Incidental Mutation 'R3727:Or2j3'
ID 270849
Institutional Source Beutler Lab
Gene Symbol Or2j3
Ensembl Gene ENSMUSG00000054940
Gene Name olfactory receptor family 2 subfamily J member 3
Synonyms Olfr137, MOR256-18, GA_x6K02T2PSCP-2749525-2748587
MMRRC Submission 040718-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.469) question?
Stock # R3727 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38615412-38616350 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38616310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 14 (I14N)
Ref Sequence ENSEMBL: ENSMUSP00000150173 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057394] [ENSMUST00000213505]
AlphaFold Q8VFC2
Predicted Effect possibly damaging
Transcript: ENSMUST00000057394
AA Change: I14N

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000051537
Gene: ENSMUSG00000054940
AA Change: I14N

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 4e-49 PFAM
Pfam:7tm_1 42 291 4.5e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213505
AA Change: I14N

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.4411 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago2 C T 15: 72,985,706 (GRCm39) V630M probably damaging Het
Alk T C 17: 72,208,395 (GRCm39) probably benign Het
Atp6v0a1 T A 11: 100,921,246 (GRCm39) S243T probably benign Het
BC035044 C A 6: 128,867,822 (GRCm39) G37* probably null Het
C3 G T 17: 57,514,379 (GRCm39) N1435K possibly damaging Het
Caly T C 7: 139,650,417 (GRCm39) E175G probably damaging Het
Ccng2 T C 5: 93,422,810 (GRCm39) F330S probably damaging Het
Cemip2 G A 19: 21,822,075 (GRCm39) A1157T probably benign Het
Cyp2c38 A G 19: 39,380,739 (GRCm39) probably benign Het
Cypt1 T A X: 16,389,674 (GRCm39) L128* probably null Het
Dmgdh A G 13: 93,828,575 (GRCm39) N239D probably damaging Het
Dnah8 C T 17: 30,958,622 (GRCm39) Q2155* probably null Het
Dpp3 A G 19: 4,973,213 (GRCm39) I127T probably benign Het
Eps15 G T 4: 109,227,882 (GRCm39) probably benign Het
Exosc10 A G 4: 148,649,734 (GRCm39) D388G probably damaging Het
Flt3 C A 5: 147,291,733 (GRCm39) R572S probably damaging Het
Gm44501 T C 17: 40,887,506 (GRCm39) F8S unknown Het
Hormad2 C A 11: 4,358,598 (GRCm39) G270C probably benign Het
Ifrd2 C T 9: 107,468,881 (GRCm39) R40* probably null Het
Ina G A 19: 47,004,158 (GRCm39) R322H possibly damaging Het
Kif13b A G 14: 65,003,197 (GRCm39) probably benign Het
Lrp2 T C 2: 69,340,773 (GRCm39) N1034S probably damaging Het
Macf1 T A 4: 123,353,104 (GRCm39) E1770V probably damaging Het
Mpi T C 9: 57,452,132 (GRCm39) I381M possibly damaging Het
Nfix CAAAAA CAAAA 8: 85,442,876 (GRCm39) probably null Het
Nt5c C T 11: 115,381,474 (GRCm39) W185* probably null Het
Or2y1e G A 11: 49,218,622 (GRCm39) R128H probably benign Het
Pcdhga9 G A 18: 37,871,995 (GRCm39) R608H probably benign Het
Pdzrn3 T A 6: 101,133,906 (GRCm39) D441V probably damaging Het
Rab42 A G 4: 132,029,964 (GRCm39) M86T probably benign Het
Slc52a3 C T 2: 151,847,701 (GRCm39) P270S probably benign Het
Stpg2 T C 3: 139,004,257 (GRCm39) F278S probably damaging Het
Styxl2 G A 1: 165,927,075 (GRCm39) R846C probably damaging Het
Tmem240 T C 4: 155,824,235 (GRCm39) probably benign Het
Vmn2r22 A G 6: 123,627,584 (GRCm39) L4P possibly damaging Het
Vmn2r95 C T 17: 18,661,744 (GRCm39) Q497* probably null Het
Wnk1 T C 6: 119,969,414 (GRCm39) H347R probably damaging Het
Zmym2 A T 14: 57,156,806 (GRCm39) probably benign Het
Other mutations in Or2j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02131:Or2j3 APN 17 38,615,539 (GRCm39) missense probably benign 0.03
IGL03169:Or2j3 APN 17 38,615,992 (GRCm39) missense probably damaging 1.00
IGL03392:Or2j3 APN 17 38,615,786 (GRCm39) missense probably benign 0.02
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0496:Or2j3 UTSW 17 38,615,549 (GRCm39) missense probably damaging 0.99
R0761:Or2j3 UTSW 17 38,616,282 (GRCm39) missense probably benign 0.00
R1126:Or2j3 UTSW 17 38,615,579 (GRCm39) missense probably damaging 0.97
R1835:Or2j3 UTSW 17 38,616,203 (GRCm39) missense probably benign 0.02
R5556:Or2j3 UTSW 17 38,615,964 (GRCm39) missense possibly damaging 0.71
R5979:Or2j3 UTSW 17 38,616,083 (GRCm39) missense probably benign
R6430:Or2j3 UTSW 17 38,616,249 (GRCm39) missense probably benign 0.04
R6433:Or2j3 UTSW 17 38,616,304 (GRCm39) missense probably damaging 1.00
R7400:Or2j3 UTSW 17 38,616,222 (GRCm39) missense possibly damaging 0.91
R8053:Or2j3 UTSW 17 38,616,101 (GRCm39) missense probably benign
R8199:Or2j3 UTSW 17 38,615,444 (GRCm39) missense probably benign 0.31
R8446:Or2j3 UTSW 17 38,615,638 (GRCm39) missense probably benign 0.01
R8865:Or2j3 UTSW 17 38,615,872 (GRCm39) missense probably damaging 0.97
R9116:Or2j3 UTSW 17 38,615,654 (GRCm39) missense probably benign 0.01
R9756:Or2j3 UTSW 17 38,615,971 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TTTTCTTTGGGCCCCAGAGG -3'
(R):5'- AGAAATTGTTTGCTTTCACCACTC -3'

Sequencing Primer
(F):5'- CTTTGGGCCCCAGAGGTTAAATAG -3'
(R):5'- AATTGTTTGCTTTCACCACTCATCAG -3'
Posted On 2015-03-18