Incidental Mutation 'R3500:Lactb2'
ID 273732
Institutional Source Beutler Lab
Gene Symbol Lactb2
Ensembl Gene ENSMUSG00000025937
Gene Name lactamase, beta 2
Synonyms Cgi-83, E430032H21Rik
MMRRC Submission 040663-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R3500 (G1)
Quality Score 184
Status Validated
Chromosome 1
Chromosomal Location 13695069-13730749 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 13730673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000027071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027071]
AlphaFold Q99KR3
Predicted Effect probably null
Transcript: ENSMUST00000027071
AA Change: M1K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027071
Gene: ENSMUSG00000025937
AA Change: M1K

DomainStartEndE-ValueType
Lactamase_B 30 199 6.69e-30 SMART
Meta Mutation Damage Score 0.9573 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.2%
Validation Efficiency 98% (53/54)
MGI Phenotype PHENOTYPE: Male mice homozygous for a null allele exhibit at 40 days of age preceeded by decreased body size, lethargy, enlarged and pale liver and hepatic steatosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amhr2 A G 15: 102,355,501 (GRCm39) D188G probably benign Het
Arl15 G A 13: 114,104,228 (GRCm39) E102K probably damaging Het
Atp10d C T 5: 72,403,066 (GRCm39) R319C probably damaging Het
Cetn4 A T 3: 37,364,109 (GRCm39) F34I probably benign Het
Chd8 G T 14: 52,443,110 (GRCm39) H510N probably benign Het
Chil5 T C 3: 105,925,536 (GRCm39) D157G probably damaging Het
Clcn1 T C 6: 42,269,929 (GRCm39) S251P probably damaging Het
Clstn3 A T 6: 124,408,670 (GRCm39) C881S probably benign Het
Cnot4 G A 6: 35,057,076 (GRCm39) probably benign Het
Copg1 G A 6: 87,872,905 (GRCm39) probably benign Het
Czib C T 4: 107,748,710 (GRCm39) R83W probably damaging Het
Eftud2 A G 11: 102,735,006 (GRCm39) M631T probably damaging Het
Elavl3 A G 9: 21,930,040 (GRCm39) V288A probably damaging Het
Fancb A G X: 163,779,104 (GRCm39) T721A probably damaging Het
Fat2 A G 11: 55,151,342 (GRCm39) F3800S probably damaging Het
Fgd2 T C 17: 29,584,575 (GRCm39) V173A possibly damaging Het
Gabrr1 T C 4: 33,158,184 (GRCm39) probably benign Het
Gata4 C T 14: 63,437,982 (GRCm39) G390S possibly damaging Het
Gm9396 C A 3: 129,862,144 (GRCm39) noncoding transcript Het
Grid2 T C 6: 63,480,383 (GRCm39) S66P probably damaging Het
Hdac9 C A 12: 34,487,352 (GRCm39) M16I probably benign Het
Kmt2c A T 5: 25,504,477 (GRCm39) D3610E probably benign Het
Ldhb T C 6: 142,447,173 (GRCm39) D47G probably damaging Het
Map3k11 A T 19: 5,740,275 (GRCm39) M1L probably benign Het
Mecom C T 3: 30,035,061 (GRCm39) R205H probably damaging Het
Mob1b A G 5: 88,897,479 (GRCm39) D129G probably benign Het
Nbea A G 3: 55,588,431 (GRCm39) V2436A possibly damaging Het
Neb T C 2: 52,215,797 (GRCm39) N170S probably damaging Het
Nedd4l G A 18: 65,345,931 (GRCm39) A848T probably damaging Het
Nr5a1 G A 2: 38,597,952 (GRCm39) R282* probably null Het
Or4c102 A G 2: 88,422,285 (GRCm39) T46A probably damaging Het
Or4c119 C T 2: 88,987,403 (GRCm39) G39R probably damaging Het
Or4d10c A G 19: 12,065,421 (GRCm39) V245A possibly damaging Het
Or4f47 T C 2: 111,972,472 (GRCm39) F61L possibly damaging Het
Or52e2 T C 7: 102,804,297 (GRCm39) Y219C probably damaging Het
Pcdhb19 T A 18: 37,630,532 (GRCm39) L109* probably null Het
Plcg2 A G 8: 118,339,717 (GRCm39) M1043V probably benign Het
Podxl2 T C 6: 88,819,900 (GRCm39) D554G probably damaging Het
Ppp3ca A G 3: 136,587,273 (GRCm39) T252A probably benign Het
Pramel6 A G 2: 87,339,569 (GRCm39) H111R probably damaging Het
Prr19 A G 7: 25,002,692 (GRCm39) E130G probably damaging Het
Rab44 C T 17: 29,357,041 (GRCm39) A57V probably benign Het
Rhbdl3 T C 11: 80,210,531 (GRCm39) F95L probably damaging Het
Sdk1 G T 5: 141,992,371 (GRCm39) probably benign Het
Tas2r122 T A 6: 132,688,523 (GRCm39) K123N probably damaging Het
Tbpl2 C T 2: 23,977,151 (GRCm39) R289Q probably benign Het
Trpm2 A G 10: 77,768,136 (GRCm39) F788L probably benign Het
Ttn G A 2: 76,560,628 (GRCm39) L29258F probably damaging Het
Ttn G T 2: 76,591,509 (GRCm39) F19307L possibly damaging Het
Vmn2r23 T C 6: 123,690,129 (GRCm39) I335T possibly damaging Het
Other mutations in Lactb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Lactb2 APN 1 13,730,598 (GRCm39) missense probably damaging 1.00
IGL00595:Lactb2 APN 1 13,700,350 (GRCm39) missense probably benign 0.05
IGL00730:Lactb2 APN 1 13,717,740 (GRCm39) splice site probably benign
R0371:Lactb2 UTSW 1 13,720,984 (GRCm39) missense possibly damaging 0.69
R0782:Lactb2 UTSW 1 13,717,675 (GRCm39) missense probably benign 0.18
R1670:Lactb2 UTSW 1 13,730,641 (GRCm39) missense probably damaging 0.99
R2324:Lactb2 UTSW 1 13,708,520 (GRCm39) missense probably damaging 1.00
R2418:Lactb2 UTSW 1 13,730,563 (GRCm39) missense possibly damaging 0.93
R4345:Lactb2 UTSW 1 13,730,574 (GRCm39) missense probably damaging 1.00
R4664:Lactb2 UTSW 1 13,717,624 (GRCm39) missense probably damaging 1.00
R4665:Lactb2 UTSW 1 13,717,624 (GRCm39) missense probably damaging 1.00
R4716:Lactb2 UTSW 1 13,708,619 (GRCm39) missense probably damaging 1.00
R5363:Lactb2 UTSW 1 13,700,356 (GRCm39) missense probably benign 0.22
R5658:Lactb2 UTSW 1 13,697,642 (GRCm39) missense probably benign 0.03
R5734:Lactb2 UTSW 1 13,730,611 (GRCm39) missense probably damaging 1.00
R5918:Lactb2 UTSW 1 13,720,954 (GRCm39) missense probably benign 0.32
R6419:Lactb2 UTSW 1 13,708,459 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTCAGACTTGGGAAGCCTG -3'
(R):5'- TAAGATAGTGGCCGCCAATC -3'

Sequencing Primer
(F):5'- TGTCCTCCGCAGAGCTC -3'
(R):5'- TGGCCGCCAATCCGCTC -3'
Posted On 2015-04-02