Incidental Mutation 'R3618:Larp1'
ID 268524
Institutional Source Beutler Lab
Gene Symbol Larp1
Ensembl Gene ENSMUSG00000037331
Gene Name La ribonucleoprotein 1, translational regulator
Synonyms Larp, 3110040D16Rik, 1810024J12Rik
MMRRC Submission 040675-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3618 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 57899890-57952860 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 57948172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 990 (E990D)
Ref Sequence ENSEMBL: ENSMUSP00000136673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071487] [ENSMUST00000178636]
AlphaFold Q6ZQ58
Predicted Effect probably benign
Transcript: ENSMUST00000071487
AA Change: E990D

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000071421
Gene: ENSMUSG00000037331
AA Change: E990D

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 37 87 N/A INTRINSIC
low complexity region 106 120 N/A INTRINSIC
low complexity region 122 136 N/A INTRINSIC
low complexity region 304 331 N/A INTRINSIC
LA 376 452 1.98e-40 SMART
low complexity region 538 555 N/A INTRINSIC
low complexity region 562 571 N/A INTRINSIC
low complexity region 575 589 N/A INTRINSIC
low complexity region 758 766 N/A INTRINSIC
DM15 861 902 7.3e-20 SMART
DM15 903 941 3.85e-19 SMART
DM15 942 977 8.59e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178636
AA Change: E990D

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000136673
Gene: ENSMUSG00000037331
AA Change: E990D

