Incidental Mutation 'R4135:Dock2'
ID 314857
Institutional Source Beutler Lab
Gene Symbol Dock2
Ensembl Gene ENSMUSG00000020143
Gene Name dedicator of cyto-kinesis 2
Synonyms CED-5, Hch, MBC
MMRRC Submission 040995-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4135 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 34176815-34674719 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 34605328 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 264 (K264E)
Ref Sequence ENSEMBL: ENSMUSP00000116893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]
AlphaFold Q8C3J5
Predicted Effect probably benign
Transcript: ENSMUST00000093193
AA Change: K264E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: K264E

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK_N 71 414 2e-113 PFAM
Pfam:DOCK-C2 419 616 1e-60 PFAM
Pfam:DHR-2 1114 1614 6.3e-96 PFAM
low complexity region 1691 1706 N/A INTRINSIC
low complexity region 1793 1800 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000101365
AA Change: K264E

PolyPhen 2 Score 0.342 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: K264E

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK_N 71 414 1.4e-113 PFAM
Pfam:DOCK-C2 419 616 5.5e-61 PFAM
low complexity region 1163 1171 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000143540
AA Change: K264E

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143
AA Change: K264E

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK-C2 418 617 1.8e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154178
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik T A 1: 159,905,092 (GRCm39) probably benign Het
Bak1 T A 17: 27,240,244 (GRCm39) T148S possibly damaging Het
Cdc25a C A 9: 109,710,585 (GRCm39) H157Q possibly damaging Het
Chst5 T C 8: 112,616,816 (GRCm39) Y268C probably damaging Het
Csnk1g2 T C 10: 80,474,130 (GRCm39) I145T possibly damaging Het
Ctsr T C 13: 61,309,084 (GRCm39) T224A probably benign Het
Cux1 T C 5: 136,336,750 (GRCm39) K921E probably damaging Het
Dcaf12l1 T C X: 43,878,330 (GRCm39) N156S probably damaging Het
Dennd2d T A 3: 106,389,977 (GRCm39) D2E probably benign Het
Eif3c C G 7: 126,165,471 (GRCm39) probably benign Het
Gabrb3 G T 7: 57,241,036 (GRCm39) A5S probably benign Het
Gcnt2 T A 13: 41,041,283 (GRCm39) N147K probably damaging Het
Gm6987 T A X: 93,068,216 (GRCm39) noncoding transcript Het
Hbp1 A T 12: 31,984,421 (GRCm39) L262Q probably damaging Het
Hsd11b2 T C 8: 106,249,798 (GRCm39) V303A probably benign Het
Htr5a A G 5: 28,047,690 (GRCm39) M82V probably benign Het
Mcc T C 18: 44,857,707 (GRCm39) D136G probably benign Het
Mrpl32 C T 13: 14,787,564 (GRCm39) V14M probably damaging Het
Msl1 A G 11: 98,687,126 (GRCm39) D157G possibly damaging Het
Mthfd1 G A 12: 76,329,648 (GRCm39) probably null Het
Nkx6-1 T A 5: 101,807,371 (GRCm39) D337V probably damaging Het
Nlrp5 T C 7: 23,117,823 (GRCm39) W516R possibly damaging Het
Or2ag1 A G 7: 106,313,210 (GRCm39) L226P probably damaging Het
Or2l13b T A 16: 19,349,452 (GRCm39) I73F possibly damaging Het
Or2y3 A G 17: 38,393,248 (GRCm39) V207A possibly damaging Het
Or4l1 T C 14: 50,166,272 (GRCm39) H243R probably damaging Het
Or5af1 C A 11: 58,722,820 (GRCm39) T280K probably damaging Het
Pate5 A G 9: 35,750,724 (GRCm39) S33P possibly damaging Het
Pold3 T A 7: 99,749,854 (GRCm39) R104* probably null Het
Rapsn A T 2: 90,867,162 (GRCm39) N155Y probably damaging Het
Rorc C A 3: 94,296,826 (GRCm39) Q269K probably damaging Het
Rreb1 A T 13: 38,131,099 (GRCm39) N1418Y probably damaging Het
