Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02476:Mtus2'

294964

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mtus2

Ensembl Gene

ENSMUSG00000029651

Gene Name

microtubule associated tumor suppressor candidate 2

Synonyms

C130038G02Rik, A730013O20Rik, 5730592G18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.174) question?

Stock #

IGL02476

Quality Score

Status

Chromosome

Chromosomal Location

147894130-148252875 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 148014748 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 514 (A514T)

Ref Sequence

ENSEMBL: ENSMUSP00000082694 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085558] [ENSMUST00000129092]

AlphaFold

Q3UHD3

Predicted Effect

probably benign
Transcript: ENSMUST00000085558
AA Change: A514T

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: A514T

Domain	Start	End	E-Value	Type
internal_repeat_1	57	290	2.46e-5	PROSPERO
internal_repeat_1	312	525	2.46e-5	PROSPERO
low complexity region	530	541	N/A	INTRINSIC
low complexity region	802	818	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
low complexity region	893	904	N/A	INTRINSIC
coiled coil region	1029	1080	N/A	INTRINSIC
SCOP:d1fxkc_	1167	1294	3e-4	SMART
low complexity region	1332	1349	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000129092

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149336

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	T	A	1: 74,320,683 (GRCm39)		probably benign	Het
Birc6	A	G	17: 75,003,386 (GRCm39)	E4752G	possibly damaging	Het
Chd1	C	T	17: 15,954,535 (GRCm39)	P468S	probably damaging	Het
Cnot3	A	G	7: 3,661,067 (GRCm39)	D556G	probably benign	Het
Csnk1d	A	G	11: 120,863,338 (GRCm39)	Y201H	probably damaging	Het
Dhtkd1	A	G	2: 5,935,717 (GRCm39)	S132P	possibly damaging	Het
Dhx58	G	T	11: 100,593,090 (GRCm39)	Q206K	probably benign	Het
Dio1	C	A	4: 107,149,574 (GRCm39)	V195F	probably damaging	Het
Dio3	T	C	12: 110,245,916 (GRCm39)	V84A	probably benign	Het
Dnai4	T	A	4: 102,944,545 (GRCm39)	I3L	possibly damaging	Het
Extl3	T	C	14: 65,314,693 (GRCm39)	K163R	probably benign	Het
Fat2	A	T	11: 55,201,950 (GRCm39)	S375T	probably damaging	Het
Fbrs	A	G	7: 127,086,841 (GRCm39)	D73G	probably damaging	Het
Fnip1	A	G	11: 54,390,393 (GRCm39)		probably benign	Het
Frmpd4	A	G	X: 166,280,851 (GRCm39)	V343A	probably damaging	Het
Gcc1	T	C	6: 28,420,468 (GRCm39)	D283G	probably benign	Het
Ghr	T	C	15: 3,349,528 (GRCm39)	D550G	probably damaging	Het
Glycam1	G	A	15: 103,471,307 (GRCm39)		probably benign	Het
Gpatch8	A	G	11: 102,369,417 (GRCm39)	S1374P	probably damaging	Het
Grm1	A	T	10: 10,565,197 (GRCm39)	M1037K	probably benign	Het
Gtpbp3	T	C	8: 71,945,242 (GRCm39)	L438P	probably damaging	Het
Ifi205	G	T	1: 173,842,627 (GRCm39)	N356K	probably damaging	Het
Ifi206	A	G	1: 173,309,132 (GRCm39)	L288P	probably benign	Het
Ift57	T	C	16: 49,584,252 (GRCm39)	V291A	probably benign	Het
Kif13a	A	C	13: 46,938,772 (GRCm39)	C166G	probably damaging	Het
Lypd6	A	G	2: 50,080,740 (GRCm39)	T143A	possibly damaging	Het
Neu2	T	C	1: 87,524,674 (GRCm39)	W220R	probably damaging	Het
Notch3	T	C	17: 32,377,612 (GRCm39)	S155G	possibly damaging	Het
Nrxn2	A	G	19: 6,505,015 (GRCm39)	E286G	probably damaging	Het
Onecut3	A	G	10: 80,349,724 (GRCm39)	E406G	probably benign	Het
Oog2	T	A	4: 143,921,799 (GRCm39)	D236E	probably benign	Het
Pck1	A	G	2: 173,000,075 (GRCm39)	H502R	probably benign	Het
Pld1	A	G	3: 28,102,188 (GRCm39)	Y313C	probably damaging	Het
Rhox3f	A	T	X: 36,763,192 (GRCm39)		probably benign	Het
Rpl34	A	G	3: 130,520,613 (GRCm39)		probably benign	Het
Sema4c	T	C	1: 36,595,031 (GRCm39)	K31E	probably damaging	Het
Septin11	T	C	5: 93,296,443 (GRCm39)		probably null	Het
Slc4a9	T	A	18: 36,668,498 (GRCm39)		probably null	Het
Snrnp200	T	A	2: 127,059,408 (GRCm39)	S434T	probably benign	Het
Snx13	A	T	12: 35,136,940 (GRCm39)	I134F	probably damaging	Het
Syt2	T	C	1: 134,675,369 (GRCm39)	S407P	probably benign	Het
Tbc1d19	T	C	5: 54,046,755 (GRCm39)		probably null	Het
Tbc1d32	G	T	10: 56,074,638 (GRCm39)	Q192K	possibly damaging	Het
Ubr4	T	A	4: 139,148,560 (GRCm39)	C1681*	probably null	Het
Vmn1r43	T	A	6: 89,847,043 (GRCm39)	I148F	possibly damaging	Het
Vwa8	T	C	14: 79,162,781 (GRCm39)	V187A	possibly damaging	Het