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 37 87 N/A INTRINSIC
low complexity region 106 120 N/A INTRINSIC
low complexity region 122 136 N/A INTRINSIC
low complexity region 304 331 N/A INTRINSIC
LA 376 452 1.98e-40 SMART
low complexity region 538 555 N/A INTRINSIC
low complexity region 562 571 N/A INTRINSIC
low complexity region 575 589 N/A INTRINSIC
low complexity region 758 766 N/A INTRINSIC
DM15 861 902 7.3e-20 SMART
DM15 903 941 3.85e-19 SMART
DM15 942 977 8.59e-1 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,774,168 (GRCm39) E1119G probably damaging Het
Ahnak2 A G 12: 112,749,842 (GRCm39) I132T probably damaging Het
Arhgap29 G A 3: 121,782,176 (GRCm39) D63N possibly damaging Het
Bsn T A 9: 107,994,760 (GRCm39) probably null Het
Cfap161 A C 7: 83,429,390 (GRCm39) Y209* probably null Het
Drp2 A C X: 133,340,717 (GRCm39) D458A probably benign Het
Efcab6 T C 15: 83,834,270 (GRCm39) H446R probably benign Het
Enpep G C 3: 129,077,807 (GRCm39) S603R possibly damaging Het
F13a1 G A 13: 37,127,967 (GRCm39) T337I probably damaging Het
Fhod3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 18: 25,153,722 (GRCm39) probably benign Het
Hcfc1 A T X: 72,993,694 (GRCm39) V1157D probably benign Het
Inava A C 1: 136,142,110 (GRCm39) V663G probably benign Het
Ino80 T C 2: 119,277,353 (GRCm39) D374G probably null Het
Kif1a T C 1: 93,004,765 (GRCm39) E143G probably null Het
Larp7 C A 3: 127,330,614 (GRCm39) E568* probably null Het
Ltn1 A T 16: 87,217,787 (GRCm39) S298R probably damaging Het
Mcm10 A G 2: 5,001,913 (GRCm39) probably null Het
Mef2a G A 7: 66,918,075 (GRCm39) S111L probably benign Het
Mroh1 A G 15: 76,336,546 (GRCm39) T1590A possibly damaging Het
Ncoa6 A T 2: 155,249,709 (GRCm39) H1198Q possibly damaging Het
Ogg1 A G 6: 113,305,334 (GRCm39) E49G probably damaging Het
Palm3 T A 8: 84,755,973 (GRCm39) V495E probably benign Het
Pam A G 1: 97,762,157 (GRCm39) F809L probably damaging Het
Parp3 T C 9: 106,352,262 (GRCm39) E88G possibly damaging Het
Ptprs A G 17: 56,735,965 (GRCm39) I156T probably benign Het
Pus7l T A 15: 94,425,788 (GRCm39) I538F probably damaging Het
Rgs8 A G 1: 153,566,742 (GRCm39) T98A probably null Het
Ryr2 C T 13: 11,787,466 (GRCm39) probably null Het
Slc8a2 A G 7: 15,886,824 (GRCm39) N656D possibly damaging Het
Stard9 C T 2: 120,529,500 (GRCm39) T1919I possibly damaging Het
Tbcel T C 9: 42,372,591 (GRCm39) probably benign Het
Trpv3 A T 11: 73,186,281 (GRCm39) I691F probably damaging Het
Uba2 A G 7: 33,853,907 (GRCm39) probably null Het
Usp53 A C 3: 122,728,061 (GRCm39) S840R probably benign Het
Vmn2r100 A T 17: 19,743,692 (GRCm39) I452F probably benign Het
Zbtb48 A T 4: 152,110,484 (GRCm39) probably null Het
Zfp385b G A 2: 77,246,233 (GRCm39) P177S probably benign Het
Zfp42 T C 8: 43,748,938 (GRCm39) R188G possibly damaging Het
Other mutations in Larp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01537:Larp1 APN 11 57,933,648 (GRCm39) missense possibly damaging 0.91
IGL02114:Larp1 APN 11 57,947,881 (GRCm39) missense probably damaging 1.00
IGL03084:Larp1 APN 11 57,947,921 (GRCm39) missense probably damaging 1.00
IGL03126:Larp1 APN 11 57,941,703 (GRCm39) missense possibly damaging 0.65
IGL03278:Larp1 APN 11 57,934,882 (GRCm39) splice site probably benign
Bayou UTSW 11 57,949,422 (GRCm39) frame shift probably null
R0009:Larp1 UTSW 11 57,946,299 (GRCm39) missense possibly damaging 0.94
R0020:Larp1 UTSW 11 57,940,849 (GRCm39) missense probably damaging 1.00
R0479:Larp1 UTSW 11 57,933,646 (GRCm39) missense possibly damaging 0.92
R0845:Larp1 UTSW 11 57,938,576 (GRCm39) missense probably benign 0.00
R1691:Larp1 UTSW 11 57,938,874 (GRCm39) missense probably benign 0.08
R1793:Larp1 UTSW 11 57,940,764 (GRCm39) missense possibly damaging 0.60
R4689:Larp1 UTSW 11 57,932,439 (GRCm39) missense probably damaging 1.00
R4797:Larp1 UTSW 11 57,938,806 (GRCm39) nonsense probably null
R5089:Larp1 UTSW 11 57,938,693 (GRCm39) missense possibly damaging 0.92
R5309:Larp1 UTSW 11 57,941,634 (GRCm39) missense possibly damaging 0.72
R5883:Larp1 UTSW 11 57,933,125 (GRCm39) missense probably damaging 0.97
R5951:Larp1 UTSW 11 57,940,765 (GRCm39) missense probably benign 0.14
R6038:Larp1 UTSW 11 57,932,431 (GRCm39) missense possibly damaging 0.68
R6038:Larp1 UTSW 11 57,932,431 (GRCm39) missense possibly damaging 0.68
R6266:Larp1 UTSW 11 57,933,089 (GRCm39) missense probably damaging 0.99
R6350:Larp1 UTSW 11 57,940,657 (GRCm39) missense probably benign 0.14
R6650:Larp1 UTSW 11 57,949,422 (GRCm39) frame shift probably null
R6687:Larp1 UTSW 11 57,948,156 (GRCm39) missense probably damaging 0.99
R6736:Larp1 UTSW 11 57,933,473 (GRCm39) splice site probably null
R6881:Larp1 UTSW 11 57,940,849 (GRCm39) missense probably damaging 1.00
R7368:Larp1 UTSW 11 57,938,904 (GRCm39) missense probably damaging 1.00
R7547:Larp1 UTSW 11 57,943,405 (GRCm39) critical splice acceptor site probably null
R7838:Larp1 UTSW 11 57,938,540 (GRCm39) missense possibly damaging 0.82
R8260:Larp1 UTSW 11 57,949,515 (GRCm39) missense probably benign 0.05
R8446:Larp1 UTSW 11 57,942,035 (GRCm39) critical splice donor site probably null
R9381:Larp1 UTSW 11 57,949,532 (GRCm39) missense probably benign
R9450:Larp1 UTSW 11 57,941,890 (GRCm39) missense probably damaging 1.00
R9466:Larp1 UTSW 11 57,943,461 (GRCm39) missense possibly damaging 0.96
Z1177:Larp1 UTSW 11 57,940,613 (GRCm39) nonsense probably null
Z1186:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1187:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1188:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1189:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1190:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1191:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1192:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGTAAGAGTGTCAGAGCTGC -3'
(R):5'- TGACACAAACTAGTAGTAGTGGGC -3'

Sequencing Primer
(F):5'- TGTCAGAGCTGCGGGAG -3'
(R):5'- CTAGTAGTAGTGGGCCTGGATAAGC -3'
Posted On 2015-02-19