL: ENSMUSP00000150734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005413] [ENSMUST00000120006] [ENSMUST00000215113]
AlphaFold Q0VAW7
Predicted Effect probably damaging
Transcript: ENSMUST00000005413
AA Change: I151N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000005413
Gene: ENSMUSG00000052675
AA Change: I151N

DomainStartEndE-ValueType
KRAB 8 68 7.93e-27 SMART
low complexity region 385 397 N/A INTRINSIC
ZnF_C2H2 523 545 4.11e-2 SMART
ZnF_C2H2 551 573 3.44e-4 SMART
ZnF_C2H2 579 601 1.6e-4 SMART
ZnF_C2H2 607 629 1.5e-4 SMART
ZnF_C2H2 635 657 3.89e-3 SMART
ZnF_C2H2 663 685 1.58e-3 SMART
ZnF_C2H2 691 713 6.42e-4 SMART
ZnF_C2H2 719 741 5.99e-4 SMART
ZnF_C2H2 747 769 7.78e-3 SMART
ZnF_C2H2 775 797 3.95e-4 SMART
ZnF_C2H2 803 825 2.01e-5 SMART
ZnF_C2H2 831 853 1.36e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120006
AA Change: I145N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113031
Gene: ENSMUSG00000052675
AA Change: I145N

DomainStartEndE-ValueType
KRAB 2 62 7.93e-27 SMART
low complexity region 379 391 N/A INTRINSIC
ZnF_C2H2 517 539 4.11e-2 SMART
ZnF_C2H2 545 567 3.44e-4 SMART
ZnF_C2H2 573 595 1.6e-4 SMART
ZnF_C2H2 601 623 1.5e-4 SMART
ZnF_C2H2 629 651 3.89e-3 SMART
ZnF_C2H2 657 679 1.58e-3 SMART
ZnF_C2H2 685 707 6.42e-4 SMART
ZnF_C2H2 713 735 5.99e-4 SMART
ZnF_C2H2 741 763 7.78e-3 SMART
ZnF_C2H2 769 791 3.95e-4 SMART
ZnF_C2H2 797 819 2.01e-5 SMART
ZnF_C2H2 825 847 1.36e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215113
AA Change: I147N

