Incidental Mutation 'R3731:Or1j19'
ID 270963
Institutional Source Beutler Lab
Gene Symbol Or1j19
Ensembl Gene ENSMUSG00000049315
Gene Name olfactory receptor family 1 subfamily J member 19
Synonyms GA_x6K02T2NLDC-33481050-33481991, Olfr348, MOR136-8
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R3731 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 36676539-36677480 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36676578 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 14 (I14F)
Ref Sequence ENSEMBL: ENSMUSP00000150343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056865] [ENSMUST00000112950] [ENSMUST00000213498] [ENSMUST00000214909] [ENSMUST00000215199] [ENSMUST00000216753] [ENSMUST00000217041]
AlphaFold Q8VGK3
Predicted Effect possibly damaging
Transcript: ENSMUST00000056865
AA Change: I14F

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000054037
Gene: ENSMUSG00000049315
AA Change: I14F

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 1.3e-56 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3e-6 PFAM
Pfam:7tm_1 42 291 2.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000112950
AA Change: I14F

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108572
Gene: ENSMUSG00000111021
AA Change: I14F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 36 306 3e-6 PFAM
Pfam:7tm_1 42 291 3.5e-34 PFAM
Pfam:7tm_4 140 284 3.9e-40 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213498
AA Change: I14F

