Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02178:Or7a35'

283182

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7a35

Ensembl Gene

ENSMUSG00000063216

Gene Name

olfactory receptor family 7 subfamily A member 35

Synonyms

Olfr1351, GA_x6K02T2QGN0-2794907-2793948, MOR139-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.145) question?

Stock #

IGL02178

Quality Score

Status

Chromosome

Chromosomal Location

78853158-78854117 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 78853554 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 133 (Y133H)

Ref Sequence

ENSEMBL: ENSMUSP00000149241 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]

AlphaFold

Q8VGU6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000080730
AA Change: Y133H

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: Y133H

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203906
AA Change: Y133H

SMART Domains

Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: Y133H

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216030
AA Change: Y133H

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219714

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,384,418 (GRCm39)	T516S	possibly damaging	Het
6820408C15Rik	T	C	2: 152,269,921 (GRCm39)		probably benign	Het
Ak5	T	C	3: 152,232,422 (GRCm39)	D331G	probably benign	Het
Ar	A	G	X: 97,349,044 (GRCm39)	D675G	probably damaging	Het
Arhgap23	A	G	11: 97,343,179 (GRCm39)	D276G	probably benign	Het
Arhgef3	C	T	14: 26,987,486 (GRCm39)	R40*	probably null	Het
Atp1b4	G	T	X: 37,421,695 (GRCm39)	R293L	possibly damaging	Het
Borcs8	T	C	8: 70,617,897 (GRCm39)	L85P	probably damaging	Het
Carmil1	T	G	13: 24,278,386 (GRCm39)	K194N	probably damaging	Het
Catsper4	T	A	4: 133,954,637 (GRCm39)	K4N	probably benign	Het
Ccdc30	T	C	4: 119,206,921 (GRCm39)		probably benign	Het
Cd101	A	G	3: 100,901,082 (GRCm39)	S997P	probably damaging	Het
Cdkl5	G	A	X: 159,599,889 (GRCm39)	T792I	probably benign	Het
Cep135	A	G	5: 76,743,321 (GRCm39)	Y185C	probably damaging	Het
Clcn5	A	G	X: 7,052,563 (GRCm39)	Y59H	possibly damaging	Het
Col6a1	A	T	10: 76,546,909 (GRCm39)	I771N	unknown	Het
Crispld1	C	T	1: 17,832,327 (GRCm39)		probably benign	Het
Fbxl13	A	G	5: 21,825,718 (GRCm39)	I128T	possibly damaging	Het
Gga1	T	A	15: 78,776,247 (GRCm39)	M430K	probably benign	Het
Has2	A	G	15: 56,545,456 (GRCm39)	Y49H	probably damaging	Het
Ivd	A	G	2: 118,701,915 (GRCm39)	I116V	probably benign	Het
Krt75	T	C	15: 101,481,226 (GRCm39)	N183D	probably benign	Het
Map3k9	A	T	12: 81,790,611 (GRCm39)	I314N	probably damaging	Het
Map6d1	T	G	16: 20,055,448 (GRCm39)	E129D	probably damaging	Het
Mettl22	T	C	16: 8,296,146 (GRCm39)	V145A	probably benign	Het
Muc5ac	T	A	7: 141,359,184 (GRCm39)		probably benign	Het
Mycbp2	A	G	14: 103,461,802 (GRCm39)	F1416L	probably benign	Het
Nlrc4	T	C	17: 74,753,838 (GRCm39)	I182V	probably damaging	Het
Or5b21	T	A	19: 12,839,907 (GRCm39)	I256N	possibly damaging	Het
Phc3	T	C	3: 30,984,012 (GRCm39)	T668A	possibly damaging	Het
Pheta2	T	A	15: 82,227,527 (GRCm39)	D15E	possibly damaging	Het
Ppp2r2a	T	C	14: 67,260,546 (GRCm39)	Y244C	probably damaging	Het
Prkcq	A	C	2: 11,281,851 (GRCm39)	Y460S	possibly damaging	Het
Prmt8	T	A	6: 127,674,770 (GRCm39)	E286V	probably benign	Het
Ptprb	A	T	10: 116,158,437 (GRCm39)	M503L	probably benign	Het
Ptprq	A	T	10: 107,522,180 (GRCm39)	D590E	probably benign	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rps6kc1	A	T	1: 190,604,033 (GRCm39)	S196R	possibly damaging	Het
Ryr3	A	G	2: 112,656,144 (GRCm39)	Y1951H	probably benign	Het
Sbno1	A	T	5: 124,538,258 (GRCm39)		probably null	Het
Sde2	T	G	1: 180,678,796 (GRCm39)	L20R	possibly damaging	Het
Slco1a5	A	T	6: 142,208,414 (GRCm39)	C81*	probably null	Het
Snx2	A	G	18: 53,332,857 (GRCm39)	E177G	possibly damaging	Het
Spg11	A	T	2: 121,927,783 (GRCm39)	V667D	probably damaging	Het
Tas2r115	T	C	6: 132,714,271 (GRCm39)	T227A	probably benign	Het
Tmed9	A	G	13: 55,741,108 (GRCm39)	H41R	possibly damaging	Het
Vmn1r35	T	G	6: 66,656,086 (GRCm39)	S28R	probably damaging	Het
Vmn2r110	A	C	17: 20,804,706 (GRCm39)		probably null	Het
Vstm2l	T	C	2: 157,777,337 (GRCm39)	Y72H	probably damaging	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Zbtb4	A	T	11: 69,667,255 (GRCm39)	R187*	probably null	Het
Zfp598	A	G	17: 24,896,517 (GRCm39)	D198G	probably damaging	Het
Zp2	G	T	7: 119,732,973 (GRCm39)	A629E	possibly damaging	Het

