Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02216:Zfp846'

284906

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp846

Ensembl Gene

ENSMUSG00000058192

Gene Name

zinc finger protein 846

Synonyms

2210010B09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02216

Quality Score

Status

Chromosome

Chromosomal Location

20492595-20516706 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20499905 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 45 (E45G)

Ref Sequence

ENSEMBL: ENSMUSP00000115945 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060063] [ENSMUST00000115557] [ENSMUST00000140668]

AlphaFold

G3X996

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060063
AA Change: E45G

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000051593
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	74	5.69e-28	SMART
ZnF_C2H2	113	137	1.02e1	SMART
ZnF_C2H2	162	184	8.6e-5	SMART
ZnF_C2H2	190	212	1.3e-4	SMART
ZnF_C2H2	218	240	1.12e-3	SMART
ZnF_C2H2	246	268	5.21e-4	SMART
ZnF_C2H2	274	297	9.58e-3	SMART
ZnF_C2H2	303	325	7.49e-5	SMART
ZnF_C2H2	331	354	2.95e-3	SMART
ZnF_C2H2	360	382	4.47e-3	SMART
ZnF_C2H2	388	410	4.11e-2	SMART
ZnF_C2H2	416	438	1.03e-2	SMART
ZnF_C2H2	444	466	5.21e-4	SMART
ZnF_C2H2	472	494	5.99e-4	SMART
ZnF_C2H2	500	522	1.72e-4	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000115557
AA Change: E45G

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000111219
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	74	5.69e-28	SMART
ZnF_C2H2	113	137	1.02e1	SMART
ZnF_C2H2	162	184	8.6e-5	SMART
ZnF_C2H2	190	212	1.3e-4	SMART
ZnF_C2H2	218	240	1.12e-3	SMART
ZnF_C2H2	246	268	5.21e-4	SMART
ZnF_C2H2	274	297	9.58e-3	SMART
ZnF_C2H2	303	325	7.49e-5	SMART
ZnF_C2H2	331	354	2.95e-3	SMART
ZnF_C2H2	360	382	4.47e-3	SMART
ZnF_C2H2	388	410	4.11e-2	SMART
ZnF_C2H2	416	438	1.03e-2	SMART
ZnF_C2H2	444	466	5.21e-4	SMART
ZnF_C2H2	472	494	5.99e-4	SMART
ZnF_C2H2	500	522	1.72e-4	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000140668
AA Change: E45G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000115945
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	67	1.99e-18	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217655

