Incidental Mutation 'IGL02411:Rsu1'
ID 292318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rsu1
Ensembl Gene ENSMUSG00000026727
Gene Name Ras suppressor protein 1
Synonyms RsuI, rsp-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # IGL02411
Quality Score
Status
Chromosome 2
Chromosomal Location 13081778-13276255 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to G at 13082308 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028059] [ENSMUST00000114791] [ENSMUST00000191959]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000028059
SMART Domains Protein: ENSMUSP00000028059
Gene: ENSMUSG00000026727

DomainStartEndE-ValueType
LRR 39 61 1.12e1 SMART
LRR 62 84 5.26e0 SMART
LRR 85 107 2.17e-1 SMART
LRR 108 132 3.65e1 SMART
LRR 133 155 1.37e1 SMART
LRR 156 177 1.71e1 SMART
LRR_TYP 179 202 8.34e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114791
SMART Domains Protein: ENSMUSP00000110439
Gene: ENSMUSG00000026727

DomainStartEndE-ValueType
Blast:CUB 1 36 6e-13 BLAST
LRR 45 67 5.26e0 SMART
LRR 68 90 2.17e-1 SMART
LRR 91 115 3.65e1 SMART
LRR 116 138 1.37e1 SMART
LRR 139 160 1.71e1 SMART
LRR_TYP 162 185 8.34e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191959
SMART Domains Protein: ENSMUSP00000141763
Gene: ENSMUSG00000026727

DomainStartEndE-ValueType
Blast:CUB 1 36 2e-15 BLAST
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik A G 5: 64,055,459 (GRCm39) E65G probably benign Het
Abcc8 G A 7: 45,756,431 (GRCm39) R1425C probably damaging Het
Adcy3 A T 12: 4,259,407 (GRCm39) probably null Het
AI661453 T G 17: 47,778,263 (GRCm39) probably benign Het
Arhgef10 A T 8: 15,004,819 (GRCm39) Y445F probably benign Het
Atrx G T X: 104,874,587 (GRCm39) S1924R possibly damaging Het
Clca3a1 T C 3: 144,733,763 (GRCm39) T58A possibly damaging Het
Clec1b A G 6: 129,378,804 (GRCm39) Y97C probably damaging Het
Cobll1 A G 2: 64,928,084 (GRCm39) S1080P probably damaging Het
Crb1 C A 1: 139,176,213 (GRCm39) C529F probably damaging Het
Crim1 C T 17: 78,642,763 (GRCm39) R494* probably null Het
Cyp3a25 A T 5: 145,938,257 (GRCm39) probably benign Het
Dntt T A 19: 41,041,424 (GRCm39) probably null Het
Gjb1 T C X: 100,428,611 (GRCm39) C280R probably damaging Het
Glp1r T A 17: 31,143,485 (GRCm39) C174S probably damaging Het
Gm5414 A T 15: 101,536,269 (GRCm39) Y119N probably benign Het
Gm9631 G A 11: 121,834,478 (GRCm39) Het
Gm9796 G T 11: 95,588,756 (GRCm39) noncoding transcript Het
Gm9956 T C 10: 56,621,388 (GRCm39) F17L unknown Het
Il1rap A T 16: 26,529,366 (GRCm39) D396V probably damaging Het
Impa1 T C 3: 10,388,018 (GRCm39) K135E possibly damaging Het
Iqub G A 6: 24,449,810 (GRCm39) A685V probably damaging Het
Jade3 T C X: 20,379,063 (GRCm39) V512A probably benign Het
Kif3a C A 11: 53,461,525 (GRCm39) P57T probably damaging Het
Kndc1 G T 7: 139,501,829 (GRCm39) probably null Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Maged2 G T X: 149,592,755 (GRCm39) D343E probably benign Het
Magi2 T C 5: 19,883,707 (GRCm39) S120P probably damaging Het
Nxph3 A T 11: 95,401,656 (GRCm39) *253R probably null Het
Oog2 A T 4: 143,921,618 (GRCm39) H194L probably damaging Het
Pcbd2 T G 13: 55,880,764 (GRCm39) W7G probably benign Het
Pcdhb14 T G 18: 37,582,823 (GRCm39) L643R possibly damaging Het
Plch1 G T 3: 63,605,177 (GRCm39) probably null Het
Poln G T 5: 34,270,666 (GRCm39) S455* probably null Het
Ppp2r1a T C 17: 21,171,596 (GRCm39) probably benign Het
Serpina10 A T 12: 103,583,202 (GRCm39) M360K possibly damaging Het
Sox30 A T 11: 45,871,951 (GRCm39) K269* probably null Het
Thbs1 T C 2: 117,945,451 (GRCm39) V310A probably benign Het
Tie1 C A 4: 118,343,760 (GRCm39) E61* probably null Het
Tm2d1 G T 4: 98,268,911 (GRCm39) P62Q probably damaging Het
Tpp1 G T 7: 105,398,826 (GRCm39) P201Q probably damaging Het
Trim13 A G 14: 61,842,598 (GRCm39) E205G probably damaging Het
Other mutations in Rsu1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02494:Rsu1 APN 2 13,222,002 (GRCm39) splice site probably null
R0276:Rsu1 UTSW 2 13,174,946 (GRCm39) intron probably benign
R3052:Rsu1 UTSW 2 13,174,946 (GRCm39) intron probably benign
R4598:Rsu1 UTSW 2 13,174,815 (GRCm39) missense probably damaging 1.00
R4599:Rsu1 UTSW 2 13,174,815 (GRCm39) missense probably damaging 1.00
R4797:Rsu1 UTSW 2 13,221,537 (GRCm39) intron probably benign
R5896:Rsu1 UTSW 2 13,229,170 (GRCm39) missense probably damaging 1.00
R7292:Rsu1 UTSW 2 13,174,827 (GRCm39) missense probably damaging 1.00
R7469:Rsu1 UTSW 2 13,082,371 (GRCm39) missense probably benign
R7485:Rsu1 UTSW 2 13,221,686 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16