Incidental Mutation 'R3731:Or4n4b'
ID 271006
Institutional Source Beutler Lab
Gene Symbol Or4n4b
Ensembl Gene ENSMUSG00000090874
Gene Name olfactory receptor family 4 subfamily N member 4B
Synonyms Olfr733, GA_x6K02T2PMLR-5992342-5991416, MOR241-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R3731 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50535794-50536787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50535962 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 268 (D268V)
Ref Sequence ENSEMBL: ENSMUSP00000149807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163469] [ENSMUST00000214372] [ENSMUST00000214756] [ENSMUST00000216195]
AlphaFold Q14AK5
Predicted Effect probably damaging
Transcript: ENSMUST00000163469
AA Change: D268V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128332
Gene: ENSMUSG00000090874
AA Change: D268V

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 6.4e-41 PFAM
Pfam:7tm_1 41 288 1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214372
AA Change: D268V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214756
AA Change: D268V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216195
AA Change: D268V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630010A05Rik T A 16: 14,427,485 (GRCm39) probably null Het
Abcc5 A T 16: 20,217,684 (GRCm39) Y5* probably null Het
Acbd6 T A 1: 155,434,471 (GRCm39) S30T probably benign Het
Adar T C 3: 89,653,962 (GRCm39) I325T probably damaging Het
Akap13 T C 7: 75,261,125 (GRCm39) S92P probably benign Het
Atp1a4 A T 1: 172,061,528 (GRCm39) V771E probably damaging Het
Cfh A G 1: 140,047,708 (GRCm39) S492P possibly damaging Het
Crlf1 A G 8: 70,952,092 (GRCm39) T95A probably benign Het
Dennd2d T G 3: 106,407,271 (GRCm39) F441V probably damaging Het
Dhx33 T C 11: 70,879,978 (GRCm39) D344G probably benign Het
Disp3 A G 4: 148,337,284 (GRCm39) S844P probably benign Het
Dock2 T C 11: 34,599,722 (GRCm39) K286E probably damaging Het
Fam228a T C 12: 4,768,671 (GRCm39) E203G probably benign Het
Fbxo38 GTGCTGCTGCTGCTGCTGCTGC GTGCTGCTGCTGCTGCTGC 18: 62,648,399 (GRCm39) probably benign Het
Frmpd4 G A X: 166,269,803 (GRCm39) T493M probably damaging Het
Galnt13 A G 2: 54,823,519 (GRCm39) N365S possibly damaging Het
Hrob A G 11: 102,148,732 (GRCm39) E381G possibly damaging Het
Ighv1-19 C A 12: 114,672,497 (GRCm39) C40F probably damaging Het
Ints4 A G 7: 97,155,308 (GRCm39) Q320R probably benign Het
Kctd5 T C 17: 24,278,212 (GRCm39) D146G probably benign Het
Loxl3 T C 6: 83,027,652 (GRCm39) probably null Het
Lrp2 G A 2: 69,294,923 (GRCm39) P3465L probably damaging Het
Lrp2 A T 2: 69,365,251 (GRCm39) probably null Het
Manba G A 3: 135,260,611 (GRCm39) V599I probably benign Het
Mbd6 A G 10: 127,121,637 (GRCm39) probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Nepn A T 10: 52,280,110 (GRCm39) N401Y probably damaging Het
Nol10 A T 12: 17,474,674 (GRCm39) K622I probably benign Het
Npas3 T C 12: 53,401,175 (GRCm39) I40T probably benign Het
Or1e29 T C 11: 73,667,565 (GRCm39) E196G probably benign Het
Or1j19 A T 2: 36,676,578 (GRCm39) I14F possibly damaging Het
Or2d4 T A 7: 106,543,684 (GRCm39) N175Y probably damaging Het
Or5p73 T C 7: 108,064,633 (GRCm39) I34T possibly damaging Het
Or8g33 T A 9: 39,338,365 (GRCm39) M1L probably benign Het
Phtf1 A G 3: 103,893,095 (GRCm39) M120V probably benign Het
Plxna2 A G 1: 194,471,193 (GRCm39) Y988C probably benign Het
Rgs12 G A 5: 35,189,595 (GRCm39) E658K probably damaging Het
Ripor3 C G 2: 167,834,739 (GRCm39) E251Q probably damaging Het
Sec24b T C 3: 129,827,482 (GRCm39) K203R possibly damaging Het
Serpina1d T A 12: 103,734,164 (GRCm39) N47Y possibly damaging Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sirpb1c T C 3: 15,887,287 (GRCm39) K184R probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Upp2 T C 2: 58,645,379 (GRCm39) S41P probably benign Het
Vmn1r10 A G 6: 57,090,719 (GRCm39) T104A probably damaging Het
Wdhd1 A C 14: 47,485,349 (GRCm39) S838R possibly damaging Het
Zer1 A G 2: 30,000,923 (GRCm39) V166A probably benign Het
Zfp217 T C 2: 169,956,308 (GRCm39) N897D probably benign Het
Zfp960 T A 17: 17,308,633 (GRCm39) L449H probably damaging Het
Other mutations in Or4n4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or4n4b APN 14 50,535,969 (GRCm39) missense probably benign 0.00
IGL02247:Or4n4b APN 14 50,536,571 (GRCm39) missense probably damaging 1.00
IGL02307:Or4n4b APN 14 50,536,295 (GRCm39) missense probably damaging 1.00
IGL02492:Or4n4b APN 14 50,536,060 (GRCm39) missense probably damaging 1.00
PIT4378001:Or4n4b UTSW 14 50,536,355 (GRCm39) missense probably benign
R0544:Or4n4b UTSW 14 50,536,139 (GRCm39) missense probably benign 0.20
R1603:Or4n4b UTSW 14 50,536,491 (GRCm39) missense possibly damaging 0.95
R1881:Or4n4b UTSW 14 50,536,472 (GRCm39) missense probably damaging 1.00
R4271:Or4n4b UTSW 14 50,535,908 (GRCm39) missense probably damaging 1.00
R4512:Or4n4b UTSW 14 50,536,453 (GRCm39) missense probably damaging 1.00
R5601:Or4n4b UTSW 14 50,536,318 (GRCm39) missense probably damaging 1.00
R6468:Or4n4b UTSW 14 50,535,924 (GRCm39) missense probably benign 0.02
R6614:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign 0.00
R7013:Or4n4b UTSW 14 50,536,656 (GRCm39) missense probably damaging 0.99
R7083:Or4n4b UTSW 14 50,536,736 (GRCm39) missense possibly damaging 0.81
R7274:Or4n4b UTSW 14 50,535,879 (GRCm39) missense probably benign 0.01
R7493:Or4n4b UTSW 14 50,536,281 (GRCm39) missense probably benign 0.02
R7653:Or4n4b UTSW 14 50,536,604 (GRCm39) missense possibly damaging 0.82
R7659:Or4n4b UTSW 14 50,536,698 (GRCm39) missense probably benign 0.00
R7885:Or4n4b UTSW 14 50,536,041 (GRCm39) missense probably damaging 1.00
R9138:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign
R9497:Or4n4b UTSW 14 50,536,362 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AATACCATGTCAAATCTTTCCTGCC -3'
(R):5'- CCTTTGCAGTCGAGATCCTTATG -3'

Sequencing Primer
(F):5'- CTGCCTGATTGATTCTTTAAAAACCC -3'
(R):5'- ATGATCTTCAATAGTGGCCTGC -3'
Posted On 2015-03-18