Mutagenetix > Incidental Mutation

Incidental Mutation 'R3780:4930432E11Rik'

272001

Institutional Source

Beutler Lab

Gene Symbol

4930432E11Rik

Ensembl Gene

ENSMUSG00000046958

Gene Name

RIKEN cDNA 4930432E11 gene

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R3780 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

29255998-29276204 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

G to T at 29260263 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000053635

SMART Domains

Protein: ENSMUSP00000049518
Gene: ENSMUSG00000046958

Domain	Start	End	E-Value	Type
Blast:WD40	43	79	3e-11	BLAST
WD40	131	172	1.97e2	SMART
WD40	175	214	2.24e-2	SMART
Blast:WD40	257	296	4e-15	BLAST
WD40	393	437	1.32e2	SMART
WD40	494	533	2.15e-4	SMART
low complexity region	598	617	N/A	INTRINSIC
low complexity region	1082	1094	N/A	INTRINSIC
low complexity region	1107	1148	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000063585

SMART Domains

Protein: ENSMUSP00000063695
Gene: ENSMUSG00000051976

Domain	Start	End	E-Value	Type
low complexity region	15	28	N/A	INTRINSIC
internal_repeat_1	35	67	3.29e-5	PROSPERO
internal_repeat_1	73	102	3.29e-5	PROSPERO
low complexity region	122	135	N/A	INTRINSIC
coiled coil region	161	182	N/A	INTRINSIC
low complexity region	216	233	N/A	INTRINSIC
low complexity region	239	249	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185541

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

93% (40/43)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam21	C	T	12: 81,606,047 (GRCm39)	V572I	probably damaging	Het
Arhgap32	T	A	9: 32,063,315 (GRCm39)		probably null	Het
Carmil1	A	T	13: 24,321,152 (GRCm39)	I281N	probably damaging	Het
Cdh12	T	A	15: 21,586,063 (GRCm39)		probably null	Het
Cdh20	T	A	1: 109,976,734 (GRCm39)	V133E	probably benign	Het
Cntrob	A	G	11: 69,193,708 (GRCm39)	L814P	probably damaging	Het
Csmd1	T	C	8: 16,252,000 (GRCm39)	N952S	probably damaging	Het
Cspg4	A	G	9: 56,795,517 (GRCm39)	Y1084C	probably damaging	Het
Dlg5	A	G	14: 24,240,378 (GRCm39)		probably benign	Het
Glis2	T	C	16: 4,431,760 (GRCm39)		probably benign	Het
Hif3a	T	C	7: 16,788,638 (GRCm39)	E111G	probably damaging	Het
Kctd4	A	G	14: 76,200,251 (GRCm39)	D74G	probably benign	Het
Kif21b	A	T	1: 136,083,964 (GRCm39)	K737M	probably damaging	Het
Ktn1	G	A	14: 47,943,860 (GRCm39)		probably benign	Het
Lama2	A	T	10: 27,335,335 (GRCm39)	N113K	probably damaging	Het
Ltv1	A	G	10: 13,054,944 (GRCm39)	S409P	probably benign	Het
Mgat4c	A	G	10: 102,224,782 (GRCm39)	E332G	probably benign	Het
Myh6	A	G	14: 55,201,415 (GRCm39)	F95L	probably benign	Het
Ndufa4l2	A	G	10: 127,351,289 (GRCm39)	I27V	probably benign	Het
Npepl1	T	G	2: 173,962,447 (GRCm39)	L371R	probably damaging	Het
Nudt9	A	G	5: 104,194,972 (GRCm39)	T23A	probably benign	Het
Ocrl	G	A	X: 47,027,180 (GRCm39)	V416I	probably benign	Het
Or2g1	T	G	17: 38,106,895 (GRCm39)	C187G	probably damaging	Het
Padi2	C	T	4: 140,645,048 (GRCm39)	T94I	probably benign	Het
Pcca	G	A	14: 122,922,297 (GRCm39)	E353K	probably damaging	Het
Pcdhgb2	T	A	18: 37,824,810 (GRCm39)	N600K	probably damaging	Het
Pex5l	A	G	3: 33,004,993 (GRCm39)	L593P	probably damaging	Het
Rbp2	G	A	9: 98,380,879 (GRCm39)	D62N	probably benign	Het
Rock1	G	T	18: 10,067,575 (GRCm39)	N1319K	probably benign	Het
Ror1	A	C	4: 100,269,314 (GRCm39)	D384A	probably benign	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,229,111 (GRCm39)		probably benign	Het
Sacm1l	A	T	9: 123,381,855 (GRCm39)	E152D	probably benign	Het
Seh1l	T	C	18: 67,908,087 (GRCm39)	V3A	probably benign	Het
Serpinb6d	T	A	13: 33,848,097 (GRCm39)	D20E	probably benign	Het
Serpini1	T	G	3: 75,521,942 (GRCm39)	N144K	probably damaging	Het
Slc22a23	G	A	13: 34,528,323 (GRCm39)	T153I	probably benign	Het
Slfn8	A	G	11: 82,908,280 (GRCm39)	S88P	probably benign	Het
Stpg3	T	A	2: 25,103,875 (GRCm39)	M154L	probably benign	Het
Vmn2r115	G	A	17: 23,564,146 (GRCm39)	C106Y	probably damaging	Het
Washc3	C	T	10: 88,055,122 (GRCm39)	T112M	probably benign	Het
Zfp280d	C	T	9: 72,229,806 (GRCm39)	T346M	probably damaging	Het

