Incidental Mutation 'IGL02344:Rnf169'
ID 289223
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf169
Ensembl Gene ENSMUSG00000058761
Gene Name ring finger protein 169
Synonyms 2900057K09Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.155) question?
Stock # IGL02344
Quality Score
Status
Chromosome 7
Chromosomal Location 99569461-99629655 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 99575642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 318 (S318P)
Ref Sequence ENSEMBL: ENSMUSP00000079631 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080817]
AlphaFold E9Q7F2
Predicted Effect probably damaging
Transcript: ENSMUST00000080817
AA Change: S318P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079631
Gene: ENSMUSG00000058761
AA Change: S318P

DomainStartEndE-ValueType
low complexity region 2 27 N/A INTRINSIC
low complexity region 32 46 N/A INTRINSIC
RING 61 96 3.16e-1 SMART
Blast:RING 133 176 7e-8 BLAST
low complexity region 302 314 N/A INTRINSIC
low complexity region 649 661 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI182371 T C 2: 34,979,198 (GRCm39) N167D probably benign Het
AI467606 G T 7: 126,691,691 (GRCm39) A89S probably damaging Het
Atrip T A 9: 108,901,692 (GRCm39) K122* probably null Het
B3glct C T 5: 149,650,313 (GRCm39) R139* probably null Het
Cep135 A G 5: 76,764,668 (GRCm39) T549A probably benign Het
Chd8 T C 14: 52,439,107 (GRCm39) N64S probably damaging Het
Dock2 T C 11: 34,622,337 (GRCm39) I101V probably damaging Het
Ipo5 T C 14: 121,180,191 (GRCm39) probably benign Het
Ly6g5c A G 17: 35,329,723 (GRCm39) T68A possibly damaging Het
Mthfd1l A G 10: 3,998,272 (GRCm39) probably null Het
Nme8 T A 13: 19,858,574 (GRCm39) E88V possibly damaging Het
Ptpn4 A T 1: 119,700,990 (GRCm39) D86E probably damaging Het
Sidt2 T C 9: 45,856,590 (GRCm39) Y493C probably null Het
Speer4c2 C A 5: 15,861,884 (GRCm39) probably benign Het
Tet3 A G 6: 83,380,815 (GRCm39) V451A probably benign Het
Tmc3 A T 7: 83,258,302 (GRCm39) I431L probably benign Het
Trp73 C T 4: 154,146,500 (GRCm39) G420S possibly damaging Het
Vmn2r108 T C 17: 20,689,405 (GRCm39) S517G probably damaging Het
Other mutations in Rnf169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Rnf169 APN 7 99,604,691 (GRCm39) missense probably damaging 1.00
IGL03066:Rnf169 APN 7 99,574,760 (GRCm39) missense possibly damaging 0.85
R0201:Rnf169 UTSW 7 99,575,210 (GRCm39) missense possibly damaging 0.85
R1087:Rnf169 UTSW 7 99,592,204 (GRCm39) missense probably benign 0.01
R1289:Rnf169 UTSW 7 99,574,943 (GRCm39) missense probably benign 0.01
R1476:Rnf169 UTSW 7 99,574,535 (GRCm39) missense possibly damaging 0.72
R1912:Rnf169 UTSW 7 99,575,461 (GRCm39) missense probably damaging 1.00
R1964:Rnf169 UTSW 7 99,574,732 (GRCm39) missense probably damaging 1.00
R2057:Rnf169 UTSW 7 99,574,615 (GRCm39) missense probably damaging 1.00
R2342:Rnf169 UTSW 7 99,574,652 (GRCm39) missense possibly damaging 0.87
R4755:Rnf169 UTSW 7 99,574,930 (GRCm39) missense probably benign 0.01
R4801:Rnf169 UTSW 7 99,575,653 (GRCm39) missense probably damaging 1.00
R4802:Rnf169 UTSW 7 99,575,653 (GRCm39) missense probably damaging 1.00
R5391:Rnf169 UTSW 7 99,584,367 (GRCm39) critical splice donor site probably null
R5395:Rnf169 UTSW 7 99,584,367 (GRCm39) critical splice donor site probably null
R5643:Rnf169 UTSW 7 99,576,338 (GRCm39) missense possibly damaging 0.85
R5817:Rnf169 UTSW 7 99,574,976 (GRCm39) missense probably benign 0.02
R5952:Rnf169 UTSW 7 99,574,840 (GRCm39) missense probably damaging 1.00
R6009:Rnf169 UTSW 7 99,576,330 (GRCm39) missense possibly damaging 0.92
R6453:Rnf169 UTSW 7 99,584,434 (GRCm39) missense probably benign 0.01
R7238:Rnf169 UTSW 7 99,574,954 (GRCm39) missense probably benign 0.10
R7500:Rnf169 UTSW 7 99,629,445 (GRCm39) missense probably damaging 0.99
R8194:Rnf169 UTSW 7 99,575,651 (GRCm39) missense probably damaging 1.00
R9227:Rnf169 UTSW 7 99,574,699 (GRCm39) missense possibly damaging 0.82
R9469:Rnf169 UTSW 7 99,575,567 (GRCm39) missense possibly damaging 0.92
R9548:Rnf169 UTSW 7 99,574,690 (GRCm39) missense probably damaging 1.00
R9729:Rnf169 UTSW 7 99,575,477 (GRCm39) missense probably damaging 1.00
Z1177:Rnf169 UTSW 7 99,575,068 (GRCm39) missense not run
Posted On 2015-04-16