Incidental Mutation 'R3552:Vmn1r38'
ID 268989
Institutional Source Beutler Lab
Gene Symbol Vmn1r38
Ensembl Gene ENSMUSG00000115170
Gene Name vomeronasal 1 receptor 38
Synonyms V1rc13
MMRRC Submission 040669-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # R3552 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 66753206-66754114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66753477 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 213 (H213R)
Ref Sequence ENSEMBL: ENSMUSP00000154495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176121] [ENSMUST00000226457] [ENSMUST00000227493] [ENSMUST00000227694]
AlphaFold Q8R2E1
Predicted Effect possibly damaging
Transcript: ENSMUST00000176121
AA Change: H213R

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000135117
Gene: ENSMUSG00000093632
AA Change: H213R

DomainStartEndE-ValueType
Pfam:V1R 28 293 3.7e-53 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226457
AA Change: H213R

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227493
AA Change: H213R

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227694
AA Change: H213R

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,152,450 (GRCm39) Y866N probably damaging Het
Agk A G 6: 40,371,615 (GRCm39) T371A probably benign Het
Akna T C 4: 63,316,361 (GRCm39) M1V probably null Het
Aldh7a1 T C 18: 56,683,364 (GRCm39) probably null Het
Ankrd26 A T 6: 118,484,737 (GRCm39) L1500H probably damaging Het
Atp13a5 T A 16: 29,129,584 (GRCm39) D452V probably damaging Het
Bahcc1 C T 11: 120,167,598 (GRCm39) T1333M possibly damaging Het
Carmil3 G T 14: 55,744,859 (GRCm39) R1276L possibly damaging Het
Ccni T C 5: 93,335,620 (GRCm39) S173G probably benign Het
Chrm2 A T 6: 36,500,745 (GRCm39) I201F probably damaging Het
Col16a1 A G 4: 129,970,834 (GRCm39) T618A probably benign Het
Dele1 A G 18: 38,391,418 (GRCm39) probably benign Het
Dock2 T C 11: 34,611,787 (GRCm39) Y192C probably benign Het
Ep400 T A 5: 110,877,153 (GRCm39) E821V unknown Het
Esrrg G A 1: 187,882,387 (GRCm39) V215I probably benign Het
Evx1 A T 6: 52,293,908 (GRCm39) S359C probably damaging Het
Fcrl2 A G 3: 87,166,717 (GRCm39) I92T possibly damaging Het
Gal3st1 T A 11: 3,948,110 (GRCm39) F106I possibly damaging Het
Gm9944 T C 4: 144,179,613 (GRCm39) probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hrc G C 7: 44,985,757 (GRCm39) E303Q possibly damaging Het
Kcnh1 A G 1: 191,921,074 (GRCm39) N118D probably damaging Het
Khdrbs1 A G 4: 129,614,584 (GRCm39) I323T possibly damaging Het
Klhdc7b T C 15: 89,271,724 (GRCm39) Y869H probably benign Het
Lrrc4c T A 2: 97,460,306 (GRCm39) W311R probably damaging Het
Megf11 A G 9: 64,602,745 (GRCm39) D862G possibly damaging Het
Muc5b A G 7: 141,415,072 (GRCm39) T2673A possibly damaging Het
Muc5b A G 7: 141,421,442 (GRCm39) S4311G probably benign Het
Myo15a C T 11: 60,400,489 (GRCm39) A1767V possibly damaging Het
Neo1 T A 9: 58,801,161 (GRCm39) K1140M probably damaging Het
Oc90 T C 15: 65,750,650 (GRCm39) Q365R possibly damaging Het
Oplah C T 15: 76,186,294 (GRCm39) D734N possibly damaging Het
Or1e19 T C 11: 73,316,678 (GRCm39) I44V probably benign Het
Or4c58 A C 2: 89,674,687 (GRCm39) M210R possibly damaging Het
Or9g3 T C 2: 85,590,237 (GRCm39) N161S possibly damaging Het