Rusc2 G A 4: 43,425,563 (GRCm39) D1223N possibly damaging Het
Sema6d T C 2: 124,506,040 (GRCm39) I616T probably damaging Het
Ttc6 T A 12: 57,679,581 (GRCm39) probably benign Het
Ugt3a1 A T 15: 9,338,810 (GRCm39) Y58F probably damaging Het
Vmn2r129 T G 4: 156,691,085 (GRCm39) noncoding transcript Het
Vwa5b1 A T 4: 138,321,641 (GRCm39) M384K possibly damaging Het
Washc3 G A 10: 88,055,142 (GRCm39) E111K probably benign Het
Xirp2 A G 2: 67,355,741 (GRCm39) S3501G probably benign Het
Zfp1004 A T 2: 150,023,788 (GRCm39) probably benign Het
Zfp352 C T 4: 90,113,261 (GRCm39) T467M probably damaging Het
Zfp729a C A 13: 67,767,925 (GRCm39) C768F probably damaging Het
Zfp810 T C 9: 22,190,369 (GRCm39) K180E probably damaging Het
Other mutations in Dock2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Dock2 APN 11 34,595,488 (GRCm39) missense probably damaging 1.00
IGL00469:Dock2 APN 11 34,179,603 (GRCm39) splice site probably benign
IGL01061:Dock2 APN 11 34,596,653 (GRCm39) missense probably damaging 1.00
IGL01319:Dock2 APN 11 34,589,617 (GRCm39) missense possibly damaging 0.61
IGL01451:Dock2 APN 11 34,260,390 (GRCm39) missense probably damaging 1.00
IGL01490:Dock2 APN 11 34,596,608 (GRCm39) missense probably damaging 0.97
IGL01601:Dock2 APN 11 34,189,528 (GRCm39) critical splice donor site probably null
IGL01800:Dock2 APN 11 34,647,100 (GRCm39) missense probably damaging 1.00
IGL01804:Dock2 APN 11 34,212,433 (GRCm39) missense probably benign 0.01
IGL01823:Dock2 APN 11 34,212,391 (GRCm39) missense probably damaging 1.00
IGL01829:Dock2 APN 11 34,596,668 (GRCm39) missense probably damaging 0.98
IGL01830:Dock2 APN 11 34,582,744 (GRCm39) nonsense probably null
IGL01835:Dock2 APN 11 34,260,435 (GRCm39) missense possibly damaging 0.51
IGL01845:Dock2 APN 11 34,599,692 (GRCm39) missense probably benign 0.02
IGL01953:Dock2 APN 11 34,623,183 (GRCm39) missense probably benign 0.28
IGL01989:Dock2 APN 11 34,218,053 (GRCm39) missense probably benign
IGL02081:Dock2 APN 11 34,204,355 (GRCm39) missense probably benign
IGL02105:Dock2 APN 11 34,605,352 (GRCm39) missense probably damaging 1.00
IGL02153:Dock2 APN 11 34,180,670 (GRCm39) missense probably benign 0.01
IGL02170:Dock2 APN 11 34,217,949 (GRCm39) missense probably damaging 1.00
IGL02344:Dock2 APN 11 34,622,337 (GRCm39) missense probably damaging 0.98
IGL02389:Dock2 APN 11 34,589,567 (GRCm39) splice site probably benign
IGL02409:Dock2 APN 11 34,451,204 (GRCm39) missense probably benign 0.00
IGL02472:Dock2 APN 11 34,199,801 (GRCm39) missense probably benign 0.00
IGL02625:Dock2 APN 11 34,451,168 (GRCm39) critical splice donor site probably null
IGL02929:Dock2 APN 11 34,218,048 (GRCm39) missense probably damaging 1.00
IGL02951:Dock2 APN 11 34,260,448 (GRCm39) unclassified probably benign
IGL02999:Dock2 APN 11 34,583,086 (GRCm39) missense probably damaging 0.99
IGL03165:Dock2 APN 11 34,578,360 (GRCm39) missense probably damaging 0.99
Arches UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
capitol_reef UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
Croesus UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
denali UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
dew UTSW 11 34,198,636 (GRCm39) nonsense probably null
Dinghy UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
Dry UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
frazz UTSW 11 34,198,572 (GRCm39) critical splice donor site probably benign
frizz UTSW 11 34,208,184 (GRCm39) splice site probably benign
gildenstern UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
godsgrace UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
