Incidental Mutation 'IGL02229:Iglc2'
ID 285426
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iglc2
Ensembl Gene ENSMUSG00000076937
Gene Name immunoglobulin lambda constant 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL02229
Quality Score
Status
Chromosome 16
Chromosomal Location 19017286-19017602 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19017483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 41 (A41T)
Ref Sequence ENSEMBL: ENSMUSP00000143153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103749] [ENSMUST00000198182]
AlphaFold P01844
Predicted Effect probably benign
Transcript: ENSMUST00000103749
AA Change: A40T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000100464
Gene: ENSMUSG00000076937
AA Change: A40T

DomainStartEndE-ValueType
IGc1 22 95 4.47e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197046
Predicted Effect probably benign
Transcript: ENSMUST00000197969
Predicted Effect probably benign
Transcript: ENSMUST00000198182
AA Change: A41T

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000143153
Gene: ENSMUSG00000076937
AA Change: A41T

DomainStartEndE-ValueType
IGc1 23 96 1.8e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198313
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik A G 5: 64,055,696 (GRCm39) D144G probably damaging Het
Adgrg1 G T 8: 95,730,139 (GRCm39) D114Y probably damaging Het
Ago4 T A 4: 126,405,325 (GRCm39) N416I probably benign Het
Aoc1 C T 6: 48,882,843 (GRCm39) Q240* probably null Het
Atl1 G A 12: 69,972,799 (GRCm39) V40I probably benign Het
Cdh2 T C 18: 16,757,810 (GRCm39) I591V probably benign Het
Cic C A 7: 24,990,375 (GRCm39) Q1959K probably damaging Het
Cmya5 C T 13: 93,229,194 (GRCm39) E1965K possibly damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Cspp1 T C 1: 10,153,781 (GRCm39) S397P probably damaging Het
D130043K22Rik T C 13: 25,059,907 (GRCm39) Y593H probably damaging Het
Dck A G 5: 88,921,964 (GRCm39) Y142C probably damaging Het
Eea1 A T 10: 95,854,046 (GRCm39) E568V probably damaging Het
Gabra3 A G X: 71,544,683 (GRCm39) probably null Het
Gucy2f A G X: 140,962,984 (GRCm39) S342P probably benign Het
Hbb-bh1 T A 7: 103,492,032 (GRCm39) I61F possibly damaging Het
Hook1 T C 4: 95,889,488 (GRCm39) S235P possibly damaging Het
Hoxd12 G A 2: 74,506,278 (GRCm39) R230H probably damaging Het
Il1r1 A G 1: 40,352,518 (GRCm39) K566E probably damaging Het
Kcns3 A T 12: 11,142,093 (GRCm39) M202K probably damaging Het
Krt7 C A 15: 101,325,497 (GRCm39) A442D probably benign Het
Ltk C T 2: 119,589,054 (GRCm39) R200H probably benign Het
Macf1 G T 4: 123,403,619 (GRCm39) D582E probably damaging Het
Mbnl3 A T X: 50,228,218 (GRCm39) Y69N probably damaging Het
Mpp1 T C X: 74,165,034 (GRCm39) probably benign Het
Myo18b A G 5: 113,025,976 (GRCm39) S25P unknown Het
Nsd3 A G 8: 26,200,775 (GRCm39) N1289S probably damaging Het
Or8d1 T A 9: 38,766,712 (GRCm39) M118K possibly damaging Het
Pacs2 A G 12: 113,020,420 (GRCm39) probably benign Het
Rab3gap2 A G 1: 184,991,580 (GRCm39) K689E possibly damaging Het
Sva T A 6: 42,019,156 (GRCm39) C109S probably damaging Het
Taf3 T C 2: 9,957,645 (GRCm39) N174S probably damaging Het
Tbc1d5 A T 17: 51,159,628 (GRCm39) M393K probably damaging Het
Tmem242 A T 17: 5,461,682 (GRCm39) S129T probably benign Het
Ttn A T 2: 76,701,513 (GRCm39) probably benign Het
Other mutations in Iglc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02125:Iglc2 APN 16 19,017,462 (GRCm39) missense probably benign 0.03
IGL02264:Iglc2 APN 16 19,017,397 (GRCm39) missense probably damaging 1.00
R0674:Iglc2 UTSW 16 19,017,591 (GRCm39) missense probably benign 0.29
R5709:Iglc2 UTSW 16 19,017,384 (GRCm39) missense probably benign 0.39
R7394:Iglc2 UTSW 16 19,013,886 (GRCm39) nonsense probably null
R8252:Iglc2 UTSW 16 19,017,520 (GRCm39) nonsense probably null
R9004:Iglc2 UTSW 16 19,017,425 (GRCm39) missense probably benign 0.17
R9121:Iglc2 UTSW 16 19,017,294 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16