Other mutations in 4930432E11Rik

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01121:4930432E11Rik	APN	7	29,273,426 (GRCm39)	unclassified	noncoding transcript
IGL01955:4930432E11Rik	APN	7	29,273,420 (GRCm39)	unclassified	noncoding transcript
IGL01971:4930432E11Rik	APN	7	29,273,987 (GRCm39)	unclassified	noncoding transcript
IGL02132:4930432E11Rik	APN	7	29,262,704 (GRCm39)	unclassified	noncoding transcript
IGL02484:4930432E11Rik	APN	7	29,262,777 (GRCm39)	unclassified	noncoding transcript
P0016:4930432E11Rik	UTSW	7	29,262,537 (GRCm39)	unclassified	noncoding transcript
R0051:4930432E11Rik	UTSW	7	29,278,526 (GRCm39)	exon	noncoding transcript
R0060:4930432E11Rik	UTSW	7	29,273,595 (GRCm39)	unclassified	noncoding transcript
R0094:4930432E11Rik	UTSW	7	29,260,236 (GRCm39)	exon	noncoding transcript
R0268:4930432E11Rik	UTSW	7	29,274,027 (GRCm39)	unclassified	noncoding transcript
R0423:4930432E11Rik	UTSW	7	29,261,825 (GRCm39)	exon	noncoding transcript
R0478:4930432E11Rik	UTSW	7	29,262,014 (GRCm39)	exon	noncoding transcript
R0646:4930432E11Rik	UTSW	7	29,260,710 (GRCm39)	exon	noncoding transcript
R1208:4930432E11Rik	UTSW	7	29,260,708 (GRCm39)	exon	noncoding transcript
R1778:4930432E11Rik	UTSW	7	29,260,131 (GRCm39)	exon	noncoding transcript
R1779:4930432E11Rik	UTSW	7	29,278,591 (GRCm39)	exon	noncoding transcript
R1918:4930432E11Rik	UTSW	7	29,273,514 (GRCm39)	unclassified	noncoding transcript
R2360:4930432E11Rik	UTSW	7	29,274,214 (GRCm39)	unclassified	noncoding transcript
R3736:4930432E11Rik	UTSW	7	29,273,996 (GRCm39)	unclassified	noncoding transcript
R4427:4930432E11Rik	UTSW	7	29,278,678 (GRCm39)	exon	noncoding transcript
R4835:4930432E11Rik	UTSW	7	29,274,326 (GRCm39)	unclassified	noncoding transcript
R4929:4930432E11Rik	UTSW	7	29,273,467 (GRCm39)	unclassified	noncoding transcript
R5042:4930432E11Rik	UTSW	7	29,273,927 (GRCm39)	unclassified	noncoding transcript
R5129:4930432E11Rik	UTSW	7	29,260,786 (GRCm39)	exon	noncoding transcript
R5371:4930432E11Rik	UTSW	7	29,261,918 (GRCm39)	exon	noncoding transcript
R5381:4930432E11Rik	UTSW	7	29,262,393 (GRCm39)	unclassified	noncoding transcript
R5586:4930432E11Rik	UTSW	7	29,277,153 (GRCm39)	unclassified	noncoding transcript
R5874:4930432E11Rik	UTSW	7	29,280,610 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- ATTGTGACGATATGCGCCTGAG -3'
(R):5'- TAGAAGGTGTTCTGTGGCAC -3'

Sequencing Primer
(F):5'- TTTGGAGACCATCACCAGGAGTTC -3'
(R):5'- CACAGCCACAGGAGCAGG -3'

Posted On

2015-03-25