Harborside UTSW 11 34,212,445 (GRCm39) missense probably benign
Landing UTSW 11 34,605,328 (GRCm39) missense possibly damaging 0.83
latest UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
Launch UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
liaoning UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
lucre UTSW 11 34,595,436 (GRCm39) frame shift probably null
midas UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
muelle UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
narrowest UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
pier UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
Plank UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
resplendent UTSW 11 34,618,287 (GRCm39) nonsense probably null
riches UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
skiff UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
Slip UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
toothskin UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
Touch UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
wassup UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
Wharf UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
BB009:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
BB019:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
IGL03052:Dock2 UTSW 11 34,182,853 (GRCm39) missense probably benign 0.01
PIT4377001:Dock2 UTSW 11 34,611,835 (GRCm39) missense probably benign 0.02
R0006:Dock2 UTSW 11 34,262,453 (GRCm39) unclassified probably benign
R0012:Dock2 UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0116:Dock2 UTSW 11 34,579,392 (GRCm39) intron probably benign
R0149:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0361:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0462:Dock2 UTSW 11 34,218,052 (GRCm39) missense possibly damaging 0.74
R0471:Dock2 UTSW 11 34,579,380 (GRCm39) missense probably benign 0.30
R0538:Dock2 UTSW 11 34,595,545 (GRCm39) splice site probably benign
R0543:Dock2 UTSW 11 34,244,325 (GRCm39) missense probably damaging 1.00
R0660:Dock2 UTSW 11 34,198,621 (GRCm39) missense probably damaging 1.00
R0676:Dock2 UTSW 11 34,586,063 (GRCm39) missense probably damaging 0.99
R0722:Dock2 UTSW 11 34,414,970 (GRCm39) splice site probably benign
R0801:Dock2 UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
R1110:Dock2 UTSW 11 34,206,535 (GRCm39) missense possibly damaging 0.78
R1171:Dock2 UTSW 11 34,586,068 (GRCm39) missense probably damaging 1.00
R1387:Dock2 UTSW 11 34,223,309 (GRCm39) splice site probably benign
R1445:Dock2 UTSW 11 34,189,705 (GRCm39) missense probably benign
R1494:Dock2 UTSW 11 34,232,761 (GRCm39) nonsense probably null
R1589:Dock2 UTSW 11 34,597,288 (GRCm39) missense probably damaging 0.99
R1597:Dock2 UTSW 11 34,595,474 (GRCm39) missense probably benign 0.00
R1629:Dock2 UTSW 11 34,212,480 (GRCm39) splice site probably null
R1749:Dock2 UTSW 11 34,182,767 (GRCm39) critical splice donor site probably null
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1899:Dock2 UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
R1924:Dock2 UTSW 11 34,414,934 (GRCm39) missense possibly damaging 0.69
R2031:Dock2 UTSW 11 34,618,297 (GRCm39) splice site probably benign
R2045:Dock2 UTSW 11 34,244,106 (GRCm39) splice site probably null
R2098:Dock2 UTSW 11 34,609,832 (GRCm39) missense probably damaging 0.99
R2098:Dock2 UTSW 11 34,216,279 (GRCm39) missense probably benign 0.16
R2129:Dock2 UTSW 11 34,618,242 (GRCm39) missense probably damaging 1.00