Other mutations in Or7a35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00913:Or7a35	APN	10	78,854,085 (GRCm39)	missense	probably benign	0.00
IGL01833:Or7a35	APN	10	78,853,770 (GRCm39)	missense	probably benign
IGL02141:Or7a35	APN	10	78,853,555 (GRCm39)	missense	probably damaging	1.00
R1070:Or7a35	UTSW	10	78,853,684 (GRCm39)	missense	probably damaging	0.99
R1631:Or7a35	UTSW	10	78,853,239 (GRCm39)	missense	probably benign	0.00
R1646:Or7a35	UTSW	10	78,853,340 (GRCm39)	nonsense	probably null
R1781:Or7a35	UTSW	10	78,853,159 (GRCm39)	start codon destroyed	probably null	0.89
R2358:Or7a35	UTSW	10	78,854,022 (GRCm39)	missense	probably damaging	1.00
R3161:Or7a35	UTSW	10	78,853,438 (GRCm39)	missense	probably benign
R3162:Or7a35	UTSW	10	78,853,438 (GRCm39)	missense	probably benign
R3162:Or7a35	UTSW	10	78,853,438 (GRCm39)	missense	probably benign
R5874:Or7a35	UTSW	10	78,853,191 (GRCm39)	missense	possibly damaging	0.95
R6382:Or7a35	UTSW	10	78,853,351 (GRCm39)	missense	probably damaging	1.00
R7108:Or7a35	UTSW	10	78,853,483 (GRCm39)	nonsense	probably null
R7567:Or7a35	UTSW	10	78,853,379 (GRCm39)	missense	probably benign	0.04
R7568:Or7a35	UTSW	10	78,853,341 (GRCm39)	missense	probably benign
R7915:Or7a35	UTSW	10	78,853,264 (GRCm39)	missense	probably damaging	1.00
R7936:Or7a35	UTSW	10	78,853,872 (GRCm39)	missense	probably damaging	1.00
R9687:Or7a35	UTSW	10	78,853,843 (GRCm39)	missense	probably damaging	1.00
Z1176:Or7a35	UTSW	10	78,854,039 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16