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214909
AA Change: I14F

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215199
AA Change: I14F

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000216753
Predicted Effect probably benign
Transcript: ENSMUST00000217041
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630010A05Rik T A 16: 14,427,485 (GRCm39) probably null Het
Abcc5 A T 16: 20,217,684 (GRCm39) Y5* probably null Het
Acbd6 T A 1: 155,434,471 (GRCm39) S30T probably benign Het
Adar T C 3: 89,653,962 (GRCm39) I325T probably damaging Het
Akap13 T C 7: 75,261,125 (GRCm39) S92P probably benign Het
Atp1a4 A T 1: 172,061,528 (GRCm39) V771E probably damaging Het
Cfh A G 1: 140,047,708 (GRCm39) S492P possibly damaging Het
Crlf1 A G 8: 70,952,092 (GRCm39) T95A probably benign Het
Dennd2d T G 3: 106,407,271 (GRCm39) F441V probably damaging Het
Dhx33 T C 11: 70,879,978 (GRCm39) D344G probably benign Het
Disp3 A G 4: 148,337,284 (GRCm39) S844P probably benign Het
Dock2 T C 11: 34,599,722 (GRCm39) K286E probably damaging Het
Fam228a T C 12: 4,768,671 (GRCm39) E203G probably benign Het
Fbxo38 GTGCTGCTGCTGCTGCTGCTGC GTGCTGCTGCTGCTGCTGC 18: 62,648,399 (GRCm39) probably benign Het
Frmpd4 G A X: 166,269,803 (GRCm39) T493M probably damaging Het
Galnt13 A G 2: 54,823,519 (GRCm39) N365S possibly damaging Het
Hrob A G 11: 102,148,732 (GRCm39) E381G possibly damaging Het
Ighv1-19 C A 12: 114,672,497 (GRCm39) C40F probably damaging Het
Ints4 A G 7: 97,155,308 (GRCm39) Q320R probably benign Het
Kctd5 T C 17: 24,278,212 (GRCm39) D146G probably benign Het
Loxl3 T C 6: 83,027,652 (GRCm39) probably null Het
Lrp2 G A 2: 69,294,923 (GRCm39) P3465L probably damaging Het
Lrp2 A T 2: 69,365,251 (GRCm39) probably null Het
Manba G A 3: 135,260,611 (GRCm39) V599I probably benign Het
Mbd6 A G 10: 127,121,637 (GRCm39) probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Nepn A T 10: 52,280,110 (GRCm39) N401Y probably damaging Het
Nol10 A T 12: 17,474,674 (GRCm39) K622I probably benign Het
Npas3 T C 12: 53,401,175 (GRCm39) I40T probably benign Het
Or1e29 T C 11: 73,667,565 (GRCm39) E196G probably benign Het
Or2d4 T A 7: 106,543,684 (GRCm39) N175Y probably damaging Het
Or4n4b T A 14: 50,535,962 (GRCm39) D268V probably damaging Het
Or5p73 T C 7: 108,064,633 (GRCm39) I34T possibly damaging Het
Or8g33 T A 9: 39,338,365 (GRCm39) M1L probably benign Het
Phtf1 A G 3: 103,893,095 (GRCm39) M120V probably benign Het
Plxna2 A G 1: 194,471,193 (GRCm39) Y988C probably benign Het
Rgs12 G A 5: 35,189,595 (GRCm39) E658K probably damaging Het
Ripor3 C G 2: 167,834,739 (GRCm39) E251Q probably damaging Het
Sec24b T C 3: 129,827,482 (GRCm39) K203R possibly damaging Het
Serpina1d T A 12: 103,734,164 (GRCm39) N47Y possibly damaging Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sirpb1c T C 3: 15,887,287 (GRCm39) K184R probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Upp2 T C 2: 58,645,379 (GRCm39) S41P probably benign Het
Vmn1r10 A G 6: 57,090,719 (GRCm39) T104A probably damaging Het
Wdhd1 A C 14: 47,485,349 (GRCm39) S838R possibly damaging Het
Zer1 A G 2: 30,000,923 (GRCm39) V166A probably benign Het
Zfp217 T C 2: 169,956,308 (GRCm39) N897D probably benign Het
Zfp960 T A 17: 17,308,633 (GRCm39) L449H probably damaging Het
Other mutations in Or1j19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or1j19 APN 2 36,677,367 (GRCm39) missense probably benign 0.03
IGL01943:Or1j19 APN 2 36,677,095 (GRCm39) missense probably benign 0.13
IGL02030:Or1j19 APN 2 36,677,410 (GRCm39) missense probably damaging 1.00
IGL02338:Or1j19 APN 2 36,676,557 (GRCm39) nonsense probably null
IGL02349:Or1j19 APN 2 36,677,058 (GRCm39) missense possibly damaging 0.95
IGL02695:Or1j19 APN 2 36,677,332 (GRCm39) missense possibly damaging 0.72
IGL03004:Or1j19 APN 2 36,677,194 (GRCm39) missense probably damaging 1.00
IGL03007:Or1j19 APN 2 36,676,812 (GRCm39) missense probably damaging 0.99
IGL03024:Or1j19 APN 2 36,676,858 (GRCm39) missense possibly damaging 0.55
R0360:Or1j19 UTSW 2 36,677,452 (GRCm39) missense probably benign 0.03
R0388:Or1j19 UTSW 2 36,676,874 (GRCm39) missense probably benign 0.43
R0614:Or1j19 UTSW 2 36,676,705 (GRCm39) missense probably damaging 1.00
R1498:Or1j19 UTSW 2 36,677,358 (GRCm39) missense probably damaging 1.00
R1562:Or1j19 UTSW 2 36,676,696 (GRCm39) missense probably damaging 1.00
R2882:Or1j19 UTSW 2 36,677,202 (GRCm39) missense probably damaging 1.00
R4513:Or1j19 UTSW 2 36,676,782 (GRCm39) missense probably benign 0.05
R4899:Or1j19 UTSW 2 36,676,810 (GRCm39) missense probably benign 0.04
R5005:Or1j19 UTSW 2 36,677,370 (GRCm39) missense probably benign
R5035:Or1j19 UTSW 2 36,676,903 (GRCm39) missense probably damaging 1.00
R5490:Or1j19 UTSW 2 36,677,193 (GRCm39) missense probably damaging 1.00
R6361:Or1j19 UTSW 2 36,676,792 (GRCm39) missense probably damaging 1.00
R7762:Or1j19 UTSW 2 36,677,022 (GRCm39) missense probably benign 0.03
R8109:Or1j19 UTSW 2 36,676,618 (GRCm39) missense probably benign 0.00
R8223:Or1j19 UTSW 2 36,677,409 (GRCm39) missense
R8826:Or1j19 UTSW 2 36,676,855 (GRCm39) nonsense probably null
R8906:Or1j19 UTSW 2 36,676,621 (GRCm39) missense probably benign 0.01
R9138:Or1j19 UTSW 2 36,676,702 (GRCm39) missense probably benign 0.00
R9147:Or1j19 UTSW 2 36,676,938 (GRCm39) missense probably benign 0.01
R9148:Or1j19 UTSW 2 36,676,938 (GRCm39) missense probably benign 0.01
R9267:Or1j19 UTSW 2 36,676,530 (GRCm39) unclassified probably benign
R9306:Or1j19 UTSW 2 36,677,407 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGGTTTCTAAGTCACCAACC -3'
(R):5'- TTTGGAGCTGTGACTGATGAGAAAG -3'

Sequencing Primer
(F):5'- TTCTAAGTCACCAACCTCCATTTAAC -3'
(R):5'- CTGTGACTGATGAGAAAGAGATGTC -3'
Posted On 2015-03-18