Other mutations in Mtus2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01104:Mtus2	APN	5	148,013,819 (GRCm39)	splice site	probably null
IGL01911:Mtus2	APN	5	148,015,030 (GRCm39)	missense	probably benign	0.00
IGL01973:Mtus2	APN	5	148,240,286 (GRCm39)	splice site	probably benign
IGL02452:Mtus2	APN	5	148,014,473 (GRCm39)	missense	probably benign	0.01
IGL02716:Mtus2	APN	5	148,173,120 (GRCm39)	missense	probably benign	0.05
IGL03194:Mtus2	APN	5	148,043,913 (GRCm39)	missense	probably damaging	1.00
rumblado	UTSW	5	148,243,518 (GRCm39)	nonsense	probably null
IGL02991:Mtus2	UTSW	5	148,250,310 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Mtus2	UTSW	5	148,013,515 (GRCm39)	missense	probably benign	0.01
R0101:Mtus2	UTSW	5	148,019,845 (GRCm39)	missense	probably damaging	1.00
R0101:Mtus2	UTSW	5	148,019,845 (GRCm39)	missense	probably damaging	1.00
R0310:Mtus2	UTSW	5	148,043,829 (GRCm39)	missense	probably benign	0.17
R0729:Mtus2	UTSW	5	148,014,097 (GRCm39)	missense	probably benign	0.08
R0968:Mtus2	UTSW	5	148,014,994 (GRCm39)	missense	probably benign	0.09
R1231:Mtus2	UTSW	5	148,014,198 (GRCm39)	missense	probably benign	0.01
R1253:Mtus2	UTSW	5	148,240,380 (GRCm39)	nonsense	probably null
R1556:Mtus2	UTSW	5	148,014,198 (GRCm39)	missense	probably benign	0.01
R1561:Mtus2	UTSW	5	148,013,362 (GRCm39)	missense	probably benign	0.07
R1574:Mtus2	UTSW	5	148,013,362 (GRCm39)	missense	probably benign	0.07
R1750:Mtus2	UTSW	5	148,214,443 (GRCm39)	missense	probably damaging	0.97
R2318:Mtus2	UTSW	5	148,043,892 (GRCm39)	nonsense	probably null
R2327:Mtus2	UTSW	5	148,014,725 (GRCm39)	missense	probably benign	0.00
R3153:Mtus2	UTSW	5	148,019,870 (GRCm39)	missense	probably damaging	1.00
R3154:Mtus2	UTSW	5	148,240,083 (GRCm39)	intron	probably benign
R3158:Mtus2	UTSW	5	148,168,637 (GRCm39)	missense	probably damaging	1.00
R3548:Mtus2	UTSW	5	148,232,316 (GRCm39)	missense	probably damaging	1.00
R3861:Mtus2	UTSW	5	148,250,223 (GRCm39)	missense	probably damaging	1.00
R4395:Mtus2	UTSW	5	148,013,432 (GRCm39)	missense	probably benign	0.17
R4396:Mtus2	UTSW	5	148,140,748 (GRCm39)	missense	possibly damaging	0.81
R4667:Mtus2	UTSW	5	148,235,070 (GRCm39)	missense	possibly damaging	0.64
R4887:Mtus2	UTSW	5	148,013,913 (GRCm39)	nonsense	probably null
R4931:Mtus2	UTSW	5	148,014,226 (GRCm39)	missense	probably benign	0.09
R5097:Mtus2	UTSW	5	148,232,392 (GRCm39)	missense	probably damaging	0.99
R5318:Mtus2	UTSW	5	148,013,382 (GRCm39)	missense	probably benign	0.05
R5372:Mtus2	UTSW	5	148,250,222 (GRCm39)	missense	probably damaging	1.00