R2147:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2149:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2150:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2176:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R2230:Dock2 UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
R2508:Dock2 UTSW 11 34,262,485 (GRCm39) missense probably benign 0.04
R2875:Dock2 UTSW 11 34,609,712 (GRCm39) missense probably damaging 1.00
R2885:Dock2 UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
R2910:Dock2 UTSW 11 34,182,910 (GRCm39) splice site probably benign
R3081:Dock2 UTSW 11 34,181,610 (GRCm39) missense probably benign
R3418:Dock2 UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
R3552:Dock2 UTSW 11 34,611,787 (GRCm39) missense probably benign 0.22
R3731:Dock2 UTSW 11 34,599,722 (GRCm39) missense probably damaging 1.00
R3846:Dock2 UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
R4598:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4599:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4715:Dock2 UTSW 11 34,244,118 (GRCm39) missense probably damaging 1.00
R4722:Dock2 UTSW 11 34,586,298 (GRCm39) missense probably damaging 1.00
R4742:Dock2 UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
R4830:Dock2 UTSW 11 34,223,767 (GRCm39) splice site probably null
R4884:Dock2 UTSW 11 34,216,248 (GRCm39) missense probably damaging 1.00
R4990:Dock2 UTSW 11 34,586,078 (GRCm39) missense probably damaging 1.00
R5334:Dock2 UTSW 11 34,178,643 (GRCm39) missense probably benign 0.00
R5570:Dock2 UTSW 11 34,618,233 (GRCm39) missense probably damaging 1.00
R5602:Dock2 UTSW 11 34,204,391 (GRCm39) missense probably benign 0.16
R5681:Dock2 UTSW 11 34,199,836 (GRCm39) missense probably benign 0.06
R5809:Dock2 UTSW 11 34,212,445 (GRCm39) missense probably benign
R5860:Dock2 UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
R6111:Dock2 UTSW 11 34,599,614 (GRCm39) missense probably damaging 0.99
R6155:Dock2 UTSW 11 34,244,123 (GRCm39) missense probably benign 0.06
R6156:Dock2 UTSW 11 34,197,789 (GRCm39) missense possibly damaging 0.51
R6173:Dock2 UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
R6182:Dock2 UTSW 11 34,179,476 (GRCm39) missense probably damaging 0.97
R6188:Dock2 UTSW 11 34,453,396 (GRCm39) missense probably damaging 0.98
R6191:Dock2 UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
R6283:Dock2 UTSW 11 34,598,152 (GRCm39) missense probably damaging 0.99
R6395:Dock2 UTSW 11 34,182,874 (GRCm39) missense probably damaging 1.00
R6465:Dock2 UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
R6500:Dock2 UTSW 11 34,312,822 (GRCm39) missense possibly damaging 0.76
R6561:Dock2 UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,670 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,669 (GRCm39) missense probably damaging 1.00
R6880:Dock2 UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
R6913:Dock2 UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
R6997:Dock2 UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
R7057:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R7057:Dock2 UTSW 11 34,177,684 (GRCm39) missense probably benign 0.10
R7134:Dock2 UTSW 11 34,260,363 (GRCm39) missense probably benign 0.03
R7188:Dock2 UTSW 11 34,189,675 (GRCm39) missense possibly damaging 0.87
R7239:Dock2 UTSW 11 34,181,677 (GRCm39) missense probably benign 0.00
R7247:Dock2 UTSW 11 34,605,340 (GRCm39) nonsense probably null
R7250:Dock2 UTSW 11 34,586,120 (GRCm39) missense probably damaging 1.00
R7250:Dock2 UTSW 11 34,586,032 (GRCm39) missense probably benign 0.01
