Incidental Mutation 'R3976:Fignl2'
ID 312662
Institutional Source Beutler Lab
Gene Symbol Fignl2
Ensembl Gene ENSMUSG00000095440
Gene Name fidgetin-like 2
Synonyms
MMRRC Submission 040842-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R3976 (G1)
Quality Score 97
Status Validated
Chromosome 15
Chromosomal Location 100948075-100976448 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 100950467 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 605 (L605P)
Ref Sequence ENSEMBL: ENSMUSP00000150618 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178140] [ENSMUST00000213610]
AlphaFold J3QK54
Predicted Effect unknown
Transcript: ENSMUST00000178140
AA Change: L605P
SMART Domains Protein: ENSMUSP00000137256
Gene: ENSMUSG00000095440
AA Change: L605P

DomainStartEndE-ValueType
low complexity region 94 105 N/A INTRINSIC
low complexity region 112 135 N/A INTRINSIC
low complexity region 152 201 N/A INTRINSIC
low complexity region 203 255 N/A INTRINSIC
low complexity region 267 296 N/A INTRINSIC
low complexity region 310 329 N/A INTRINSIC
low complexity region 394 412 N/A INTRINSIC
AAA 419 550 3.31e-8 SMART
Predicted Effect unknown
Transcript: ENSMUST00000213610
AA Change: L605P
Meta Mutation Damage Score 0.0583 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,039,615 (GRCm39) D466G probably benign Het
Asb4 A T 6: 5,390,771 (GRCm39) M55L probably benign Het
Atxn7l1 T C 12: 33,375,954 (GRCm39) S10P probably damaging Het
Bola3 T C 6: 83,328,249 (GRCm39) L45P probably benign Het
Cacna2d4 A G 6: 119,255,134 (GRCm39) probably null Het
Cfap54 A G 10: 92,675,333 (GRCm39) S2863P possibly damaging Het
Cyb5r3 A G 15: 83,044,330 (GRCm39) V180A possibly damaging Het
Dglucy A T 12: 100,807,648 (GRCm39) T186S probably benign Het
Eml5 A T 12: 98,768,724 (GRCm39) probably benign Het
Fam90a1a G A 8: 22,451,432 (GRCm39) D98N probably damaging Het
Fbxo16 T A 14: 65,524,606 (GRCm39) L42Q probably damaging Het
Fbxw16 A G 9: 109,268,697 (GRCm39) V231A probably benign Het
Fermt3 G A 19: 6,979,792 (GRCm39) A447V possibly damaging Het
Gcsam T G 16: 45,440,192 (GRCm39) N78K probably damaging Het
Gdf2 T A 14: 33,666,791 (GRCm39) V171D probably damaging Het
Gm28042 C T 2: 119,867,237 (GRCm39) H218Y probably benign Het
Herpud2 A G 9: 25,021,734 (GRCm39) V304A probably damaging Het
Kcnma1 C T 14: 24,053,815 (GRCm39) probably null Het
Lrp3 T C 7: 34,903,530 (GRCm39) D251G probably benign Het
Mapkbp1 T C 2: 119,852,339 (GRCm39) V957A possibly damaging Het
Mepe C T 5: 104,484,944 (GRCm39) P28L probably benign Het
Muc2 T A 7: 141,300,541 (GRCm39) probably benign Het
Nt5dc2 T C 14: 30,860,832 (GRCm39) S439P probably damaging Het
Opn4 C T 14: 34,319,066 (GRCm39) R173H probably benign Het
Or2k2 A G 4: 58,785,164 (GRCm39) L186P probably damaging Het
Or4f14 C T 2: 111,742,951 (GRCm39) G108D possibly damaging Het
Phf8-ps A T 17: 33,285,405 (GRCm39) S466T probably benign Het
Ppp1r12a T C 10: 108,089,341 (GRCm39) V660A probably benign Het
Prdm6 T C 18: 53,673,278 (GRCm39) I186T possibly damaging Het
Rab18 T A 18: 6,778,529 (GRCm39) D53E probably benign Het
Rel A G 11: 23,692,939 (GRCm39) S365P probably benign Het
Rhbg C A 3: 88,151,843 (GRCm39) G383V probably damaging Het
Rnps1-ps A T 6: 7,983,149 (GRCm39) noncoding transcript Het
Rp1l1 T A 14: 64,267,758 (GRCm39) Y1115N probably damaging Het
Runx2 T C 17: 44,920,966 (GRCm39) T339A possibly damaging Het
Ryr3 T C 2: 112,506,182 (GRCm39) E3455G possibly damaging Het
Serpina1d A T 12: 103,734,107 (GRCm39) S66T probably benign Het
Setd3 T C 12: 108,131,417 (GRCm39) K3R possibly damaging Het
Spg7 A G 8: 123,806,187 (GRCm39) D299G probably damaging Het
Sptbn5 C T 2: 119,878,742 (GRCm39) noncoding transcript Het
Srcap A G 7: 127,148,411 (GRCm39) T1859A probably benign Het
Suox A G 10: 128,506,906 (GRCm39) V374A probably damaging Het
Tesk1 C T 4: 43,445,786 (GRCm39) P280S possibly damaging Het
Tsc22d1 T C 14: 76,656,049 (GRCm39) S761P probably damaging Het
Tubal3 C T 13: 3,982,946 (GRCm39) S242L probably benign Het
Ugt2b1 C A 5: 87,065,534 (GRCm39) V502L probably benign Het
Other mutations in Fignl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0068:Fignl2 UTSW 15 100,952,129 (GRCm39) missense probably damaging 1.00
R0068:Fignl2 UTSW 15 100,952,129 (GRCm39) missense probably damaging 1.00
R0375:Fignl2 UTSW 15 100,951,974 (GRCm39) missense probably benign 0.06
R1616:Fignl2 UTSW 15 100,951,997 (GRCm39) missense probably damaging 0.96
R2240:Fignl2 UTSW 15 100,951,916 (GRCm39) missense probably damaging 1.00
R3440:Fignl2 UTSW 15 100,951,004 (GRCm39) missense unknown
R4418:Fignl2 UTSW 15 100,951,830 (GRCm39) missense possibly damaging 0.84
R5869:Fignl2 UTSW 15 100,951,161 (GRCm39) missense unknown
R6249:Fignl2 UTSW 15 100,952,060 (GRCm39) missense possibly damaging 0.49
R6894:Fignl2 UTSW 15 100,951,854 (GRCm39) missense probably benign 0.00
R7302:Fignl2 UTSW 15 100,951,259 (GRCm39) missense unknown
R7323:Fignl2 UTSW 15 100,951,382 (GRCm39) missense unknown
R7548:Fignl2 UTSW 15 100,951,079 (GRCm39) missense unknown
R7558:Fignl2 UTSW 15 100,952,264 (GRCm39) missense probably damaging 1.00
R7776:Fignl2 UTSW 15 100,951,301 (GRCm39) missense unknown
R7782:Fignl2 UTSW 15 100,951,188 (GRCm39) missense unknown
R8708:Fignl2 UTSW 15 100,950,734 (GRCm39) missense unknown
R8936:Fignl2 UTSW 15 100,951,339 (GRCm39) missense unknown
R9328:Fignl2 UTSW 15 100,951,271 (GRCm39) missense unknown
R9393:Fignl2 UTSW 15 100,951,466 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTTGGCCAAAGACATCACCC -3'
(R):5'- CTAGAGGAGGAGCTGCTTTG -3'

Sequencing Primer
(F):5'- CAACTAACGAGTCCAGCT -3'
(R):5'- TCTACTGACCTGCCTGGACG -3'
Posted On 2015-04-30