Incidental Mutation 'IGL02131:Or2j3'
ID 281201
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2j3
Ensembl Gene ENSMUSG00000054940
Gene Name olfactory receptor family 2 subfamily J member 3
Synonyms Olfr137, MOR256-18, GA_x6K02T2PSCP-2749525-2748587
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.432) question?
Stock # IGL02131
Quality Score
Status
Chromosome 17
Chromosomal Location 38615412-38616350 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38615539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 271 (H271L)
Ref Sequence ENSEMBL: ENSMUSP00000150173 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057394] [ENSMUST00000213505]
AlphaFold Q8VFC2
Predicted Effect probably benign
Transcript: ENSMUST00000057394
AA Change: H271L

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000051537
Gene: ENSMUSG00000054940
AA Change: H271L

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 4e-49 PFAM
Pfam:7tm_1 42 291 4.5e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213505
AA Change: H271L

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513D11Rik T A 17: 79,935,084 (GRCm39) probably benign Het
Adamts19 A G 18: 59,185,732 (GRCm39) Y1202C probably damaging Het
Adgrf1 T A 17: 43,614,638 (GRCm39) F241I probably damaging Het
Ankrd11 A T 8: 123,621,149 (GRCm39) I901N probably damaging Het
Anxa8 A T 14: 33,812,588 (GRCm39) D46V possibly damaging Het
Ap4e1 A G 2: 126,903,849 (GRCm39) Y917C probably benign Het
Arhgap40 G A 2: 158,373,859 (GRCm39) probably null Het
Dnah17 A G 11: 117,963,734 (GRCm39) V2513A probably damaging Het
Dnhd1 T C 7: 105,370,009 (GRCm39) L4478P probably damaging Het
Dtx3 T C 10: 127,029,148 (GRCm39) D30G probably damaging Het
Fat2 A G 11: 55,199,868 (GRCm39) Y1069H probably damaging Het
Fbxo21 T A 5: 118,140,155 (GRCm39) N538K possibly damaging Het
Frem1 T C 4: 82,843,091 (GRCm39) T1748A probably benign Het
Kcnh6 T C 11: 105,911,001 (GRCm39) Y466H probably damaging Het
Kif2c G A 4: 117,035,150 (GRCm39) S41L possibly damaging Het
Kir3dl2 T A X: 135,358,462 (GRCm39) H52L possibly damaging Het
Mageb18 A G X: 91,163,655 (GRCm39) C196R possibly damaging Het
Mrpl9 T A 3: 94,352,020 (GRCm39) probably null Het
Nt5c1b A G 12: 10,425,491 (GRCm39) I345V possibly damaging Het
Or10a49 T C 7: 108,467,415 (GRCm39) *315W probably null Het
Or8c11 A G 9: 38,289,203 (GRCm39) T9A probably benign Het
Parp8 T C 13: 117,047,409 (GRCm39) N221S probably benign Het
Plbd1 T C 6: 136,638,681 (GRCm39) probably benign Het
Recql5 C A 11: 115,814,068 (GRCm39) W86L probably benign Het
Rgs6 T C 12: 83,116,269 (GRCm39) S232P probably damaging Het
Rnf182 A G 13: 43,821,818 (GRCm39) H123R probably benign Het
Rtf2 A G 2: 172,308,212 (GRCm39) T204A unknown Het
Sema4d T C 13: 51,856,973 (GRCm39) probably null Het
Septin8 T C 11: 53,428,684 (GRCm39) S408P possibly damaging Het
Serpini1 A G 3: 75,548,011 (GRCm39) N396D probably benign Het
Slc26a2 A C 18: 61,331,884 (GRCm39) F516V possibly damaging Het
Tcf4 A G 18: 69,697,697 (GRCm39) probably benign Het
Trrap G T 5: 144,777,246 (GRCm39) G3045W probably damaging Het
Tspo2 T A 17: 48,756,089 (GRCm39) T91S possibly damaging Het
Ttn T C 2: 76,567,958 (GRCm39) D27645G probably damaging Het
Uba6 G T 5: 86,297,936 (GRCm39) T246K probably benign Het
Vmn2r9 G A 5: 108,991,502 (GRCm39) L620F probably damaging Het
Wwp2 T A 8: 108,278,950 (GRCm39) M136K probably damaging Het
Zranb3 A T 1: 127,920,688 (GRCm39) V412D probably damaging Het
Other mutations in Or2j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03169:Or2j3 APN 17 38,615,992 (GRCm39) missense probably damaging 1.00
IGL03392:Or2j3 APN 17 38,615,786 (GRCm39) missense probably benign 0.02
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0496:Or2j3 UTSW 17 38,615,549 (GRCm39) missense probably damaging 0.99
R0761:Or2j3 UTSW 17 38,616,282 (GRCm39) missense probably benign 0.00
R1126:Or2j3 UTSW 17 38,615,579 (GRCm39) missense probably damaging 0.97
R1835:Or2j3 UTSW 17 38,616,203 (GRCm39) missense probably benign 0.02
R3727:Or2j3 UTSW 17 38,616,310 (GRCm39) missense possibly damaging 0.64
R5556:Or2j3 UTSW 17 38,615,964 (GRCm39) missense possibly damaging 0.71
R5979:Or2j3 UTSW 17 38,616,083 (GRCm39) missense probably benign
R6430:Or2j3 UTSW 17 38,616,249 (GRCm39) missense probably benign 0.04
R6433:Or2j3 UTSW 17 38,616,304 (GRCm39) missense probably damaging 1.00
R7400:Or2j3 UTSW 17 38,616,222 (GRCm39) missense possibly damaging 0.91
R8053:Or2j3 UTSW 17 38,616,101 (GRCm39) missense probably benign
R8199:Or2j3 UTSW 17 38,615,444 (GRCm39) missense probably benign 0.31
R8446:Or2j3 UTSW 17 38,615,638 (GRCm39) missense probably benign 0.01
R8865:Or2j3 UTSW 17 38,615,872 (GRCm39) missense probably damaging 0.97
R9116:Or2j3 UTSW 17 38,615,654 (GRCm39) missense probably benign 0.01
R9756:Or2j3 UTSW 17 38,615,971 (GRCm39) missense probably benign 0.13
Posted On 2015-04-16