Incidental Mutation 'IGL02411:Iqub'
ID 292311
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iqub
Ensembl Gene ENSMUSG00000046192
Gene Name IQ motif and ubiquitin domain containing
Synonyms 4932408B21Rik, Trs4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02411
Quality Score
Status
Chromosome 6
Chromosomal Location 24444864-24515066 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24449810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 685 (A685V)
Ref Sequence ENSEMBL: ENSMUSP00000051177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052277]
AlphaFold Q8CDK3
Predicted Effect probably damaging
Transcript: ENSMUST00000052277
AA Change: A685V

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000051177
Gene: ENSMUSG00000046192
AA Change: A685V

DomainStartEndE-ValueType
PDB:2DAF|A 119 216 1e-38 PDB
Blast:UBQ 129 199 3e-26 BLAST
low complexity region 218 229 N/A INTRINSIC
low complexity region 289 306 N/A INTRINSIC
IQ 333 355 1.74e-1 SMART
low complexity region 357 383 N/A INTRINSIC
low complexity region 735 742 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik A G 5: 64,055,459 (GRCm39) E65G probably benign Het
Abcc8 G A 7: 45,756,431 (GRCm39) R1425C probably damaging Het
Adcy3 A T 12: 4,259,407 (GRCm39) probably null Het
AI661453 T G 17: 47,778,263 (GRCm39) probably benign Het
Arhgef10 A T 8: 15,004,819 (GRCm39) Y445F probably benign Het
Atrx G T X: 104,874,587 (GRCm39) S1924R possibly damaging Het
Clca3a1 T C 3: 144,733,763 (GRCm39) T58A possibly damaging Het
Clec1b A G 6: 129,378,804 (GRCm39) Y97C probably damaging Het
Cobll1 A G 2: 64,928,084 (GRCm39) S1080P probably damaging Het
Crb1 C A 1: 139,176,213 (GRCm39) C529F probably damaging Het
Crim1 C T 17: 78,642,763 (GRCm39) R494* probably null Het
Cyp3a25 A T 5: 145,938,257 (GRCm39) probably benign Het
Dntt T A 19: 41,041,424 (GRCm39) probably null Het
Gjb1 T C X: 100,428,611 (GRCm39) C280R probably damaging Het
Glp1r T A 17: 31,143,485 (GRCm39) C174S probably damaging Het
Gm5414 A T 15: 101,536,269 (GRCm39) Y119N probably benign Het
Gm9631 G A 11: 121,834,478 (GRCm39) Het
Gm9796 G T 11: 95,588,756 (GRCm39) noncoding transcript Het
Gm9956 T C 10: 56,621,388 (GRCm39) F17L unknown Het
Il1rap A T 16: 26,529,366 (GRCm39) D396V probably damaging Het
Impa1 T C 3: 10,388,018 (GRCm39) K135E possibly damaging Het
Jade3 T C X: 20,379,063 (GRCm39) V512A probably benign Het
Kif3a C A 11: 53,461,525 (GRCm39) P57T probably damaging Het
Kndc1 G T 7: 139,501,829 (GRCm39) probably null Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Maged2 G T X: 149,592,755 (GRCm39) D343E probably benign Het
Magi2 T C 5: 19,883,707 (GRCm39) S120P probably damaging Het
Nxph3 A T 11: 95,401,656 (GRCm39) *253R probably null Het
Oog2 A T 4: 143,921,618 (GRCm39) H194L probably damaging Het
Pcbd2 T G 13: 55,880,764 (GRCm39) W7G probably benign Het
Pcdhb14 T G 18: 37,582,823 (GRCm39) L643R possibly damaging Het
Plch1 G T 3: 63,605,177 (GRCm39) probably null Het
Poln G T 5: 34,270,666 (GRCm39) S455* probably null Het
Ppp2r1a T C 17: 21,171,596 (GRCm39) probably benign Het
Rsu1 T G 2: 13,082,308 (GRCm39) probably benign Het
Serpina10 A T 12: 103,583,202 (GRCm39) M360K possibly damaging Het
Sox30 A T 11: 45,871,951 (GRCm39) K269* probably null Het
Thbs1 T C 2: 117,945,451 (GRCm39) V310A probably benign Het
Tie1 C A 4: 118,343,760 (GRCm39) E61* probably null Het
Tm2d1 G T 4: 98,268,911 (GRCm39) P62Q probably damaging Het
Tpp1 G T 7: 105,398,826 (GRCm39) P201Q probably damaging Het
Trim13 A G 14: 61,842,598 (GRCm39) E205G probably damaging Het
Other mutations in Iqub
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Iqub APN 6 24,501,005 (GRCm39) splice site probably benign