R5388:Mtus2	UTSW	5	148,243,518 (GRCm39)	nonsense	probably null
R5622:Mtus2	UTSW	5	148,015,244 (GRCm39)	missense	probably benign	0.09
R6009:Mtus2	UTSW	5	148,243,462 (GRCm39)	missense	probably damaging	1.00
R6379:Mtus2	UTSW	5	148,014,008 (GRCm39)	missense	probably benign	0.00
R6409:Mtus2	UTSW	5	148,014,425 (GRCm39)	missense	probably benign
R6527:Mtus2	UTSW	5	148,214,408 (GRCm39)	critical splice acceptor site	probably null
R6853:Mtus2	UTSW	5	148,043,821 (GRCm39)	missense	probably damaging	1.00
R7001:Mtus2	UTSW	5	148,214,438 (GRCm39)	missense	probably damaging	1.00
R7187:Mtus2	UTSW	5	148,013,515 (GRCm39)	missense	probably benign	0.01
R7276:Mtus2	UTSW	5	148,013,368 (GRCm39)	missense	probably benign
R7594:Mtus2	UTSW	5	148,014,216 (GRCm39)	missense	probably benign	0.44
R7790:Mtus2	UTSW	5	148,014,998 (GRCm39)	missense	probably benign	0.09
R7967:Mtus2	UTSW	5	148,014,656 (GRCm39)	missense	probably benign	0.32
R7987:Mtus2	UTSW	5	148,168,836 (GRCm39)	splice site	probably null
R8112:Mtus2	UTSW	5	148,013,713 (GRCm39)	nonsense	probably null
R8273:Mtus2	UTSW	5	148,043,815 (GRCm39)	missense	probably damaging	1.00
R8527:Mtus2	UTSW	5	148,240,408 (GRCm39)	missense	probably damaging	1.00
R8542:Mtus2	UTSW	5	148,240,408 (GRCm39)	missense	probably damaging	1.00
R8783:Mtus2	UTSW	5	148,019,861 (GRCm39)	missense	probably damaging	1.00
R8805:Mtus2	UTSW	5	148,015,303 (GRCm39)	missense	possibly damaging	0.58
R9204:Mtus2	UTSW	5	148,238,293 (GRCm39)	missense	probably damaging	1.00
R9210:Mtus2	UTSW	5	148,014,124 (GRCm39)	missense	probably benign	0.00
R9261:Mtus2	UTSW	5	148,243,453 (GRCm39)	nonsense	probably null
R9419:Mtus2	UTSW	5	148,243,451 (GRCm39)	missense	probably damaging	1.00
R9477:Mtus2	UTSW	5	148,014,740 (GRCm39)	missense	probably benign
R9483:Mtus2	UTSW	5	148,232,300 (GRCm39)	missense	possibly damaging	0.80
R9563:Mtus2	UTSW	5	148,250,217 (GRCm39)	missense
R9643:Mtus2	UTSW	5	148,014,025 (GRCm39)	missense	probably benign	0.04
R9716:Mtus2	UTSW	5	148,013,464 (GRCm39)	missense	possibly damaging	0.82
R9745:Mtus2	UTSW	5	148,013,311 (GRCm39)	missense	possibly damaging	0.81
X0017:Mtus2	UTSW	5	148,214,410 (GRCm39)	missense	possibly damaging	0.83
X0028:Mtus2	UTSW	5	148,014,128 (GRCm39)	missense	probably benign	0.03
Z1088:Mtus2	UTSW	5	148,240,073 (GRCm39)	intron	probably benign
Z1176:Mtus2	UTSW	5	148,014,068 (GRCm39)	missense	probably benign	0.05
Z1176:Mtus2	UTSW	5	148,013,552 (GRCm39)	missense	probably benign	0.31
Z1177:Mtus2	UTSW	5	148,140,887 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16