Incidental Mutation 'R3618:Zfp42'
ID 268519
Institutional Source Beutler Lab
Gene Symbol Zfp42
Ensembl Gene ENSMUSG00000051176
Gene Name zinc finger protein 42
Synonyms Rex-1, Rex1, Zfp-42
MMRRC Submission 040675-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3618 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 43748100-43760017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 43748938 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 188 (R188G)
Ref Sequence ENSEMBL: ENSMUSP00000147606 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082120] [ENSMUST00000209356] [ENSMUST00000211248]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000082120
AA Change: R188G

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000080765
Gene: ENSMUSG00000051176
AA Change: R188G

DomainStartEndE-ValueType
low complexity region 111 122 N/A INTRINSIC
ZnF_C2H2 170 194 6.88e-4 SMART
ZnF_C2H2 199 221 2.2e-2 SMART
ZnF_C2H2 227 251 3.95e-4 SMART
ZnF_C2H2 257 281 1.67e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000209356
AA Change: R188G

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000211248
AA Change: R188G

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for one knock-out allele exhibit premature age-related male germ cell loss, abnormal sperm morphology, and mild testicular atrophy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,774,168 (GRCm39) E1119G probably damaging Het
Ahnak2 A G 12: 112,749,842 (GRCm39) I132T probably damaging Het
Arhgap29 G A 3: 121,782,176 (GRCm39) D63N possibly damaging Het
Bsn T A 9: 107,994,760 (GRCm39) probably null Het
Cfap161 A C 7: 83,429,390 (GRCm39) Y209* probably null Het
Drp2 A C X: 133,340,717 (GRCm39) D458A probably benign Het
Efcab6 T C 15: 83,834,270 (GRCm39) H446R probably benign Het
Enpep G C 3: 129,077,807 (GRCm39) S603R possibly damaging Het
F13a1 G A 13: 37,127,967 (GRCm39) T337I probably damaging Het
Fhod3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 18: 25,153,722 (GRCm39) probably benign Het
Hcfc1 A T X: 72,993,694 (GRCm39) V1157D probably benign Het
Inava A C 1: 136,142,110 (GRCm39) V663G probably benign Het
Ino80 T C 2: 119,277,353 (GRCm39) D374G probably null Het
Kif1a T C 1: 93,004,765 (GRCm39) E143G probably null Het
Larp1 A T 11: 57,948,172 (GRCm39) E990D probably benign Het
Larp7 C A 3: 127,330,614 (GRCm39) E568* probably null Het
Ltn1 A T 16: 87,217,787 (GRCm39) S298R probably damaging Het
Mcm10 A G 2: 5,001,913 (GRCm39) probably null Het
Mef2a G A 7: 66,918,075 (GRCm39) S111L probably benign Het
Mroh1 A G 15: 76,336,546 (GRCm39) T1590A possibly damaging Het
Ncoa6 A T 2: 155,249,709 (GRCm39) H1198Q possibly damaging Het
Ogg1 A G 6: 113,305,334 (GRCm39) E49G probably damaging Het
Palm3 T A 8: 84,755,973 (GRCm39) V495E probably benign Het
Pam A G 1: 97,762,157 (GRCm39) F809L probably damaging Het
Parp3 T C 9: 106,352,262 (GRCm39) E88G possibly damaging Het
Ptprs A G 17: 56,735,965 (GRCm39) I156T probably benign Het
Pus7l T A 15: 94,425,788 (GRCm39) I538F probably damaging Het
Rgs8 A G 1: 153,566,742 (GRCm39) T98A probably null Het
Ryr2 C T 13: 11,787,466 (GRCm39) probably null Het
Slc8a2 A G 7: 15,886,824 (GRCm39) N656D possibly damaging Het
Stard9 C T 2: 120,529,500 (GRCm39) T1919I possibly damaging Het
Tbcel T C 9: 42,372,591 (GRCm39) probably benign Het
Trpv3 A T 11: 73,186,281 (GRCm39) I691F probably damaging Het
Uba2 A G 7: 33,853,907 (GRCm39) probably null Het
Usp53 A C 3: 122,728,061 (GRCm39) S840R probably benign Het
Vmn2r100 A T 17: 19,743,692 (GRCm39) I452F probably benign Het
Zbtb48 A T 4: 152,110,484 (GRCm39) probably null Het
Zfp385b G A 2: 77,246,233 (GRCm39) P177S probably benign Het
Other mutations in Zfp42
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0325:Zfp42 UTSW 8 43,748,988 (GRCm39) missense probably damaging 0.98
R0648:Zfp42 UTSW 8 43,749,015 (GRCm39) missense probably benign
R1494:Zfp42 UTSW 8 43,748,638 (GRCm39) missense possibly damaging 0.96
R4695:Zfp42 UTSW 8 43,749,168 (GRCm39) missense probably damaging 0.99
R4877:Zfp42 UTSW 8 43,748,725 (GRCm39) missense possibly damaging 0.94
R6683:Zfp42 UTSW 8 43,749,093 (GRCm39) missense possibly damaging 0.88
R6684:Zfp42 UTSW 8 43,749,093 (GRCm39) missense possibly damaging 0.88
R6685:Zfp42 UTSW 8 43,749,093 (GRCm39) missense possibly damaging 0.88
R7264:Zfp42 UTSW 8 43,749,312 (GRCm39) missense probably damaging 0.96
R9297:Zfp42 UTSW 8 43,748,772 (GRCm39) missense possibly damaging 0.92
R9608:Zfp42 UTSW 8 43,749,172 (GRCm39) missense possibly damaging 0.70
Z1088:Zfp42 UTSW 8 43,748,842 (GRCm39) missense probably benign 0.37
Z1176:Zfp42 UTSW 8 43,749,277 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- ATGGGTGCGCAAGTTGAAATC -3'
(R):5'- CAGGTTCTGGAAGCGAGTTC -3'

Sequencing Primer
(F):5'- ATCCAGGGAGAAGCGCTTC -3'
(R):5'- CTTCTTTGGAGTACATGACAAAGGG -3'
Posted On 2015-02-19