Incidental Mutation 'IGL02691:Naa15'
ID 303769
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # IGL02691
Quality Score
Status
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 51358747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 294 (E294G)
Ref Sequence ENSEMBL: ENSMUSP00000141433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000029303
AA Change: E344G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: E344G

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192197
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192523
Predicted Effect probably damaging
Transcript: ENSMUST00000193266
AA Change: E294G

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: E294G

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 T C 4: 128,655,457 (GRCm39) S40P probably benign Het
Actl9 G T 17: 33,652,092 (GRCm39) V51L probably damaging Het
Adcy6 A T 15: 98,502,185 (GRCm39) F143Y probably damaging Het
Agps A T 2: 75,722,204 (GRCm39) I465F probably benign Het
Armc3 T A 2: 19,240,295 (GRCm39) F17L probably damaging Het
Arsk A C 13: 76,223,069 (GRCm39) M176R probably damaging Het
Asz1 G A 6: 18,076,556 (GRCm39) T212I probably damaging Het
Atp6v1a A G 16: 43,931,982 (GRCm39) I102T probably damaging Het
Bpifb6 T A 2: 153,744,565 (GRCm39) L2Q unknown Het
Cad A G 5: 31,212,638 (GRCm39) Y45C probably damaging Het
Ccdc93 A G 1: 121,414,342 (GRCm39) D451G possibly damaging Het
Cenpj A G 14: 56,789,547 (GRCm39) I834T probably benign Het
Cyp2j12 C T 4: 96,021,231 (GRCm39) probably null Het
Dhx8 G A 11: 101,642,830 (GRCm39) probably benign Het
Dync1i1 A G 6: 5,800,767 (GRCm39) probably benign Het
Ell2 T A 13: 75,904,605 (GRCm39) D99E probably damaging Het
Enpp1 G T 10: 24,587,790 (GRCm39) P34T probably damaging Het
Fras1 T A 5: 96,892,564 (GRCm39) V2888E possibly damaging Het
Gmfg A G 7: 28,144,295 (GRCm39) Y40C probably damaging Het
Gnal T C 18: 67,355,746 (GRCm39) I369T probably damaging Het
Gzmn T C 14: 56,404,370 (GRCm39) T156A probably benign Het
H2-DMb2 A T 17: 34,366,832 (GRCm39) H88L probably benign Het
Ighv7-3 T C 12: 114,117,016 (GRCm39) T49A probably benign Het
Jakmip3 C T 7: 138,628,573 (GRCm39) Q450* probably null Het
Klhl20 A T 1: 160,934,444 (GRCm39) probably benign Het
Klk6 A G 7: 43,477,924 (GRCm39) T99A probably benign Het
Lhx3 A G 2: 26,093,097 (GRCm39) C118R probably damaging Het
Mapkbp1 T C 2: 119,803,655 (GRCm39) probably benign Het
Nfia C T 4: 97,970,045 (GRCm39) Q373* probably null Het
Notch2 C A 3: 98,042,923 (GRCm39) Y1429* probably null Het
Oc90 A G 15: 65,754,410 (GRCm39) S252P probably damaging Het
Or56a3b A G 7: 104,771,338 (GRCm39) I225V probably damaging Het
Or8k37 T C 2: 86,469,182 (GRCm39) Y290C probably damaging Het
Pde3b T A 7: 114,107,320 (GRCm39) probably benign Het
Pdss1 G A 2: 22,805,253 (GRCm39) V211I probably benign Het
Phactr1 G T 13: 43,231,213 (GRCm39) M226I probably benign Het
Phf11c A G 14: 59,622,236 (GRCm39) S259P probably damaging Het
Phf20l1 A G 15: 66,476,713 (GRCm39) N269S probably damaging Het
Piezo1 A G 8: 123,228,688 (GRCm39) V229A possibly damaging Het
Plcb2 T C 2: 118,541,444 (GRCm39) K997R probably benign Het
Ppm1m A T 9: 106,072,568 (GRCm39) V449E probably damaging Het
Ppp1r36dn T C 12: 76,498,073 (GRCm39) noncoding transcript Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Rgs14 A G 13: 55,526,836 (GRCm39) probably null Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Scamp5 G T 9: 57,358,660 (GRCm39) R39S probably damaging Het
Slc5a6 C T 5: 31,199,518 (GRCm39) V15I probably damaging Het
Snx25 A T 8: 46,558,302 (GRCm39) V235E possibly damaging Het
Tdrd1 G T 19: 56,832,284 (GRCm39) E400D probably damaging Het
Tln1 T C 4: 43,539,544 (GRCm39) R1593G probably benign Het
Trdv2-2 T C 14: 54,199,039 (GRCm39) F110L possibly damaging Het
Ush2a A C 1: 188,466,949 (GRCm39) Y2871S probably damaging Het
Vars2 A C 17: 35,971,140 (GRCm39) L592R probably damaging Het
Vipr2 T A 12: 116,099,849 (GRCm39) C239S probably benign Het
Vmn1r200 A T 13: 22,579,428 (GRCm39) D68V probably damaging Het
Vmn1r7 A T 6: 57,001,373 (GRCm39) S296T probably benign Het
Vmn2r95 T C 17: 18,672,120 (GRCm39) I619T probably benign Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL01837:Naa15 APN 3 51,351,369 (GRCm39) nonsense probably null
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R1941:Naa15 UTSW 3 51,363,355 (GRCm39) nonsense probably null
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4591:Naa15 UTSW 3 51,349,345 (GRCm39) missense probably damaging 1.00
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5527:Naa15 UTSW 3 51,349,368 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7797:Naa15 UTSW 3 51,356,031 (GRCm39) missense probably damaging 0.99
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16