Pbx1 G A 1: 167,986,362 (GRCm39) P411L possibly damaging Het
Pcdhga6 G T 18: 37,841,270 (GRCm39) R330L probably benign Het
Phox2b C A 5: 67,254,999 (GRCm39) R150L probably damaging Het
Plscr2 A G 9: 92,172,848 (GRCm39) E169G probably damaging Het
Ptprn2 A T 12: 116,852,497 (GRCm39) Q518L probably benign Het
Rbl1 A T 2: 157,037,505 (GRCm39) I214K probably benign Het
Ryr1 T A 7: 28,756,422 (GRCm39) Q3464L probably damaging Het
Ryr3 T A 2: 112,582,132 (GRCm39) I2854F probably damaging Het
Shtn1 T C 19: 58,963,470 (GRCm39) Y615C probably benign Het
Sirt5 A T 13: 43,536,643 (GRCm39) N226Y probably damaging Het
Slc30a3 G A 5: 31,252,422 (GRCm39) probably benign Het
Slc5a4b A G 10: 75,917,358 (GRCm39) V226A probably damaging Het
Slf2 C A 19: 44,923,390 (GRCm39) S68* probably null Het
Smyd5 G A 6: 85,419,193 (GRCm39) E292K probably damaging Het
Spns1 A G 7: 125,969,543 (GRCm39) V512A possibly damaging Het
Sry T A Y: 2,663,141 (GRCm39) Q173L unknown Het
Ssrp1 C A 2: 84,874,736 (GRCm39) Q519K probably benign Het
Tgfbr3 T C 5: 107,287,705 (GRCm39) E498G probably damaging Het
Tnrc6b T G 15: 80,764,448 (GRCm39) L650W probably damaging Het
Tnxb A T 17: 34,937,695 (GRCm39) E3861D probably damaging Het
Trbc1 G T 6: 41,516,579 (GRCm39) probably benign Het
Trpm7 T A 2: 126,668,630 (GRCm39) probably benign Het
Usp39 G A 6: 72,314,815 (GRCm39) T197I possibly damaging Het
Washc2 A G 6: 116,197,529 (GRCm39) D168G probably damaging Het
Washc4 A G 10: 83,382,720 (GRCm39) I45V probably benign Het
Zfp352 A G 4: 90,113,339 (GRCm39) E493G probably benign Het
Zfp692 C T 11: 58,200,254 (GRCm39) T170I possibly damaging Het
Zfp735 C A 11: 73,602,067 (GRCm39) S337* probably null Het
Other mutations in Vmn1r38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01892:Vmn1r38 APN 6 66,753,360 (GRCm39) missense probably benign 0.00
IGL02471:Vmn1r38 APN 6 66,753,751 (GRCm39) missense probably benign 0.06
R0483:Vmn1r38 UTSW 6 66,753,979 (GRCm39) missense probably benign 0.10
R0890:Vmn1r38 UTSW 6 66,753,514 (GRCm39) missense probably benign 0.01
R1242:Vmn1r38 UTSW 6 66,753,344 (GRCm39) nonsense probably null
R1557:Vmn1r38 UTSW 6 66,753,370 (GRCm39) missense probably benign 0.01
R2266:Vmn1r38 UTSW 6 66,753,433 (GRCm39) missense probably benign 0.02
R2320:Vmn1r38 UTSW 6 66,753,534 (GRCm39) missense possibly damaging 0.94
R2568:Vmn1r38 UTSW 6 66,753,955 (GRCm39) missense probably benign 0.00
R3104:Vmn1r38 UTSW 6 66,753,430 (GRCm39) missense probably benign 0.31
R3792:Vmn1r38 UTSW 6 66,753,891 (GRCm39) missense probably benign 0.01
R4061:Vmn1r38 UTSW 6 66,753,832 (GRCm39) missense possibly damaging 0.87
R4532:Vmn1r38 UTSW 6 66,754,016 (GRCm39) missense probably benign 0.38
R5299:Vmn1r38 UTSW 6 66,753,682 (GRCm39) missense probably benign 0.06
R7173:Vmn1r38 UTSW 6 66,753,278 (GRCm39) missense possibly damaging 0.88
R8044:Vmn1r38 UTSW 6 66,753,516 (GRCm39) missense probably benign 0.12
R8935:Vmn1r38 UTSW 6 66,753,979 (GRCm39) missense probably benign 0.12
R9144:Vmn1r38 UTSW 6 66,753,612 (GRCm39) missense probably benign 0.21
X0022:Vmn1r38 UTSW 6 66,754,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTAATTGTGGGATAGGCATTCAAC -3'
(R):5'- CTATACTGGTGCTTATATCAACGTG -3'

Sequencing Primer
(F):5'- GGATAGGCATTCAACACAAACTTCTG -3'
(R):5'- CGTGAGTGAGACCAACCAG -3'
Posted On 2015-02-19