R7271:Dock2 UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
R7284:Dock2 UTSW 11 34,180,672 (GRCm39) missense probably benign 0.01
R7397:Dock2 UTSW 11 34,609,816 (GRCm39) missense probably benign 0.00
R7464:Dock2 UTSW 11 34,586,105 (GRCm39) missense probably damaging 0.99
R7512:Dock2 UTSW 11 34,262,542 (GRCm39) missense possibly damaging 0.95
R7556:Dock2 UTSW 11 34,611,778 (GRCm39) missense probably benign 0.43
R7663:Dock2 UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
R7779:Dock2 UTSW 11 34,605,282 (GRCm39) missense probably benign 0.38
R7797:Dock2 UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
R7855:Dock2 UTSW 11 34,223,698 (GRCm39) missense probably damaging 1.00
R7922:Dock2 UTSW 11 34,598,154 (GRCm39) missense probably benign 0.29
R7932:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
R8013:Dock2 UTSW 11 34,596,677 (GRCm39) missense probably damaging 0.96
R8192:Dock2 UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
R8244:Dock2 UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
R8307:Dock2 UTSW 11 34,260,362 (GRCm39) missense possibly damaging 0.95
R8418:Dock2 UTSW 11 34,609,795 (GRCm39) missense probably benign 0.01
R8460:Dock2 UTSW 11 34,180,825 (GRCm39) critical splice acceptor site probably null
R8495:Dock2 UTSW 11 34,181,622 (GRCm39) missense probably benign 0.14
R8556:Dock2 UTSW 11 34,212,457 (GRCm39) missense possibly damaging 0.84
R8690:Dock2 UTSW 11 34,618,287 (GRCm39) nonsense probably null
R8743:Dock2 UTSW 11 34,223,252 (GRCm39) nonsense probably null
R8757:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8759:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8793:Dock2 UTSW 11 34,451,215 (GRCm39) missense probably benign 0.00
R8882:Dock2 UTSW 11 34,595,436 (GRCm39) frame shift probably null
R8885:Dock2 UTSW 11 34,260,396 (GRCm39) missense probably benign 0.01
R8943:Dock2 UTSW 11 34,599,646 (GRCm39) missense possibly damaging 0.63
R9171:Dock2 UTSW 11 34,589,670 (GRCm39) missense probably benign 0.12
R9182:Dock2 UTSW 11 34,260,398 (GRCm39) missense possibly damaging 0.51
R9203:Dock2 UTSW 11 34,622,366 (GRCm39) missense possibly damaging 0.92
R9310:Dock2 UTSW 11 34,244,139 (GRCm39) missense possibly damaging 0.71
R9388:Dock2 UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
R9490:Dock2 UTSW 11 34,589,582 (GRCm39) missense possibly damaging 0.90
R9568:Dock2 UTSW 11 34,599,638 (GRCm39) missense possibly damaging 0.83
R9593:Dock2 UTSW 11 34,178,607 (GRCm39) missense probably benign 0.34
R9694:Dock2 UTSW 11 34,218,054 (GRCm39) missense probably benign
R9697:Dock2 UTSW 11 34,204,417 (GRCm39) missense probably benign
R9753:Dock2 UTSW 11 34,223,673 (GRCm39) missense possibly damaging 0.68
R9783:Dock2 UTSW 11 34,208,128 (GRCm39) missense possibly damaging 0.83
X0017:Dock2 UTSW 11 34,216,271 (GRCm39) missense probably benign 0.08
X0018:Dock2 UTSW 11 34,182,833 (GRCm39) missense possibly damaging 0.65
X0058:Dock2 UTSW 11 34,206,564 (GRCm39) missense probably damaging 1.00
X0066:Dock2 UTSW 11 34,260,357 (GRCm39) missense possibly damaging 0.95
Z1088:Dock2 UTSW 11 34,583,209 (GRCm39) missense probably damaging 1.00
Z1088:Dock2 UTSW 11 34,388,300 (GRCm39) missense probably benign 0.14
Z1088:Dock2 UTSW 11 34,586,039 (GRCm39) nonsense probably null
Z1176:Dock2 UTSW 11 34,609,751 (GRCm39) missense probably benign 0.04
Z1177:Dock2 UTSW 11 34,262,553 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- ACACACCATGCTTCTGTGAGC -3'
(R):5'- AACTTGTCTTTCAGAGGGAAGG -3'

Sequencing Primer
(F):5'- GCTTCTGTGAGCAATGAATCC -3'
(R):5'- CAGAGGGAAGGGATATATTTTTCAC -3'
Posted On 2015-05-14