IGL01447:Iqub APN 6 24,505,627 (GRCm39) missense probably benign 0.01
IGL01621:Iqub APN 6 24,446,211 (GRCm39) missense probably benign 0.45
IGL01702:Iqub APN 6 24,500,312 (GRCm39) missense probably benign 0.13
IGL01917:Iqub APN 6 24,479,318 (GRCm39) missense probably damaging 0.97
IGL02580:Iqub APN 6 24,501,398 (GRCm39) missense probably benign 0.06
IGL02704:Iqub APN 6 24,505,909 (GRCm39) splice site probably benign
IGL02901:Iqub APN 6 24,454,194 (GRCm39) missense probably damaging 1.00
D4043:Iqub UTSW 6 24,505,750 (GRCm39) missense possibly damaging 0.81
R0304:Iqub UTSW 6 24,454,290 (GRCm39) missense probably damaging 0.99
R0391:Iqub UTSW 6 24,446,154 (GRCm39) missense probably benign 0.00
R0453:Iqub UTSW 6 24,450,829 (GRCm39) missense probably damaging 1.00
R0464:Iqub UTSW 6 24,479,262 (GRCm39) nonsense probably null
R0465:Iqub UTSW 6 24,503,783 (GRCm39) missense probably damaging 1.00
R0479:Iqub UTSW 6 24,505,809 (GRCm39) missense probably benign 0.28
R0606:Iqub UTSW 6 24,501,260 (GRCm39) splice site probably benign
R1146:Iqub UTSW 6 24,505,627 (GRCm39) missense possibly damaging 0.89
R1146:Iqub UTSW 6 24,505,627 (GRCm39) missense possibly damaging 0.89
R1238:Iqub UTSW 6 24,505,884 (GRCm39) missense probably benign 0.03
R1452:Iqub UTSW 6 24,491,558 (GRCm39) missense probably benign 0.13
R1927:Iqub UTSW 6 24,491,670 (GRCm39) missense probably benign 0.11
R3195:Iqub UTSW 6 24,462,036 (GRCm39) splice site probably benign
R4438:Iqub UTSW 6 24,505,867 (GRCm39) missense probably benign 0.01
R4577:Iqub UTSW 6 24,501,290 (GRCm39) missense probably damaging 0.99
R4671:Iqub UTSW 6 24,479,183 (GRCm39) missense probably benign 0.00
R4860:Iqub UTSW 6 24,450,841 (GRCm39) missense probably damaging 0.99
R4860:Iqub UTSW 6 24,450,841 (GRCm39) missense probably damaging 0.99
R4906:Iqub UTSW 6 24,501,368 (GRCm39) missense probably damaging 0.99
R5605:Iqub UTSW 6 24,505,620 (GRCm39) missense probably benign
R5772:Iqub UTSW 6 24,454,250 (GRCm39) missense possibly damaging 0.64
R5801:Iqub UTSW 6 24,449,768 (GRCm39) missense probably benign 0.11
R5853:Iqub UTSW 6 24,491,601 (GRCm39) missense probably benign 0.00
R6423:Iqub UTSW 6 24,491,528 (GRCm39) missense probably damaging 0.98
R6475:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6476:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6477:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6701:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6702:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6703:Iqub UTSW 6 24,449,744 (GRCm39) missense probably damaging 1.00
R6860:Iqub UTSW 6 24,505,737 (GRCm39) missense possibly damaging 0.81
R7331:Iqub UTSW 6 24,500,393 (GRCm39) missense possibly damaging 0.73
R7530:Iqub UTSW 6 24,450,622 (GRCm39) missense probably benign 0.00
R7997:Iqub UTSW 6 24,501,413 (GRCm39) missense possibly damaging 0.86
R8050:Iqub UTSW 6 24,503,784 (GRCm39) missense possibly damaging 0.95
R8141:Iqub UTSW 6 24,491,608 (GRCm39) missense probably benign 0.00
R8153:Iqub UTSW 6 24,450,789 (GRCm39) nonsense probably null
R8163:Iqub UTSW 6 24,449,714 (GRCm39) missense probably benign 0.01
R8702:Iqub UTSW 6 24,461,914 (GRCm39) missense probably damaging 1.00
R8824:Iqub UTSW 6 24,479,307 (GRCm39) nonsense probably null
R8899:Iqub UTSW 6 24,505,768 (GRCm39) missense probably benign 0.00
R9075:Iqub UTSW 6 24,446,124 (GRCm39) missense probably damaging 1.00
R9186:Iqub UTSW 6 24,450,766 (GRCm39) missense possibly damaging 0.92
R9240:Iqub UTSW 6 24,505,622 (GRCm39) missense probably benign
R9256:Iqub UTSW 6 24,446,198 (GRCm39) missense possibly damaging 0.92
X0025:Iqub UTSW 6 24,500,383 (GRCm39) missense probably damaging 0.96
Z1088:Iqub UTSW 6 24,500,242 (GRCm39) splice site probably null
Posted On 2015-04-16