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Meta Mutation Damage Score 0.1080 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 98% (54/55)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A G 15: 76,478,535 (GRCm39) probably benign Het
Akr1b1 A C 6: 34,281,202 (GRCm39) probably benign Het
Armh4 T A 14: 50,007,893 (GRCm39) T527S probably damaging Het
Asns A T 6: 7,677,978 (GRCm39) S367T probably damaging Het
BC034090 T C 1: 155,101,904 (GRCm39) N120S probably benign Het
Bub1 A T 2: 127,647,156 (GRCm39) probably benign Het
Csf1 T A 3: 107,664,055 (GRCm39) T38S probably damaging Het
Ctsz T C 2: 174,270,378 (GRCm39) E268G possibly damaging Het
Dach1 G A 14: 98,065,186 (GRCm39) T685I possibly damaging Het
Dclre1a A G 19: 56,533,874 (GRCm39) L240S probably benign Het
Ercc1 G A 7: 19,081,057 (GRCm39) probably benign Het
Esam C T 9: 37,445,492 (GRCm39) T71I probably benign Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Gde1 A G 7: 118,297,781 (GRCm39) L35P possibly damaging Het
Gm10382 A G 5: 125,466,647 (GRCm39) probably benign Het
H2-M10.6 T C 17: 37,123,958 (GRCm39) Y141H probably damaging Het
Hk1 C A 10: 62,151,319 (GRCm39) K10N probably damaging Het
Lamc3 A G 2: 31,788,244 (GRCm39) K135E probably damaging Het
Lrtm2 A G 6: 119,297,489 (GRCm39) F184S probably damaging Het
Marchf11 A G 15: 26,309,532 (GRCm39) E62G probably damaging Het
Mtcl1 T A 17: 66,687,074 (GRCm39) T611S probably benign Het
Myc A T 15: 61,861,513 (GRCm39) H373L probably damaging Het
Myh6 T A 14: 55,199,565 (GRCm39) I249F probably damaging Het
Naaa T C 5: 92,426,002 (GRCm39) probably benign Het
Nfib A G 4: 82,241,895 (GRCm39) V432A probably damaging Het
Nmt1 A G 11: 102,934,026 (GRCm39) K55R probably damaging Het
Opa3 C T 7: 18,978,699 (GRCm39) R55W probably damaging Het
Or4c122 T C 2: 89,079,589 (GRCm39) R150G possibly damaging Het
Pfn4 T A 12: 4,820,182 (GRCm39) D10E probably damaging Het
Pld5 T A 1: 175,967,583 (GRCm39) I91F probably damaging Het
Plec A C 15: 76,067,317 (GRCm39) S1350A probably damaging Het
Polq G T 16: 36,833,543 (GRCm39) V79F probably damaging Het
Ppp1r16b T C 2: 158,603,685 (GRCm39) Y537H probably damaging Het
Prdm8 T C 5: 98,334,367 (GRCm39) S645P probably damaging Het
Rgs1 T C 1: 144,123,644 (GRCm39) T94A probably benign Het
Rpl11 G A 4: 135,778,454 (GRCm39) probably benign Het
Sanbr A T 11: 23,565,265 (GRCm39) probably null Het
Scamp3 G A 3: 89,089,234 (GRCm39) probably null Het
Sgsm1 TTTTATATT TTT 5: 113,405,989 (GRCm39) probably benign Het
Sirpb1b A T 3: 15,613,821 (GRCm39) I87K probably damaging Het
Slc14a2 G A 18: 78,250,283 (GRCm39) R62C probably damaging Het
Stat4 T C 1: 52,111,100 (GRCm39) probably null Het
Tex9 A T 9: 72,387,877 (GRCm39) probably null Het
Tsku T C 7: 98,002,038 (GRCm39) T98A probably benign Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Vmn2r116 A C 17: 23,620,395 (GRCm39) I710L probably benign Het
Vmn2r16 A T 5: 109,511,667 (GRCm39) I625F probably damaging Het
Xpo4 G A 14: 57,828,479 (GRCm39) Q794* probably null Het
Zmiz1 T C 14: 25,636,434 (GRCm39) S140P probably damaging Het
Other mutations in Zfp112
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Zfp112 APN 7 23,821,668 (GRCm39) missense probably damaging 1.00
IGL00575:Zfp112 APN 7 23,825,757 (GRCm39) missense probably damaging 1.00
IGL00944:Zfp112 APN 7 23,825,021 (GRCm39) missense probably benign 0.02
IGL01662:Zfp112 APN 7 23,825,379 (GRCm39) missense probably benign 0.44
IGL03383:Zfp112 APN 7 23,825,103 (GRCm39) missense probably damaging 1.00
2107:Zfp112 UTSW 7 23,826,266 (GRCm39) missense probably damaging 1.00
FR4737:Zfp112 UTSW 7 23,824,832 (GRCm39) small insertion probably benign
R0566:Zfp112 UTSW 7 23,825,102 (GRCm39) missense probably benign 0.09
R0581:Zfp112 UTSW 7 23,825,288 (GRCm39) missense probably damaging 0.97
R0613:Zfp112 UTSW 7 23,826,453 (GRCm39) missense probably benign 0.33
R1521:Zfp112 UTSW 7 23,825,210 (GRCm39) missense probably damaging 0.97
R1614:Zfp112 UTSW 7 23,826,024 (GRCm39) missense probably damaging 1.00
R1827:Zfp112 UTSW 7 23,824,385 (GRCm39) missense probably damaging 1.00
R1906:Zfp112 UTSW 7 23,821,720 (GRCm39) missense probably benign 0.34
R1920:Zfp112 UTSW 7 23,824,662 (GRCm39) missense probably benign 0.01
R2008:Zfp112 UTSW 7 23,826,176 (GRCm39) missense probably damaging 1.00
R2012:Zfp112 UTSW 7 23,824,725 (GRCm39) missense possibly damaging 0.69
R2192:Zfp112 UTSW 7 23,824,863 (GRCm39) missense probably damaging 0.98
R2985:Zfp112 UTSW 7 23,821,720 (GRCm39) missense probably benign 0.34
R4191:Zfp112 UTSW 7 23,825,568 (GRCm39) missense probably benign 0.19
R4374:Zfp112 UTSW 7 23,825,798 (GRCm39) missense probably damaging 1.00
R4674:Zfp112 UTSW 7 23,826,399 (GRCm39) missense probably damaging 1.00
R4676:Zfp112 UTSW 7 23,825,685 (GRCm39) missense probably damaging 0.97
R5023:Zfp112 UTSW 7 23,825,909 (GRCm39) missense probably damaging 0.99
R5198:Zfp112 UTSW 7 23,824,281 (GRCm39) missense possibly damaging 0.49
R6559:Zfp112 UTSW 7 23,825,888 (GRCm39) nonsense probably null
R6835:Zfp112 UTSW 7 23,825,231 (GRCm39) missense probably damaging 1.00
R6946:Zfp112 UTSW 7 23,824,766 (GRCm39) missense probably damaging 0.98
R7263:Zfp112 UTSW 7 23,824,952 (GRCm39) missense probably benign 0.04
R7512:Zfp112 UTSW 7 23,824,604 (GRCm39) missense possibly damaging 0.73
R7533:Zfp112 UTSW 7 23,824,752 (GRCm39) missense possibly damaging 0.58
R7535:Zfp112 UTSW 7 23,826,135 (GRCm39) missense probably damaging 1.00
R8179:Zfp112 UTSW 7 23,825,063 (GRCm39) missense probably benign 0.10
R8516:Zfp112 UTSW 7 23,823,389 (GRCm39) missense probably benign
R8525:Zfp112 UTSW 7 23,825,322 (GRCm39) missense probably benign 0.38
R8701:Zfp112 UTSW 7 23,825,165 (GRCm39) missense probably damaging 1.00
R8756:Zfp112 UTSW 7 23,824,997 (GRCm39) missense probably benign 0.03
R8853:Zfp112 UTSW 7 23,823,390 (GRCm39) synonymous silent
R8994:Zfp112 UTSW 7 23,825,490 (GRCm39) missense probably benign 0.06
R9295:Zfp112 UTSW 7 23,824,805 (GRCm39) missense probably benign
R9530:Zfp112 UTSW 7 23,824,665 (GRCm39) missense probably benign 0.01
R9537:Zfp112 UTSW 7 23,826,512 (GRCm39) missense probably damaging 1.00
R9559:Zfp112 UTSW 7 23,826,108 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGAAGTAAACTCCCTTTGTCCC -3'
(R):5'- TAGCTCCTCATTGTCACTGTGG -3'

Sequencing Primer
(F):5'- GTCCCGAGGACCTCTCC -3'
(R):5'- CTGCCATACCTACAGAAGTGATTTC -3'
Posted On 2015-07-06