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930544D05Rik	T	C	11: 70,507,005 (GRCm39)	F48L	possibly damaging	Het
Adamts12	A	G	15: 11,241,571 (GRCm39)	N381S	possibly damaging	Het
Akp3	A	T	1: 87,055,372 (GRCm39)	Q473L	probably damaging	Het
Albfm1	T	C	5: 90,727,438 (GRCm39)		probably benign	Het
Ap5s1	T	A	2: 131,054,887 (GRCm39)		probably benign	Het
Atp10b	T	A	11: 43,150,616 (GRCm39)	L1438Q	probably damaging	Het
B3galt4	G	A	17: 34,169,539 (GRCm39)	P233L	probably damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Cc2d1a	C	A	8: 84,865,942 (GRCm39)	E393*	probably null	Het
Cd209a	G	T	8: 3,795,576 (GRCm39)	T165N	probably damaging	Het
Chid1	T	C	7: 141,076,506 (GRCm39)		probably benign	Het
Cln3	A	T	7: 126,174,514 (GRCm39)		probably null	Het
Cped1	A	T	6: 22,059,944 (GRCm39)	R203S	probably damaging	Het
Dele1	A	T	18: 38,385,913 (GRCm39)	I102F	probably damaging	Het
Dnttip2	G	T	3: 122,069,910 (GRCm39)	W375L	probably benign	Het
Dync1h1	T	C	12: 110,629,436 (GRCm39)	F4280S	probably damaging	Het
Ephb4	A	G	5: 137,370,332 (GRCm39)	D844G	possibly damaging	Het
Fhl2	T	A	1: 43,170,879 (GRCm39)	E145V	probably null	Het
Gne	T	C	4: 44,044,761 (GRCm39)	K458E	probably benign	Het
Grid2	G	T	6: 64,322,650 (GRCm39)	R550L	probably damaging	Het
Klhl1	T	A	14: 96,360,658 (GRCm39)	T731S	probably benign	Het
Kng1	T	A	16: 22,877,283 (GRCm39)	D30E	probably damaging	Het
Kyat1	A	G	2: 30,077,264 (GRCm39)	V158A	probably benign	Het
Mcm8	G	T	2: 132,681,449 (GRCm39)	V642F	probably damaging	Het
Mdn1	C	T	4: 32,739,092 (GRCm39)	H3638Y	probably benign	Het
Neb	T	G	2: 52,116,502 (GRCm39)	T4158P	probably benign	Het
Neo1	T	C	9: 58,824,336 (GRCm39)	I697M	probably damaging	Het
Nfkb1	A	T	3: 135,300,724 (GRCm39)	V614D	probably damaging	Het
Or7e169	G	A	9: 19,757,861 (GRCm39)	S18L	probably damaging	Het
Otog	T	C	7: 45,950,892 (GRCm39)	S2555P	probably damaging	Het
Pkd1l1	T	A	11: 8,784,897 (GRCm39)	R1962S	probably damaging	Het
Plxnb1	A	G	9: 108,929,918 (GRCm39)	Y258C	probably damaging	Het
Pramel12	T	A	4: 143,144,298 (GRCm39)		probably null	Het
Prl3a1	A	G	13: 27,454,127 (GRCm39)	D35G	probably benign	Het
Rag1	A	T	2: 101,473,726 (GRCm39)	V472D	possibly damaging	Het
Rbpj-ps3	G	A	6: 46,506,641 (GRCm39)		probably benign	Het
Rnf112	C	T	11: 61,340,804 (GRCm39)	V472M	probably damaging	Het
Rps18	A	G	17: 34,171,015 (GRCm39)		probably benign	Het
Rptn	T	C	3: 93,303,080 (GRCm39)	S138P	possibly damaging	Het
Sbpl	A	C	17: 24,172,690 (GRCm39)	N76K	probably benign	Het
Sh3bp1	A	T	15: 78,789,364 (GRCm39)	M241L	probably benign	Het
Slc22a17	T	C	14: 55,145,433 (GRCm39)	*198W	probably null	Het
Smc3	C	T	19: 53,610,275 (GRCm39)	R221C	probably damaging	Het
Snai1	A	G	2: 167,380,768 (GRCm39)	E87G	probably benign	Het
Snx22	C	A	9: 65,976,470 (GRCm39)	A49S	probably benign	Het
Tas2r143	A	T	6: 42,377,268 (GRCm39)	R33*	probably null	Het
Try4	A	G	6: 41,281,965 (GRCm39)	I184V	probably benign	Het
Ttn	T	A	2: 76,584,896 (GRCm39)	K20355*	probably null	Het
Ttn	A	G	2: 76,622,069 (GRCm39)	V15491A	probably benign	Het
Tut7	T	C	13: 59,948,237 (GRCm39)	T293A	probably benign	Het
Vmn1r170	A	G	7: 23,305,915 (GRCm39)	T106A	probably damaging	Het
Vmn2r59	A	T	7: 41,661,817 (GRCm39)	V666E	probably damaging	Het
Vsx1	T	C	2: 150,526,495 (GRCm39)	N221S	possibly damaging	Het

Other mutations in Zfp846

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02440:Zfp846	APN	9	20,499,796 (GRCm39)	splice site	probably benign
R0077:Zfp846	UTSW	9	20,505,303 (GRCm39)	missense	probably benign	0.00
R0528:Zfp846	UTSW	9	20,499,224 (GRCm39)	splice site	probably benign
R0675:Zfp846	UTSW	9	20,504,853 (GRCm39)	missense	probably benign
R1116:Zfp846	UTSW	9	20,504,559 (GRCm39)	missense	possibly damaging	0.96
R1439:Zfp846	UTSW	9	20,505,393 (GRCm39)	missense	possibly damaging	0.83
R3803:Zfp846	UTSW	9	20,505,735 (GRCm39)	missense	probably benign
R4586:Zfp846	UTSW	9	20,504,809 (GRCm39)	missense	probably damaging	0.96
R4872:Zfp846	UTSW	9	20,502,111 (GRCm39)	missense	probably benign
R6221:Zfp846	UTSW	9	20,504,591 (GRCm39)	missense	possibly damaging	0.53
R6416:Zfp846	UTSW	9	20,505,016 (GRCm39)	missense	possibly damaging	0.93
R6420:Zfp846	UTSW	9	20,505,007 (GRCm39)	missense	probably damaging	1.00
R6526:Zfp846	UTSW	9	20,505,167 (GRCm39)	missense	probably benign	0.23
R7003:Zfp846	UTSW	9	20,499,188 (GRCm39)	start codon destroyed	probably null	0.99
R7332:Zfp846	UTSW	9	20,505,521 (GRCm39)	missense	probably benign	0.00
R7651:Zfp846	UTSW	9	20,499,808 (GRCm39)	missense	possibly damaging	0.86
R8254:Zfp846	UTSW	9	20,504,587 (GRCm39)	missense	probably benign
R8724:Zfp846	UTSW	9	20,505,352 (GRCm39)	missense	possibly damaging	0.88
R8997:Zfp846	UTSW	9	20,505,726 (GRCm39)	missense	probably benign	0.41
R9045:Zfp846	UTSW	9	20,505,189 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16