Incidental Mutation 'R3904:Or2y10'
ID 309111
Institutional Source Beutler Lab
Gene Symbol Or2y10
Ensembl Gene ENSMUSG00000107645
Gene Name olfactory receptor family 2 subfamily Y member 10
Synonyms GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380
MMRRC Submission 040812-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R3904 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49454750-49455685 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49455585 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 279 (I279T)
Ref Sequence ENSEMBL: ENSMUSP00000151039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204300] [ENSMUST00000215360]
AlphaFold Q7TQT5
Predicted Effect possibly damaging
Transcript: ENSMUST00000071426
AA Change: I279T

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071373
Gene: ENSMUSG00000091308
AA Change: I279T

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.4e-47 PFAM
Pfam:7tm_1 41 289 9.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000188518
AA Change: I279T

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000140977
Gene: ENSMUSG00000100997
AA Change: I279T

DomainStartEndE-ValueType
Pfam:7tm_1 41 289 1.5e-31 PFAM
Pfam:7tm_4 139 282 1.4e-39 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204300
AA Change: I279T

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000145428
Gene: ENSMUSG00000107645
AA Change: I279T

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.4e-47 PFAM
Pfam:7tm_1 41 289 9.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215360
AA Change: I279T

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
Meta Mutation Damage Score 0.2707 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A C 3: 137,772,400 (GRCm39) I530L probably benign Het
5930422O12Rik T C 8: 33,919,467 (GRCm39) S96P probably damaging Het
Acot4 A G 12: 84,090,101 (GRCm39) probably null Het
Alms1 A G 6: 85,598,660 (GRCm39) D1631G probably benign Het
Amd1 C T 10: 40,166,453 (GRCm39) R210H probably benign Het
Amt C T 9: 108,174,420 (GRCm39) R62C possibly damaging Het
Anapc1 A G 2: 128,484,439 (GRCm39) F1175S probably damaging Het
Ano4 A G 10: 88,860,867 (GRCm39) F337S probably damaging Het
Bub1 A C 2: 127,663,862 (GRCm39) I207S probably benign Het
Cfap53 T A 18: 74,440,445 (GRCm39) L405M probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Col6a1 C T 10: 76,547,175 (GRCm39) R730H unknown Het
Esp3 A T 17: 40,946,820 (GRCm39) T48S possibly damaging Het
Fmo1 G T 1: 162,661,337 (GRCm39) N315K possibly damaging Het
Fsip2l T C X: 47,930,421 (GRCm39) N649S possibly damaging Het
Impg1 A G 9: 80,252,867 (GRCm39) S438P possibly damaging Het
Jsrp1 T A 10: 80,648,246 (GRCm39) M1L probably benign Het
Klra14-ps T A 6: 130,129,512 (GRCm39) noncoding transcript Het
Mrm3 A G 11: 76,135,112 (GRCm39) M108V probably benign Het
Mtf2 T A 5: 108,228,866 (GRCm39) F61I probably damaging Het
Nat10 A T 2: 103,556,592 (GRCm39) probably benign Het
Or7c70 T G 10: 78,683,132 (GRCm39) I206L probably benign Het
Pcgf5 T C 19: 36,417,495 (GRCm39) I140T probably damaging Het
Pfpl T C 19: 12,407,801 (GRCm39) L684P probably benign Het
Psmd10 T C X: 139,850,052 (GRCm39) *152W probably null Het
Ptpn23 A C 9: 110,218,313 (GRCm39) M600R probably benign Het
Pxmp4 C T 2: 154,429,969 (GRCm39) R140H probably damaging Het
Rnf112 T C 11: 61,341,211 (GRCm39) E410G probably damaging Het
Samd9l T A 6: 3,376,830 (GRCm39) K144* probably null Het
Shld2 A G 14: 33,981,666 (GRCm39) W491R probably damaging Het
Slc46a3 C T 5: 147,823,264 (GRCm39) E193K probably benign Het
Snap23 A C 2: 120,429,815 (GRCm39) D209A possibly damaging Het
Tg C T 15: 66,638,011 (GRCm39) Q656* probably null Het
Tshz2 A G 2: 169,726,307 (GRCm39) Y301C probably damaging Het
Ttn T A 2: 76,670,638 (GRCm39) probably benign Het
Unc80 C T 1: 66,678,455 (GRCm39) Q2011* probably null Het
Vwa3a A G 7: 120,358,099 (GRCm39) T57A probably benign Het
Zfp518a C T 19: 40,903,364 (GRCm39) Q1098* probably null Het
Other mutations in Or2y10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or2y10 APN 11 49,454,747 (GRCm39) utr 5 prime probably benign
IGL01354:Or2y10 APN 11 49,455,024 (GRCm39) missense probably damaging 0.99
R0183:Or2y10 UTSW 11 49,455,675 (GRCm39) missense probably benign 0.14
R0849:Or2y10 UTSW 11 49,455,129 (GRCm39) missense probably damaging 0.99
R3855:Or2y10 UTSW 11 49,454,918 (GRCm39) missense probably damaging 0.98
R4598:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R4599:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R5089:Or2y10 UTSW 11 49,455,240 (GRCm39) missense possibly damaging 0.94
R6029:Or2y10 UTSW 11 49,455,428 (GRCm39) missense possibly damaging 0.94
R6551:Or2y10 UTSW 11 49,454,816 (GRCm39) missense probably benign
R6953:Or2y10 UTSW 11 49,455,117 (GRCm39) missense probably damaging 1.00
R7223:Or2y10 UTSW 11 49,454,925 (GRCm39) missense probably damaging 0.99
R7343:Or2y10 UTSW 11 49,455,329 (GRCm39) missense possibly damaging 0.91
R7725:Or2y10 UTSW 11 49,455,359 (GRCm39) missense probably benign 0.01
R7762:Or2y10 UTSW 11 49,455,588 (GRCm39) missense possibly damaging 0.76
R8881:Or2y10 UTSW 11 49,455,209 (GRCm39) missense probably benign 0.01
R9361:Or2y10 UTSW 11 49,455,303 (GRCm39) missense probably damaging 0.99
R9380:Or2y10 UTSW 11 49,454,904 (GRCm39) missense possibly damaging 0.91
R9421:Or2y10 UTSW 11 49,455,201 (GRCm39) missense probably benign 0.03
R9733:Or2y10 UTSW 11 49,454,961 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGTGCTGAACATCAGGTC -3'
(R):5'- TTTCACCTTCCAGTCAAGACAG -3'

Sequencing Primer
(F):5'- ACATCAGGTCAATGGCTGGTC -3'
(R):5'- CCTTCCAGTCAAGACAGGAGATG -3'
Posted On 2015-04-17