Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02122:Zdhhc18'

280693

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc18

Ensembl Gene

ENSMUSG00000037553

Gene Name

zinc finger, DHHC domain containing 18

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.137) question?

Stock #

IGL02122

Quality Score

Status

Chromosome

Chromosomal Location

133331969-133360801 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 133340946 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000081260 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084238]

AlphaFold

Q5Y5T2

Predicted Effect

probably benign
Transcript: ENSMUST00000084238

SMART Domains

Protein: ENSMUSP00000081260
Gene: ENSMUSG00000037553

Domain	Start	End	E-Value	Type
low complexity region	10	60	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
transmembrane domain	110	132	N/A	INTRINSIC
Pfam:zf-DHHC	179	308	1.4e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135999

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138639

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142382

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	C	T	12: 71,217,299 (GRCm39)	T756I	possibly damaging	Het
Abi3bp	T	C	16: 56,507,491 (GRCm39)		probably benign	Het
Adcy5	G	A	16: 35,103,982 (GRCm39)		probably benign	Het
Adcy6	T	A	15: 98,496,763 (GRCm39)	H504L	possibly damaging	Het
Ank2	A	G	3: 126,731,523 (GRCm39)		probably benign	Het
Atxn2	A	G	5: 121,916,093 (GRCm39)	D34G	probably damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Carmil1	T	C	13: 24,220,541 (GRCm39)	E657G	possibly damaging	Het
Cdc25c	T	C	18: 34,877,038 (GRCm39)	I212V	probably benign	Het
Chl1	A	G	6: 103,652,098 (GRCm39)	D338G	probably benign	Het
Cog6	T	C	3: 52,905,763 (GRCm39)	I361V	probably benign	Het
Dip2c	T	C	13: 9,556,695 (GRCm39)	S80P	possibly damaging	Het
Dmrtc2	A	T	7: 24,572,008 (GRCm39)	R34S	possibly damaging	Het
Exph5	A	G	9: 53,284,974 (GRCm39)	N685S	probably benign	Het
Flnc	A	T	6: 29,444,335 (GRCm39)	I684L	possibly damaging	Het
Foxk1	T	A	5: 142,437,184 (GRCm39)		probably benign	Het
Gprc6a	T	C	10: 51,502,819 (GRCm39)	N348S	probably benign	Het
Gspt1	T	C	16: 11,047,080 (GRCm39)	K445R	probably damaging	Het
Hace1	T	C	10: 45,494,700 (GRCm39)	V170A	probably damaging	Het
Hydin	T	C	8: 111,221,047 (GRCm39)	I1481T	possibly damaging	Het
Ighv4-1	A	T	12: 113,912,145 (GRCm39)	L36Q	possibly damaging	Het
Ints1	G	A	5: 139,750,905 (GRCm39)	Q833*	probably null	Het
Myo15a	T	C	11: 60,374,292 (GRCm39)	F96L	probably benign	Het
Myom1	G	T	17: 71,399,132 (GRCm39)	R998L	probably damaging	Het
Nacc2	A	G	2: 25,979,960 (GRCm39)	S159P	probably benign	Het
Or5k15	T	C	16: 58,710,134 (GRCm39)	T150A	probably benign	Het
Or5w10	A	G	2: 87,375,447 (GRCm39)	V147A	probably benign	Het
Or7e177	T	A	9: 20,211,880 (GRCm39)	L128Q	probably damaging	Het
Pbrm1	A	G	14: 30,811,573 (GRCm39)	I1197V	probably damaging	Het
Pde4dip	G	A	3: 97,674,737 (GRCm39)	R60C	probably damaging	Het
Pfkfb4	C	T	9: 108,854,178 (GRCm39)	R351W	probably damaging	Het
Pitpnm1	T	C	19: 4,157,796 (GRCm39)	Y499H	probably damaging	Het
Plekhn1	C	T	4: 156,308,313 (GRCm39)		probably null	Het
Prmt8	A	G	6: 127,667,680 (GRCm39)	Y332H	probably benign	Het
Prpf38a	A	G	4: 108,436,238 (GRCm39)	I25T	possibly damaging	Het
Rpf1	T	C	3: 146,227,022 (GRCm39)	K44E	probably benign	Het
Rusc2	T	C	4: 43,421,685 (GRCm39)	F702L	possibly damaging	Het
Ryr2	A	T	13: 11,756,755 (GRCm39)	I1633K	probably damaging	Het
Slc39a10	G	A	1: 46,857,288 (GRCm39)	A696V	probably damaging	Het
Tkt	T	C	14: 30,293,158 (GRCm39)	V510A	possibly damaging	Het
Tmem106a	C	A	11: 101,481,240 (GRCm39)	N249K	probably damaging	Het
Tmpo	A	T	10: 90,999,998 (GRCm39)	S157T	possibly damaging	Het
Tspan32	A	T	7: 142,569,372 (GRCm39)	I144F	probably damaging	Het
Ufsp2	G	A	8: 46,448,685 (GRCm39)	V429I	probably benign	Het
Unc13c	T	A	9: 73,641,679 (GRCm39)		probably benign	Het
Usp47	A	T	7: 111,706,115 (GRCm39)	K1259M	probably damaging	Het
Zfp507	G	T	7: 35,475,520 (GRCm39)	L898I	probably damaging	Het

Other mutations in Zdhhc18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01100:Zdhhc18	APN	4	133,340,269 (GRCm39)	missense	probably damaging	1.00
IGL01575:Zdhhc18	APN	4	133,341,210 (GRCm39)	missense	probably damaging	1.00
R0316:Zdhhc18	UTSW	4	133,340,966 (GRCm39)	nonsense	probably null
R1398:Zdhhc18	UTSW	4	133,354,608 (GRCm39)	missense	probably benign	0.00
R1764:Zdhhc18	UTSW	4	133,335,987 (GRCm39)	missense	probably benign	0.00
R1912:Zdhhc18	UTSW	4	133,341,171 (GRCm39)	missense	probably damaging	1.00
R2253:Zdhhc18	UTSW	4	133,360,388 (GRCm39)	critical splice donor site	probably null
R2921:Zdhhc18	UTSW	4	133,360,455 (GRCm39)	missense	probably benign	0.00
R2923:Zdhhc18	UTSW	4	133,360,455 (GRCm39)	missense	probably benign	0.00
R4735:Zdhhc18	UTSW	4	133,341,178 (GRCm39)	missense	probably damaging	1.00
R4985:Zdhhc18	UTSW	4	133,340,228 (GRCm39)	splice site	probably null
R6551:Zdhhc18	UTSW	4	133,340,960 (GRCm39)	missense	probably benign	0.03
R7358:Zdhhc18	UTSW	4	133,360,482 (GRCm39)	nonsense	probably null
R7577:Zdhhc18	UTSW	4	133,342,520 (GRCm39)	nonsense	probably null
R8194:Zdhhc18	UTSW	4	133,341,165 (GRCm39)	missense	probably damaging	1.00
R9532:Zdhhc18	UTSW	4	133,342,541 (GRCm39)	missense	possibly damaging	0.92
X0024:Zdhhc18	UTSW	4	133,342,618 (GRCm39)	nonsense	probably null

Posted On

2015-04-16