Incidental Mutation 'IGL01829:Vmn1r77'
| ID |
278902 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r77
|
| Ensembl Gene |
ENSMUSG00000095864 |
| Gene Name |
vomeronasal 1 receptor 77 |
| Synonyms |
Gm6935 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
IGL01829
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11775226-11776146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11775358 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 45
(K45E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164446]
[ENSMUST00000226525]
[ENSMUST00000227320]
[ENSMUST00000228213]
|
| AlphaFold |
E9PY60 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164446
AA Change: K45E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000130869
Gene: ENSMUSG00000095864
AA Change: K45E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
300 |
1.9e-12 |
PFAM |
|
Pfam:V1R
|
35 |
299 |
5.3e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226525
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227320
AA Change: K45E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228213
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bod1l |
A |
G |
5: 41,977,811 (GRCm39) |
S1168P |
probably benign |
Het |
| Csn1s2a |
A |
T |
5: 87,934,569 (GRCm39) |
T173S |
unknown |
Het |
| Dchs1 |
T |
A |
7: 105,404,604 (GRCm39) |
D2646V |
probably damaging |
Het |
| Dennd4a |
C |
T |
9: 64,749,843 (GRCm39) |
R145* |
probably null |
Het |
| Dnah7a |
G |
T |
1: 53,657,227 (GRCm39) |
R850S |
possibly damaging |
Het |
| Dock2 |
T |
C |
11: 34,596,668 (GRCm39) |
D396G |
probably damaging |
Het |
| E2f7 |
A |
G |
10: 110,614,955 (GRCm39) |
Y553C |
probably benign |
Het |
| Elf2 |
A |
G |
3: 51,215,521 (GRCm39) |
M63T |
probably damaging |
Het |
| Hydin |
A |
C |
8: 111,316,154 (GRCm39) |
T4349P |
possibly damaging |
Het |
| Kcnk13 |
T |
A |
12: 100,027,257 (GRCm39) |
|
probably benign |
Het |
| Nr1h5 |
T |
A |
3: 102,856,395 (GRCm39) |
I295L |
probably benign |
Het |
| Or9s23 |
A |
T |
1: 92,501,051 (GRCm39) |
I53F |
probably benign |
Het |
| Ptprk |
A |
G |
10: 28,449,383 (GRCm39) |
H986R |
probably damaging |
Het |
| Rufy1 |
T |
A |
11: 50,307,071 (GRCm39) |
R300* |
probably null |
Het |
| Sfxn4 |
C |
A |
19: 60,847,172 (GRCm39) |
S37I |
probably damaging |
Het |
| Slc12a9 |
A |
T |
5: 137,325,627 (GRCm39) |
|
probably benign |
Het |
| Slc37a1 |
T |
C |
17: 31,541,180 (GRCm39) |
I224T |
possibly damaging |
Het |
| Slc6a6 |
T |
C |
6: 91,712,170 (GRCm39) |
F233S |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,536,927 (GRCm39) |
K4233E |
possibly damaging |
Het |
| Trp53bp1 |
A |
T |
2: 121,046,377 (GRCm39) |
M1141K |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,612,011 (GRCm39) |
D17297G |
probably damaging |
Het |
| Vmn1r12 |
T |
C |
6: 57,136,649 (GRCm39) |
Y205H |
probably damaging |
Het |
| Vmn2r129 |
T |
C |
4: 156,685,614 (GRCm39) |
|
noncoding transcript |
Het |
| Vps13a |
T |
C |
19: 16,596,807 (GRCm39) |
T3104A |
probably benign |
Het |
|
| Other mutations in Vmn1r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,403 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01304:Vmn1r77
|
APN |
7 |
11,775,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01360:Vmn1r77
|
APN |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01714:Vmn1r77
|
APN |
7 |
11,775,277 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02336:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0456:Vmn1r77
|
UTSW |
7 |
11,775,665 (GRCm39) |
nonsense |
probably null |
|
|
R0622:Vmn1r77
|
UTSW |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1244:Vmn1r77
|
UTSW |
7 |
11,775,847 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1696:Vmn1r77
|
UTSW |
7 |
11,775,547 (GRCm39) |
nonsense |
probably null |
|
|
R1836:Vmn1r77
|
UTSW |
7 |
11,775,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1898:Vmn1r77
|
UTSW |
7 |
11,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4533:Vmn1r77
|
UTSW |
7 |
11,775,756 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4668:Vmn1r77
|
UTSW |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5381:Vmn1r77
|
UTSW |
7 |
11,775,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Vmn1r77
|
UTSW |
7 |
11,775,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Vmn1r77
|
UTSW |
7 |
11,775,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7032:Vmn1r77
|
UTSW |
7 |
11,776,017 (GRCm39) |
nonsense |
probably null |
|
|
R7044:Vmn1r77
|
UTSW |
7 |
11,775,761 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7302:Vmn1r77
|
UTSW |
7 |
11,775,983 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7417:Vmn1r77
|
UTSW |
7 |
11,775,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7436:Vmn1r77
|
UTSW |
7 |
11,775,694 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8487:Vmn1r77
|
UTSW |
7 |
11,775,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8862:Vmn1r77
|
UTSW |
7 |
11,776,060 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9614:Vmn1r77
|
UTSW |
7 |
11,775,766 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9753:Vmn1r77
|
UTSW |
7 |
11,775,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,508 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
| Posted On |
2015-04-16 |
Incidental Mutation